T Ghafourian

Summary

Affiliation: University of Kent
Country: UK

Publications

  1. doi request reprint The impact of training set data distributions for modelling of passive intestinal absorption
    Taravat Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, Kent, ME4 4TB, UK
    Int J Pharm 436:711-20. 2012
  2. ncbi request reprint A drug release study from hydroxypropylmethylcellulose (HPMC) matrices using QSPR modeling
    Taravat Ghafourian
    Drug Applied Research Center and School of Pharmacy, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Iran
    J Pharm Sci 96:3334-51. 2007
  3. ncbi request reprint QSPR models for the prediction of apparent volume of distribution
    Taravat Ghafourian
    Drug Design and Chemometrics Laboratory, Drug Applied Research Centre and School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    Int J Pharm 319:82-97. 2006
  4. doi request reprint Estimation of drug solubility in water, PEG 400 and their binary mixtures using the molecular structures of solutes
    Taravat Ghafourian
    University of Kent, UK
    Eur J Pharm Sci 40:430-40. 2010
  5. doi request reprint Modelling the effect of mixture components on permeation through skin
    T Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, Kent ME4 4TB, UK
    Int J Pharm 398:28-32. 2010
  6. doi request reprint Validated models for predicting skin penetration from different vehicles
    Taravat Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK
    Eur J Pharm Sci 41:612-6. 2010
  7. ncbi request reprint The effect of surfactants on the skin penetration of diazepam
    J Shokri
    Drug Applied Research Centre, School of Pharmacy, Tabriz Medical Sciences University, Tabriz, Iran
    Int J Pharm 228:99-107. 2001
  8. ncbi request reprint The effect of terpene concentrations on the skin penetration of diclofenac sodium
    A Nokhodchi
    Medway School of Pharmacy, Central Ave, University of Kent and Greenwich, Chatham, Kent ME4 4TB, England, United Kingdom
    Int J Pharm 335:97-105. 2007
  9. ncbi request reprint Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure
    A Jouyban
    Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Pharmazie 63:113-21. 2008
  10. ncbi request reprint Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30 degrees C using practical approaches
    Abolghasem Jouyban
    Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Chem Pharm Bull (Tokyo) 56:602-6. 2008

Collaborators

Detail Information

Publications36

  1. doi request reprint The impact of training set data distributions for modelling of passive intestinal absorption
    Taravat Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, Kent, ME4 4TB, UK
    Int J Pharm 436:711-20. 2012
    ..939. Thus, under-sampling the majority class of the highly absorbed compounds leads to a balanced training set (TS1) that can achieve more applicable in silico regression and classification models for the use in the industry...
  2. ncbi request reprint A drug release study from hydroxypropylmethylcellulose (HPMC) matrices using QSPR modeling
    Taravat Ghafourian
    Drug Applied Research Center and School of Pharmacy, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Iran
    J Pharm Sci 96:3334-51. 2007
    ..The results indicated that the source of the difference could be sought in the drug properties (as exemplified by the aqueous solubility and surface area) as well as the rate of erosion (that depends mainly on the polymer type)...
  3. ncbi request reprint QSPR models for the prediction of apparent volume of distribution
    Taravat Ghafourian
    Drug Design and Chemometrics Laboratory, Drug Applied Research Centre and School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    Int J Pharm 319:82-97. 2006
    ..The structural descriptors in the model can be interpreted based on the known mechanisms of distribution and the molecular structures of the drugs...
  4. doi request reprint Estimation of drug solubility in water, PEG 400 and their binary mixtures using the molecular structures of solutes
    Taravat Ghafourian
    University of Kent, UK
    Eur J Pharm Sci 40:430-40. 2010
    ..Aqueous or PEG/water solubilities can be estimated by these models with root mean square error of below 0.70...
  5. doi request reprint Modelling the effect of mixture components on permeation through skin
    T Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, Kent ME4 4TB, UK
    Int J Pharm 398:28-32. 2010
    ..396. The chemical space of the dataset was compared with that of the known skin permeability datasets and gaps were identified for future skin permeability measurements...
  6. doi request reprint Validated models for predicting skin penetration from different vehicles
    Taravat Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK
    Eur J Pharm Sci 41:612-6. 2010
    ..The QSAR was validated internally, using a leave-many-out procedure, giving a mean absolute error of 0.454 for the logkp value of the test set...
  7. ncbi request reprint The effect of surfactants on the skin penetration of diazepam
    J Shokri
    Drug Applied Research Centre, School of Pharmacy, Tabriz Medical Sciences University, Tabriz, Iran
    Int J Pharm 228:99-107. 2001
    ..The results showed that the nature of enhancer greatly influences cutaneous barrier impairment...
  8. ncbi request reprint The effect of terpene concentrations on the skin penetration of diclofenac sodium
    A Nokhodchi
    Medway School of Pharmacy, Central Ave, University of Kent and Greenwich, Chatham, Kent ME4 4TB, England, United Kingdom
    Int J Pharm 335:97-105. 2007
    ..The most outstanding penetration enhancer was nerolidol, providing an almost 198-fold increase in permeability coefficient of diclofenac sodium, followed by farnesol with a 78-fold increase...
  9. ncbi request reprint Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure
    A Jouyban
    Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Pharmazie 63:113-21. 2008
    ....
  10. ncbi request reprint Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30 degrees C using practical approaches
    Abolghasem Jouyban
    Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Chem Pharm Bull (Tokyo) 56:602-6. 2008
    ..0+/-8.7 and 55.4+/-17.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of <50% were 12.0+/-9.1 and 22.0+/-11.0%...
  11. ncbi request reprint The effect of structural QSAR parameters on skin penetration
    T Ghafourian
    School of Pharmacy, Tabriz Medical Sciences University, 51664, Tabriz, Iran
    Int J Pharm 217:1-11. 2001
    ..Diffusion estimated from the expression log(D/h)=log kp-log Km, where D is the diffusion coefficient and h is the path length for diffusion was also analyzed successfully by the structural parameters...
  12. ncbi request reprint Quantitative structure-pharmacokinetic relationship modelling: apparent volume of distribution
    Taravat Ghafourian
    Tabriz University of Medical Sciences, Tabriz 51664, Iran
    J Pharm Pharmacol 56:339-50. 2004
    ..01 for Vd compared with 2.28 for unbound Vd). Moreover, the separation of the compounds into acids and bases did not reduce the prediction error significantly...
  13. ncbi request reprint The enhancement effect of surfactants on the penetration of lorazepam through rat skin
    A Nokhodchi
    School of Pharmacy, Tabriz Medical Sciences University, Tabriz, Iran
    Int J Pharm 250:359-69. 2003
    ....
  14. ncbi request reprint Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists
    Siavoush Dastmalchi
    School of Pharmacy, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz 51664, Iran
    J Mol Graph Model 26:834-44. 2008
    ..The results of this investigation are expected to be useful in the process of design and development of new potent H3 receptor antagonists...
  15. ncbi request reprint The effect of penetration enhancers on drug delivery through skin: a QSAR study
    Taravat Ghafourian
    School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    J Control Release 99:113-25. 2004
    ..The possible mechanisms of penetration enhancement as suggested by the QSARs will be discussed...
  16. ncbi request reprint Factors affecting the release of nifedipine from a swellable elementary osmotic pump
    Ali Nokhodchi
    School of Pharmacy at Medway, Universities of Kent and Greenwich, Kent, England
    Drug Deliv 15:43-8. 2008
    ..The zero-order release lasted for 10 hr at pH 6.8 dissolution medium. The designed SEOP is suggested as an efficient controlled delivery system for oral delivery of a poorly water soluble drug such as nifedipine...
  17. ncbi request reprint An in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release matrix tablet
    Ali Nokhodchi
    Medway School of Pharmacy, The University of Kent and Greenwich, Chatham Maritime, Kent, UK
    Drug Dev Ind Pharm 34:323-9. 2008
    ..This is due to a reduction in tortuoisity and increased pore size of channels caused by lactose through which propranolol diffuses and therefore diffusion of water into the tablet is facilitated...
  18. ncbi request reprint Physicochemical characterization of solid dispersions of indomethacin with PEG 6000, Myrj 52, lactose, sorbitol, dextrin, and Eudragit E100
    Hadi Valizadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    Drug Dev Ind Pharm 30:303-17. 2004
    ..However, the results from infrared spectroscopy together with those from x-ray diffraction showed well-defined drug-carrier interactions for dextrin coevaporates...
  19. ncbi request reprint Mechanistic evaluation of the effect of thermal-treating on Eudragit RS matrices
    Shirzad Azarmi
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Farmaco 60:925-30. 2005
    ..FTIR results did not show any drug-polymer interaction due to heat-treatment. DSC and PXD studies ruled out the occurrence of solid solution and polymorphic change of the drug...
  20. ncbi request reprint Kinetic analysis of drug release from nanoparticles
    Mohammad Barzegar-Jalali
    Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    J Pharm Pharm Sci 11:167-77. 2008
    ..Theoretical justification for the two best general models was also provided for the first time...
  21. doi request reprint Effect of various surfactants and their concentration on controlled release of captopril from polymeric matrices
    Ali Nokhodchi
    Medway School of Pharmacy, The University of Kent and Greenwich, Central Av, Chatham Maritime ME4 4TB Kent, UK
    Acta Pharm 58:151-62. 2008
    ..The kinetic analysis of drug release data from various formulations showed that incorporation of surfactants in HPMC/EC matrices did not produce a zero-order release pattern...
  22. ncbi request reprint Development and evaluation of buccoadhesive propranolol hydrochloride tablet formulations: effect of fillers
    Jafar Akbari
    Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran Sari Medical Sciences University, Sari, Iran
    Farmaco 59:155-61. 2004
    ..The values of n in this study were calculated to be between 0.461 and 0.619, indicating both diffusional release and erosional mechanism...
  23. ncbi request reprint The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethylcellulose (HPMC)-Eudragit matrices
    Ali Nokhodchi
    School of Pharmacy, Tabriz Medical Sciences University, Tabriz, Iran
    Eur J Pharm Biopharm 54:349-56. 2002
    ..It can be concluded that, the type and ionization of surfactant, hydrophilicity and lipophilicity of surface active agent and various ratios of surfactants are important factors in controlling the release rate of propranolol...
  24. ncbi request reprint Propranolol hydrochloride osmotic capsule with controlled onset of release
    Mohammad Barzegar-Jalali
    Department of Pharmaceutics, School of Pharmacy, and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Drug Deliv 14:461-8. 2007
    ..2, 4.8, 5.9, 5.5, 7.5, 5.0, 7.8 and 10.5 hr could be of use for either chronotherapeutic purposes in protection of patients against heart attacks and strokes during early morning hours or reducing daily frequency of dosage...
  25. ncbi request reprint Particle design of naproxen-disintegrant agglomerates for direct compression by a crystallo-co-agglomeration technique
    Maryam Maghsoodi
    School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Int J Pharm 351:45-54. 2008
    ....
  26. ncbi request reprint Piroxicam nanoparticles for ocular delivery: physicochemical characterization and implementation in endotoxin-induced uveitis
    Khosro Adibkia
    Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
    J Drug Target 15:407-16. 2007
    ..Upon these findings, we propose that the piroxicam:Eudragit RS100 nanosuspensions may be considered as an improved ocular delivery system for locally inhibition of inflammation...
  27. ncbi request reprint The microsponge delivery system of benzoyl peroxide: preparation, characterization and release studies
    M Jelvehgari
    School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Int J Pharm 308:124-32. 2006
    ..The results showed that, generally, an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from microsponges which was attributed to a decreased internal porosity of the microsponges...
  28. ncbi request reprint The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts
    Ali Nokhodchi
    Department of Pharmacy, School of Health and Life Sciences, King s College London, London, United Kingdom
    J Pharm Pharm Sci 8:18-25. 2005
    ..The object of the present study is to increase dissolution rate of indomethacin using liquisolid compacts...
  29. ncbi request reprint The influence of thermal treatment on the release behavior of diclofenac sodium from acrylic matrices
    Shirzad Azarmi
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    Pharm Dev Technol 10:233-9. 2005
    ..These structural changes in the tablet compacts resulted in a matrix structure that decreased the release rate of the diclofenac sodium from Eudragit matrices...
  30. ncbi request reprint Preparation and characterization of solid dispersions of piroxicam with hydrophilic carriers
    Hadi Valizadeh
    Department of Pharmaceutics, Tabriz University of Medical Sciences, Tabriz, Iran
    Drug Dev Ind Pharm 33:45-56. 2007
    ..Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit E100...
  31. ncbi request reprint Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)
    Yousef Javadzadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
    Int J Pharm 341:26-34. 2007
    ..The results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process...
  32. ncbi request reprint In situ cross-linking of sodium alginate with calcium and aluminum ions to sustain the release of theophylline from polymeric matrices
    Ali Nokhodchi
    Pharmacy Department, Kings College London, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NN, UK
    Farmaco 59:999-1004. 2004
    ....
  33. ncbi request reprint Swellable elementary osmotic pump (SEOP): an effective device for delivery of poorly water-soluble drugs
    Javad Shokri
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Eur J Pharm Biopharm 68:289-97. 2008
    ..This study also revealed that optimization of semipermeable membrane thickness is very important for approaching zero order kinetics...
  34. ncbi request reprint Factors affecting the morphology of benzoyl peroxide microsponges
    Ali Nokhodchi
    Chemistry and Drug Delivery Group, Medway School of Pharmacy, Universities of Kent and Greenwich, Central Avenue, Anson Building, Chatham Maritime, Kent ME4 4TB, UK
    Micron 38:834-40. 2007
    ..The kinetics of release study showed that the release data followed Peppas model and the main mechanism of drug release from BPO microsponges was diffusion...
  35. ncbi request reprint An investigation of physicochemical properties of piroxicam liquisolid compacts
    Yousef Javadzadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
    Pharm Dev Technol 12:337-43. 2007
    ..The results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between piroxicam and exipients (Avicel and silica) during the process...
  36. ncbi request reprint Inhibition of endotoxin-induced uveitis by methylprednisolone acetate nanosuspension in rabbits
    Khosro Adibkia
    Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
    J Ocul Pharmacol Ther 23:421-32. 2007
    ....