Research Topics
| John GeddesSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Lack of effect of chromium supplementation on mental state and body weight in people with schizophreniaRena A Hockney
J Clin Psychopharmacol 26:544-5. 2006
Mood stability versus mood instability in bipolar disorder: a possible role for emotional mental imageryEmily A Holmes
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
Behav Res Ther 49:707-13. 2011..The findings were consistent with predictions. Further investigation of imagery in bipolar disorder appears warranted as it may highlight processes that contribute to mood instability with relevance for cognitive behaviour therapy...- Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysisJ Geddes
Department of Psychiatry University of Oxford, Warneford Hospital, Oxford OX3 7JX
BMJ 321:1371-6. 2000..To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia... - Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trialsAndrea Cipriani
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Am J Psychiatry 162:1805-19. 2005.... - Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trialsJohn R Geddes
Department of Psychiatry, University of Oxford, Warneford Hospital, UK
Am J Psychiatry 161:217-22. 2004..The authors sought to determine the efficacy and acceptability of lithium for relapse prevention in bipolar disorder... - Meta-analysis in the assessment of treatment outcomeJohn Geddes
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
J Psychopharmacol 20:67-71. 2006..Despite practical difficulties, IPDMAs are increasingly being conducted... 
Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trialsJohn R Geddes
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Br J Psychiatry 194:4-9. 2009..There is uncertainty about the efficacy of lamotrigine in bipolar depressive episodes...- Generating evidence to inform policy and practice: the example of the second generation "atypical" antipsychoticsJohn Geddes
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Schizophr Bull 29:105-14. 2003..Premature clinical practice guidelines or expert opinion can lead to changes in clinical practice that make it difficult or impossible to conduct the required trials and are therefore a disservice to patients... - Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic reviewJohn R Geddes
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Lancet 361:653-61. 2003..Antidepressant drugs can promote remission from acute depressive episodes. Our aim was to establish how long such treatments should be continued to prevent relapse... - Evidence-based medicine and neurophysiologyJohn R Geddes
Department of Psychiatry, University of Oxford, UK
Clin EEG Neurosci 40:59-61. 2009..Although the main driver of the development of EBM has been to get existing research into practice, the same approach can be used to inform the development of treatments... - Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trialJohn R Geddes
Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Lancet 375:385-95. 2010..We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder... - Bipolar disorder: clinical uncertainty, evidence-based medicine and large-scale randomised trialsJ Geddes
Department of Psychiatry, University of Oxford, UK
Br J Psychiatry Suppl 41:s191-4. 2001..The increasing use of the methods of evidence-based medicine to keep up-to-date with the research literature highlights the absence of high-quality evidence in many areas in psychiatry... - Recent advances in evidence-based psychiatryJ Geddes
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Can J Psychiatry 46:403-6. 2001..In this article, we describe some of the recent advances in evidence-based psychiatry and outline future challenges... - Bipolar disorder--services need to catch up with rapidly developing evidence baseJohn Geddes
University of Oxford, Warneford Hospital, Oxford OX10 0RU
BMJ 332:32-3. 2006 - Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for PsychopharmacologyG M Goodwin
University Department of Psychiatry, Warneford Hospital, Oxford, UK
J Psychopharmacol 23:346-88. 2009..The strength of supporting evidence was rated. The guidelines cover the diagnosis of bipolar disorder, clinical management, and strategies for the use of medicines in treatment of episodes, relapse prevention and stopping treatment... - Comparison of systematic and narrative reviews: the example of the atypical antipsychoticsAndrea Cipriani
Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
Epidemiol Psichiatr Soc 12:146-53. 2003 - The prevalence of mental disorders among the homeless in western countries: systematic review and meta-regression analysisSeena Fazel
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
PLoS Med 5:e225. 2008..We undertook a systematic review of surveys of such disorders in homeless people... - Bipolar disorderJohn Geddes
Department of Psychiatry, University of Oxford, UK
Evid Based Ment Health 6:101-2. 2003 - Antidepressants for bipolar depression: a systematic review of randomized, controlled trialsHarm J Gijsman
Department of Psychiatry, Warneford Hospital, Oxford, UK
Am J Psychiatry 161:1537-47. 2004..This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression... - A cluster randomized controlled trial to assess the effectiveness of an intervention to educate students about depressionRowena K Merritt
Department of Psychiatry, University of Oxford, UK
Psychol Med 37:363-72. 2007..A thoughtful health campaign might therefore increase the likelihood of successful treatment... - What is the heartland of psychiatry?Guy M Goodwin
Br J Psychiatry 191:189-91. 2007..They have also meant that services for other disorders do not meet the needs of patients. To continue to allow schizophrenia to be the paradigm condition is against the interests of psychiatrists and their patients... - Depressive disorder needs an evidence base commensurate with its public health importanceJohn R Geddes
Can J Psychiatry 52:543-4. 2007 - Meta-analysis of brain weight in schizophreniaPaul J Harrison
Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Warneford Lane, Oxford OX3 7JX, UK
Schizophr Res 64:25-34. 2003..The result encourages a continuing search for the histological and molecular correlates of schizophrenia... - Fluvoxamine and graded psychotherapy in the treatment of bulimia nervosa: a randomized, double-blind, placebo-controlled, multicenter study of short-term and long-term pharmacotherapy combined with a stepped care approach to psychotherapyUlrike Schmidt
J Clin Psychopharmacol 24:549-52. 2004 - Older patients are eligible for trial of lithium and valproateJennifer M Rendell
BMJ 327:395-6. 2003 - Can we conduct some large simple trials in bipolar disorder?John R Geddes
Bipolar Disord 4:62-3. 2002 - Depressive disordersJohn R Geddes
University of Oxford, UK
Am Fam Physician 65:1395-7. 2002 - Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysisMatthew J Taylor
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England
Arch Gen Psychiatry 63:1217-23. 2006..Selective serotonin reuptake inhibitors (SSRIs) are often described as having a delayed onset of effect in the treatment of depression. However, some trials have reported clinical improvement as early as the first week of treatment... - Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trialsMatthew J Taylor
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
J Psychopharmacol 18:251-6. 2004..It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency... - Suicide, depression, and antidepressantsAndrea Cipriani
BMJ 330:373-4. 2005 - Introduction to systematic reviewsGuy M Goodwin
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
J Psychopharmacol 18:249-50. 2004 - Psychosocial interventions for the prevention of relapse in bipolar disorder: systematic review of controlled trialsSuzanne Beynon
Centre for Reviews and Dissemination, University of York, York YO10 5DD, UK
Br J Psychiatry 192:5-11. 2008..Pharmacological interventions alone do not provide sufficient benefit for some individuals with bipolar disorder... - Large simple trials in psychiatry: providing reliable answers to important clinical questionsJohn R Geddes
Epidemiol Psichiatr Soc 14:122-6. 2005 - Developing the BALANCE trail--the role of the pilot study and start-up phaseJennifer M Rendell
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Bipolar Disord 6:26-31. 2004..BALANCE is now actively recruiting in the UK and USA... - Pharmacological treatment for unipolar psychotic depression: Systematic review and meta-analysisJaap Wijkstra
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, HP B01 206, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Br J Psychiatry 188:410-5. 2006..The optimal pharmacological treatment of unipolar psychotic depression is uncertain... - Are all antidepressants really the same? The case of fluoxetine: a systematic reviewAndrea Cipriani
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
J Clin Psychiatry 67:850-64. 2006..To systematically review the efficacy and tolerability of fluoxetine, the most widely studied of newer antidepressants, in comparison with all other antidepressants in the acute treatment of depression in patients aged more than 18 years... - Selective serotonin reuptake inhibitorsJohn R Geddes
BMJ 329:809-10. 2004 - Latest maintenance data on lithium in bipolar disorderGuy M Goodwin
Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
Eur Neuropsychopharmacol 13:S51-5. 2003..72; 95% CI 0.49, 1.07). Factors such as disease subtype, likelihood of adherence to treatment regimen, tolerability, and dose uncertainty should be considered in the selection of lithium maintenance therapy... - Metareview on short-term effectiveness and safety of antidepressants for depression: an evidence-based approach to inform clinical practiceAndrea Cipriani
Department of Medicine and Public Health, University of Verona, Italy
Can J Psychiatry 52:553-62. 2007.... - Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorderMatthew J Kempton
Centre for Neuroimaging Sciences, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 65:1017-32. 2008..Despite 25 years of structural imaging in bipolar disorder, brain regions affected in the disorder are ill defined... - Antidepressants and suicide symptoms: compelling new insights from the FDA's analysis of individual patient level dataCorrado Barbui
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
Evid Based Ment Health 11:34-5. 2008 - Long-term treatment of depression with antidepressants: a systematic narrative reviewToshi A Furukawa
Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Japan
Can J Psychiatry 52:545-52. 2007..To examine the available scientific evidence for answers to clinically relevant questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long-term treatment of depression... - Randomized controlled trials for schizophrenia: study designs targeted to distinct goalsT Scott Stroup
Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7160, USA
Schizophr Bull 34:266-74. 2008..The different objectives of trials should be considered in the interpretation of the complete body of randomized evidence on antipsychotic drugs... - Common and specific elements of psychosocial treatments for bipolar disorder: a survey of clinicians participating in randomized trialsDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
J Psychiatr Pract 14:77-85. 2008..We investigated whether different forms of psychotherapy consisted of overlapping versus modality-specific ingredients...