K M Gillespie

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells
    Jody Ye
    Diabetes and Metabolism Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 9:e86985. 2014
  2. pmc Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis
    Yi Ye
    Learning and Research, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Rheumatology (Oxford) 51:987-91. 2012
  3. pmc Early-onset, coexisting autoimmunity and decreased HLA-mediated susceptibility are the characteristics of diabetes in Down syndrome
    Rachel J Aitken
    University of Bristol, Bristol, U K
    Diabetes Care 36:1181-5. 2013
  4. pmc Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury
    Andrew R L Medford
    Department of Clinical Science at North Bristol, University of Bristol Paul O Gorman Lifeline Centre, Southmead Hospital, Westbury on Trym, Bristol, UK
    Respir Res 10:27. 2009
  5. ncbi request reprint Islet autoimmunity in children with Down's syndrome
    Kathleen M Gillespie
    Medical School Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Diabetes 55:3185-8. 2006
  6. pmc Type 1 diabetes: pathogenesis and prevention
    Kathleen M Gillespie
    Department of Clinical Science at North Bristol, University of Bristol, UK
    CMAJ 175:165-70. 2006
  7. ncbi request reprint Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
    Kathleen M Gillespie
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetes 54:1245-8. 2005
  8. ncbi request reprint HLA class II typing of whole genome amplified mouth swab DNA
    K M Gillespie
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Tissue Antigens 56:530-8. 2000
  9. ncbi request reprint Three generations of autoimmune diabetes: an extended family study
    I F Douek
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetologia 46:1313-8. 2003
  10. doi request reprint Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2
    A J K Williams
    Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 51:1444-8. 2008

Collaborators

Detail Information

Publications27

  1. pmc Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells
    Jody Ye
    Diabetes and Metabolism Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 9:e86985. 2014
    ..The aim of this study was to define the cellular phenotype of MMc in control (n = 14) and type 1 diabetes pancreas (n = 8)...
  2. pmc Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis
    Yi Ye
    Learning and Research, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Rheumatology (Oxford) 51:987-91. 2012
    ..K. and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies and sections of muscle controls (age range 2-12 years)...
  3. pmc Early-onset, coexisting autoimmunity and decreased HLA-mediated susceptibility are the characteristics of diabetes in Down syndrome
    Rachel J Aitken
    University of Bristol, Bristol, U K
    Diabetes Care 36:1181-5. 2013
    ..HLA-mediated risk is however decreased in children with DS and diabetes (DSD). We hypothesized that early-onset diabetes in children with DS is etiologically different from autoimmune diabetes...
  4. pmc Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury
    Andrew R L Medford
    Department of Clinical Science at North Bristol, University of Bristol Paul O Gorman Lifeline Centre, Southmead Hospital, Westbury on Trym, Bristol, UK
    Respir Res 10:27. 2009
    ..The purpose of this study was to determine VEGF isoform expression and source in normal and ARDS subjects and investigate the expression and regulation of VEGF isoforms by human alveolar type 2 (ATII) cells...
  5. ncbi request reprint Islet autoimmunity in children with Down's syndrome
    Kathleen M Gillespie
    Medical School Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Diabetes 55:3185-8. 2006
    ..Other factors, possibly including genes on chromosome 21, may increase the penetrance of type 1 diabetes in Down's syndrome...
  6. pmc Type 1 diabetes: pathogenesis and prevention
    Kathleen M Gillespie
    Department of Clinical Science at North Bristol, University of Bristol, UK
    CMAJ 175:165-70. 2006
    ..This may be overcome as the processes controlling the differentiation of pancreatic and nonpancreatic progenitors as well as replication of existing islet beta cells are unravelled...
  7. ncbi request reprint Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
    Kathleen M Gillespie
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetes 54:1245-8. 2005
    ..012). These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter...
  8. ncbi request reprint HLA class II typing of whole genome amplified mouth swab DNA
    K M Gillespie
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Tissue Antigens 56:530-8. 2000
    ..We have optimised conditions for HLA class II typing on whole genome amplified DNA collected by mouth swab, but this method could potentially be applied to low concentrations of DNA from other sources...
  9. ncbi request reprint Three generations of autoimmune diabetes: an extended family study
    I F Douek
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetologia 46:1313-8. 2003
    ..We set out to study the clinical and immune features of diabetes in the grandparents' generation, and to examine sharing of HLA class II susceptibility haplotypes between grandparent and grandchild...
  10. doi request reprint Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2
    A J K Williams
    Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 51:1444-8. 2008
    ..To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A)...
  11. ncbi request reprint The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
    A J K Williams
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetologia 46:1354-6. 2003
    ..Humoral responses to the beta cell antigen insulin could help to reveal the mechanism underlying this difference. We therefore determined the influence of sex on the prevalence of insulin autoantibodies (IAA) at diagnosis...
  12. ncbi request reprint Diabetes and gender
    E A Gale
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetologia 44:3-15. 2001
    ..Women are, however, more likely to transmit Type II diabetes to their offspring. Understanding these experiments of nature might suggest ways of influencing the early course of both forms of the disease...
  13. ncbi request reprint The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
    Kathleen M Gillespie
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Lancet 364:1699-700. 2004
    ..003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect...
  14. ncbi request reprint Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetes
    A Paul Lambert
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetes Care 26:333-7. 2003
    ..We examined the prevalence of HNF-1alpha mutations in families with three generations of diabetes identified in a population-based study of childhood diabetes, representing a subpopulation in which misclassification was likely...
  15. ncbi request reprint An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetes
    K L Mehers
    Diabetes and Metabolism, Learning and Research, University of Bristol, Southmead Hospital, Bristol, UK
    Diabetologia 54:3062-70. 2011
    ....
  16. ncbi request reprint Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom
    A Paul Lambert
    Division of Medicine, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 89:4037-43. 2004
    ..4%), whereas inclusion of 11 genotypes achieved the same sensitivity for diagnosis for ages 10-14 yr. Analysis of genotype-specific risk should form the basis for design of future primary prevention trials in the general population...
  17. ncbi request reprint Diabetes in the parents of children with Type I diabetes
    I F Douek
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetologia 45:495-501. 2002
    ..We set out to characterise the clinical and immunogenetic features of diabetes in parents of affected children, and to test the hypothesis that there is no excess of Type II diabetes within this population...
  18. ncbi request reprint The genetic basis for type 1 diabetes
    Kay L Mehers
    Medical School Unit, Southmead Hospital, Bristol BS105NB, UK
    Br Med Bull 88:115-29. 2008
    ..The increasing incidence over recent decades remains unexplained, but the capacity of identifying infants at highest genetic risk has become an increasing requirement for potential therapeutic intervention trials...
  19. ncbi request reprint High familial risk and genetic susceptibility in early onset childhood diabetes
    Kathleen M Gillespie
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetes 51:210-4. 2002
    ..001). Diabetes with onset before age 5 years is therefore a marker of high familial risk...
  20. ncbi request reprint Microchimerism in type 1 diabetes
    Berendine vanZyl
    University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Curr Diab Rep 9:125-9. 2009
    ....
  21. ncbi request reprint Association of intercellular adhesion molecule-1 gene with type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, CB2 2XY, Cambridge, UK
    Lancet 362:1723-4. 2003
    ..91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments...
  22. ncbi request reprint Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    Hironori Ueda
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nature 423:506-11. 2003
    ..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction...
  23. ncbi request reprint HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 months
    Emma L Edghill
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 55:1895-8. 2006
    ..0001). We conclude that infants diagnosed with diabetes before 6 months of age are unlikely to have autoimmune type 1 diabetes and are most likely to have a monogenic etiology...
  24. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
    ..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny...
  25. ncbi request reprint Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Diabetes 53:2709-12. 2004
    ..K. and found no evidence of association. Overall, our results indicate that common sequence variation in the VDR gene has no major effect in type 1 diabetes in the populations tested...
  26. ncbi request reprint Remapping the insulin gene/IDDM2 locus in type 1 diabetes
    Bryan J Barratt
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 53:1884-9. 2004
    ....
  27. ncbi request reprint Activating mutations in the KCNJ11 gene encoding the ATP-sensitive K+ channel subunit Kir6.2 are rare in clinically defined type 1 diabetes diagnosed before 2 years
    Emma L Edghill
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5AX, UK
    Diabetes 53:2998-3001. 2004
    ..Although activating KCNJ11 mutations are rare in patients diagnosed with type 1 diabetes, the identification of a KCNJ11 mutation may have important treatment implications...