John Geddes

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Lack of effect of chromium supplementation on mental state and body weight in people with schizophrenia
    Rena A Hockney
    J Clin Psychopharmacol 26:544-5. 2006
  2. pmc Mood stability versus mood instability in bipolar disorder: a possible role for emotional mental imagery
    Emily A Holmes
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Behav Res Ther 49:707-13. 2011
  3. pmc Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis
    J Geddes
    Department of Psychiatry University of Oxford, Warneford Hospital, Oxford OX3 7JX
    BMJ 321:1371-6. 2000
  4. pmc Bipolar disorder--services need to catch up with rapidly developing evidence base
    John Geddes
    University of Oxford, Warneford Hospital, Oxford OX10 0RU
    BMJ 332:32-3. 2006
  5. ncbi request reprint Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Am J Psychiatry 161:217-22. 2004
  6. ncbi request reprint Meta-analysis in the assessment of treatment outcome
    John Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 20:67-71. 2006
  7. ncbi request reprint Evidence-based medicine and neurophysiology
    John R Geddes
    Department of Psychiatry, University of Oxford, UK
    Clin EEG Neurosci 40:59-61. 2009
  8. doi request reprint Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Br J Psychiatry 194:4-9. 2009
  9. ncbi request reprint Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials
    Andrea Cipriani
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 162:1805-19. 2005
  10. ncbi request reprint Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Lack of effect of chromium supplementation on mental state and body weight in people with schizophrenia
    Rena A Hockney
    J Clin Psychopharmacol 26:544-5. 2006
  2. pmc Mood stability versus mood instability in bipolar disorder: a possible role for emotional mental imagery
    Emily A Holmes
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Behav Res Ther 49:707-13. 2011
    ..The findings were consistent with predictions. Further investigation of imagery in bipolar disorder appears warranted as it may highlight processes that contribute to mood instability with relevance for cognitive behaviour therapy...
  3. pmc Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis
    J Geddes
    Department of Psychiatry University of Oxford, Warneford Hospital, Oxford OX3 7JX
    BMJ 321:1371-6. 2000
    ..To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia...
  4. pmc Bipolar disorder--services need to catch up with rapidly developing evidence base
    John Geddes
    University of Oxford, Warneford Hospital, Oxford OX10 0RU
    BMJ 332:32-3. 2006
  5. ncbi request reprint Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Am J Psychiatry 161:217-22. 2004
    ..The authors sought to determine the efficacy and acceptability of lithium for relapse prevention in bipolar disorder...
  6. ncbi request reprint Meta-analysis in the assessment of treatment outcome
    John Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 20:67-71. 2006
    ..Despite practical difficulties, IPDMAs are increasingly being conducted...
  7. ncbi request reprint Evidence-based medicine and neurophysiology
    John R Geddes
    Department of Psychiatry, University of Oxford, UK
    Clin EEG Neurosci 40:59-61. 2009
    ..Although the main driver of the development of EBM has been to get existing research into practice, the same approach can be used to inform the development of treatments...
  8. doi request reprint Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Br J Psychiatry 194:4-9. 2009
    ..There is uncertainty about the efficacy of lamotrigine in bipolar depressive episodes...
  9. ncbi request reprint Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials
    Andrea Cipriani
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 162:1805-19. 2005
    ....
  10. ncbi request reprint Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010
    ..We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder...
  11. ncbi request reprint Generating evidence to inform policy and practice: the example of the second generation "atypical" antipsychotics
    John Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Schizophr Bull 29:105-14. 2003
    ..Premature clinical practice guidelines or expert opinion can lead to changes in clinical practice that make it difficult or impossible to conduct the required trials and are therefore a disservice to patients...
  12. ncbi request reprint Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Lancet 361:653-61. 2003
    ..Antidepressant drugs can promote remission from acute depressive episodes. Our aim was to establish how long such treatments should be continued to prevent relapse...
  13. ncbi request reprint Bipolar disorder: clinical uncertainty, evidence-based medicine and large-scale randomised trials
    J Geddes
    Department of Psychiatry, University of Oxford, UK
    Br J Psychiatry Suppl 41:s191-4. 2001
    ..The increasing use of the methods of evidence-based medicine to keep up-to-date with the research literature highlights the absence of high-quality evidence in many areas in psychiatry...
  14. ncbi request reprint Recent advances in evidence-based psychiatry
    J Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Can J Psychiatry 46:403-6. 2001
    ..In this article, we describe some of the recent advances in evidence-based psychiatry and outline future challenges...
  15. doi request reprint Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology
    G M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 23:346-88. 2009
    ..The strength of supporting evidence was rated. The guidelines cover the diagnosis of bipolar disorder, clinical management, and strategies for the use of medicines in treatment of episodes, relapse prevention and stopping treatment...
  16. doi request reprint Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder
    Andrea Cipriani
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK, OX3 7JX
    Cochrane Database Syst Rev 10:CD003196. 2013
    ..When the acceptability of long-term treatment is considered, together with efficacy, the adverse event profile of a medication is also important. This is an update of a Cochrane review first published in 2001 and last updated in 2009...
  17. doi request reprint Aripiprazole alone or in combination for acute mania
    Rachel Brown
    Clinical Pharmacy Support Unit, Oxford Health NHS Foundation Trust, Unit 46, Sandford Lane, Kennington, Oxford, UK, OX1 5RW
    Cochrane Database Syst Rev 12:CD005000. 2013
    ..The British Association of Psychopharmacology guidelines report that, in monotherapy placebo-controlled trials, the atypical antipsychotics, including aripiprazole, have been shown to be effective for acute manic or mixed episodes...
  18. pmc The effects of using cognitive behavioural therapy to improve sleep for patients with delusions and hallucinations (the BEST study): study protocol for a randomized controlled trial
    Daniel Freeman
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Trials 14:214. 2013
    ..The clear next step is a pilot randomized controlled test. The clinical aim is to test whether CBT-I can reduce both insomnia and psychotic symptoms. The trial will inform decisions for a definitive large-scale evaluation...
  19. ncbi request reprint Comparison of systematic and narrative reviews: the example of the atypical antipsychotics
    Andrea Cipriani
    Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
    Epidemiol Psichiatr Soc 12:146-53. 2003
  20. pmc The prevalence of mental disorders among the homeless in western countries: systematic review and meta-regression analysis
    Seena Fazel
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    PLoS Med 5:e225. 2008
    ..We undertook a systematic review of surveys of such disorders in homeless people...
  21. ncbi request reprint Bipolar disorder
    John Geddes
    Department of Psychiatry, University of Oxford, UK
    Evid Based Ment Health 6:101-2. 2003
  22. ncbi request reprint Pharmacological treatment for unipolar psychotic depression: Systematic review and meta-analysis
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, HP B01 206, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Br J Psychiatry 188:410-5. 2006
    ..The optimal pharmacological treatment of unipolar psychotic depression is uncertain...
  23. doi request reprint Psychosocial interventions for the prevention of relapse in bipolar disorder: systematic review of controlled trials
    Suzanne Beynon
    Centre for Reviews and Dissemination, University of York, York YO10 5DD, UK
    Br J Psychiatry 192:5-11. 2008
    ..Pharmacological interventions alone do not provide sufficient benefit for some individuals with bipolar disorder...
  24. ncbi request reprint Can we conduct some large simple trials in bipolar disorder?
    John R Geddes
    Bipolar Disord 4:62-3. 2002
  25. ncbi request reprint Depressive disorder needs an evidence base commensurate with its public health importance
    John R Geddes
    Can J Psychiatry 52:543-4. 2007
  26. ncbi request reprint Meta-analysis of brain weight in schizophrenia
    Paul J Harrison
    Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Warneford Lane, Oxford OX3 7JX, UK
    Schizophr Res 64:25-34. 2003
    ..The result encourages a continuing search for the histological and molecular correlates of schizophrenia...
  27. ncbi request reprint What is the heartland of psychiatry?
    Guy M Goodwin
    Br J Psychiatry 191:189-91. 2007
    ..They have also meant that services for other disorders do not meet the needs of patients. To continue to allow schizophrenia to be the paradigm condition is against the interests of psychiatrists and their patients...
  28. pmc Older patients are eligible for trial of lithium and valproate
    Jennifer M Rendell
    BMJ 327:395-6. 2003
  29. pmc Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England
    Arch Gen Psychiatry 63:1217-23. 2006
    ..Selective serotonin reuptake inhibitors (SSRIs) are often described as having a delayed onset of effect in the treatment of depression. However, some trials have reported clinical improvement as early as the first week of treatment...
  30. ncbi request reprint Fluvoxamine and graded psychotherapy in the treatment of bulimia nervosa: a randomized, double-blind, placebo-controlled, multicenter study of short-term and long-term pharmacotherapy combined with a stepped care approach to psychotherapy
    Ulrike Schmidt
    J Clin Psychopharmacol 24:549-52. 2004
  31. ncbi request reprint A cluster randomized controlled trial to assess the effectiveness of an intervention to educate students about depression
    Rowena K Merritt
    Department of Psychiatry, University of Oxford, UK
    Psychol Med 37:363-72. 2007
    ..A thoughtful health campaign might therefore increase the likelihood of successful treatment...
  32. pmc Suicide, depression, and antidepressants
    Andrea Cipriani
    BMJ 330:373-4. 2005
  33. ncbi request reprint Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:251-6. 2004
    ..It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency...
  34. ncbi request reprint Large simple trials in psychiatry: providing reliable answers to important clinical questions
    John R Geddes
    Epidemiol Psichiatr Soc 14:122-6. 2005
  35. ncbi request reprint Introduction to systematic reviews
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:249-50. 2004
  36. ncbi request reprint Developing the BALANCE trail--the role of the pilot study and start-up phase
    Jennifer M Rendell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Bipolar Disord 6:26-31. 2004
    ..This report describes the adaptations to the initial design and trial procedures following the initial phases of the study. The rationale for the trial and full protocol have been published elsewhere...
  37. ncbi request reprint Depressive disorders
    John R Geddes
    University of Oxford, UK
    Am Fam Physician 65:1395-7. 2002
  38. ncbi request reprint Antidepressants for bipolar depression: a systematic review of randomized, controlled trials
    Harm J Gijsman
    Department of Psychiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 161:1537-47. 2004
    ..This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression...
  39. ncbi request reprint Latest maintenance data on lithium in bipolar disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 13:S51-5. 2003
    ..72; 95% CI 0.49, 1.07). Factors such as disease subtype, likelihood of adherence to treatment regimen, tolerability, and dose uncertainty should be considered in the selection of lithium maintenance therapy...
  40. doi request reprint Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder
    Matthew J Kempton
    Centre for Neuroimaging Sciences, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 65:1017-32. 2008
    ..Despite 25 years of structural imaging in bipolar disorder, brain regions affected in the disorder are ill defined...
  41. pmc Common and specific elements of psychosocial treatments for bipolar disorder: a survey of clinicians participating in randomized trials
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    J Psychiatr Pract 14:77-85. 2008
    ..We investigated whether different forms of psychotherapy consisted of overlapping versus modality-specific ingredients...
  42. pmc Randomized controlled trials for schizophrenia: study designs targeted to distinct goals
    T Scott Stroup
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    Schizophr Bull 34:266-74. 2008
    ..The different objectives of trials should be considered in the interpretation of the complete body of randomized evidence on antipsychotic drugs...
  43. ncbi request reprint Metareview on short-term effectiveness and safety of antidepressants for depression: an evidence-based approach to inform clinical practice
    Andrea Cipriani
    Department of Medicine and Public Health, University of Verona, Italy
    Can J Psychiatry 52:553-62. 2007
    ....
  44. ncbi request reprint Long-term treatment of depression with antidepressants: a systematic narrative review
    Toshi A Furukawa
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Japan
    Can J Psychiatry 52:545-52. 2007
    ..To examine the available scientific evidence for answers to clinically relevant questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long-term treatment of depression...
  45. pmc Selective serotonin reuptake inhibitors
    John R Geddes
    BMJ 329:809-10. 2004
  46. ncbi request reprint Are all antidepressants really the same? The case of fluoxetine: a systematic review
    Andrea Cipriani
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    J Clin Psychiatry 67:850-64. 2006
    ..To systematically review the efficacy and tolerability of fluoxetine, the most widely studied of newer antidepressants, in comparison with all other antidepressants in the acute treatment of depression in patients aged more than 18 years...
  47. doi request reprint Antidepressants and suicide symptoms: compelling new insights from the FDA's analysis of individual patient level data
    Corrado Barbui
    Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Evid Based Ment Health 11:34-5. 2008