A Geerts

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
    A Geerts
    Department of Medical Cell Biology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Semin Liver Dis 21:311-35. 2001
  2. ncbi Formation of normal desmin intermediate filaments in mouse hepatic stellate cells requires vimentin
    A Geerts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Belgium
    Hepatology 33:177-88. 2001
  3. ncbi Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Jette, Belgium
    J Hepatol 34:230-8. 2001
  4. ncbi Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Belgium
    Br J Pharmacol 134:224-32. 2001
  5. ncbi Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gastroenterology 121:915-30. 2001
  6. ncbi Trichostatin A, lead compound for development of antifibrogenic drugs
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Acta Gastroenterol Belg 64:239-46. 2001
  7. ncbi Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gut 53:1180-9. 2004
  8. ncbi Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University Brussels VUB, Brussels, Belgium
    Gut 50:571-81. 2002

Detail Information

Publications8

  1. ncbi History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
    A Geerts
    Department of Medical Cell Biology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Semin Liver Dis 21:311-35. 2001
    ..They are important sources of paracrine, autocrine, juxtacrine, and chemoattractant factors that maintain homeostasis in the microenvironment of the hepatic sinusoid...
  2. ncbi Formation of normal desmin intermediate filaments in mouse hepatic stellate cells requires vimentin
    A Geerts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Belgium
    Hepatology 33:177-88. 2001
    ..Thus, to form normal IFs in stellate cells, desmin is required to partnerize with vimentin. In addition, these mouse models will prove to be instrumental in addressing the role of IFs in the process of stellate cell transdifferentiation...
  3. ncbi Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Jette, Belgium
    J Hepatol 34:230-8. 2001
    ..This study aims at evaluating the effect of aldosterone on extracellular matrix synthesis by rat hepatic stellate cells...
  4. ncbi Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Belgium
    Br J Pharmacol 134:224-32. 2001
    ....
  5. ncbi Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gastroenterology 121:915-30. 2001
    ..To elucidate some of the hemodynamic effects of somatostatin (SST) on portal pressure, the presence and function of SST receptors (SSTRs) on HSCs were investigated...
  6. ncbi Trichostatin A, lead compound for development of antifibrogenic drugs
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Acta Gastroenterol Belg 64:239-46. 2001
    ..Hyperacetylation of histone H4 showed to be maximal at 10(-7) M TSA. Primary hepatic stellate cells were more affected by TSA than subcultured stellate cells...
  7. ncbi Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gut 53:1180-9. 2004
    ....
  8. ncbi Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University Brussels VUB, Brussels, Belgium
    Gut 50:571-81. 2002
    ..Because stellate cells play a role in both fibrosis and portal hypertension, they are currently regarded as therapeutic targets to prevent and treat the complications of chronic liver disease...