Research Topics
| C GardinerSummaryAffiliation: University College London Country: UK Publications
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Publications
A randomised control trial of patient self-management of oral anticoagulation compared with patient self-testingChris Gardiner
Department of Haematology, University College London Hospitals, London, UK
Br J Haematol 132:598-603. 2006..86) also showed a significant difference. The quality of warfarin control in both PST and PSM may be superior to that achieved by conventional management in a specialised hospital anticoagulation clinic...
Recommendations for evaluation of coagulation analyzersChris Gardiner
University College London Hospitals, London, UK
Lab Hematol 12:32-8. 2006
Can oral anticoagulation be managed using telemedicine and patient self-testing? A pilot studyC Gardiner
Department of Haematology, University College London Hospitals, London, UK
Clin Lab Haematol 28:122-5. 2006..In conclusion, this pilot study showed that telemedicine is a feasible option for anticoagulant management, but that the technology requires thorough testing prior to installation...
Self-monitoring of oral anticoagulation: does it work outside trial conditions?C Gardiner
Department of Haematology, University College London Hospitals, London, UK
J Clin Pathol 62:168-71. 2009..Patient self-monitoring (PSM) of oral anticoagulation therapy (OAT) can improve anticoagulant control, but poor uptake and high dropout rates have prompted suggestions that PSM is suitable for only a minority of patients in the UK...
Measuring thrombin generation based sensitivity to activated protein C using an automated coagulometer (ACL 9000)C Gardiner
Department of Haematology, University College London, London, UK
Int J Lab Hematol 30:261-8. 2008..73-1.06; ETP(+APC) 0.42-1.07. ETP(+APC) was found to be sensitive to factor V Leiden, oral contraceptive use, low levels of protein S and tissue factor pathway inhibitor and increased plasma factor VIII...
The clinical significance of differences between point-of-care and laboratory INR methods in over-anticoagulated patientsA S Lawrie
Haemostasis Research Unit, Department of Haematology, University College London, London, UK
Thromb Res 130:110-4. 2012..5; the relationships between the INR and levels of vitamin K-dependent coagulation factors (VKD-CF) and thrombin generation test (TGT) parameters; and the impact that variation in results would have on warfarin dosing...
The importance of locally derived reference ranges and standardized calculation of dilute Russell's viper venom time results in screening for lupus anticoagulantC Gardiner
Department of Haematology, University College London Hospitals, London, UK
Br J Haematol 111:1230-5. 2000..Standardizing DRVVT interpretation in this way should improve the consistency of LA detection...
An evaluation of screening tests for defects in the protein C pathway: commercial kits lack sensitivity and specificityC Gardiner
Department of Haematology, University College London Hospital, London, UK
Blood Coagul Fibrinolysis 13:155-63. 2002..We conclude that all four kits lack the sensitivity and specificity required for routine laboratory screening for defects in the protein C pathway and cannot replace assays for the individual proteins of this system...
Diagnosis of antiphospholipid syndrome in routine clinical practiceC Gardiner
Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK
Lupus 22:18-25. 2013..5% and 29.4% of patients, respectively. Our data suggest that LA, aCL and aβ(2)GPI testing are all required for the accurate diagnosis of APS and that low-titre antibodies should be included in the diagnosis of obstetric APS...
Individual patient meta-analysis of self-monitoring of an oral anticoagulation protocolRafael Perera
Department of Primary Health Care, University of Oxford, UK
J Heart Valve Dis 17:233-8. 2008..In order to overcome these limitations and allow further investigation of the data, the study aim is to undertake an Individual Patient Data (IPD) meta-analysis...
Detection of acquired resistance to activated protein C associated with antiphospholipid antibodies using a novel clotting assayChris Gardiner
Department of Haematology, University College London, UK
Blood Coagul Fibrinolysis 17:477-83. 2006..Purified aPA IgG caused a dose-dependent increase in APC resistance when added to normal plasma. We conclude that aPA-associated acquired APC resistance is a common feature of APS and may be independent of anti-beta2GPI...
Patient self-testing is a reliable and acceptable alternative to laboratory INR monitoringChris Gardiner
Department of Haematology, University College London Hospitals NHS Trust, London, UK
Br J Haematol 128:242-7. 2005..We conclude that PST is a reliable alternative to hospital clinic attendance and is acceptable to the majority of suitably trained patients...
Performance evaluation of a new small-volume coagulation monitor: the SmartCheck INR systemChris Gardiner
Department of Haematology, University College London Hospitals, London, England
Am J Clin Pathol 129:500-4. 2008..7%. The SmartCheck INR provides accurate and reproducible results and is suitable for routine monitoring of oral anticoagulant therapy in the majority of patients...
The SmartCheck INR systemChris Gardiner
Am J Clin Pathol 129:826. 2008
