Anna M Geretti

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Primary antiretroviral resistance in newly diagnosed patients with established heterosexually acquired HIV-1
    Anna Maria Geretti
    AIDS 16:2358-60. 2002
  2. ncbi Clinical implications of HIV drug resistance to nucleoside and nucleotide reverse transcriptase inhibitors
    Anna Maria Geretti
    Dept of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
    AIDS Rev 8:210-20. 2006
  3. doi Effect of HIV-1 subtype on virologic and immunologic response to starting highly active antiretroviral therapy
    Anna Maria Geretti
    Royal Free Hampstead NHS Trust, Department of Virology, University College London Medical School, Health Protection Agency, London, England
    Clin Infect Dis 48:1296-305. 2009
  4. doi Antiretroviral drug resistance in HIV-1-infected patients with low-level viremia
    Nicola E Mackie
    Imperial College Healthcare National Health Service Trust, London, United Kingdom
    J Infect Dis 201:1303-7. 2010
  5. ncbi HIV-1 subtypes: epidemiology and significance for HIV management
    Anna Maria Geretti
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 19:1-7. 2006
  6. ncbi Epidemiology of antiretroviral drug resistance in drug-naïve persons
    Anna Maria Geretti
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 20:22-32. 2007
  7. pmc Genital herpes
    A M Geretti
    Department of Virology, Royal Free Hospital, London NW3 2QG, UK
    Sex Transm Infect 82:iv31-4. 2006
  8. doi Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
  9. doi Immunization for HIV-positive individuals
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, UK
    Curr Opin Infect Dis 23:32-8. 2010
  10. pmc National survey of diagnostic services for genital herpes
    A M Geretti
    Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, UK
    Sex Transm Infect 81:316-7. 2005

Collaborators

Detail Information

Publications47

  1. ncbi Primary antiretroviral resistance in newly diagnosed patients with established heterosexually acquired HIV-1
    Anna Maria Geretti
    AIDS 16:2358-60. 2002
  2. ncbi Clinical implications of HIV drug resistance to nucleoside and nucleotide reverse transcriptase inhibitors
    Anna Maria Geretti
    Dept of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
    AIDS Rev 8:210-20. 2006
    ..In spite of these limitations, resistance testing with appropriate interpretation provides an important guide to successful treatment outcomes and necessary support to the introduction of new treatment strategies...
  3. doi Effect of HIV-1 subtype on virologic and immunologic response to starting highly active antiretroviral therapy
    Anna Maria Geretti
    Royal Free Hampstead NHS Trust, Department of Virology, University College London Medical School, Health Protection Agency, London, England
    Clin Infect Dis 48:1296-305. 2009
    ..Studies to date, however, have described treatment outcomes predominantly in persons with subtype B infection or compared subtype B with diverse non-B subtypes grouped together...
  4. doi Antiretroviral drug resistance in HIV-1-infected patients with low-level viremia
    Nicola E Mackie
    Imperial College Healthcare National Health Service Trust, London, United Kingdom
    J Infect Dis 201:1303-7. 2010
    ..7%] of 7861 tests). We conclude that HIV-1 genotypic resistance testing is informative for patients with low viral loads...
  5. ncbi HIV-1 subtypes: epidemiology and significance for HIV management
    Anna Maria Geretti
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 19:1-7. 2006
    ....
  6. ncbi Epidemiology of antiretroviral drug resistance in drug-naïve persons
    Anna Maria Geretti
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 20:22-32. 2007
    ..An update is given on the epidemiology of transmitted antiretroviral drug resistance among HIV-1-infected adults...
  7. pmc Genital herpes
    A M Geretti
    Department of Virology, Royal Free Hospital, London NW3 2QG, UK
    Sex Transm Infect 82:iv31-4. 2006
  8. doi Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
    ..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
  9. doi Immunization for HIV-positive individuals
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, UK
    Curr Opin Infect Dis 23:32-8. 2010
    ..This review summarizes recent literature addressing immunization in the setting of HIV infection, with a specific focus on emerging evidence that can guide the care of HIV-positive adults...
  10. pmc National survey of diagnostic services for genital herpes
    A M Geretti
    Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, UK
    Sex Transm Infect 81:316-7. 2005
    ..To investigate the provision of diagnostic services for genital herpes simplex virus (HSV) infection in the United Kingdom...
  11. ncbi Determinants of virological failure after successful viral load suppression in first-line highly active antiretroviral therapy
    Anna M Geretti
    Royal Free and University College Medical School, London, UK
    Antivir Ther 13:927-36. 2008
    ....
  12. doi Shifting paradigms: the resistance profile of etravirine
    Anna Maria Geretti
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
    J Antimicrob Chemother 62:643-7. 2008
    ....
  13. ncbi Resistance testing methodologies and mechanisms of resistance
    Anna Maria Geretti
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J HIV Ther 12:84-7. 2007
  14. pmc Detection of highly prevalent hepatitis B virus coinfection among HIV-seropositive persons in Ghana
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust and UCL Medical School, Pond Street, London NW3 2QG, United Kingdom
    J Clin Microbiol 48:3223-30. 2010
    ..6%). The prevalence of HBV coinfection was high in this HIV-positive Ghanaian cohort. The two rapid assays identified HBsAg-positive patients at risk for liver disease with high specificity, albeit with only moderate sensitivity...
  15. ncbi Predictors and kinetics of occult hepatitis B virus infection in HIV-infected persons
    Gaia Nebbia
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J Med Virol 79:1464-71. 2007
    ..The intermittent nature of HBV-DNA detection poses a diagnostic challenge, but no association is observed with ALT levels...
  16. ncbi Population trends in the prevalence and patterns of protease resistance related to exposure to unboosted and boosted protease inhibitors
    David Dunn
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 13:771-7. 2008
    ..These changes might be expected to affect the prevalence and patterns of protease resistance in the population of patients who experience treatment failure...
  17. doi Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphism
    Ana Garcia-Diaz
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J Antimicrob Chemother 62:1188-90. 2008
    ....
  18. doi Long-term trends in adherence to antiretroviral therapy from start of HAART
    Valentina Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    AIDS 24:1153-62. 2010
    ..We aimed to investigate long-term trends in highly active antiretroviral therapy (HAART) adherence to identify the main predictors and to evaluate whether participants experience periods of low adherence (<or=60%)...
  19. ncbi Emergence of the H208Y mutation in the reverse transcriptase (RT) of HIV-1 in association with nucleoside RT inhibitor therapy
    G Nebbia
    Department of Virology, Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF London, UK
    J Antimicrob Chemother 59:1013-6. 2007
    ..The aim of the study was to determine whether mutations at RT codon 208 are associated with nucleoside RT inhibitor (NRTI) exposure, NRTI resistance patterns and HIV-1 subtype...
  20. doi The impact of different definitions on the estimated rate of transmitted HIV drug resistance in the United Kingdom
    Hannah Green
    HIV Group, Medical Research Council Clinical Trials Unit, 222 Euston Road, London, United Kingdom
    J Acquir Immune Defic Syndr 49:196-204. 2008
    ..The use of different lists of resistance mutations has resulted in estimates of transmitted HIV drug resistance (THDR) that are often not comparable...
  21. ncbi Essential benefits of nucleoside analogue regimens in failing therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
    J HIV Ther 9:28-33. 2004
    ..This may reflect residual direct viral load suppression, as well as indirect effects related to impaired viral fitness of NRTI-resistant mutants and antagonist interactions between resistance mutations...
  22. ncbi The clinical significance of viral fitness
    Anna Maria Geretti
    Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, UK
    J HIV Ther 10:6-10. 2005
    ..In this context, it remains controversial whether it is preferable to continue failing therapy with nucleoside reverse transcriptase inhibitors, protease inhibitors or both...
  23. ncbi The ability of four genotypic interpretation systems to predict virological response to ritonavir-boosted protease inhibitors
    Zoe V Fox
    Copenhagen HIV Programme, Medical Faculty at University of Copenhagen, Denmark
    AIDS 21:2033-42. 2007
    ..We compared PI/r resistance levels ascribed by four GIS and examined their abilities to predict HIV-RNA reductions after starting a PI/r-based regimen (baseline)...
  24. ncbi Impact of transmitted drug-resistance on treatment selection and outcome of first-line Highly Active Antiretroviral Therapy (HAART)
    Loveleen Bansi
    HIV Epidemiology nad Biostatistics Group, Research Department of Infection and Population Health, Division of Population Health, Hampstead Campus, University College Medical School, University College London, Rowland Street, NW3 2PF, London, United Kingdom
    J Acquir Immune Defic Syndr 53:633-9. 2010
    ..The study aim was to determine how resistance testing influences outcome of first-line highly active antiretroviral therapy (HAART) in routine practice in the United Kingdom...
  25. ncbi Interactions and management issues in HSV and HIV coinfection
    Meghna Ramaswamy
    Royal Free Hospital and Royal Free and University College Medical School, Department of Virology, Pond Street, London NW3 2QG, UK
    Expert Rev Anti Infect Ther 5:231-43. 2007
    ..The aim of this review is to address the more speculative issues surrounding the management of HSV/HIV coinfection and to summarize the data that inform them...
  26. doi Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion
    Andrew N Phillips
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free Campus, UCL Royal Free Campus, London, UK
    AIDS 24:1561-7. 2010
    ..Understanding of the interplay between plasma HIV RNA level and CD4 cell count depletion in untreated infection remains incomplete...
  27. ncbi Reconstitution of herpes simplex virus-specific T cell immunity in HIV-infected patients receiving highly active antiretroviral therapy
    Meghna Ramaswamy
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, North Middlesex University Hospital, London, UK
    J Infect Dis 195:410-5. 2007
    ..6/month (95% confidence interval, 1.2-9.9 [P=.01]) and 21.3/100 CD4 cells/mm(3) gained (95% confidence interval, 13.8-28.7 [P<.0001]). Responses were correlated with LTNP status and CD4 cell count...
  28. pmc Demonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naïve individuals
    Stephane Hue
    UCL MRC Centre for Medical Molecular Virology, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, United Kingdom
    J Virol 83:2645-54. 2009
    ..These findings provide new insights for the planning and management of treatment programs in resource-rich and developing countries...
  29. ncbi Prevalence and determinants of transmitted antiretroviral drug resistance in HIV-1 infection
    Clare L Booth
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J Antimicrob Chemother 59:1047-56. 2007
    ..In addition, factors such as superinfection and possible differences in resistance patterns between plasma and cellular reservoirs and between anatomical compartments should be considered when evaluating TDR...
  30. ncbi Evidence for onward transmission of HIV-1 non-B subtype strains in the United Kingdom
    Ila Aggarwal
    Department of HIV GU Medicine, Kings College London School of Medicine at Guy s, Kings College and St Thomas Hospitals, West Education Centre, London, UK
    J Acquir Immune Defic Syndr 41:201-9. 2006
    ..This study provides the first evidence for onward transmission of non-B subtypes in the United Kingdom, particularly among the black Caribbean population...
  31. ncbi Travel-associated acquisition of hepatitis C virus infection in patients receiving haemodialysis
    Abdul Ghafur
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Nephrol Dial Transplant 22:2640-4. 2007
    ..This carries important implications for the design of surveillance policies...
  32. ncbi Prevalence and predictors of antiretroviral drug resistance in newly diagnosed HIV-1 infection
    Clare L Booth
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J Antimicrob Chemother 59:517-24. 2007
    ..To determine prevalence and predictors of antiretroviral drug resistance in newly diagnosed individuals with HIV-1 infection, using a systematic approach to avoid selection bias...
  33. pmc Comparative evaluation of the ExaVir Load version 3 reverse transcriptase assay for measurement of human immunodeficiency virus type 1 plasma load
    Wendy Labbett
    Department of Virology, Royal Free Hampstead NHS Trust and University College London Medical School, London, United Kingdom
    J Clin Microbiol 47:3266-70. 2009
    ..2 (range, 0.0 to 0.5) log10 copies/ml. The ExaVir assay showed excellent concordance with real-time molecular assays, offering a suitable option for virological monitoring in settings with limited infrastructure...
  34. ncbi Detection and typing of herpes simplex DNA in genital swabs by real-time polymerase chain reaction
    Meghna Ramaswamy
    Department of Virology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    J Virol Methods 126:203-6. 2005
    ..Alternative typing methods are recommended for specimens with atypical melting curves...
  35. ncbi Herpes simplex virus type 2 (HSV-2) seroprevalence at the time of HIV-1 diagnosis and seroincidence after HIV-1 diagnosis in an ethnically diverse cohort of HIV-1-infected persons
    Meghna Ramaswamy
    Department of Virology, Royal Free and University College Medical School, London, UK
    Sex Transm Dis 33:96-101. 2006
    ..The objective of this study was to determine herpes simplex virus type 2 (HSV-2) seroprevalence at HIV-1 diagnosis and seroincidence > or =1 year after HIV-1 diagnosis...
  36. ncbi Disseminated neonatal herpes simplex virus (HSV) type 2 infection diagnosed by HSV DNA detection in blood and successfully managed by liver transplantation
    Mary Twagira
    Department of Infection, King s College Hospital and Guy s King s and St Thomas Medical School, London, UK
    Eur J Pediatr 163:166-9. 2004
    ..It is one of very few reports where liver transplantation has been successfully carried out in a neonate with herpes simplex virus-induced liver failure...
  37. doi Seroprevalence of common vaccine-preventable viral infections in HIV-positive adults
    James Molton
    Department of Virology, Royal Free Hampstead NHS Trust and University College London Medical School, Pond Street, London NW3 2QG, United Kingdom
    J Infect 61:73-80. 2010
    ..The study determined serostatus and recalled infection and vaccination history for measles, mumps, rubella, varicella-zoster virus (VZV), hepatitis A, and hepatitis B among HIV-positive adults accessing routine care...
  38. ncbi Long term probability of detection of HIV-1 drug resistance after starting antiretroviral therapy in routine clinical practice
    Andrew N Phillips
    AIDS 19:487-94. 2005
    ..Little is known about the long term risk of development of HIV-1 drug resistance for patients starting antiretroviral therapy (ART) with three or four drug regimens in routine clinical practice...
  39. ncbi High levels of discordance between sequencing and serological subtyping in a predominantly non-B subtype HIV-1 infected cohort
    Melvyn Smith
    Health Protection Agency London, King s College Hospital Dulwich Site, East Dulwich Grove, London SE22 8QF, UK
    J Clin Virol 33:312-8. 2005
    ..The overall agreement between the three methods was 89%. Four out of 11 samples agreed between the phylogenetic and Los Alamos methods, 1/11 between phylogenetic and BLAST and 2/11 between Los Alamos and BLAST...
  40. ncbi Antiretroviral resistance
    Anna Maria Geretti
    J HIV Ther 11:72-3. 2006
  41. pmc Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study
    Patricia Cane
    BMJ 331:1368. 2005
    ..To examine whether the level of primary resistance to HIV drugs is increasing in the United Kingdom...
  42. doi HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004
    Rana Chakraborty
    Paediatric Infectious Diseases Unit, St George s Hospital, London
    Pediatr Infect Dis J 27:457-9. 2008
    ..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...
  43. ncbi New horizons in antiretroviral drug resistance
    Anna Maria Geretti
    J HIV Ther 12:81-2. 2007
  44. ncbi Immunization of the HIV infected traveller
    David R Chadwick
    AIDS 21:787-94. 2007
  45. pmc HIV phylogenetics
    Deenan Pillay
    BMJ 335:460-1. 2007
  46. ncbi Human T-cell lymphotropic virus antibody prevalence in HIV-1-infected individuals attending a sexual health clinic in South-East London
    Fiona J Cooke
    Health Protection Agency London and King s College Hospital NHS Trust, Guy s, King s and St Thomas School of Medicine, London South Specialist Virology Centre, England
    J Med Virol 76:143-5. 2005
    ..The results suggest HTLV antibody screening should be considered in the local HIV infected population of south London...
  47. pmc Missed opportunities: Undiagnosed HIV infection in patients with viral hepatitis
    Anna Maria Geretti
    BMJ 336:1451-2. 2008