A R Gennery

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Primary immunodeficiency syndromes associated with defective DNA double-strand break repair
    A R Gennery
    Department of Paediatric Immunology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Br Med Bull 77:71-85. 2006
  2. ncbi request reprint Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002
    Andrew R Gennery
    Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE United Kingdom
    Blood 103:1152-7. 2004
  3. doi request reprint Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better?
    Andrew R Gennery
    Institute of Cellular Medicine, Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 126:602-10.e1-11. 2010
  4. ncbi request reprint Omenn's syndrome occurring in patients without mutations in recombination activating genes
    Andrew R Gennery
    Department of Paediatrics, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Clin Immunol 116:246-56. 2005
  5. ncbi request reprint The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia
    A R Gennery
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Clin Immunol 113:214-9. 2004
  6. pmc Mutations in CHD7 in patients with CHARGE syndrome cause T-B + natural killer cell + severe combined immune deficiency and may cause Omenn-like syndrome
    A R Gennery
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Clin Exp Immunol 153:75-80. 2008
  7. ncbi request reprint Cord blood stem cell transplantation in primary immune deficiencies
    Andrew R Gennery
    Institute of Cellular Medicine, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, UK
    Curr Opin Allergy Clin Immunol 7:528-34. 2007
  8. ncbi request reprint Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome
    Andrew R Gennery
    Paediatric Immunology Department, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Pediatrics 120:e1341-4. 2007
  9. doi request reprint Immunological aspects of 22q11.2 deletion syndrome
    A R Gennery
    Institute of Cellular Medicine, Old Children s Outpatients, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Cell Mol Life Sci 69:17-27. 2012
  10. ncbi request reprint Single centre experience of umbilical cord stem cell transplantation for primary immunodeficiency
    A Bhattacharya
    Paediatric Immunology Department, Newcastle General Hospital, Newcastle upon Tyne, UK
    Bone Marrow Transplant 36:295-9. 2005

Detail Information

Publications50

  1. ncbi request reprint Primary immunodeficiency syndromes associated with defective DNA double-strand break repair
    A R Gennery
    Department of Paediatric Immunology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Br Med Bull 77:71-85. 2006
    ..Conventional treatment with immunoglobulin replacement or haematopoietic stem cell transplantation (HSCT) can be effective. A greater understanding of the molecular defect will enable better, tailored therapies to improve survival...
  2. ncbi request reprint Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002
    Andrew R Gennery
    Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE United Kingdom
    Blood 103:1152-7. 2004
    ..Preexisting lung damage was the most important adverse risk factor. Further studies will determine optimal timing and type of HSCT...
  3. doi request reprint Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better?
    Andrew R Gennery
    Institute of Cellular Medicine, Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 126:602-10.e1-11. 2010
    ..Hematopoietic stem cell transplantation remains the only treatment for most patients with severe combined immunodeficiencies (SCIDs) or other primary immunodeficiencies (non-SCID PIDs)...
  4. ncbi request reprint Omenn's syndrome occurring in patients without mutations in recombination activating genes
    Andrew R Gennery
    Department of Paediatrics, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Clin Immunol 116:246-56. 2005
    ..OS is a genetically heterogeneous condition, and patients with similar immunophenotypes may have as yet unidentified gene defects...
  5. ncbi request reprint The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia
    A R Gennery
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Clin Immunol 113:214-9. 2004
    ..The importance of genetic diagnosis with respect to treatment and prognosis is discussed...
  6. pmc Mutations in CHD7 in patients with CHARGE syndrome cause T-B + natural killer cell + severe combined immune deficiency and may cause Omenn-like syndrome
    A R Gennery
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Clin Exp Immunol 153:75-80. 2008
    ..Immunodeficiency in patients with DiGeorge syndrome is well recognized--CHARGE syndrome should now be added to the causes of T-B + NK + SCID, and mutations in the CHD7 gene may be associated with Omenn-like syndrome...
  7. ncbi request reprint Cord blood stem cell transplantation in primary immune deficiencies
    Andrew R Gennery
    Institute of Cellular Medicine, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, UK
    Curr Opin Allergy Clin Immunol 7:528-34. 2007
    ..Cord blood biology is reviewed, and advantages and disadvantages of umbilical cord blood stem cell transplantation for primary immunodeficiencies discussed. Clinical outcome data and future developments are reviewed...
  8. ncbi request reprint Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome
    Andrew R Gennery
    Paediatric Immunology Department, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Pediatrics 120:e1341-4. 2007
    ..In all cases, donor chimerism led to resolution of intestinal complications and infections, growth improvement, and correction of the immunodeficiency...
  9. doi request reprint Immunological aspects of 22q11.2 deletion syndrome
    A R Gennery
    Institute of Cellular Medicine, Old Children s Outpatients, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Cell Mol Life Sci 69:17-27. 2012
    ..Combined partial immunodeficiency is more common, leading to recurrent sinopulmonary infection in early childhood. Autoimmunity is an increasingly recognized complication. New insights into pathophysiology are reviewed...
  10. ncbi request reprint Single centre experience of umbilical cord stem cell transplantation for primary immunodeficiency
    A Bhattacharya
    Paediatric Immunology Department, Newcastle General Hospital, Newcastle upon Tyne, UK
    Bone Marrow Transplant 36:295-9. 2005
    ..Two patients died of multi-organ failure related to pre-existing infection and inflammatory complications respectively. UCSCT should be considered for patients requiring stem cell therapy for PID...
  11. pmc Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED
    K R Ryan
    Institute for Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Clin Exp Immunol 154:406-14. 2008
    ..We demonstrate different pathogenic mechanisms on the same immune response pathway underlying increased susceptibility to Candida infection in these patients...
  12. ncbi request reprint Outcome of boost haemopoietic stem cell transplant for decreased donor chimerism or graft dysfunction in primary immunodeficiency
    M A Slatter
    Department of Paediatric Immunology, University of Newcastle upon Tyne, Newcastle General Hospital, NHS Trust, Newcastle upon Tyne, UK
    Bone Marrow Transplant 35:683-9. 2005
    ..Boost infusion was successful or partially successful in 84% of patients. The risk of adverse effects is low...
  13. ncbi request reprint Polysaccharide antibody responses are impaired post bone marrow transplantation for severe combined immunodeficiency, but not other primary immunodeficiencies
    M A Slatter
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Bone Marrow Transplant 32:225-9. 2003
    ..This is the first study to specifically examine PPS antibody responses following SCID and PID BMT. Pneumococcal conjugate vaccine antibody responses should be examined in these children...
  14. pmc Bone marrow transplantation for CD40 ligand deficiency: a single centre experience
    K Khawaja
    Department of Paediatric Immunology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Arch Dis Child 84:508-11. 2001
    ..CONCLUSIONS: Bone marrow transplantation can be curative in CD40L deficiency. Better outcome is associated with younger age at transplantation and normal liver histology...
  15. pmc Neonatal bone marrow transplantation for severe combined immunodeficiency
    L Kane
    Department of Paediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, UK
    Arch Dis Child Fetal Neonatal Ed 85:F110-3. 2001
    ..CONCLUSION: These results are better than those published for in utero BMT for SCID. Early postnatal BMT should be the preferred option in neonatal SCID...
  16. pmc Antibody deficiency and autoimmunity in 22q11.2 deletion syndrome
    A R Gennery
    Department of Paediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Arch Dis Child 86:422-5. 2002
    ..Isolated cases of autoimmunity have been reported. Several patients with 22q11.2 deletion attending our immunology clinic suffered recurrent sinopulmonary infection or autoimmune phenomena...
  17. pmc Responses to a conjugate pneumococcal vaccine in preterm infants immunized at 2, 3, and 4 months of age
    S J Moss
    Newcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Clin Vaccine Immunol 17:1810-6. 2010
    ..35 μg/ml for 2 serotypes. In nonboosted infants, GMCs for all serotypes except 6B had fallen by 12 months of age. These results support the need for a booster dose in the second year of life...
  18. ncbi request reprint Lymphocyte subset populations in children with polysaccharide antibody deficiency following cardiac transplantation
    A R Gennery
    Department of Pediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, England
    J Clin Immunol 21:37-42. 2001
    ..PPS antibody deficiency following pediatric cardiac transplantation may be related to an immaturity in B cells due to immunosuppression commenced in early childhood...
  19. ncbi request reprint Characterization of the impaired antipneumococcal polysacharide antibody production in immunosuppressed pediatric patients following cardiac transplantation
    A R Gennery
    Department of Pediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, England
    J Clin Immunol 21:43-50. 2001
    ..These findings confirm data regarding the effect of immunosuppressive agents derived from animal models in humans...
  20. ncbi request reprint Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases
    M A Slatter
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Bone Marrow Transplant 40:529-33. 2007
    ..Routine non-bronchoscopic BAL is safe in immunodeficient patients about to undergo HSCT, and leads to management changes...
  21. ncbi request reprint Use of two unrelated umbilical cord stem cell units in stem cell transplantation for Wiskott-Aldrich syndrome
    M A Slatter
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, Newcastle, United Kingdom
    Pediatr Blood Cancer 47:332-4. 2006
    ..We report the case of a child with Wiskott-Aldrich syndrome who underwent cord blood stem cell transplantation with two separate cord blood units, 8 days apart...
  22. ncbi request reprint Thyroid dysfunction after bone marrow transplantation for primary immunodeficiency without the use of total body irradiation in conditioning
    M A Slatter
    Department of Paediatric Immunology Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK
    Bone Marrow Transplant 33:949-53. 2004
    ..Abnormalities of thyroid function including severe primary hypothyroidism may occur post-BMT in children receiving chemotherapy conditioning without TBI. Thyroid function should be assessed regularly in this group of patients...
  23. ncbi request reprint Immunodeficiency and autoimmunity in 22q11.2 deletion syndrome
    A McLean-Tooke
    Department of Immunology, Royal Victoria Infirmary, Newcastle General Hospital, Newcastle upon Tyne, UK
    Scand J Immunol 66:1-7. 2007
    ..A number of immune defects may predispose to the development of autoimmunity in these patients including increased infection, impaired development of natural T-regulatory cells and impaired thymic central tolerance...
  24. doi request reprint Advances in hematopoietic stem cell transplantation for primary immunodeficiency
    Andrew R Gennery
    Institute of Cellular Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK Children s Bone Marrow Transplant Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Immunol Allergy Clin North Am 28:439-56, x-xi. 2008
    ..This article examines the advances in HSCT for PID and argues that HSCT should be considered earlier for most patients...
  25. doi request reprint Outcome of children requiring intensive care following haematopoietic SCT for primary immunodeficiency and other non-malignant disorders
    T S Cole
    Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    Bone Marrow Transplant 47:40-5. 2012
    ..This information is useful when counselling families of children that have deteriorated and been admitted to intensive care during the HSCT procedure...
  26. pmc T cell receptor Vbeta repertoire of T lymphocytes and T regulatory cells by flow cytometric analysis in healthy children
    A McLean-Tooke
    Department of Immunology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Clin Exp Immunol 151:190-8. 2008
    ....
  27. pmc Clinical immunology review series: an approach to the patient with recurrent infections in childhood
    M A Slatter
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Clin Exp Immunol 152:389-96. 2008
    ..This paper describes important presenting features of primary immunodeficiency and indicates when further investigation is warranted...
  28. ncbi request reprint Umbilical cord stem cell transplantation for primary immunodeficiencies
    M A Slatter
    Department of Paediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Expert Opin Biol Ther 6:555-65. 2006
    ....
  29. pmc Diagnosis of severe combined immunodeficiency
    A R Gennery
    Department of Paediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Clin Pathol 54:191-5. 2001
    ..This review outlines clinical, microbiological, and immunopathological clues that aid the diagnosis of SCID and emphasises the multidisciplinary approach needed to diagnose and treat these infants...
  30. doi request reprint Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007)
    Mario Abinun
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
    Mol Immunol 47:46-51. 2009
    ..Here we report on the outcome and transplant-related complications...
  31. doi request reprint Prevention and management of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation--a systematic review and evidence-based guidance for clinical management
    Christian Harkensee
    Supra regional Children s Bone Marrow Transplant Unit CBMTU, Newcastle General Hospital, Newcastle upon Tyne, UK
    Br J Haematol 142:717-31. 2008
    ..Further high-quality studies are required to establish effective and safe prevention and treatment options for HC...
  32. ncbi request reprint GvHD-associated cytokine polymorphisms do not associate with Omenn syndrome rather than T-B- SCID in patients with defects in RAG genes
    Iram J Haq
    Institute of Cellular Medicine, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Clin Immunol 124:165-9. 2007
    ..No significant differences in allele frequencies were found between the groups, and no trends identified. The mechanisms determining the OS or T-B-NK+ SCID phenotype remain to be determined...
  33. pmc Special article: chronic granulomatous disease in the United Kingdom and Ireland: a comprehensive national patient-based registry
    L B K R Jones
    School of Clinical Medical Sciences, Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Clin Exp Immunol 152:211-8. 2008
    ..Morbidity remains significant, severe infectious complications common. Curative treatments including stem cell transplantation should be considered for patients with frequent or serious complications...
  34. pmc Anhidrotic ectodermal dysplasia and immunodeficiency: the role of NEMO
    E D Carrol
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK
    Arch Dis Child 88:340-1. 2003
    ..This protein is essential for activation of the transcription factor NF-kappaB, which plays an important role in human development, skin homoeostasis, and immunity...
  35. pmc Impact of the 7-valent pneumococcal conjugate vaccine on the incidence of childhood pneumonia
    M A Elemraid
    Department of Paediatric Infectious Disease and Immunology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK
    Epidemiol Infect 141:1697-704. 2013
    ..In conclusion, PCV7 has reduced both incidence and rate of hospitalization of pneumonia in children, particularly in the <2 years age group...
  36. pmc Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
    M Hong
    Institute for Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Clin Exp Immunol 156:40-51. 2009
    ..Thus, impaired DC maturation and consequent altered regulation of PRR signalling pathways rather than defects in PRR expression may be responsible for inadequate Candida handling in CMC patients...
  37. ncbi request reprint Long-term immune reconstitution after anti-CD52-treated or anti-CD34-treated hematopoietic stem cell transplantation for severe T-lymphocyte immunodeficiency
    Mary A Slatter
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 121:361-7. 2008
    ..T cell-depleted haploidentical transplantations are successful if there is no HLA-identical donor. Methods to remove T lymphocytes include addition of anti-CD52 antibodies and CD34(+) HSC selection...
  38. doi request reprint Unrelated donor and HLA-identical sibling haematopoietic stem cell transplantation cure chronic granulomatous disease with good long-term outcome and growth
    Elena Soncini
    Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Br J Haematol 145:73-83. 2009
    ..Transplant-associated complications were restricted to those with pre-existing infection or inflammation, supporting the argument for early HSCT for more CGD patients with a well matched donor...
  39. pmc Immunogenicity of a heptavalent conjugate pneumococcal vaccine administered concurrently with a combination diphtheria, tetanus, five-component acellular pertussis, inactivated polio, and Haemophilus influenzae type B vaccine and a meningococcal group C c
    S J Moss
    Newcastle Neonatal Services, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Clin Vaccine Immunol 17:311-6. 2010
    ..Despite this finding, there was a good response following a 4th dose of PCV7...
  40. ncbi request reprint Posttransplantation B lymphoblastic leukemia with Burkitt-like features
    D A Tweddle
    Department of Child Health, Royal Victoria Infirmary, Newcastle, United Kingdom
    Transplantation 67:1379-80. 1999
    ..To our knowledge, PTLPD has not been previously reported to present as acute lymphoblastic leukemia...
  41. ncbi request reprint Outcome of hematopoietic stem cell transplantation in severe combined immune deficiency with central nervous system viral infection
    Cathy Waruiru
    Paediatric Immunology Department, Newcastle General Hospital, Newcastle upon Tyne, UK
    Pediatr Infect Dis J 26:129-33. 2007
    ..With inhaled steroid and antitumor necrosis factor alpha antibody treatment, results improved. The poor outcome of patients with viral central nervous system infection prompted this retrospective single center review...
  42. doi request reprint Primary immunodeficiencies associated with DNA-repair disorders
    Mary A Slatter
    Department of Paediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, UK
    Expert Rev Mol Med 12:e9. 2010
    ..We describe the mechanisms involved in the development of adaptive immunity relating to DNA repair, and the clinical consequences and treatment of the primary immunodeficiency resulting from such defects...
  43. pmc Adenovirus type F subtype 41 causing disseminated disease following bone marrow transplantation for immunodeficiency
    Mary A Slatter
    Paediatric Immunology Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    J Clin Microbiol 43:1462-4. 2005
    ..Serotypes 40 and 41, associated with gastrointestinal disease, have not previously been implicated in disseminated disease...
  44. ncbi request reprint Primary immunodeficiency syndromes
    Mary A Slatter
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, England
    Adv Exp Med Biol 685:146-65. 2010
    ..We describe the mechanisms involved in the development of adaptive immunity relating to DNA repair and describe the clinical consequences and treatment developments of primary immunodeficiency resulting from such defects...
  45. doi request reprint Immunologic defects in 22q11.2 deletion syndrome
    Andrew McLean-Tooke
    Department of Immunology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 122:362-7, 367.e1-4. 2008
    ..These patients have variable defects in T-cell immunity with an increased incidence of infection and autoimmune disease...
  46. ncbi request reprint Radiation-induced delayed cell death in a hypomorphic Artemis cell line
    Paul M Evans
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Hum Mol Genet 15:1303-11. 2006
    ..F96-224 therefore represents a novel phenotype for a hypomorphic cell line. We suggest that delayed cell death contributes to the progressive CID phenotype of the Artemis patient...
  47. ncbi request reprint Bone marrow transplantation for Nijmegan breakage syndrome
    Andrew R Gennery
    J Pediatr Hematol Oncol 27:239. 2005
  48. pmc Use of a heminested reverse transcriptase PCR assay for detection of astrovirus in environmental swabs from an outbreak of gastroenteritis in a pediatric primary immunodeficiency unit
    Chris I Gallimore
    Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, Colindale, London, NW9 5HT, United Kingdom
    J Clin Microbiol 43:3890-4. 2005
    ....
  49. pmc Environmental monitoring for gastroenteric viruses in a pediatric primary immunodeficiency unit
    Chris I Gallimore
    Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, Colindale, London NW9 5HT, United Kingdom
    J Clin Microbiol 44:395-9. 2006
    ..New cleaning schedules and changes in some of the PPIU sanitary furniture have been suggested as a means of reducing environmental contamination...
  50. pmc A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation
    Likun Du
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 3:e2482. 2008
    ..The Mre11-Rad50-NBS1 complex is thus unlikely to be the major nuclease involved in cleavage of the abasic sites during SHM, whereas NBS1 might have a specific role in regulating the strand-biased repair during phase Ib mutagenesis...