Research Topics
Genomes and Genes
Species | Simon A GaytherSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancerSimon A Gayther
Translational Research Laboratories, University College London, London, United Kingdom
Cancer Res 67:3027-35. 2007..This study highlights the need for multicenter collaborations for genetic association studies...
Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS studyDeborah J Thompson
Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
Breast Cancer Res 11:R80. 2009....- A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survivalJyotsna Batra
Australian Prostate Cancer Research centre Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
BMC Cancer 11:119. 2011..Our aim was to analyse the KLK15 gene for putative functional single nucleotide polymorphisms (SNPs) and assess the association of these and KLK15 HapMap tag SNPs with ovarian cancer survival... - The inherited genetics of ovarian and endometrial cancerSimon A Gayther
EGA Institute for Women s Health, Gynaecological Cancer Research Laboratories, University College London, London, UK
Curr Opin Genet Dev 20:231-8. 2010.... 
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survivalLydia Quaye
Gynaecological Oncology Unit, UCL EGA Institute for Women s Health, University College London, UK
Hum Mol Genet 18:1869-78. 2009..In summary, a novel in vitro functional approach in ovarian cancer cells has identified RBBP8 as a gene for which both germline genetic variation and somatic alterations in tumours are associated with survival in ovarian cancer patients...- Modelling genetic and clinical heterogeneity in epithelial ovarian cancersKate Lawrenson
UCL EGA Institute for Women s Health, University College London, London, UK
Carcinogenesis 32:1540-9. 2011..Molecular genetic characteristics of these models correlated with molecular and clinical features of primary EOCs... - Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancerSusan J Ramus
Translational Research Laboratory, University College London UCL, Elizabeth Garrett Anderson EGA Institute for Women s Health, University College London, London, United Kingdom
Hum Mutat 28:1207-15. 2007..Finally, it is likely that these data will be of clinical importance for individuals in families with a history of epithelial ovarian cancer, in providing accurate estimates of their disease risks... - Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancerMaria Notaridou
Gynaecological Oncology Unit, UCL EGA Institute for Women s Health, University College London, United Kingdom
Int J Cancer 128:2063-74. 2011..In conclusion, we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer... - Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancerLydia Quaye
Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
PLoS ONE 4:e5983. 2009.... - The clonal evolution of metastases from primary serous epithelial ovarian cancersLalarukh Khalique
Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, UK
Int J Cancer 124:1579-86. 2009.... - Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancersDimitra Dafou
EGA Institute for Women s Health, Gynaecological Cancer Research Laboratories, University College London, London, UK
Neoplasia 12:579-89. 2010..Finally, an inducible model of EPB41L3 expression in three-dimensional spheroids confirmed that reexpression of EPB41L3 induces extensive apoptotic cell death in ovarian cancers... - Consortium analysis of 7 candidate SNPs for ovarian cancerSusan J Ramus
Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
Int J Cancer 123:380-8. 2008..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach... - Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancerSusan J Ramus
Gynaecological Cancer Research Laboratory, University College London Elizabeth Garrett Anderson Institute for Women s Health, University College London, London, UK
Clin Cancer Res 14:5840-8. 2008..The diagnosis given will influence the patient's treatment and prognosis. Currently, a diagnosis of SPM or DP is made using histologic criteria, which are frequently unable to make a definitive diagnosis... - Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancerAndrew E Teschendorff
University College London, London WC1E 6BT, UK
Genome Res 20:440-6. 2010..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features... - The effects of common genetic variants in oncogenes on ovarian cancer survivalLydia Quaye
Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
Clin Cancer Res 14:5833-9. 2008..The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer... - Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancerKate Lawrenson
Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, UK
Neoplasia 12:317-25. 2010.... - An epigenetic signature in peripheral blood predicts active ovarian cancerAndrew E Teschendorff
Medical Genomics Group, University College London Cancer Institute, University College London, London, United Kingdom
PLoS ONE 4:e8274. 2009..However, to date no study has evaluated the diagnostic and predictive potential of such markers in a large case control cohort and on a genome-wide basis... - The contribution of BRCA1 and BRCA2 to ovarian cancerSusan J Ramus
Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, Paul O Gorman Building, University College London, 72 Huntley Street, London, United Kingdom
Mol Oncol 3:138-50. 2009..In some populations with frequent founder mutations screening may not be dependent on whether a mutation is identified in an affected relative... - Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriersSusan J Ramus
Department of Gynaecological Oncology, UCL EGA Institute for Women s Health, University College London, London, UK
J Natl Cancer Inst 103:105-16. 2011..We evaluated the association of this SNP with ovarian cancer risk among BRCA1 or BRCA2 mutation carriers by use of data from the Consortium of Investigators of Modifiers of BRCA1/2... - Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cellsDimitra Dafou
Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
Int J Cancer 124:1037-44. 2009..The future identification of these genes may have a significant impact on the understanding and treatment of the disease and the identification of novel therapeutic targets... - A Perl toolkit for LIMS developmentJames A Morris
Translational Research Laboratories, UCL EGA Institute for Women s Health, University College London, UK
Source Code Biol Med 3:4. 2008.... - Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. OnlineSusan J Ramus
Translational Research Laboratory, Institute for Women s Health, University College London, United Kingdom
Hum Mutat 28:525-6. 2007.... - Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking studyNyaladzi Balogun
Gynaecological Cancer Research Centre, EGA Institute for Women s Health, University College London, London W1T 7DN, UK
J Clin Epidemiol 64:525-30. 2011..To explore the challenges of recruiting ovarian cancer patients and healthy controls to a cancer biobanking study... - Profiling signatures of ovarian cancer tumour suppression using 2D-DIGE and 2D-LC-MS/MS with tandem mass taggingJohn Sinclair
Cancer Proteomics Laboratory, EGA Institute for Women s Health, University College London UCL, UK
J Proteomics 74:451-65. 2011..One candidate marker was also tested in sera from a set of ovarian cancer cases and controls. We have identified a list of promising candidate biomarkers for further testing and functional characterization... - Ovarian cancer aetiology: facts and fictionKarim Elmasry
Translational Research Laboratories, Department of Gynaecological Oncology, Windeyer Institute, London, UK
J Fam Plann Reprod Health Care 32:82-6. 2006 - A molecular genetic and statistical approach for the diagnosis of dual-site cancersDirk Brinkmann
Gynaecology Cancer Research Unit, St. Bartholomew's and the London, Queen Mary's School of Medicine and Dentistry, University of London, London, UK
J Natl Cancer Inst 96:1441-6. 2004..The results suggest that genetic analysis has implications for clinical management and can be performed rapidly as a diagnostic test with paraffin-embedded tissues... - A suite of Perl modules for handling microarray dataJames A Morris
Translational Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
Bioinformatics 24:1102-3. 2008..The coherent interface and well-documented code enables rapid analysis by even inexperienced Perl developers. AVAILABILITY: Software is available at http://sourceforge.net/projects/perlmat.. - BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer casesSusan J Ramus
Department of Oncology, Strangeways Research Laboratories, Cambridge, United Kingdom
Cancer Res 63:417-23. 2003.... - STK15 polymorphisms and association with risk of invasive ovarian cancerRichard A Dicioccio
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 13:1589-94. 2004..These results suggest a model of dominant inheritance of ovarian cancer risk by the I31 allele of F31I and that the I31 allele may be a common ovarian cancer susceptibility allele of low penetrance... - Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 geneStephen M Edwards
Translational Cancer Genetics Team, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Am J Hum Genet 72:1-12. 2003..These results confirm that BRCA2 is a high-risk prostate-cancer-susceptibility gene and have potential implications for the management of early-onset prostate cancer, in both patients and their relatives... - Common variants in mismatch repair genes and risk of invasive ovarian cancerHonglin Song
CR UK Department of Oncology, University of Cambridge Strangeways Research Laboratory, Cambridge, UK
Carcinogenesis 27:2235-42. 2006..The observed association of PMS2 rs7797466 with ovarian cancer warrants confirmation in an independent study... - Common variants in RB1 gene and risk of invasive ovarian cancerHonglin Song
Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Cancer Res 66:10220-6. 2006..The possible associations of rs2854344 and rs4151620 with ovarian cancer risk warrant confirmation in independent case-control studies before studies on their biological mode of action... - Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation setJonathan Beesley
Queensland Institute of Medical Research, Herston, Queensland, Australia
Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition... - Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survivalHonglin Song
CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
Clin Cancer Res 14:1090-5. 2008..Of particular interest are genes involved in cell cycle pathways, which regulate cell division and could plausibly influence clinical characteristics of multiple tumors types... - Multiple loci with different cancer specificities within the 8q24 gene desertMaya Ghoussaini
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
J Natl Cancer Inst 100:962-6. 2008..We conclude that there are at least five separate functional variants in this region... - BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from DenmarkMarie Soegaard
Institute of Cancer Epidemiology, Danish Cancer Society
Clin Cancer Res 14:3761-7. 2008..To evaluate the prevalence of BRCA1 and BRCA2 mutations and associations with clinical correlates of disease in a population-based series of ovarian cancer cases from Denmark... - BRCA1 and BRCA2 mutations in a population-based study of male breast cancerVictoria M Basham
CRC Human Cancer Genetics Group, Department of Oncology, University of Cambridge, Cambridge, UK
Breast Cancer Res 4:R2. 2002.... - Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer RegistryBruce A Werness
Department of Pathology, Inova Fair Oaks Hospital, Fairfax, Virginia 22033, USA
Int J Gynecol Pathol 23:29-34. 2004..Borderline and mucinous tumors do not appear to be part of the phenotype of families with germline mutations in the BRCA genes...