- Reduction of cytochrome C oxidase during vasovagal hypoxia-ischemia in human adult brain: a case study
Neurocritical Care Unit, University College Hospitals, WC1N 3BG, London, UK
Adv Exp Med Biol 789:21-7. 2013
..This unexpected physiological event provides an unusual example of a severe reduction in cerebral oxygen delivery and is the first report correlating change in clinical status with changes in [oxCCO]. ..
- Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury
Institute of Neurology, University College London, London, UK
Adv Exp Med Biol 765:67-72. 2013
..These results suggest that the measurement of chromophore concentration in the injured brain is not confounded by changes in optical scattering or pathlength and that NBH induces an increase in cerebral aerobic metabolism...
- Dependence on NIRS source-detector spacing of cytochrome c oxidase response to hypoxia and hypercapnia in the adult brain
Department of Medical Physics and Bioengineering, University College London, London, UK
Adv Exp Med Biol 789:353-9. 2013
..We conclude that the Δ[oxCCO] response to hypoxia and hypercapnia appears to be dependent on penetration depth, possibly reflecting differences between the intra- and extracerebral tissue concentration of cytochrome c oxidase. ..
- Modelling cerebrovascular reactivity: a novel near-infrared biomarker of cerebral autoregulation?
University College Hospitals, Queen Square, London, UK
Adv Exp Med Biol 765:87-93. 2013
..Further development of this technique could be used to track CVPR providing targets for individualised management of patients with altered vascular reactivity, minimising secondary neurological insults...
- Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin
Dept of Medical Physics and Bioengineering, University College London, London, UK Electronic address
Neuroimage 85:234-44. 2014
- Analysis of the changes in the oxidation of brain tissue cytochrome-c-oxidase in traumatic brain injury patients during hypercapnoea: a broadband NIRS study
Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
Adv Exp Med Biol 701:9-14. 2011
..Further work using model informed data interpretation may be helpful in understanding the multimodal signals acquired in this heterogeneous patient group...
- Analysis of slow wave oscillations in cerebral haemodynamics and metabolism following subarachnoid haemorrhage
Neurocritical Care, University College Hospitals, Queen Square, London, UK
Adv Exp Med Biol 812:195-201. 2014
..1Hz-0.01Hz consistent with compromised flow-metabolism coupling. NIRS derived variables might offer unique insights into microvascular and metabolic dysfunction following SAH, and in the future identify therapeutic windows or targets. ..
- Systematic investigation of changes in oxidized cerebral cytochrome c oxidase concentration during frontal lobe activation in healthy adults
Medical Physics and Bioengineering, University College London, London WC1E 6BT, UK
Biomed Opt Express 3:2550-66. 2012
..We conclude that the heterogeneity in the Δ[oxCCO] response is physiological and not induced by confounding factors in the measurements...