Stephen F Garner
Affiliation: University of Cambridge
- Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopeniaStephen F Garner
Division of Transfusion Medicine, University of Cambridge and National Blood Service East Anglia Centre, United Kingdom
Blood 100:344-6. 2002..Autoantibodies recognizing GPV were not seen in the 28 nonthrombocytopenic control RA patients. Thus, GPV seems to be targeted in gold-induced autoimmune thrombocytopenia...
- Teicoplanin-dependent antibodies: detection and characterizationStephen F Garner
National Blood Service, Cambridge, UK
Br J Haematol 129:279-81. 2005....
- Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteinsMarie N O'Connor
Department of Haematology, University of Cambridge, Cambridge, United Kingdom
Blood 113:4754-62. 2009..We conclude that phenotypic analysis of MO-injected zebrafish is a fast and powerful method for initial screening of novel platelet proteins for function in thrombosis...
- Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formationAdam Walker
Domantis Ltd, 315 Cambridge Science Park, Cambridge, UK
Platelets 20:268-76. 2009..These data, together with the desirable properties of Domain Antibodies, show that dAbs could potentially be used to generate novel biopharmaceuticals with anti-thrombotic properties...
- A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and functionNicole Soranzo
Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
Blood 113:3831-7. 2009....
- A HaemAtlas: characterizing gene expression in differentiated human blood cellsNicholas A Watkins
Department of Haematology, University of Cambridge, National Health Service Blood and Transplant, Cambridge, United Kingdom
Blood 113:e1-9. 2009..The data, which are freely accessible, will be invaluable for future studies on hematopoiesis and the role of specific genes and will also aid the understanding of the recent genome-wide association studies...
- A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopeniaCedric Ghevaert
Department of Haematology, University of Cambridge, UK
Blood 111:3407-14. 2008..We conclude that the constitutive activation of the alphaIIbbeta3-H723 receptor causes abnormal proplatelet formation, leading to incorrect sizing of platelets and the thrombocytopenia observed in the pedigree...
- Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibodyPeter A Smethurst
Department of Haematology, University of Cambridge and National Blood Service Cambridge, Long Road, Cambridge, CB2 2PT, United Kingdom
Blood 103:903-11. 2004..Antibody 10B12 showed significantly reduced binding to the hD1D2-E59, and, on that basis, the GPVI:10B12 interface was modeled...
- A single-nucleotide polymorphism in the human ITGB3 gene is associated with the platelet-specific alloantigen Va (HPA-17bw) involved in fetal maternal alloimmune thrombocytopeniaPrachi Stafford
The Department of Haematology, University of Cambridge and NHS Blood and Transplant, Cambridge, UK
Transfusion 48:1432-8. 2008..This PLT antigen was localized to the integrin alphaIIbbeta3 (GPIIbIIIa) but its genetic basis was not defined...
- Apheresis donors and platelet function: inherent platelet responsiveness influences platelet qualityStephen F Garner
Department of Haematology, University of Cambridge, Cambridge, UK
Transfusion 48:673-80. 2008....
- Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells: a novel system for antigen production and phage antibody isolationNicola S Jennings
Department of Haematology, University of Cambridge and the National Blood Service Cambridge, Cambridge, UK
J Immunol Methods 316:75-83. 2006....