J S H Gaston

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Uptake and processing of Chlamydia trachomatis by human dendritic cells
    Malgosia K Matyszak
    University of Cambridge Clinical School, Department of Medicine, Addenbrooke s Hospital, Cambridge, GB
    Eur J Immunol 32:742-51. 2002
  2. ncbi request reprint Arthritis associated with enteric infection
    J S Hill Gaston
    Department of Medicine, Box 157, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Rheumatol 17:219-39. 2003
  3. pmc Investigation of infectious agents associated with arthritis by reverse transcription PCR of bacterial rRNA
    Charles J Cox
    Department of Rheumatology, University of Cambridge, Cambridge
    Arthritis Res Ther 5:R1-8. 2003
  4. ncbi request reprint Cytokines in arthritis--the 'big numbers' move centre stage
    J S H Gaston
    Division of Rheumatology, Department of Medicine, University of Cambridge, UK
    Rheumatology (Oxford) 47:8-12. 2008
  5. pmc Shigella induced reactive arthritis
    J S Hill Gaston
    University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Ann Rheum Dis 64:517-8. 2005
  6. ncbi request reprint Dendritic cell: T-cell interactions in spondyloarthritis
    J S Hill Gaston
    Department of Rheumatology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Adv Exp Med Biol 649:263-76. 2009
  7. ncbi request reprint Mechanisms of Disease: the immunopathogenesis of spondyloarthropathies
    Hill Gaston
    Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Clin Pract Rheumatol 2:383-92. 2006
  8. ncbi request reprint Immune responses to Chlamydia antigens in atherosclerosis
    J S Gaston
    Department of Medicine, University of Cambridge, UK
    Herz 25:73-8. 2000
  9. ncbi request reprint Heat shock proteins and arthritis--new readers start here
    J S Gaston
    Department of Medicine, University of Cambridge
    Autoimmunity 26:33-42. 1997
  10. pmc Recognition of the 60 kilodalton cysteine-rich outer membrane protein OMP2 by CD4(+) T cells from humans infected with Chlamydia trachomatis
    J C Goodall
    Department of Medicine, University of Cambridge, Cambridge, UK
    Clin Exp Immunol 126:488-93. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Uptake and processing of Chlamydia trachomatis by human dendritic cells
    Malgosia K Matyszak
    University of Cambridge Clinical School, Department of Medicine, Addenbrooke s Hospital, Cambridge, GB
    Eur J Immunol 32:742-51. 2002
    ..This is largely due to the difficulties in studying CTL responses at the clonal level. The use of DC as antigen-presenting cells should enable more detailed characterization of these CTL responses...
  2. ncbi request reprint Arthritis associated with enteric infection
    J S Hill Gaston
    Department of Medicine, Box 157, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Rheumatol 17:219-39. 2003
    ..Recent work exploring evidence for traffic of pathogenic organisms to the joint is highlighted. A practical approach to the diagnosis and management of the condition is then formulated based, where possible, on clinical trial evidence...
  3. pmc Investigation of infectious agents associated with arthritis by reverse transcription PCR of bacterial rRNA
    Charles J Cox
    Department of Rheumatology, University of Cambridge, Cambridge
    Arthritis Res Ther 5:R1-8. 2003
    ....
  4. ncbi request reprint Cytokines in arthritis--the 'big numbers' move centre stage
    J S H Gaston
    Division of Rheumatology, Department of Medicine, University of Cambridge, UK
    Rheumatology (Oxford) 47:8-12. 2008
    ..The role of dendritic cells as coordinators of T cell differentiation in response to pathogen-derived signals in also emphasized...
  5. pmc Shigella induced reactive arthritis
    J S Hill Gaston
    University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Ann Rheum Dis 64:517-8. 2005
  6. ncbi request reprint Dendritic cell: T-cell interactions in spondyloarthritis
    J S Hill Gaston
    Department of Rheumatology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Adv Exp Med Biol 649:263-76. 2009
    ....
  7. ncbi request reprint Mechanisms of Disease: the immunopathogenesis of spondyloarthropathies
    Hill Gaston
    Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Clin Pract Rheumatol 2:383-92. 2006
    ..The concept that spondyloarthropathies are the result of interactions between susceptibility genes, bacteria and the immune system remains a useful model for the pathogenesis of these diseases...
  8. ncbi request reprint Immune responses to Chlamydia antigens in atherosclerosis
    J S Gaston
    Department of Medicine, University of Cambridge, UK
    Herz 25:73-8. 2000
    ..However, since Chlamydia pneumoniae is present in the atheromatous plaque, activation of Chlamydia-reactive T cells by local antigen is a potential pro-inflammatory mechanism which could contribute to the pathogenesis of atherosclerosis...
  9. ncbi request reprint Heat shock proteins and arthritis--new readers start here
    J S Gaston
    Department of Medicine, University of Cambridge
    Autoimmunity 26:33-42. 1997
    ..The extent to which findings in experimental animals have led to further insights applicable to human disease is also emphasised...
  10. pmc Recognition of the 60 kilodalton cysteine-rich outer membrane protein OMP2 by CD4(+) T cells from humans infected with Chlamydia trachomatis
    J C Goodall
    Department of Medicine, University of Cambridge, Cambridge, UK
    Clin Exp Immunol 126:488-93. 2001
    ..Thus OMP2 is a target antigen of the T cell-mediated immune response to CT infection...
  11. doi request reprint Increased IL-4+ CD8+ T cells in peripheral blood and autoreactive CD8+ T cell lines of patients with inflammatory arthritis
    H J Baek
    Department of Medicine, Box 157, Level 5, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Rheumatology (Oxford) 47:795-803. 2008
    ..To measure the frequencies of IL-4+ CD8+ T cells from patients with AS and RA, and to assess their clinical relevance and properties...
  12. ncbi request reprint Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function
    Lorna B Jarvis
    University of Cambridge Clinical School, Dept of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Eur J Immunol 35:2896-908. 2005
    ..Likewise, human HLA-restricted CD8+ regulatory T cells that can be cloned and expanded in vitro may have therapeutic applications...
  13. pmc Characterization of the humoral immune response to Chlamydia outer membrane protein 2 in chlamydial infection
    I Portig
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Clin Diagn Lab Immunol 10:103-7. 2003
    ..Thus, OMP2 ELISA has distinct advantages over MIF and commercially available ELISAs and might be a useful tool for the serodiagnosis of chlamydial infection...
  14. pmc Effects of Chlamydia trachomatis infection on the expression of natural killer (NK) cell ligands and susceptibility to NK cell lysis
    C E Hook
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge UK
    Clin Exp Immunol 138:54-60. 2004
    ..A candidate activating signal is MICA/B, which was shown to be expressed constitutively on epithelial cells...
  15. pmc HLA-B27 expression does not modulate intracellular Chlamydia trachomatis infection of cell lines
    J L Young
    Department of Medicine, University of Cambridge Clinical School, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Infect Immun 69:6670-5. 2001
    ..trachomatis serovar L2 within cell lines. Consequently, the role of HLA-B27 in the pathogenesis of reactive arthritis may lie downstream of the invasion and replication stages of the triggering pathogenic infection...
  16. ncbi request reprint Identification of Chlamydia trachomatis antigens recognized by human CD4+ T lymphocytes by screening an expression library
    J C Goodall
    Department of Medicine, University of Cambridge, GB
    Eur J Immunol 31:1513-22. 2001
    ....
  17. ncbi request reprint In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells
    J L Young
    University of Cambridge, School of Clinical Medicine, Department of Medicine, Addenbrooke s Hospital, Cambridge, Great Britain
    Eur J Immunol 27:2383-90. 1997
    ..Our data support the view that in human peripheral blood, CD45R0bright and CD45RAbright expression identify memory and naive CD4+ T cells, respectively...
  18. doi request reprint Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells
    Lorna B Jarvis
    Department of Rheumatology, University of Cambridge, Cambridge, UK
    Hum Immunol 69:687-95. 2008
    ..TRIM acts to chaperone CTLA-4 transport to the cell surface; this function would be required to account for the phenotypic and functional properties of CD8(+) Tregs...
  19. ncbi request reprint Analysis of antigen reactive T-cells
    Clare Alexander
    University of Cambridge Addenbrooke s Hospital, Department of Medicine, UK
    Methods Mol Med 136:51-68. 2007
    ..Lastly, because the techniques differ in many respects, methods for isolating antigen-specific CD8+ T-cells, particularly those which recognize bacteria, are also included...
  20. pmc CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells
    Richard C Duggleby
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Immunology 121:129-39. 2007
    ....
  21. ncbi request reprint The recognition of abnormal forms of HLA-B27 by CD4+ T cells
    Louise H Boyle
    Cambridge Institute of Medical Research, University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge, UK
    Curr Mol Med 4:51-8. 2004
    ..Here we discuss how such interactions between HLA-B27 and CD4+ T cells could occur in vivo and potential contributions of such interactions to the pathogenesis of SpA...
  22. pmc Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
    Jane C Goodall
    Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom
    Proc Natl Acad Sci U S A 107:17698-703. 2010
    ..Therefore, the effects of pathogens and other environmental factors on ER stress can profoundly affect the nature of innate and adaptive immune responses...
  23. ncbi request reprint Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid
    C H Van Krinks
    Department of Rheumatology, University of Cambridge, Cambridge, UK
    Rheumatology (Oxford) 43:453-60. 2004
    ..To examine the phenotype of dendritic cell subsets in synovial fluid and peripheral blood from patients with rheumatoid arthritis (RA) or spondyloarthropathy (SpA)...
  24. pmc Major histocompatibility complex class I-restricted alloreactive CD4+ T cells
    Louise H Boyle
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Immunology 112:54-63. 2004
    ....
  25. ncbi request reprint Does HLA-B27 influence the monocyte inflammatory response to lipopolysaccharide?
    J C Goodall
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Box 157, Level 5, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Rheumatology (Oxford) 46:232-7. 2007
    ..This study investigated whether HLA-B27 modulates the innate response to lipopolysaccharide (LPS), a component shared between all Gram negative bacteria that can trigger reactive arthritis...
  26. ncbi request reprint Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII
    T D Jones
    Biovation Ltd, Babraham, Cambridge, UK
    J Thromb Haemost 3:991-1000. 2005
    ..The development of inhibitors in hemophiliacs is a severe complication of factor VIII (FVIII) replacement therapy and is a process driven by FVIII specific T helper cells...
  27. pmc Chlamydia trachomatis-specific human CD8+ T cells show two patterns of antigen recognition
    Malgosia K Matyszak
    University of Cambridge Clinical School, Department of Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    Infect Immun 72:4357-67. 2004
    ..trachomatis infection, facilitated by unrestricted CD8(+)-T-cell clones, may be important in ensuring a subsequent Th1 T-cell-mediated response by classical major histocompatibility complex-restricted CD4(+) and CD8(+) T cells...
  28. ncbi request reprint The recognition of HLA-B27 by human CD4(+) T lymphocytes
    L H Boyle
    University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge, United Kingdom
    J Immunol 167:2619-24. 2001
    ..We suggest that B27-reactive CD4(+) T cells may be pathogenic in spondyloarthropathies, particularly if factors such as infection influence expression of abnormal forms of B27...
  29. ncbi request reprint T cell recognition of a highly conserved epitope in heat shock protein 60: self-tolerance maintained by TCR distinguishing between asparagine and aspartic acid
    Mark S Lillicrap
    Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, UK
    Int Immunol 16:405-14. 2004
    ....
  30. ncbi request reprint How much HLA-B27 expression is needed for spondyloarthritis?
    J S Hill Gaston
    J Rheumatol 35:738-40. 2008
  31. ncbi request reprint 2006 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)
    Muhammad Asim Khan
    Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    J Rheumatol 34:1118-24. 2007