Genomes and Genes
Affiliation: University of Cambridge
- Retinoid X receptor-gamma gene expression is developmentally regulated in the embryonic rodent peripheral nervous systemP Georgiades
Department of Molecular Pathology, University College London Medical School, UK
Anat Embryol (Berl) 197:477-84. 1998..We discuss the possible significance of the timing of RXRgamma expression in the developing PNS and suggest that closer examination of the structure and function of the PNS of RXRgamma null mutant mice would be of interest...
- Comparative developmental anatomy of the murine and human definitive placentaeP Georgiades
Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
Placenta 23:3-19. 2002..This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work...
- Differential expression of the rat retinoid X receptor gamma gene during skeletal muscle differentiation suggests a role in myogenesisP Georgiades
Department of Molecular Pathology, University College London Medical School, England
Dev Dyn 210:227-35. 1997..This dynamic expression pattern of RXRgamma during myogenesis suggests its possible involvement in the differentiation of limb myoblasts but excludes a role in the differentiation of early myotomal myoblasts...
- Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12P Georgiades
Department of Anatomy, University of Cambridge, Downing St, Cambridge CB2 3DY, UK
Development 127:4719-28. 2000..Thus, imprinted genes on chromosome 12 are essential for viability, the regulation of prenatal growth, and the development of mesodermal and neural crest-derived lineages...
- Regulation of retinoid X receptor-gamma gene transcript levels in rat heart cellsP Georgiades
Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, 46 Cleveland Street, London, W1P 6DB, U K
Cell Biol Int 22:457-63. 1998..It was shown by Northern blot experiments, that in this system, RXRgamma transcript levels are differentially influenced by these two hormones. The significance of these findings in relation to previously published work is discussed...
- Roles for genomic imprinting and the zygotic genome in placental developmentP Georgiades
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
Proc Natl Acad Sci U S A 98:4522-7. 2001..They provide insights into the function of imprinting in placental development and have evolutionary and clinical implications...
- Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal developmentP Georgiades
Department of Immunology, University College London Medical School, UK
Immunology 88:447-51. 1996..The steady-state levels of H2-Ab mRNA appeared to be approximately 10 to 14 times greater that the level of H2-Mb mRNA molecules, irrespectively of the tissue and age, reflecting the different functions of the two molecules...
- Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12S Takada
Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK
Curr Biol 10:1135-8. 2000..Like H19 and Igf2, Gtl2 and Dlk were found to be co-expressed in the same tissues throughout development, though not after birth. These results have implications for the regulation, function and evolution of imprinted domains...