Simon A Gayther

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
  2. pmc Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer
    L Quaye
    Gynaecological Oncology Department, UCL EGA Institute for Women s Health, University College London, London, UK
    Br J Cancer 100:993-1001. 2009
  3. pmc Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study
    Deborah J Thompson
    Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 11:R80. 2009
  4. pmc A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival
    Jyotsna Batra
    Australian Prostate Cancer Research centre Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
    BMC Cancer 11:119. 2011
  5. pmc The inherited genetics of ovarian and endometrial cancer
    Simon A Gayther
    EGA Institute for Women s Health, Gynaecological Cancer Research Laboratories, University College London, London, UK
    Curr Opin Genet Dev 20:231-8. 2010
  6. doi request reprint Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival
    Lydia Quaye
    Gynaecological Oncology Unit, UCL EGA Institute for Women s Health, University College London, UK
    Hum Mol Genet 18:1869-78. 2009
  7. doi request reprint The effects of common genetic variants in oncogenes on ovarian cancer survival
    Lydia Quaye
    Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 14:5833-9. 2008
  8. doi request reprint Modelling genetic and clinical heterogeneity in epithelial ovarian cancers
    Kate Lawrenson
    UCL EGA Institute for Women s Health, University College London, London, UK
    Carcinogenesis 32:1540-9. 2011
  9. doi request reprint The sex hormone system in carriers of BRCA1/2 mutations: a case-control study
    Martin Widschwendter
    Department of Women s Cancer, UCL EGA Institute for Women s Health, University College London, London, UK Electronic address
    Lancet Oncol 14:1226-32. 2013
  10. ncbi request reprint Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London UCL, Elizabeth Garrett Anderson EGA Institute for Women s Health, University College London, London, United Kingdom
    Hum Mutat 28:1207-15. 2007

Detail Information

Publications40

  1. ncbi request reprint Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..This study highlights the need for multicenter collaborations for genetic association studies...
  2. pmc Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer
    L Quaye
    Gynaecological Oncology Department, UCL EGA Institute for Women s Health, University College London, London, UK
    Br J Cancer 100:993-1001. 2009
    ..034) and a haplotype in BRAF that had a protective effect (P(global)=0.005). In conclusion, these data provide borderline evidence of association for common allelic variation in the NMI with risk of epithelial OC...
  3. pmc Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study
    Deborah J Thompson
    Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 11:R80. 2009
    ....
  4. pmc A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival
    Jyotsna Batra
    Australian Prostate Cancer Research centre Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
    BMC Cancer 11:119. 2011
    ..Our aim was to analyse the KLK15 gene for putative functional single nucleotide polymorphisms (SNPs) and assess the association of these and KLK15 HapMap tag SNPs with ovarian cancer survival...
  5. pmc The inherited genetics of ovarian and endometrial cancer
    Simon A Gayther
    EGA Institute for Women s Health, Gynaecological Cancer Research Laboratories, University College London, London, UK
    Curr Opin Genet Dev 20:231-8. 2010
    ....
  6. doi request reprint Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival
    Lydia Quaye
    Gynaecological Oncology Unit, UCL EGA Institute for Women s Health, University College London, UK
    Hum Mol Genet 18:1869-78. 2009
    ..In summary, a novel in vitro functional approach in ovarian cancer cells has identified RBBP8 as a gene for which both germline genetic variation and somatic alterations in tumours are associated with survival in ovarian cancer patients...
  7. doi request reprint The effects of common genetic variants in oncogenes on ovarian cancer survival
    Lydia Quaye
    Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 14:5833-9. 2008
    ..The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer...
  8. doi request reprint Modelling genetic and clinical heterogeneity in epithelial ovarian cancers
    Kate Lawrenson
    UCL EGA Institute for Women s Health, University College London, London, UK
    Carcinogenesis 32:1540-9. 2011
    ..Molecular genetic characteristics of these models correlated with molecular and clinical features of primary EOCs...
  9. doi request reprint The sex hormone system in carriers of BRCA1/2 mutations: a case-control study
    Martin Widschwendter
    Department of Women s Cancer, UCL EGA Institute for Women s Health, University College London, London, UK Electronic address
    Lancet Oncol 14:1226-32. 2013
    ..We sought to identify differences in hormone regulation between carriers of BRCA1/2 and women who are negative for BRCA1/2 mutations...
  10. ncbi request reprint Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London UCL, Elizabeth Garrett Anderson EGA Institute for Women s Health, University College London, London, United Kingdom
    Hum Mutat 28:1207-15. 2007
    ..Finally, it is likely that these data will be of clinical importance for individuals in families with a history of epithelial ovarian cancer, in providing accurate estimates of their disease risks...
  11. pmc Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer
    Maria Notaridou
    Gynaecological Oncology Unit, UCL EGA Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 128:2063-74. 2011
    ..In conclusion, we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer...
  12. pmc Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer
    Lydia Quaye
    Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 4:e5983. 2009
    ....
  13. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  14. doi request reprint The clonal evolution of metastases from primary serous epithelial ovarian cancers
    Lalarukh Khalique
    Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, UK
    Int J Cancer 124:1579-86. 2009
    ....
  15. pmc Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers
    Dimitra Dafou
    EGA Institute for Women s Health, Gynaecological Cancer Research Laboratories, University College London, London, UK
    Neoplasia 12:579-89. 2010
    ..Finally, an inducible model of EPB41L3 expression in three-dimensional spheroids confirmed that reexpression of EPB41L3 induces extensive apoptotic cell death in ovarian cancers...
  16. doi request reprint Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer
    Susan J Ramus
    Gynaecological Cancer Research Laboratory, University College London Elizabeth Garrett Anderson Institute for Women s Health, University College London, London, UK
    Clin Cancer Res 14:5840-8. 2008
    ..The diagnosis given will influence the patient's treatment and prognosis. Currently, a diagnosis of SPM or DP is made using histologic criteria, which are frequently unable to make a definitive diagnosis...
  17. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
    ..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features...
  18. pmc An epigenetic signature in peripheral blood predicts active ovarian cancer
    Andrew E Teschendorff
    Medical Genomics Group, University College London Cancer Institute, University College London, London, United Kingdom
    PLoS ONE 4:e8274. 2009
    ..However, to date no study has evaluated the diagnostic and predictive potential of such markers in a large case control cohort and on a genome-wide basis...
  19. pmc Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer
    Kate Lawrenson
    Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, UK
    Neoplasia 12:317-25. 2010
    ....
  20. doi request reprint The contribution of BRCA1 and BRCA2 to ovarian cancer
    Susan J Ramus
    Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, Paul O Gorman Building, University College London, 72 Huntley Street, London, United Kingdom
    Mol Oncol 3:138-50. 2009
    ..In some populations with frequent founder mutations screening may not be dependent on whether a mutation is identified in an affected relative...
  21. pmc Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers
    Susan J Ramus
    Department of Gynaecological Oncology, UCL EGA Institute for Women s Health, University College London, London, UK
    J Natl Cancer Inst 103:105-16. 2011
    ..We evaluated the association of this SNP with ovarian cancer risk among BRCA1 or BRCA2 mutation carriers by use of data from the Consortium of Investigators of Modifiers of BRCA1/2...
  22. doi request reprint Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells
    Dimitra Dafou
    Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    Int J Cancer 124:1037-44. 2009
    ..The future identification of these genes may have a significant impact on the understanding and treatment of the disease and the identification of novel therapeutic targets...
  23. pmc A Perl toolkit for LIMS development
    James A Morris
    Translational Research Laboratories, UCL EGA Institute for Women s Health, University College London, UK
    Source Code Biol Med 3:4. 2008
    ....
  24. doi request reprint Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking study
    Nyaladzi Balogun
    Gynaecological Cancer Research Centre, EGA Institute for Women s Health, University College London, London W1T 7DN, UK
    J Clin Epidemiol 64:525-30. 2011
    ..To explore the challenges of recruiting ovarian cancer patients and healthy controls to a cancer biobanking study...
  25. ncbi request reprint Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online
    Susan J Ramus
    Translational Research Laboratory, Institute for Women s Health, University College London, United Kingdom
    Hum Mutat 28:525-6. 2007
    ....
  26. doi request reprint Profiling signatures of ovarian cancer tumour suppression using 2D-DIGE and 2D-LC-MS/MS with tandem mass tagging
    John Sinclair
    Cancer Proteomics Laboratory, EGA Institute for Women s Health, University College London UCL, UK
    J Proteomics 74:451-65. 2011
    ..One candidate marker was also tested in sera from a set of ovarian cancer cases and controls. We have identified a list of promising candidate biomarkers for further testing and functional characterization...
  27. ncbi request reprint A molecular genetic and statistical approach for the diagnosis of dual-site cancers
    Dirk Brinkmann
    Gynaecology Cancer Research Unit, St Bartholomew s and the London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    J Natl Cancer Inst 96:1441-6. 2004
    ..Concurrent tumors can be synchronous, independently derived, non-metastatic tumors or metastatic tumors. The prognosis and clinical management of patients with these different concurrent tumor types are different...
  28. doi request reprint A suite of Perl modules for handling microarray data
    James A Morris
    Translational Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    Bioinformatics 24:1102-3. 2008
    ..The coherent interface and well-documented code enables rapid analysis by even inexperienced Perl developers...
  29. ncbi request reprint Ovarian cancer aetiology: facts and fiction
    Karim Elmasry
    Translational Research Laboratories, Department of Gynaecological Oncology, Windeyer Institute, London, UK
    J Fam Plann Reprod Health Care 32:82-6. 2006
  30. ncbi request reprint Common variants in mismatch repair genes and risk of invasive ovarian cancer
    Honglin Song
    CR UK Department of Oncology, University of Cambridge Strangeways Research Laboratory, Cambridge, UK
    Carcinogenesis 27:2235-42. 2006
    ..The observed association of PMS2 rs7797466 with ovarian cancer warrants confirmation in an independent study...
  31. pmc Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene
    Stephen M Edwards
    Translational Cancer Genetics Team, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Am J Hum Genet 72:1-12. 2003
    ..These results confirm that BRCA2 is a high-risk prostate-cancer-susceptibility gene and have potential implications for the management of early-onset prostate cancer, in both patients and their relatives...
  32. ncbi request reprint BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases
    Susan J Ramus
    Department of Oncology, Strangeways Research Laboratories, Cambridge, United Kingdom
    Cancer Res 63:417-23. 2003
    ....
  33. ncbi request reprint BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark
    Marie Soegaard
    Institute of Cancer Epidemiology, Danish Cancer Society
    Clin Cancer Res 14:3761-7. 2008
    ..To evaluate the prevalence of BRCA1 and BRCA2 mutations and associations with clinical correlates of disease in a population-based series of ovarian cancer cases from Denmark...
  34. pmc Multiple loci with different cancer specificities within the 8q24 gene desert
    Maya Ghoussaini
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
    J Natl Cancer Inst 100:962-6. 2008
    ..We conclude that there are at least five separate functional variants in this region...
  35. pmc Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival
    Honglin Song
    CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
    Clin Cancer Res 14:1090-5. 2008
    ..Of particular interest are genes involved in cell cycle pathways, which regulate cell division and could plausibly influence clinical characteristics of multiple tumors types...
  36. ncbi request reprint STK15 polymorphisms and association with risk of invasive ovarian cancer
    Richard A Dicioccio
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1589-94. 2004
    ..These results suggest a model of dominant inheritance of ovarian cancer risk by the I31 allele of F31I and that the I31 allele may be a common ovarian cancer susceptibility allele of low penetrance...
  37. pmc Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    Jonathan Beesley
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007
    ..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition...
  38. ncbi request reprint Common variants in RB1 gene and risk of invasive ovarian cancer
    Honglin Song
    Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
    Cancer Res 66:10220-6. 2006
    ..The possible associations of rs2854344 and rs4151620 with ovarian cancer risk warrant confirmation in independent case-control studies before studies on their biological mode of action...
  39. pmc BRCA1 and BRCA2 mutations in a population-based study of male breast cancer
    Victoria M Basham
    CRC Human Cancer Genetics Group, Department of Oncology, University of Cambridge, Cambridge, UK
    Breast Cancer Res 4:R2. 2002
    ....
  40. ncbi request reprint Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer Registry
    Bruce A Werness
    Department of Pathology, Inova Fair Oaks Hospital, Fairfax, Virginia 22033, USA
    Int J Gynecol Pathol 23:29-34. 2004
    ..Borderline and mucinous tumors do not appear to be part of the phenotype of families with germline mutations in the BRCA genes...