Thomas H Gillingwater

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor
    Helen J Newbery
    Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neuropathol Exp Neurol 64:295-303. 2005
  2. pmc Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose
    Ann K Wright
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e15108. 2010
  3. pmc Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research
    Laura H Comley
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, Lothian, United Kingdom
    PLoS ONE 6:e17639. 2011
  4. pmc Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy
    Sophie R Thomson
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e52605. 2012
  5. pmc Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?
    Thomas H Gillingwater
    School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 165:858-60. 2012
  6. pmc Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues
    Thomas M Wishart
    Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh EH89XD, UK
    BMC Neurosci 10:148. 2009
  7. ncbi request reprint Myo-GDNF increases non-functional polyinnervation of reinnervated mouse muscle
    Thomas H Gillingwater
    Division of Neuroscience, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    Neuroreport 15:21-5. 2004
  8. ncbi request reprint Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice
    Thomas H Gillingwater
    Division of Neuroscience, University of Edinburgh, Edinburgh, UK
    J Cereb Blood Flow Metab 24:62-6. 2004
  9. ncbi request reprint Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion
    Thomas H Gillingwater
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    Brain 129:1546-56. 2006
  10. ncbi request reprint The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells
    Thomas H Gillingwater
    Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    Hum Mol Genet 15:625-35. 2006

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor
    Helen J Newbery
    Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neuropathol Exp Neurol 64:295-303. 2005
    ..The early initiation and rapid progression of motor unit degeneration in wst/wst mice suggest that they should be considered an important and accessible model of early-onset motor neuron degeneration in humans...
  2. pmc Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose
    Ann K Wright
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e15108. 2010
    ....
  3. pmc Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research
    Laura H Comley
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, Lothian, United Kingdom
    PLoS ONE 6:e17639. 2011
    ..However, these mice are often used under the assumption that the fluorescent proteins present are biologically inert...
  4. pmc Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy
    Sophie R Thomson
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e52605. 2012
    ..This suggests that subtle molecular differences between motor neurons, or extrinsic factors arising from other cell types, are more likely to determine relative susceptibility in SMA...
  5. pmc Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?
    Thomas H Gillingwater
    School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 165:858-60. 2012
    ..LINKED ARTICLE This article is a commentary on Rossi et al., pp. 861-869 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476-5381.2011.01579.x...
  6. pmc Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues
    Thomas M Wishart
    Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh EH89XD, UK
    BMC Neurosci 10:148. 2009
    ..This may be of particular importance for the development and application of neuroprotective therapeutic strategies based around Wld(S)-mediated pathways designed for use in human patients...
  7. ncbi request reprint Myo-GDNF increases non-functional polyinnervation of reinnervated mouse muscle
    Thomas H Gillingwater
    Division of Neuroscience, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    Neuroreport 15:21-5. 2004
    ..Thus, myo-GDNF over-expression enhances reinnervation, but at the expense of both neurofilament integrity, and functional reliability...
  8. ncbi request reprint Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice
    Thomas H Gillingwater
    Division of Neuroscience, University of Edinburgh, Edinburgh, UK
    J Cereb Blood Flow Metab 24:62-6. 2004
    ..0%; wild-type mice, 41.9 +/- 28.0%; P < 0.023). Thus, these results clearly demonstrate that the Wld gene confers substantial neuroprotection after cerebral ischemia, and suggest a new role to that previously described for Wld(s)...
  9. ncbi request reprint Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion
    Thomas H Gillingwater
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    Brain 129:1546-56. 2006
    ..The data suggest that targeting Wallerian-like mechanisms of synaptic degeneration could lead to the development of new therapies for the treatment of CNS disorders where synapse loss is a primary feature...
  10. ncbi request reprint The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells
    Thomas H Gillingwater
    Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    Hum Mol Genet 15:625-35. 2006
    ..Targeting Wld(S)-induced gene expression may lead to novel therapies for neurodegeneration induced by trauma or by disease in humans...
  11. pmc Ultrastructural correlates of synapse withdrawal at axotomized neuromuscular junctions in mutant and transgenic mice expressing the Wld gene
    Thomas H Gillingwater
    Department of Neuroscience, University of Edinburgh, UK
    J Anat 203:265-76. 2003
    ..These findings suggest that the Wld gene interacts with the mechanisms regulating transmitter release and vesicle recycling...
  12. doi request reprint The importance of exposure to human material in anatomical education: a philosophical perspective
    Thomas H Gillingwater
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Anat Sci Educ 1:264-6. 2008
    ..These insights support the hypothesis that direct experience of human material is required for "deep," rather than "superficial," understanding of anatomy...
  13. ncbi request reprint Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy
    Lyndsay M Murray
    Centre for Integrative Physiology, University of Edinburgh Medical School, Edinburgh EH8 9XD, UK
    Hum Mol Genet 17:949-62. 2008
    ....
  14. pmc Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying-back neuronal pathology
    Lyndsay M Murray
    Centre for Integrative Physiology, College of Medicine, and Veterinary Medicine, University of Edinburgh, Edinburgh, EH8 9XD, UK
    J Anat 213:633-45. 2008
    ....
  15. pmc Age-dependent synapse withdrawal at axotomised neuromuscular junctions in Wld(s) mutant and Ube4b/Nmnat transgenic mice
    Thomas H Gillingwater
    Department of Neuroscience, University of Edinburgh, Edinburgh, EH8 9JZ, UK
    J Physiol 543:739-55. 2002
    ..Thus, Wld expression unmasks age-dependent, compartmentally organised programmes of synapse withdrawal and degeneration...
  16. pmc Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo
    Thomas M Wishart
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 8:e1002936. 2012
    ..We propose that the proteins and functional pathways identified in the current study represent attractive targets for developing therapeutics aimed at modulating synaptic and axonal stability and neurodegeneration in vivo...
  17. pmc mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex
    Lasani S Wijetunge
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 28:13028-37. 2008
    ..Together these data indicate a key role for mGluR5 at both early and late stages of neuronal development in the trigeminal system of mice...
  18. ncbi request reprint Axotomy-dependent and -independent synapse elimination in organ cultures of Wld(s) mutant mouse skeletal muscle
    Simon H Parson
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds, UK
    J Neurosci Res 76:64-75. 2004
    ..This offers several advantages over repeated visualization of synaptic remodeling that has thus far been possible only in vivo...
  19. pmc ApoE isoform-specific regulation of regeneration in the peripheral nervous system
    Laura H Comley
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh EH8 9XD, UK
    Hum Mol Genet 20:2406-21. 2011
    ..Taken together, these findings have identified isoform-specific roles for apoE in determining the protein composition of peripheral nerve as well as regulating nerve regeneration pathways in vivo...
  20. ncbi request reprint Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation
    Richard R Ribchester
    Division of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, UK
    Eur J Neurosci 20:3092-114. 2004
    ..However, irrespective of the cause, the abnormalities at neuromuscular junctions we report here are likely to contribute to the pathological phenotype in R6/2 mice, particularly in late stages of the disease...
  21. pmc Rapid loss of motor nerve terminals following hypoxia-reperfusion injury occurs via mechanisms distinct from classic Wallerian degeneration
    Becki Baxter
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Old Medical School, Edinburgh, UK
    J Anat 212:827-35. 2008
    ....
  22. ncbi request reprint Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy
    Lyndsay M Murray
    Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh, UK
    Hum Mol Genet 19:420-33. 2010
    ....
  23. pmc Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease
    Catherine Kielar
    Department of Neuroscience, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, London SE5 9NU, UK
    Hum Mol Genet 18:4066-80. 2009
    ....
  24. doi request reprint Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions
    Felipe A Court
    Euan MacDonald Centre for Motor Neurone Disease Research, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    J Cell Sci 121:3901-11. 2008
    ..We conclude that NMJ-capping cells (proposed name 'kranocytes') represent a neglected, canonical cellular constituent of neuromuscular junctions where they could play a permissive role in synaptic regeneration...
  25. pmc SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy
    Thomas M Wishart
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh Medical School, Edinburgh, UK
    Hum Mol Genet 19:4216-28. 2010
    ..This study reveals novel roles for SMN protein in brain development and maintenance and provides the first insights into cellular and molecular pathways disrupted in the brain in a severe form of SMA...
  26. ncbi request reprint Involvement of protein kinase A in patterning of the mouse somatosensory cortex
    Ruth F Watson
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:5393-401. 2006
    ..These results give insight into activity-dependent mechanisms that regulate barrel formation...
  27. ncbi request reprint Synaptic vulnerability in neurodegenerative disease
    Thomas M Wishart
    Centre for Integrative Physiology and Centre for Neuroscience Research, University of Edinburgh Medical School, UK
    J Neuropathol Exp Neurol 65:733-9. 2006
    ....
  28. doi request reprint The response of neuromuscular junctions to injury is developmentally regulated
    Lyndsay M Murray
    Euan MacDonald Centre for Motor Neurone Disease Research and Centre for Integrative Physiology, University of Edinburgh Medical School, Edinburgh, UK
    FASEB J 25:1306-13. 2011
    ..We conclude that neonatal neuromuscular junctions are resistant to a range of neurodegenerative insults in vivo and that this resistance is developmentally regulated...
  29. ncbi request reprint Quantitative tractography and tract shape modeling in amyotrophic lateral sclerosis
    Mark E Bastin
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom Brain Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    J Magn Reson Imaging 38:1140-5. 2013
    ....
  30. doi request reprint Reversible molecular pathology of skeletal muscle in spinal muscular atrophy
    Chantal A Mutsaers
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    Hum Mol Genet 20:4334-44. 2011
    ..We conclude that intrinsic pathology of skeletal muscle is an important and reversible event in SMA and also suggest that muscle proteins have the potential to act as novel biomarkers in SMA...
  31. pmc Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene
    Thomas M Wishart
    Centres for Integrative Physiology, University of Edinburgh Medical School, Edinburgh EH8 9XD, United Kingdom
    Mol Cell Proteomics 6:1318-30. 2007
    ....
  32. pmc Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
    Sabine Koch
    Institute of Biomedicine Biochemistry and Neuroscience Center and Department of Biosciences and Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland
    J Neuropathol Exp Neurol 70:1089-96. 2011
    ....
  33. pmc Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?
    Sophie R Thomson
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    J Anat 220:122-30. 2012
    ....
  34. doi request reprint Increasing SMN levels using the histone deacetylase inhibitor SAHA ameliorates defects in skeletal muscle microvasculature in a mouse model of severe spinal muscular atrophy
    Eilidh Somers
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    Neurosci Lett 544:100-4. 2013
    ..SAHA significantly increases SMN levels and also increased vascular density in SMA mice (P<0.05), suggesting that the vascular defect in SMA mice is amenable to SAHA treatment...
  35. doi request reprint Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome
    Sally M Till
    Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, UK
    Hum Mol Genet 21:2143-56. 2012
    ..Instead, our results suggest that inaccurate timing of developmental processes caused by the loss of FMRP may lead to alterations in neural circuitry that underlie behavioral and cognitive dysfunctions associated with FXS...
  36. pmc Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)
    Thomas M Wishart
    Centre for Integrative Physiology, University of Edinburgh Medical School, Edinburgh, UK
    Genome Biol 9:R101. 2008
    ....
  37. pmc Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene
    Thomas M Wishart
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
    Mol Neurodegener 2:21. 2007
    ..Current approaches to genotype Wlds mice are based on either Southern blots or pulsed field gel electrophoresis, neither of which are as rapid or efficient as quantitative PCR (QPCR)...
  38. ncbi request reprint The relationship of neuromuscular synapse elimination to synaptic degeneration and pathology: insights from WldS and other mutant mice
    Thomas H Gillingwater
    Division of Neuroscience, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK
    J Neurocytol 32:863-81. 2003
    ....
  39. doi request reprint Effect of limb lengthening on internodal length and conduction velocity of peripheral nerve
    A Hamish Simpson
    Department of Orthopaedic Surgery, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Neurosci 33:4536-9. 2013
    ....
  40. doi request reprint VAPB interacts with and modulates the activity of ATF6
    Christos Gkogkas
    The Centre for Neuroscience Research, The University of Edinburgh, The Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Hum Mol Genet 17:1517-26. 2008
    ..The mis-function of such regulatory systems may contribute to the pathological mechanisms of degenerative motor neuron disease...
  41. ncbi request reprint A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton
    Sarah M Carpanini
    MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK
    Dis Model Mech 7:711-22. 2014
    ....
  42. doi request reprint Development of a supported self-directed learning approach for anatomy education
    Gordon S Findlater
    School of Biomedical Sciences Anatomy, University of Edinburgh, Edinburgh, United Kingdom
    Anat Sci Educ 5:114-21. 2012
    ..We conclude that the introduction of supported self-directed learning improved students' engagement, leading to deeper learning and better understanding and knowledge of anatomy...
  43. doi request reprint Spinal muscular atrophy: going beyond the motor neuron
    Gillian Hamilton
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    Trends Mol Med 19:40-50. 2013
    ....
  44. doi request reprint A neurological phenotype in mice with DNA repair gene Ercc1 deficiency
    Nicola J Lawrence
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    DNA Repair (Amst) 7:281-91. 2008
    ..The structural changes observed in the brains of liver-corrected Ercc1 knockouts appear to be a secondary consequence of kidney failure arising from Ercc1 deficiency...
  45. ncbi request reprint Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice
    Mark W Barnett
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:1355-65. 2006
    ....
  46. ncbi request reprint SMN-dependent intrinsic defects in Schwann cells in mouse models of spinal muscular atrophy
    Gillian Hunter
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh EH16 4SB, UK and
    Hum Mol Genet 23:2235-50. 2014
    ....
  47. doi request reprint Executive deficits, not processing speed relates to abnormalities in distinct prefrontal tracts in amyotrophic lateral sclerosis
    Lewis D Pettit
    1 Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    Brain 136:3290-304. 2013
    ....
  48. pmc Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting
    Samantha L Eaton
    Division of Neurobiology, The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e72457. 2013
    ....
  49. pmc Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin
    Francesc X Soriano
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK
    Mol Cells 27:279-82. 2009
    ....
  50. ncbi request reprint The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
    Weiqian Mi
    ZMMK and Institute for Genetics, University of Cologne, Cologne, Germany
    Brain 128:405-16. 2005
    ..We conclude that axon degeneration mechanisms are more closely related than previously thought and that a link exists in gad between spheroid pathology and Wallerian degeneration that could hold for other disorders...
  51. ncbi request reprint A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses
    Robert Adalbert
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Eur J Neurosci 21:271-7. 2005
    ..Thus, the slow Wallerian degeneration phenotype can be transferred to another mammalian species and synapses may be more effectively preserved after axotomy in species with longer axons...
  52. ncbi request reprint Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis
    Sanna Partanen
    Institute of Biomedicine Biochemistry, University of Helsinki, Finland
    J Neuropathol Exp Neurol 67:16-29. 2008
    ....