Genomes and Genes
Affiliation: University of Cambridge
- Polygenic susceptibility to breast cancer: current state-of-the-artMaya Ghoussaini
Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Future Oncol 5:689-701. 2009....
- Multiple loci with different cancer specificities within the 8q24 gene desertMaya Ghoussaini
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
J Natl Cancer Inst 100:962-6. 2008..We conclude that there are at least five separate functional variants in this region...
- A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general populationAntonis C Antoniou
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Nat Genet 42:885-92. 2010..80, 95% CI 0.74-0.87, P(trend) = 1.1 × 10⁻⁷..
- Genome-wide association analysis identifies three new breast cancer susceptibility lociMaya Ghoussaini
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK
Nat Genet 44:312-8. 2012....
- Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2Shahana Ahmed
Department of Oncology, University of Cambridge, UK
Nat Genet 41:585-90. 2009..11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q...
- Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancerBolot Kalmyrzaev
University of Cambridge Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN United Kingdom
Cancer Epidemiol Biomarkers Prev 17:3618-20. 2008..87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6]...
- Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetesDavid Meyre
CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
Nat Genet 37:863-7. 2005..These findings suggest that several variants of ENPP1 have a primary role in mediating insulin resistance and in the development of both obesity and T2D, suggesting that an underlying molecular mechanism is common to both conditions...
- Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French populationMaya Ghoussaini
CNRS UMR 8090, Institute of Biology of Lille, Pasteur Institute, Lille, France
BMC Med Genet 6:11. 2005..The aim of this study was to evaluate the impact of this SNP with regards to T2D and childhood and adult obesity in the French Caucasian population...
- Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous populationRamin Badii
Molecular Genetics and Lab Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
Acta Diabetol 45:15-21. 2008..5%) were obese (BMI > 30) compared to nondiabetic subjects (29.8%) (P < 0.001). In this study, no association is seen between the Pro12Ala polymorphism in PPAR gamma 2 gene and the type 2 diabetes in Qatar...
- Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesityMaya Ghoussaini
Centre National de la Recherche Scientifique Unité Mixte de Recherche 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
J Clin Endocrinol Metab 92:4403-9. 2007..MCHR2 maps on chromosome 6q16.3, in a susceptibility locus for childhood obesity...