Angel Garcia

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Analyzing the platelet proteome
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Semin Thromb Hemost 30:485-9. 2004
  2. ncbi request reprint Applying proteomics technology to platelet research
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Mass Spectrom Rev 24:918-30. 2005
  3. ncbi request reprint Proteome analysis of signaling cascades in human platelets
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Blood Cells Mol Dis 36:152-6. 2006
  4. ncbi request reprint The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
    Int J Cancer 119:1014-22. 2006
  5. ncbi request reprint Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
    Proteomics 4:656-68. 2004
  6. ncbi request reprint Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Proteome Res 6:2802-11. 2007
  7. pmc A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter
    Angel Garcia
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK
    Proteomics 6:5332-43. 2006
  8. ncbi request reprint Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Proteomics 5:4980-93. 2005
  9. ncbi request reprint Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, United Kingdom
    Blood 103:2088-95. 2004
  10. ncbi request reprint Abnormal cell cycle regulation in primary human uveal melanoma cultures
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    J Cell Biochem 93:708-20. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Analyzing the platelet proteome
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Semin Thromb Hemost 30:485-9. 2004
    ..Each method has particular advantages and disadvantages. Proteomics can be used to compare the proteome of basal and diseased platelets, helping to reveal information on the molecular basis of the disease...
  2. ncbi request reprint Applying proteomics technology to platelet research
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Mass Spectrom Rev 24:918-30. 2005
    ..This review presents the major advances in mass spectrometry-based proteomics techniques and their application to platelet research, and analyzes in detail the most relevant contributions to the field...
  3. ncbi request reprint Proteome analysis of signaling cascades in human platelets
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Blood Cells Mol Dis 36:152-6. 2006
    ..This article focus on the application of 2-DE-based proteomics to the study of signaling cascades in human platelets...
  4. ncbi request reprint The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
    Int J Cancer 119:1014-22. 2006
    ..The secretion of DJ-1 by UM cells, and the ability to detect this protein in UM patients' sera implicate it as a potential noninvasive biomarker for this malignancy...
  5. ncbi request reprint Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
    Proteomics 4:656-68. 2004
    ..In conclusion, this study provides a unique inventory of the platelet proteome, contributing to our understanding of platelet function and building the basis for the identification of new drug targets...
  6. ncbi request reprint Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Proteome Res 6:2802-11. 2007
    ..We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers...
  7. pmc A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter
    Angel Garcia
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK
    Proteomics 6:5332-43. 2006
    ..This study provides new insights into the mechanism of platelet activation through the GPVI collagen receptor, helping to build the basis for the development of new drug targets for thrombotic disease...
  8. ncbi request reprint Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Proteomics 5:4980-93. 2005
    ..This study represents the first step towards the establishment of a UM protein database as a valuable resource for the study of this malignancy...
  9. ncbi request reprint Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins
    Angel Garcia
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, United Kingdom
    Blood 103:2088-95. 2004
    ....
  10. ncbi request reprint Abnormal cell cycle regulation in primary human uveal melanoma cultures
    Maria Pardo
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    J Cell Biochem 93:708-20. 2004
    ..Our results indicate that the overexpression of cyclins D1/E and CDKIs p16 and p27, together with a deregulation of the Rb/E2F pathway, may be implicated in the development of human UM...
  11. pmc A microtubule interactome: complexes with roles in cell cycle and mitosis
    Julian R Hughes
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Biol 6:e98. 2008
    ..This study therefore demonstrates that biologically relevant data can be harvested using such a multidisciplinary approach, and identifies new MAPs, many of which appear to be important in cell division...