J M Gibbins

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Affinity purification of 61- and 65-kDa rat brain corticotropin-releasing factor receptors and receptor-associated G proteins
    J M Gibbins
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, U K
    Int J Biochem Cell Biol 28:1017-29. 1996
  2. ncbi request reprint Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
    J M Gibbins
    Department of Pharmacology, University of Oxford, UK
    FEBS Lett 413:255-9. 1997
  3. pmc Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation
    L A Moraes
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK
    J Thromb Haemost 8:577-87. 2010
  4. pmc Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
    L A Moraes
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK
    J Thromb Haemost 8:2530-41. 2010
  5. ncbi request reprint The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
    J M Gibbins
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire, RG6 6AJ, United Kingdom
    J Biol Chem 273:34437-43. 1998
  6. ncbi request reprint Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation
    O Berlanga
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 96:2740-5. 2000
  7. ncbi request reprint The regulation of integrin-linked kinase in human platelets: evidence for involvement in the regulation of integrin alpha 2 beta 1
    J M Stevens
    School of Animal and Microbial Sciences, University of Reading, Reading, UK
    J Thromb Haemost 2:1443-52. 2004
  8. ncbi request reprint Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases
    M Cicmil
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, United Kingdom
    J Biol Chem 275:27339-47. 2000
  9. pmc The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
    A Poole
    Department of Pharmacology, University of Oxford, UK
    EMBO J 16:2333-41. 1997
  10. ncbi request reprint A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1
    J Asselin
    Department of Pharmacology, University of Oxford, UK
    Blood 89:1235-42. 1997

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Affinity purification of 61- and 65-kDa rat brain corticotropin-releasing factor receptors and receptor-associated G proteins
    J M Gibbins
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, U K
    Int J Biochem Cell Biol 28:1017-29. 1996
    ..In addition, we confirm the involvement of G proteins in CRF stimulated cell signalling by demonstrating their association with purified CRF receptor...
  2. ncbi request reprint Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
    J M Gibbins
    Department of Pharmacology, University of Oxford, UK
    FEBS Lett 413:255-9. 1997
    ..These results support a model where GPVI couples collagen-stimulation of platelets to phosphorylation of the Fc receptor gamma-chain leading to activation of Syk and phospholipase Cgamma2...
  3. pmc Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation
    L A Moraes
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK
    J Thromb Haemost 8:577-87. 2010
    ..Peroxisome proliferator-activated receptor-(gamma) (PPAR(gamma)) is expressed in human platelets although in the absence of genomic regulation in these cells, its functions are unclear...
  4. pmc Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
    L A Moraes
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK
    J Thromb Haemost 8:2530-41. 2010
    ....
  5. ncbi request reprint The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
    J M Gibbins
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire, RG6 6AJ, United Kingdom
    J Biol Chem 273:34437-43. 1998
    ..The present results provide a molecular basis for the regulation of the p85/110 form of phosphatidylinositol 3-kinase by GPVI, the collagen receptor that underlies activation...
  6. ncbi request reprint Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation
    O Berlanga
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 96:2740-5. 2000
    ..The results demonstrate that expression of GPVI is up-regulated along with the FcR gamma-chain during differentiation of megakaryocytes. (Blood. 2000;96:2740-2745)..
  7. ncbi request reprint The regulation of integrin-linked kinase in human platelets: evidence for involvement in the regulation of integrin alpha 2 beta 1
    J M Stevens
    School of Animal and Microbial Sciences, University of Reading, Reading, UK
    J Thromb Haemost 2:1443-52. 2004
    ..Activation of the platelet integrin alpha 2 beta 1 is closely regulated due to the high thrombogenicity of its ligand. As a beta 1 interacting kinase, ILK represents a candidate intracellular regulator of alpha 2 beta 1 in human platelets...
  8. ncbi request reprint Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases
    M Cicmil
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, United Kingdom
    J Biol Chem 275:27339-47. 2000
    ..The involvement of Src family kinases in this process was confirmed through the study of mouse platelets deficient in Fyn...
  9. pmc The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
    A Poole
    Department of Pharmacology, University of Oxford, UK
    EMBO J 16:2333-41. 1997
    ..These observations provide the first direct evidence of an essential role for the immunoreceptor tyrosine-based activation motif (ITAM) in signalling by a non-immune receptor stimulus...
  10. ncbi request reprint A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1
    J Asselin
    Department of Pharmacology, University of Oxford, UK
    Blood 89:1235-42. 1997
    ..The results show an alpha2beta1-independent pathway of platelet activation by CRP that involves phosphorylation of syk and PLC gamma2. This pathway appears to contribute to platelet activation by collagen...
  11. ncbi request reprint Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans
    G P Hubbard
    School of Food Biosciences, University of Reading, Reading, UK
    J Thromb Haemost 2:2138-45. 2004
    ..Consequently, it has been proposed that quercetin may contribute to the protective effects against cardiovascular disease of a diet rich in fruit and vegetables...
  12. ncbi request reprint Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway
    G P Hubbard
    School of Food Biosciences and School of Animal and Microbial Sciences, University of Reading, Reading, UK
    J Thromb Haemost 1:1079-88. 2003
    ..A variety of molecules present in the diet have been shown to inhibit platelet activation, including the antioxidant quercetin...
  13. pmc The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function
    L M Holbrook
    Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Berkshire, UK
    J Thromb Haemost 10:278-88. 2012
    ..Previous studies have identified important roles for the thiol isomerases PDI and ERp5 in the regulation of normal platelet function...
  14. pmc Future innovations in anti-platelet therapies
    N E Barrett
    School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire, UK
    Br J Pharmacol 154:918-39. 2008
    ....
  15. ncbi request reprint Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for SHP-1 phosphatase
    B Patel
    Medical Biosciences, University of Bradford, Bradford, UK
    J Thromb Haemost 4:2423-32. 2006
    ..However, the post-translational regulation of eNOS in platelets is poorly defined...