Simon Gibbons

Summary

Affiliation: University of London
Country: UK

Publications

  1. ncbi request reprint An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum
    Liam Evans
    Hypha Discovery Ltd, School of Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK
    Phytochemistry 67:2110-4. 2006
  2. doi request reprint An introduction to planar chromatography and its application to natural products isolation
    Simon Gibbons
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, UCL School of Pharmacy, London, UK
    Methods Mol Biol 864:117-53. 2012
  3. doi request reprint 'Legal highs'--novel and emerging psychoactive drugs: a chemical overview for the toxicologist
    Simon Gibbons
    Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, UK
    Clin Toxicol (Phila) 50:15-24. 2012
  4. doi request reprint Phytochemicals for bacterial resistance--strengths, weaknesses and opportunities
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK
    Planta Med 74:594-602. 2008
  5. doi request reprint An analysis of the 'legal high' mephedrone
    Simon Gibbons
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, WC1N 1AX London, UK
    Bioorg Med Chem Lett 20:4135-9. 2010
  6. pmc An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis
    Khadijo Osman
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, Bloomsbury, London WC1N 1AX, UK
    Int J Antimicrob Agents 39:124-9. 2012
  7. ncbi request reprint Bioactive constituents of Artemisia monosperma
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 66:233-9. 2005
  8. ncbi request reprint Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx
    Sharon Tang
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
    Planta Med 69:247-53. 2003
  9. pmc The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus
    Eileen C J Smith
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Antimicrob Agents Chemother 51:4480-3. 2007
  10. ncbi request reprint Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus
    Eileen Smith
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytother Res 19:538-42. 2005

Collaborators

Detail Information

Publications69

  1. ncbi request reprint An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum
    Liam Evans
    Hypha Discovery Ltd, School of Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK
    Phytochemistry 67:2110-4. 2006
    ..Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml...
  2. doi request reprint An introduction to planar chromatography and its application to natural products isolation
    Simon Gibbons
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, UCL School of Pharmacy, London, UK
    Methods Mol Biol 864:117-53. 2012
    ..Examples of methods for isolation of several classes of natural product are detailed and protocols for TLC bioassays are given...
  3. doi request reprint 'Legal highs'--novel and emerging psychoactive drugs: a chemical overview for the toxicologist
    Simon Gibbons
    Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, UK
    Clin Toxicol (Phila) 50:15-24. 2012
    ..This review covers the basic chemistry of these novel psychoactive compounds and relates them to endogenous neurotransmitters and existing drugs of abuse...
  4. doi request reprint Phytochemicals for bacterial resistance--strengths, weaknesses and opportunities
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK
    Planta Med 74:594-602. 2008
    ..A summary on future trends and directions in this fruitful and interesting area is also given...
  5. doi request reprint An analysis of the 'legal high' mephedrone
    Simon Gibbons
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, WC1N 1AX London, UK
    Bioorg Med Chem Lett 20:4135-9. 2010
    ..The presence of a ketone in the side chain introduces a far more planar quality to the methyl-cathinones which is absent in the methyl-amphetamine series, and this planarity may contribute to toxicity...
  6. pmc An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis
    Khadijo Osman
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, Bloomsbury, London WC1N 1AX, UK
    Int J Antimicrob Agents 39:124-9. 2012
    ..tuberculosis, a crucial enzyme in the cytoplasmic steps of peptidoglycan biosynthesis. Hyperenone A inhibited MurE selectively, whereas hypercalin B did not have any effect on enzyme activity...
  7. ncbi request reprint Bioactive constituents of Artemisia monosperma
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 66:233-9. 2005
    ..8 to 37.6 microg/ml. Against a panel of fast-growing mycobacteria and a standard ATCC strain of Staphylococcus aureus, compound 6 exhibited minimum inhibitory concentrations in the range of 64-128 microg/ml...
  8. ncbi request reprint Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx
    Sharon Tang
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
    Planta Med 69:247-53. 2003
    ..The ethanolic extract of the bark also showed NF-kappaB inhibitory activity...
  9. pmc The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus
    Eileen C J Smith
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Antimicrob Agents Chemother 51:4480-3. 2007
    ..These data suggest that totarol is a NorA EPI as well as an antistaphylococcal antimicrobial agent...
  10. ncbi request reprint Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus
    Eileen Smith
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytother Res 19:538-42. 2005
    ..It is proposed that this may be due to complex formation between abietic acid and reserpine and that this complex formation is responsible for a reduction in activity and elevation of MIC...
  11. ncbi request reprint An anti-staphylococcal acylphloroglucinol from Hypericum foliosum
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 66:1472-5. 2005
    ..This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 microg/ml...
  12. doi request reprint Antibacterial acylphloroglucinols from Hypericum olympicum
    Winnie K P Shiu
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Nat Prod 75:336-43. 2012
    ..aureus strains. Compounds 2 to 5 were also shown to be active, with MICs ranging from 64 to 128 mg/L. Compound 1 was synthesized using a simple four-step method that can be readily utilized to give a number of structural analogues of 1...
  13. ncbi request reprint The anti-staphylococcal activity of Angelica dahurica (Bai Zhi)
    Doris Lechner
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 65:331-5. 2004
    ..These MIC values compare favourably with some of the newest agents in development for the treatment of MRSA infection and indicate that further evaluation of the antibiotic activity of acetylenes is warranted...
  14. ncbi request reprint The antimycobacterial components of hops (Humulus lupulus) and their dereplication
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK
    Phytother Res 18:774-6. 2004
    ..We propose that GC-MS of derivatised components of lipophilic extracts be a first step before any antimycobacterial bioassay-guided study, as this technique is the method of choice for dereplication of fatty acids...
  15. doi request reprint Antibacterial diterpenes from Plectranthus ernstii
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK
    J Nat Prod 72:1191-4. 2009
    ..All three diterpenes exhibited antimycobacterial activity against three strains of rapidly growing mycobacteria with MIC values ranging from 8 to 128 microg/mL...
  16. ncbi request reprint Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytother Res 21:653-7. 2007
    ..Compound 3 displayed antimycobacterial activity in the range of 16-32 microg/mL...
  17. pmc Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics
    Juan David Guzman
    Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    J Antimicrob Chemother 66:1766-72. 2011
    ..The aim of this study was to comprehensively evaluate the antibacterial activity and MurE inhibition of a set of N-methyl-2-alkenyl-4-quinolones found to inhibit the growth of fast-growing mycobacteria...
  18. ncbi request reprint Antimycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds
    Juan D Guzman
    Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London WC1E 7HX, UK
    Front Biosci (Landmark Ed) 17:1861-81. 2012
    ..Finally a summary of the most potent recent natural antimycobacterials is displayed...
  19. ncbi request reprint Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade
    Nadia J Jacobo-Herrera
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK
    J Nat Prod 69:328-31. 2006
    ..It is suggested that the presence of a double bond and an epoxy ring between carbons 5 and 6 in compounds 1 and 2, respectively (which are not present in compound 3), are related to their anti-inflammatory activity...
  20. ncbi request reprint Antimicrobial constituents of Scrophularia deserti
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 67:1530-3. 2006
    ....
  21. doi request reprint Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum
    Winnie Ka Po Shiu
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 70:403-6. 2009
    ..Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 microg/ml, whereas compound 2 was inactive at a concentration of 512 microg/ml...
  22. ncbi request reprint Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK
    Planta Med 70:1240-2. 2004
    ..This phenomenon has not been encountered previously in the analysis of inhibitors of multidrug efflux...
  23. pmc Bioactive pyridine-N-oxide disulfides from Allium stipitatum
    Gemma O'Donnell
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Nat Prod 72:360-5. 2009
    ..This compound was also assessed in a mouse model for in vivo toxicity...
  24. ncbi request reprint New constituents of Artemisia monosperma
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, WC1N 1AX, UK
    J Nat Prod 67:892-4. 2004
    ..The absolute stereochemistry of 2 was determined using Mosher ester methodology in which the terminal primary hydroxyl group was first protected to simplify the stereochemical analysis...
  25. doi request reprint Structural characterization and antimicrobial evaluation of atractyloside, atractyligenin, and 15-didehydroatractyligenin methyl ester
    Federico Brucoli
    UCL School of Pharmacy, London, WC1N 1AX, UK
    J Nat Prod 75:1070-5. 2012
    ..Compound 3 exhibited moderate activity against all of the Staph. aureus strains with an MIC value of 128 mg/L...
  26. ncbi request reprint Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana
    Eileen C J Smith
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 68:210-7. 2007
    ..86 microg/ml). We report the (1)H and (13)C NMR data for the cis A/B ring junction epimer of pisiferol which we have named 5-epipisiferol. We also unambiguously assign all (1)H and (13)C NMR resonances for trans-communic acid...
  27. ncbi request reprint Anti-staphylococcal acylphloroglucinols from Hypericum beanii
    Winnie Ka Po Shiu
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 67:2568-72. 2006
    ..The minimum inhibitory concentration (MIC) values the acylphloroglucinol mixture and (3) against a panel of multidrug-resistant strains of Staphylococcus aureus ranged from 16-32 microg/ml to 128-256 microg/ml, respectively...
  28. ncbi request reprint NF-kappaB modulators from Valeriana officinalis
    Nadia J Jacobo-Herrera
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK
    Phytother Res 20:917-9. 2006
    ..Acetylvalerenolic acid (1) reduced NF-kappaB activity to 4%, whereas valerenic acid (3) reduced NF-kappaB activity to 25%...
  29. doi request reprint In silico screening for antibiotic escort molecules to overcome efflux
    Sheikh S Rahman
    The School of Pharmacy, University of London, 29 39 Brunswick Square, London, WC1N 1AX, UK
    J Mol Model 17:2863-72. 2011
    ..Encouragingly, two molecules were proven to act as efflux pump modulators, and hence provide evidence that complex formation between a substrate and a drug can be used for in silico screening for novel escort molecules...
  30. doi request reprint Antibacterial terpenes from the oleo-resin of Commiphora molmol (Engl.)
    M Mukhlesur Rahman
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytother Res 22:1356-60. 2008
    ..Compound 2 also displayed weak potentiation of ciprofloxacin and tetracycline activity against strains of Salmonella enterica serovar Typhimurium SL1344 and L10...
  31. ncbi request reprint Bacterial efflux pump inhibitors from natural sources
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London 29 39 Brunswick Square, London, UK
    J Antimicrob Chemother 59:1247-60. 2007
    ..The resistance-modifying activities of many new chemical classes of EPIs warrant further studies to assess their potential as leads for clinical development...
  32. ncbi request reprint Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates
    Mire Zloh
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Bioorg Med Chem Lett 14:881-5. 2004
    ..This affinity may facilitate drug entry into cells and a large inhibitor-drug complex may be a poorer substrate for the MDR mechanism. This complex would effectively 'cloak' the drug rendering it unavailable for efflux...
  33. ncbi request reprint Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK
    Phytother Res 17:274-5. 2003
    ..This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug ef flux mechanisms...
  34. ncbi request reprint Antibacterial and resistance modifying activity of Rosmarinus officinalis
    Moyosoluwa Oluwatuyi
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 65:3249-54. 2004
    ..The antibacterial and efflux inhibitory activities of these natural products make them interesting potential targets for synthesis...
  35. ncbi request reprint Phytochemistry and antimycobacterial activity of Chlorophytum inornatum
    Gemma O'Donnell
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 67:178-82. 2006
    ..The antimycobacterial activity of this plant was mainly due to the homoisoflavonoid which exhibited minimum inhibitory values ranging from 16-256 microg/ml against four strains of fast-growing mycobacteria...
  36. ncbi request reprint The antimycobacterial constituents of dill (Anethum graveolens)
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, UK
    Phytother Res 19:938-41. 2005
    ..The three known compounds exhibited antibacterial activity against a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values in the range 2-128 microg/mL...
  37. doi request reprint A new dihydrodibenzodioxinone from Hypericum x 'Hidcote'
    Longru Sun
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Fitoterapia 80:226-9. 2009
    ..The structure of the new compound, as well as its absolute configuration, was established by means of spectroscopic data analyses, including 2D NMR spectroscopy and X-ray structural analysis...
  38. doi request reprint Antimycobacterials from lovage root (Ligusticum officinale Koch)
    Juan David Guzman
    Mycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
    Phytother Res 27:993-8. 2013
    ..Colony forming unit analysis at different concentrations of this phytochemical showed mycobacteriostatic mode of action...
  39. pmc Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis
    Tulika Munshi
    Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, London, United Kingdom
    PLoS ONE 8:e60143. 2013
    ....
  40. ncbi request reprint Pangelin, an antimycobacterial coumarin from Ducrosia anethifolia
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, U K
    Planta Med 69:956-9. 2003
    ....
  41. ncbi request reprint Anti-staphylococcal plant natural products
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, University of London School of Pharmacy, 29 39 Brunswick Square, London, UKWC1N 1AX
    Nat Prod Rep 21:263-77. 2004
  42. doi request reprint Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv
    Michael Stavri
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 69:1915-8. 2008
    ..Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8+/-0.2 microM) in a human bladder carcinoma cell line, EJ-138...
  43. doi request reprint Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis
    Juan D Guzman
    Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, UK
    J Antimicrob Chemother 65:2101-7. 2010
    ..The purpose of this study was to evaluate anti-tubercular activity and selectivity of seven recently isolated natural products from Colombian plants...
  44. doi request reprint Natural product 'legal highs'
    Warunya Arunotayanun
    Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29 39 Brunswick Square, London, WC1N 1AX, United Kingdom
    Nat Prod Rep 29:1304-16. 2012
    ....
  45. doi request reprint Efficient synthesis and biological evaluation of proximicins A, B and C
    Federico Brucoli
    UCL School of Pharmacy, 29 39 Brunswick Square, London, WC1N 1AX, UK
    Bioorg Med Chem 20:2019-24. 2012
    ..Proximicin B showed noteworthy activity against antibiotic-resistant Gram-positive cocci...
  46. ncbi request reprint Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytother Res 17:434-6. 2003
    ..sanguinolenta extracts to treat infections, highlight the potential of the cryptolepine template for development of antimycobacterial agents...
  47. ncbi request reprint A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Antimicrob Chemother 51:13-7. 2003
    ..Using GG918 as a lead compound, a structure-activity evaluation may reveal a more potent and broader spectrum inhibitor of S. aureus antibiotic efflux pumps...
  48. ncbi request reprint Bacterial resistance modifying agents from Lycopus europaeus
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytochemistry 62:83-7. 2003
    ..aureus that were highly resistant to these agents due to the presence of the multidrug efflux mechanisms Tet(K) (tetracycline resistance) and Msr(A) (macrolide resistance)...
  49. ncbi request reprint Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties
    Joanne Barnes
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Pharm Pharmacol 57:929-54. 2005
    ..Safety issues include the possibility of allergic reactions, the use of echinacea by patients with autoimmune diseases and the potential for echinacea preparations to interact with conventional medicines...
  50. ncbi request reprint The genus Hypericum--a valuable resource of anti-Staphylococcal leads
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Fitoterapia 73:300-4. 2002
    ....
  51. doi request reprint An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'
    Warunya Arunotayanun
    Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Bioorg Med Chem Lett 23:3411-5. 2013
    ..Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine...
  52. doi request reprint Near-infrared spectroscopy (NIRS) and chemometric analysis of Malaysian and UK paracetamol tablets: a spectral database study
    Mazlina M Said
    The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Int J Pharm 415:102-9. 2011
    ..A database of spectra was created and search methods were evaluated for correct identification of tablets. The approach presented here can be further developed as a method for identifying substandard pharmaceutical products...
  53. doi request reprint Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense
    Wei Wang
    School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    J Nat Prod 73:1815-20. 2010
    ..4 μM) and 4 μg/mL (16.8 μM), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 μg/mL (100 μM)...
  54. doi request reprint Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides
    Lilia Chérigo
    Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico City 04510 DF, Mexico
    J Nat Prod 71:1037-45. 2008
    ..Therefore, this type of amphipathic oligosaccharide could be developed further to provide more potent inhibitors of this multidrug efflux pump...
  55. doi request reprint Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis
    Doris Lechner
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl Franzens University of Graz, Universitaetsplatz 4 I, A 8010 Graz, Austria
    J Antimicrob Chemother 62:345-8. 2008
    ..Efflux pumps can cause multidrug resistance and have recently evoked much interest as promising new targets in antimicrobial therapy...
  56. doi request reprint Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus
    Hossein Nazemiyeh
    Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medicinal Sciences, Tabriz, Iran
    J Nat Med 62:91-5. 2008
    ..While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations...
  57. ncbi request reprint Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity
    Abraham Abebe Wube
    Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Karl Franzens University Graz, Universitaetsplatz 4 1, A 8010 Graz, Austria
    Phytochemistry 66:2309-15. 2005
    ..phlei and M. smegmatis; and the active constituents showed MIC values ranged from 4 to 128 microg/ml compared to the antibiotic drugs ethambutol (MIC ranged from 0.5 to 8 microg/ml) and isoniazid (MIC ranged from 1 to 4 microg/ml)...
  58. ncbi request reprint Naturally derived anti-HIV agents
    Kaleab Asres
    Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Phytother Res 19:557-81. 2005
    ..It is our strong conviction that the results and experiences with many of the anti-HIV natural products will inspire and motivate even more researchers to look for new leads from plants and other natural sources...
  59. ncbi request reprint A furanocoumarin and polymethoxylated flavonoids from the Yucatec Mayan plant Casimiroa tetrameria
    Bilkis Heneka
    Institute of Pharmaceutical Biology, Stefan Meier Str 19, Albert Ludwigs University, 79104 Freiburg, Federal Republic of Germany
    Phytochemistry 66:649-52. 2005
    ....
  60. ncbi request reprint Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus
    Rogelio Pereda-Miranda
    Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, DF Mexico
    J Nat Prod 69:406-9. 2006
    ..aureus multidrug efflux pumps...
  61. ncbi request reprint Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis)
    Giovanni Appendino
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy
    J Nat Prod 69:251-4. 2006
    ..Despite their close similarity, significant antibacterial activity was shown only by one of these compounds (3b, gallomyrtucommulone B), while the G3 hormone (4) was inactive...
  62. ncbi request reprint Anti-staphylococcal and cytotoxic compounds from Hyptis pectinata
    Mabel Fragoso-Serrano
    Departamento de Farmacia Facultad de Química Universidad Nacional Autónoma de México, University City, 04510 DF Mexico City, Mexico
    Planta Med 71:278-80. 2005
    ..Mosher ester derivatives were used with pectinolide B ( 2) for confirmation of the 3'-( S) absolute stereochemistry on the side chain chiral center of pectinolides A-C...
  63. ncbi request reprint Oligomeric acylphloroglucinols from myrtle (Myrtus communis)
    Giovanni Appendino
    DiSCAFF, Universita del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy
    J Nat Prod 65:334-8. 2002
    ..Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active...
  64. ncbi request reprint N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors
    Serge Michalet
    DPM UMR 5063 CNRS UJF, Equipe de Pharmacognosie, UFR de Pharmacie de Grenoble, Domaine de la Merci, 38706 La Tronche Cedex, France
    Bioorg Med Chem Lett 17:1755-8. 2007
    ..Among the synthetic compounds, some were more active than the natural compound and N-trans-3,4-O-dimethylcaffeoyl tryptamine showed potentiation of norfloxacin in MDR S. aureus comparable to that of the standard reserpine...
  65. ncbi request reprint Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii
    Zhi Yong Xiao
    School of Pharmacy, Fudan University, Shanghai 200032, People s Republic of China
    J Nat Prod 70:1779-82. 2007
    ..3 microM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 microM...
  66. ncbi request reprint Iridoid glycosides from Eremostachys glabra
    Abbas Delazar
    School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    J Nat Prod 67:1584-7. 2004
    ..Their structures were elucidated on the basis of spectroscopic data interpretation. The free-radical scavenging activity of these compounds was assessed using the DPPH assay...
  67. ncbi request reprint Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis)
    Giovanni Appendino
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy
    J Nat Prod 67:2108-10. 2004
    ..The outstanding activity of 1a, its low toxicity, and the evidence for definite structure-activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation...
  68. doi request reprint Chemical and antibacterial constituents of Skimmia anquetelia
    Rajni Kant Sharma
    Department of Chemistry, HNB Garhwal University, Srinagar Garhwal, Uttarakhand, India
    Planta Med 74:175-7. 2008
    ..Structures were determined on the basis of analyses of spectral evidence including 1D, 2 D NMR (COSY, HMQC, HMBC and NOESY) and mass spectroscopy...
  69. ncbi request reprint Inhibitory activities of lichen-derived compounds against methicillin- and multidrug-resistant Staphylococcus aureus
    Tetsuo Kokubun
    Royal Botanic Gardens, Kew, Richmond, Surrey, UK
    Planta Med 73:176-9. 2007
    ..13-16.3 microM) against a range of multidrug efflux pump expressing strains of S. aureus...