R L Gardner

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome
    Frances A Brook
    Department of Zoology, University of Oxford, Oxford, U K
    Diabetes 52:205-8. 2003
  2. ncbi request reprint Stem cells and regenerative medicine: principles, prospects and problems
    Richard L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    C R Biol 330:465-73. 2007
  3. ncbi request reprint Thoughts and observations on patterning in early mammalian development
    R L Gardner
    University of Oxford, Department of Zoology, South Parks Road, Oxford, OX1 3PS, UK
    Reprod Biomed Online 4:46-51. 2002
  4. ncbi request reprint Experimental analysis of second cleavage in the mouse
    R L Gardner
    University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Hum Reprod 17:3178-89. 2002
  5. ncbi request reprint Trophectoderm growth and bilateral symmetry of the blastocyst in the mouse
    Richard L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Hum Reprod 17:1839-45. 2002
  6. pmc Stem cells: potency, plasticity and public perception
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, UK
    J Anat 200:277-82. 2002
  7. ncbi request reprint Patterning is initiated before cleavage in the mouse
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Roads, Oxford OX1 3PS, UK
    Ann Anat 184:577-81. 2002
  8. ncbi request reprint Is the plane of first cleavage related to the point of sperm entry in the mouse?
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Reprod Biomed Online 6:157-60. 2003
  9. pmc The basis and significance of pre-patterning in mammals
    Richard L Gardner
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Philos Trans R Soc Lond B Biol Sci 358:1331-8; discussion 1338-9. 2003
  10. ncbi request reprint The case for prepatterning in the mouse
    Richard L Gardner
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Birth Defects Res C Embryo Today 75:142-50. 2005

Detail Information

Publications31

  1. ncbi request reprint The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome
    Frances A Brook
    Department of Zoology, University of Oxford, Oxford, U K
    Diabetes 52:205-8. 2003
    ..Consequently, we developed ES cell lines derived from (NOD x 129)F1 x 129 backcross 1 mice, which were intercrossed to select for homozygosity of particular regions of NOD genome known to contain disease loci...
  2. ncbi request reprint Stem cells and regenerative medicine: principles, prospects and problems
    Richard L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    C R Biol 330:465-73. 2007
    ..Moreover, claims that some stem cells are more likely than others to yield successful allografts have yet to be confirmed and explained...
  3. ncbi request reprint Thoughts and observations on patterning in early mammalian development
    R L Gardner
    University of Oxford, Department of Zoology, South Parks Road, Oxford, OX1 3PS, UK
    Reprod Biomed Online 4:46-51. 2002
    ..Finally, regularities in axial relationships between the blastocyst and zygote have been revealed employing strictly non-invasive techniques. These show that, at least in normal development, patterning begins before cleavage...
  4. ncbi request reprint Experimental analysis of second cleavage in the mouse
    R L Gardner
    University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Hum Reprod 17:3178-89. 2002
    ..The aim of the present study was to ascertain whether this was also true for the mouse...
  5. ncbi request reprint Trophectoderm growth and bilateral symmetry of the blastocyst in the mouse
    Richard L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Hum Reprod 17:1839-45. 2002
    ....
  6. pmc Stem cells: potency, plasticity and public perception
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, UK
    J Anat 200:277-82. 2002
    ..Likewise, introduction of the term 'therapeutic cloning' has complicated the present one regarding extension of such research to stem cell therapy...
  7. ncbi request reprint Patterning is initiated before cleavage in the mouse
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Roads, Oxford OX1 3PS, UK
    Ann Anat 184:577-81. 2002
    ..Second, it raises the practical question whether the increasing use of in vitro manipulation of gametes and zygotes for assisting human reproduction carries a risk of perturbing development...
  8. ncbi request reprint Is the plane of first cleavage related to the point of sperm entry in the mouse?
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Reprod Biomed Online 6:157-60. 2003
  9. pmc The basis and significance of pre-patterning in mammals
    Richard L Gardner
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Philos Trans R Soc Lond B Biol Sci 358:1331-8; discussion 1338-9. 2003
    ..Finally, the two-cell blastomere inheriting the sperm entry point has not been found to differ consistently in fate from the one that does not...
  10. ncbi request reprint The case for prepatterning in the mouse
    Richard L Gardner
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Birth Defects Res C Embryo Today 75:142-50. 2005
    ..Nevertheless, there is still no general consensus regarding the extent to which such prepatterning depends on intrinsic organization of the oocyte, as opposed to events that are contingent on fertilization...
  11. ncbi request reprint Human experimental chimaerism: Chimaeras as a source of stem cells
    Richard L Gardner
    University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Reprod Biomed Online 5:103. 2002
  12. ncbi request reprint An investigation of the origin and significance of bilateral symmetry of the pronuclear zygote in the mouse
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Hum Reprod 21:492-502. 2006
    ....
  13. ncbi request reprint The axis of polarity of the mouse blastocyst is specified before blastulation and independently of the zona pellucida
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford, UK
    Hum Reprod 22:798-806. 2007
    ..This hypothesis merited closer scrutiny, because it seemed at variance with observations on living conceptuses...
  14. ncbi request reprint Specification of embryonic axes begins before cleavage in normal mouse development
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Development 128:839-47. 2001
    ..Therefore, during normal mouse development the axes of the blastocyst, which have been implicated in establishing those of the fetus, are already specified by the onset of cleavage...
  15. ncbi request reprint Reflections on the biology of embryonic stem (ES) cells
    R L Gardner
    Department of Zoology, University of Oxford, United Kingdom
    Int J Dev Biol 41:235-43. 1997
    ..Finally, it has yet to be explained why ES chimeras evidently differ from those obtained by combining cells from different conceptuses in showing greater variation between tissues in the level of chimerism...
  16. ncbi request reprint The plane of first cleavage is not related to the distribution of sperm components in the mouse
    T J Davies
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Hum Reprod 17:2368-79. 2002
    ..Because of concerns about the specificity of lectin binding, the distribution of sperm components has been investigated directly...
  17. ncbi request reprint Complete dissipation of coherent clonal growth occurs before gastrulation in mouse epiblast
    R L Gardner
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Development 125:2397-402. 1998
    ..These findings have implications both for patterning of the early amniote embryo and for the growth of tall columnar epithelia in general...
  18. ncbi request reprint Insulin-like growth factor-2 regulation of conceptus composition: effects of the trophectoderm and inner cell mass genotypes in the mouse
    R L Gardner
    Zoology Department, Oxford University, Oxford OX1 3PS, United Kingdom
    Biol Reprod 60:190-5. 1999
    ....
  19. ncbi request reprint The initial phase of embryonic patterning in mammals
    R L Gardner
    University of Oxford, United Kingdom
    Int Rev Cytol 203:233-90. 2001
    ..Consequently, at present, the possibility of adverse effects of techniques used to assist human reproduction cannot be disregarded...
  20. ncbi request reprint Translational inhibition of cyclin B1 and appearance of cyclin D1 very early in the differentiation of mouse trophoblast giant cells
    L S Palazón
    Department of Zoology, University of Oxford, UK
    Mol Hum Reprod 4:1013-20. 1998
    ..The results suggest that supression of MPF activity, by inhibition of translation of cyclin B1, is a key mechanism for the establishment of the endocycle in the mouse trophoblast...
  21. ncbi request reprint Contributions of blastocyst micromanipulation to the study of mammalian development
    R L Gardner
    Department of Zoology, University of Oxford, United Kingdom
    Bioessays 20:168-80. 1998
    ....
  22. ncbi request reprint Polarity in early mammalian development
    R L Gardner
    Department of Zoology, South Parks Road, Oxford, OX1 3PS, UK
    Curr Opin Genet Dev 9:417-21. 1999
    ....
  23. ncbi request reprint Directed differentiation of dendritic cells from mouse embryonic stem cells
    P J Fairchild
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
    Curr Biol 10:1515-8. 2000
    ..This novel source should prove valuable for the generation of primary, untransformed DCs in which candidate genes have been overexpressed or functionally ablated, while providing insights into the earliest stages of DC ontogeny...
  24. ncbi request reprint Weaknesses in the case against prepatterning in the mouse
    R L Gardner
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Reprod Biomed Online 12:144-9. 2006
    ..Moreover, this 'mechanical constraint' hypothesis fails to account for key findings on which the case for prepatterning is based...
  25. pmc Epigenesis versus preformation during mammalian development. Introduction
    R L Gardner
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Philos Trans R Soc Lond B Biol Sci 358:1313-5. 2003
  26. ncbi request reprint Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse
    Gary D Uy
    Mammalian Development Laboratory, University of Oxford, Department of Zoology, South Parks Road, Oxford, OX1 3PS, UK
    Development 129:3913-24. 2002
    ..Together with previous observations, we discuss the possibility that fluid-filled cavities may play a general role in the development of tissues that border them...
  27. ncbi request reprint New cell lines from mouse epiblast share defining features with human embryonic stem cells
    Paul J Tesar
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 448:196-9. 2007
    ..These results show that epiblast cells can be maintained as stable cell lines and interrogated to understand how pluripotent cells generate distinct fates during early development...
  28. ncbi request reprint Experimental analysis of the transdifferentiation of visceral to parietal endoderm in the mouse
    Youichirou Ninomiya
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, United Kingdom
    Dev Dyn 233:837-46. 2005
    ..The presence of mesoderm seems to be necessary to enable the VE to grow rather than convert to PE, as occurs if it retains contact with the extraembryonic ectoderm...
  29. ncbi request reprint Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
    Tilo Kunath
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Development 132:1649-61. 2005
    ..Based on gene expression analysis, chimera studies and imprinted X-inactivation, XEN cell lines are representative of extra-embryonic endoderm and provide a new cell culture model of an early mammalian lineage...
  30. ncbi request reprint Application of alginate gels to the study of Mammalian development
    Richard L Gardner
    Mammalian Development Laboratory, Department of Zoology, University of Oxford, UK
    Methods Mol Biol 254:383-92. 2004
  31. pmc Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance
    Nathan J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 104:20920-5. 2007
    ....