Research Topics
Genomes and GenesSpecies | K M GillespieSummaryAffiliation: University of Bristol Country: UK Publications
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Publications
Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injuryAndrew R L Medford
Department of Clinical Science at North Bristol, University of Bristol Paul O Gorman Lifeline Centre, Southmead Hospital, Westbury on Trym, Bristol, UK
Respir Res 10:27. 2009..The purpose of this study was to determine VEGF isoform expression and source in normal and ARDS subjects and investigate the expression and regulation of VEGF isoforms by human alveolar type 2 (ATII) cells...- HLA class II typing of whole genome amplified mouth swab DNAK M Gillespie
Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
Tissue Antigens 56:530-8. 2000..We have optimised conditions for HLA class II typing on whole genome amplified DNA collected by mouth swab, but this method could potentially be applied to low concentrations of DNA from other sources... - Is puberty an accelerator of type 1 diabetes in IL6-174CC females?Kathleen M Gillespie
Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
Diabetes 54:1245-8. 2005..012). These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter... - Type 1 diabetes: pathogenesis and preventionKathleen M Gillespie
Department of Clinical Science at North Bristol, University of Bristol, UK
CMAJ 175:165-70. 2006..This may be overcome as the processes controlling the differentiation of pancreatic and nonpancreatic progenitors as well as replication of existing islet beta cells are unravelled... - Islet autoimmunity in children with Down's syndromeKathleen M Gillespie
Medical School Unit, Southmead Hospital, Bristol BS10 5NB, UK
Diabetes 55:3185-8. 2006..Other factors, possibly including genes on chromosome 21, may increase the penetrance of type 1 diabetes in Down's syndrome... - Three generations of autoimmune diabetes: an extended family studyI F Douek
Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
Diabetologia 46:1313-8. 2003..Diabetes in the grandparents of children with Type 1 diabetes often has an autoimmune basis, even when it presents late in life and does not require insulin treatment... - The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescenceA J K Williams
Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
Diabetologia 46:1354-6. 2003..The lower prevalence of IAA in adolescent females implies sex-specific modulation of the autoimmune process during puberty... - Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2A J K Williams
Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
Diabetologia 51:1444-8. 2008..To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A)... - Diabetes and genderE A Gale
Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
Diabetologia 44:3-15. 2001..Women are, however, more likely to transmit Type II diabetes to their offspring. Understanding these experiments of nature might suggest ways of influencing the early course of both forms of the disease... - Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetesA Paul Lambert
Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
Diabetes Care 26:333-7. 2003..We examined the prevalence of HNF-1alpha mutations in families with three generations of diabetes identified in a population-based study of childhood diabetes, representing a subpopulation in which misclassification was likely... - The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypesKathleen M Gillespie
Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
Lancet 364:1699-700. 2004..003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect... - An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetesK L Mehers
Diabetes and Metabolism, Learning and Research, University of Bristol, Southmead Hospital, Bristol, UK
Diabetologia 54:3062-70. 2011.... - Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United KingdomA Paul Lambert
Division of Medicine, University of Bristol, Bristol BS10 5NB, United Kingdom
J Clin Endocrinol Metab 89:4037-43. 2004..4%), whereas inclusion of 11 genotypes achieved the same sensitivity for diagnosis for ages 10-14 yr. Analysis of genotype-specific risk should form the basis for design of future primary prevention trials in the general population... - Diabetes in the parents of children with Type I diabetesI F Douek
Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
Diabetologia 45:495-501. 2002..Previous studies have categorised this as Type II diabetes. Our study suggests that there is no excess of non-autoimmune diabetes in the families of children with Type I diabetes... - High familial risk and genetic susceptibility in early onset childhood diabetesKathleen M Gillespie
Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
Diabetes 51:210-4. 2002..001). Diabetes with onset before age 5 years is therefore a marker of high familial risk... - The genetic basis for type 1 diabetesKay L Mehers
Medical School Unit, Southmead Hospital, Bristol BS105NB, UK
Br Med Bull 88:115-29. 2008..The increasing incidence over recent decades remains unexplained, but the capacity of identifying infants at highest genetic risk has become an increasing requirement for potential therapeutic intervention trials... - Microchimerism in type 1 diabetesBerendine vanZyl
University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
Curr Diab Rep 9:125-9. 2009.... - HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 monthsEmma L Edghill
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Diabetes 55:1895-8. 2006..0001). We conclude that infants diagnosed with diabetes before 6 months of age are unlikely to have autoimmune type 1 diabetes and are most likely to have a monogenic etiology... - Association of intercellular adhesion molecule-1 gene with type 1 diabetesSergey Nejentsev
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, CB2 2XY, Cambridge, UK
Lancet 362:1723-4. 2003..91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments... - Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseHironori Ueda
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
Nature 423:506-11. 2003..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction... - Analysis of the vitamin D receptor gene sequence variants in type 1 diabetesSergey Nejentsev
Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
Diabetes 53:2709-12. 2004..K. and found no evidence of association. Overall, our results indicate that common sequence variation in the VDR gene has no major effect in type 1 diabetes in the populations tested... - Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerismJ Lee Nelson
Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 104:1637-42. 2007..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny... - Remapping the insulin gene/IDDM2 locus in type 1 diabetesBryan J Barratt
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
Diabetes 53:1884-9. 2004.... - Activating mutations in the KCNJ11 gene encoding the ATP-sensitive K+ channel subunit Kir6.2 are rare in clinically defined type 1 diabetes diagnosed before 2 yearsEmma L Edghill
Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5AX, UK
Diabetes 53:2998-3001. 2004..Although activating KCNJ11 mutations are rare in patients diagnosed with type 1 diabetes, the identification of a KCNJ11 mutation may have important treatment implications...