Maya Ghoussaini

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Multiple loci with different cancer specificities within the 8q24 gene desert
    Maya Ghoussaini
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
    J Natl Cancer Inst 100:962-6. 2008
  2. doi request reprint Polygenic susceptibility to breast cancer: current state-of-the-art
    Maya Ghoussaini
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    Future Oncol 5:689-701. 2009
  3. pmc Large-scale genotyping identifies 41 new loci associated with breast cancer risk
    Kyriaki Michailidou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Nat Genet 45:353-61, 361e1-2. 2013
  4. pmc A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Nat Genet 42:885-92. 2010
  5. pmc Genome-wide association analysis identifies three new breast cancer susceptibility loci
    Maya Ghoussaini
    Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK
    Nat Genet 44:312-8. 2012
  6. pmc Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
    Shahana Ahmed
    Department of Oncology, University of Cambridge, UK
    Nat Genet 41:585-90. 2009
  7. ncbi request reprint Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer
    Bolot Kalmyrzaev
    University of Cambridge Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3618-20. 2008
  8. doi request reprint Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?
    Maya Ghoussaini
    Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom Electronic address
    Am J Pathol 183:1038-51. 2013
  9. pmc Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 37:863-7. 2005
  10. pmc Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population
    Maya Ghoussaini
    CNRS UMR 8090, Institute of Biology of Lille, Pasteur Institute, Lille, France
    BMC Med Genet 6:11. 2005

Detail Information

Publications12

  1. pmc Multiple loci with different cancer specificities within the 8q24 gene desert
    Maya Ghoussaini
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
    J Natl Cancer Inst 100:962-6. 2008
    ..We conclude that there are at least five separate functional variants in this region...
  2. doi request reprint Polygenic susceptibility to breast cancer: current state-of-the-art
    Maya Ghoussaini
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    Future Oncol 5:689-701. 2009
    ....
  3. pmc Large-scale genotyping identifies 41 new loci associated with breast cancer risk
    Kyriaki Michailidou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Nat Genet 45:353-61, 361e1-2. 2013
    ..We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility...
  4. pmc A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Nat Genet 42:885-92. 2010
    ..80, 95% CI 0.74-0.87, P(trend) = 1.1 × 10⁻⁷..
  5. pmc Genome-wide association analysis identifies three new breast cancer susceptibility loci
    Maya Ghoussaini
    Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK
    Nat Genet 44:312-8. 2012
    ....
  6. pmc Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
    Shahana Ahmed
    Department of Oncology, University of Cambridge, UK
    Nat Genet 41:585-90. 2009
    ..11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q...
  7. ncbi request reprint Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer
    Bolot Kalmyrzaev
    University of Cambridge Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3618-20. 2008
    ..87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6]...
  8. doi request reprint Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?
    Maya Ghoussaini
    Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom Electronic address
    Am J Pathol 183:1038-51. 2013
    ..Finally, we discuss the potential impact of such findings on personalized medicine and future avenues for screening, prediction, and prevention programs. ..
  9. pmc Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 37:863-7. 2005
    ..These findings suggest that several variants of ENPP1 have a primary role in mediating insulin resistance and in the development of both obesity and T2D, suggesting that an underlying molecular mechanism is common to both conditions...
  10. pmc Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population
    Maya Ghoussaini
    CNRS UMR 8090, Institute of Biology of Lille, Pasteur Institute, Lille, France
    BMC Med Genet 6:11. 2005
    ..The aim of this study was to evaluate the impact of this SNP with regards to T2D and childhood and adult obesity in the French Caucasian population...
  11. ncbi request reprint Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population
    Ramin Badii
    Molecular Genetics and Lab Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
    Acta Diabetol 45:15-21. 2008
    ..5%) were obese (BMI > 30) compared to nondiabetic subjects (29.8%) (P < 0.001). In this study, no association is seen between the Pro12Ala polymorphism in PPAR gamma 2 gene and the type 2 diabetes in Qatar...
  12. ncbi request reprint Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity
    Maya Ghoussaini
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
    J Clin Endocrinol Metab 92:4403-9. 2007
    ..MCHR2 maps on chromosome 6q16.3, in a susceptibility locus for childhood obesity...