G Garcea

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Impact of a critical care outreach team on critical care readmissions and mortality
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, Gwendolen, Leicester, UK
    Acta Anaesthesiol Scand 48:1096-100. 2004
  2. ncbi request reprint Patient information following emergency laparoscopy for right iliac fossa pain
    Giuseppe Garcea
    Hepatobiliary Research Office, The Leicester General Hospital, United Kingdom
    Surg Laparosc Endosc Percutan Tech 14:136-40. 2004
  3. ncbi request reprint Diagnosis and management of colovesical fistulae; six-year experience of 90 consecutive cases
    G Garcea
    Department of Surgery, The Leicester General Hospital, Leicester, UK
    Colorectal Dis 8:347-52. 2006
  4. ncbi request reprint Early warning scores predict outcome in acute pancreatitis
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, England
    J Gastrointest Surg 10:1008-15. 2006
  5. ncbi request reprint Nine-year single-center experience with nonparastic liver cysts: diagnosis and management
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK
    Dig Dis Sci 52:185-91. 2007
  6. doi request reprint Surgical management of cystic lesions in the liver
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    ANZ J Surg 83:516-22. 2013
  7. doi request reprint Surgical management of cystic lesions in the liver
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    ANZ J Surg 83:E3-E20. 2013
  8. doi request reprint Patient satisfaction and cost-effectiveness following total pancreatectomy with islet cell transplantation for chronic pancreatitis
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, United Kingdom
    Pancreas 42:322-8. 2013
  9. doi request reprint Results from a consecutive series of laparoscopic incisional and ventral hernia repairs
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester Royal Infirmary, Leicester, UK
    Surg Laparosc Endosc Percutan Tech 22:131-5. 2012
  10. doi request reprint Improving the diagnostic yield from staging laparoscopy for periampullary malignancies: the value of preoperative inflammatory markers and radiological tumor size
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    Pancreas 41:233-7. 2012

Detail Information

Publications91

  1. ncbi request reprint Impact of a critical care outreach team on critical care readmissions and mortality
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, Gwendolen, Leicester, UK
    Acta Anaesthesiol Scand 48:1096-100. 2004
    ....
  2. ncbi request reprint Patient information following emergency laparoscopy for right iliac fossa pain
    Giuseppe Garcea
    Hepatobiliary Research Office, The Leicester General Hospital, United Kingdom
    Surg Laparosc Endosc Percutan Tech 14:136-40. 2004
    ..More effort must be made to enable patients to retain such necessary information...
  3. ncbi request reprint Diagnosis and management of colovesical fistulae; six-year experience of 90 consecutive cases
    G Garcea
    Department of Surgery, The Leicester General Hospital, Leicester, UK
    Colorectal Dis 8:347-52. 2006
    ..As a result, few centres have sufficient experience in the investigation and surgical treatment of colovesical fistulae to develop clear protocols in its management...
  4. ncbi request reprint Early warning scores predict outcome in acute pancreatitis
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, England
    J Gastrointest Surg 10:1008-15. 2006
    ..EWS of 3 or above is an indicator of adverse outcome in patients with acute pancreatitis. EWS can accurately and reliably select both patients with severe acute pancreatitis and those at risk of local complications...
  5. ncbi request reprint Nine-year single-center experience with nonparastic liver cysts: diagnosis and management
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK
    Dig Dis Sci 52:185-91. 2007
    ..We conclude that laparoscopic liver cyst deroofing is an effective method of dealing with symptomatic nonparasitic liver cysts...
  6. doi request reprint Surgical management of cystic lesions in the liver
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    ANZ J Surg 83:516-22. 2013
    ..Liver cysts are common, occurring in up to 5% of the population. For many types of cysts, a variety of different treatment options exist and the preferred management is unclear...
  7. doi request reprint Surgical management of cystic lesions in the liver
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    ANZ J Surg 83:E3-E20. 2013
    ..Liver cysts are common, occurring in up to 5% of the population. For many types of cysts, a variety of different treatment options exist and the preferred management is unclear...
  8. doi request reprint Patient satisfaction and cost-effectiveness following total pancreatectomy with islet cell transplantation for chronic pancreatitis
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, United Kingdom
    Pancreas 42:322-8. 2013
    ..Chronic pancreatitis (CP) results in an extremely poor quality of life and substantially increases health care utilization. Few data exist regarding the cost-effectiveness of surgical treatment for CP...
  9. doi request reprint Results from a consecutive series of laparoscopic incisional and ventral hernia repairs
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester Royal Infirmary, Leicester, UK
    Surg Laparosc Endosc Percutan Tech 22:131-5. 2012
    ..Laparoscopic repair has been gaining popularity for both incisional and ventral herniae. However, the perceived benefits have not been convincingly demonstrated by randomized-controlled studies or meta-analyses...
  10. doi request reprint Improving the diagnostic yield from staging laparoscopy for periampullary malignancies: the value of preoperative inflammatory markers and radiological tumor size
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    Pancreas 41:233-7. 2012
    ..Owing to improvements in preoperative imaging, some centers no longer undertake routine laparoscopic staging, whereas others still find it a useful pre-exploration tool...
  11. doi request reprint Progression of early warning scores (EWS) in patients with acute pancreatitis: a re-evaluation of a retrospective cohort of patients
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Postgrad Med J 84:271-5. 2008
    ..Early warning scores (EWS) is a physiological scoring system measured hourly. This study determined how progression of EWS affected outcome in acute pancreatitis...
  12. doi request reprint Cystic lesions of the pancreas. A diagnostic and management dilemma
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    Pancreatology 8:236-51. 2008
    ..The exact diagnostic and management pathway of these cysts remains problematic and this review attempts to provide an overview of the pathology underlying pancreatic cystic lesions and suggests appropriate methods of management...
  13. doi request reprint Preoperative biliary drainage for distal obstruction: the case against revisited
    Giuseppe Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Pancreas 39:119-26. 2010
    ..This review examined the impact of PBD and the outcomes after surgery...
  14. ncbi request reprint Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital Leicester, United Kingdom
    JOP 9:99-132. 2008
    ..In the light of such bleak statistics, data regarding what factors may influence outcome, following attempted curative resection is essential in order to optimise the treatment options for patients...
  15. ncbi request reprint Glycogen synthase kinase-3 beta; a new target in pancreatic cancer?
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, UK
    Curr Cancer Drug Targets 7:209-15. 2007
    ..Hence, GSK has potential as an important new target both in the treatment of resectable pancreatic cancer as an adjuvant to surgery, and in the palliation of inoperable tumours...
  16. ncbi request reprint Tumour characteristics predictive of survival following resection for ductal adenocarcinoma of the head of pancreas
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, UK
    Eur J Surg Oncol 33:892-7. 2007
    ..This study investigated our survival rates following pancreatic resection and examined clinicopathological predictors of survival...
  17. ncbi request reprint Hypoxia and angiogenesis in pancreatic cancer
    Giuseppe Garcea
    Department of Hepatobiliary Surgery, The Leicester General Hospital, Leicester, UK
    ANZ J Surg 76:830-42. 2006
    ..Increasing knowledge regarding the molecular events behind the growth and invasion of pancreatic cancer may lead to new targets for intervention...
  18. doi request reprint Total pancreatectomy with and without islet cell transplantation for chronic pancreatitis: a series of 85 consecutive patients
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
    Pancreas 38:1-7. 2009
    ..This study examined 85 consecutive patients undergoing total pancreatectomy (+/-islet cell transplant), examining pain relief, insulin requirements, and glycemic control postoperatively...
  19. doi request reprint Inoperable colorectal liver metastases: a declining entity?
    G Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    Eur J Cancer 44:2555-72. 2008
    ..Until recently, the outlook for such patients was bleak. The purpose of this review was to report on available options in the treatment CLMs, which would be considered unresectable by conventional evaluation...
  20. doi request reprint Palliation of malignant obstructive jaundice
    G Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    Dig Dis Sci 54:1184-98. 2009
    ..An overview of present treatment modalities for palliation of obstructive jaundice is provided, including a systematic review of the English literature regarding the optimum choice of palliation...
  21. doi request reprint Is intraoperative confirmation of malignancy during pancreaticoduodenectomy mandatory?
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, LE5 4PW, UK
    J Gastrointest Surg 16:370-5. 2012
    ..In this situation, surgeons may have to proceed to "blind" pancreaticoduodenectomy or attempt to confirm malignancy intraoperatively with frozen section (FS) histology...
  22. pmc Bilirubin levels predict malignancy in patients with obstructive jaundice
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    HPB (Oxford) 13:426-30. 2011
    ..In patients with obstructive jaundice, the predictive accuracy of bilirubin levels at presentation was examined in order to determine whether such data could be used to differentiate between malignant and benign disease...
  23. doi request reprint Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, LE5 4PW, UK
    World J Surg 35:868-72. 2011
    ..This study determined the prognostic value of the preoperative value of these markers in patients with resectable pancreatic adenocarcinoma...
  24. doi request reprint Caveat reporting in ultrasound interpretation of surgical pathology: a comparison of sonographer versus radiologist
    Giuseppe Garcea
    Cancer Studies and Molecular Medicine, Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Eval Clin Pract 16:97-9. 2010
    ..This study compared ultrasound (USS) reports generated by radiologists and sonographers to determine if any significant or clinically relevant differences existed...
  25. doi request reprint Prediction of mortality in acute pancreatitis: a systematic review of the published evidence
    G Gravante
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    Pancreatology 9:601-14. 2009
    ..With the exception of the APACHE II, the other scores and indexes do not have a high degree of sensitivity, specificity and predictive values...
  26. doi request reprint Predicting liver failure following major hepatectomy
    G Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia
    Dig Liver Dis 41:798-806. 2009
    ..Published data would not suggest any difference in mortality, morbidity or liver failure rates between these groups. This review outlines and presents the evidence for pre-operative quantification of functional liver remnant volume...
  27. doi request reprint Preoperative early warning scores can predict in-hospital mortality and critical care admission following emergency surgery
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
    J Surg Res 159:729-34. 2010
    ..This study examined preoperative early warning scoring (EWS) and its ability to predict mortality and critical care admission. Postoperative EWS was also evaluated as a predictor of mortality...
  28. doi request reprint Liver failure after major hepatic resection
    Giuseppe Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    J Hepatobiliary Pancreat Surg 16:145-55. 2009
    ..The focus of this review will be to investigate factors contributing to hepatocyte loss and impaired regeneration...
  29. doi request reprint Predictors of severity and survival in acute pancreatitis: validation of the efficacy of early warning scores
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
    Pancreas 37:e54-61. 2008
    ..This study examined EWS from a larger group of patients to confirm if this predictive value held true...
  30. ncbi request reprint Oxidative stress in humans following the Pringle manoeuvre
    Giuseppe Garcea
    University Department of Oncology, 5th Floor, The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Hepatobiliary Pancreat Dis Int 5:210-4. 2006
    ..This study was undertaken to determine the suitability of M1G as a novel marker of ischemia-reperfusion injury in the liver and its correlation with both the length of Pringle clamp application and the overall length of the operation...
  31. ncbi request reprint Diagnostic value of MRCP in the management of hilar strictures after extended liver resection
    G Garcea
    Department of Hepatobiliary Surgery, The Leicester General Hospital, Leicester, UK
    Clin Radiol 59:846-8. 2004
  32. ncbi request reprint Chemoprevention of gastrointestinal malignancies
    Giuseppe Garcea
    University Department of Oncology, The Leicester Royal Infirmary, Leicester, United Kingdom
    ANZ J Surg 73:680-6. 2003
    ..This concept is known as chemoprevention and although the potential for such agents is tremendous, evaluating their clinical benefit is beset with difficulties...
  33. pmc Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
    G Garcea
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Biochemistry, University of Leicester, 5th Floor Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, UK
    Br J Cancer 90:1011-5. 2004
    ..The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans...
  34. ncbi request reprint Haemorrhage from pancreatic pseudocysts presenting as upper gastrointestinal haemorrhage
    Giuseppe Garcea
    Hepatobiliary Research Fellow s Office, Ward 12, Leicester General Hospital, Gwendolen Road, Leicester LE1 6PY, United Kingdom
    Asian J Surg 27:137-40. 2004
    ..When managing patients with pancreatic pseudocysts who present with the stigmata of upper gastrointestinal bleeding, the possibility that the bleeding originates from the pancreas must always be borne in mind...
  35. ncbi request reprint Percutaneous splanchnic nerve radiofrequency ablation for chronic abdominal pain
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, Leicester, United Kingdom
    ANZ J Surg 75:640-4. 2005
    ..It produces predictable and accurate lesions and hence is useful alternative to more conventional phenol and alcohol neurolytic methods...
  36. ncbi request reprint Differences in attitudes between patients with primary colorectal cancer and patients with secondary colorectal cancer: is it reflected in their willingness to participate in drug trials?
    G Garcea
    The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, UK
    Eur J Cancer Care (Engl) 14:166-70. 2005
    ..The importance of the initial contact is demonstrated. Unrealistic expectations regarding the trial drug are common despite clear information to the contrary...
  37. ncbi request reprint Angiogenesis of gastrointestinal tumours and their metastases--a target for intervention?
    G Garcea
    Cancer Studies and Molecular Medicine, 5th Floor, The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Cancer 40:1302-13. 2004
    ..However, early results suggest that anti-angiogenic therapy could be an important adjunct to conventional chemotherapy treatment of gastrointestinal neoplasia...
  38. ncbi request reprint Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences
    Giuseppe Garcea
    Department of Oncology, RKCSB, LRI, University of Leicester, Leicester, LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:120-5. 2005
    ..The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut...
  39. ncbi request reprint Two-stage liver resection and chemotherapy for bilobar colorectal liver metastases
    G Garcea
    Department of Oncology, 5th Floor, The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Surg Oncol 30:759-64. 2004
    ..The authors present a series of patients with inoperable disease despite down-staging with chemotherapy, who underwent a two-stage resection to clear their metastatic disease...
  40. ncbi request reprint The emergent role of focal liver ablation techniques in the treatment of primary and secondary liver tumours
    G Garcea
    Department of Hepatobiliary Surgery, The Leicester General Hospital, Gwendolen Road, Leicester LE2 7LX, UK
    Eur J Cancer 39:2150-64. 2003
    ..Ablative techniques offer a promising therapeutic modality to treat unresectable tumours. Large-scale randomised controlled trials are required before widespread acceptance of these techniques can occur...
  41. ncbi request reprint Role of inflammation in pancreatic carcinogenesis and the implications for future therapy
    G Garcea
    Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, UK
    Pancreatology 5:514-29. 2005
    ..This review examines the role of inflammation in pancreatic carcinogenesis and how it can be utilised to develop new therapies against pancreatic cancer...
  42. ncbi request reprint Results following conservative lateral sphincteromy for the treatment of chronic anal fissures
    G Garcea
    Ward 12, Leicester General Hospital, Leicester, UK
    Colorectal Dis 5:311-4. 2003
    ..Traditional sphincterotomy comprises of division of the internal sphincter up to the level of the dentate line, a more conservative division could lead to a lower incontinence rate, with an equivalent healing rate...
  43. ncbi request reprint Molecular prognostic markers in pancreatic cancer: a systematic review
    G Garcea
    Cancer Studies and Molecular Medicine, The Robert Kilpatrick Clinical Sciences Building, University of Leicester, The Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Cancer 41:2213-36. 2005
    ..This 'protein/gene signature' could revolutionise work in this field and allow researchers to develop accurate and reproducible predictions of survival based on protein or gene profiles...
  44. ncbi request reprint Molecular biomarkers of colorectal carcinogenesis and their role in surveillance and early intervention
    G Garcea
    University Department of Oncology, 5th Floor, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, UK
    Eur J Cancer 39:1041-52. 2003
    ..Research should be directed at assessing complementary biomarkers to increase clinical effectiveness in determining management options for patients...
  45. doi request reprint Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases
    C P Neal
    Cancer Biomarkers and Prevention Group, Biocentre, Department of Biochemistry and Oncology, University of Leicester, Leicester, United Kingdom
    Eur J Cancer 45:56-64. 2009
    ....
  46. doi request reprint Combined percutaneous-endoscopic stenting of malignant biliary obstruction: results from 106 consecutive procedures and identification of factors associated with adverse outcome
    C P Neal
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    Surg Endosc 24:423-31. 2010
    ..The objective of this study was to present the short- and long-term results of a large series of combined percutaneous-endoscopic stenting procedures and identify factors associated with adverse outcome...
  47. ncbi request reprint Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinoma
    S L Ong
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE4 5PW, UK
    J Gastrointest Surg 12:1068-73. 2008
    ..Preoperative serology including platelet count, NLR, CA19.9, and CA19.9-bilirubin ratio may be used as additional discriminators of resectability particularly for high-risk patients...
  48. doi request reprint A fuller understanding of pancreatic neuroendocrine tumours combined with aggressive management improves outcome
    S L Ong
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    Pancreatology 9:583-600. 2009
    ..The terms 'islet cell tumours' and 'carcinoids' of the pancreas should be avoided. The aim of this review is to offer an overview of the history and diagnosis of PNETs followed by a discussion of the available treatment options...
  49. ncbi request reprint Molecular prognostic markers in resectable colorectal liver metastases: a systematic review
    C P Neal
    Department of Biochemistry, Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    Eur J Cancer 42:1728-43. 2006
    ..Conventional clinicopathological factors lack the sensitivity to accurately achieve this goal. Consideration of tumour biology and the identification of molecular prognostic markers may allow more accurate risk stratification...
  50. doi request reprint Elevation of carbohydrate antigen 19.9 in benign hepatobiliary conditions and its correlation with serum bilirubin concentration
    S L Ong
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE4 5PW, UK
    Dig Dis Sci 53:3213-7. 2008
    ..9 and serum bilirubin concentration in patients with benign conditions and to determine the frequency of a false-positive increase in CA19.9 in patients being investigated for potential HPB malignancies...
  51. doi request reprint Changing trends in the presentation of colorectal liver metastases in a single hepatobiliary tertiary referral centre over fourteen years
    S C Thomasset
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK Electronic address
    Eur J Surg Oncol 39:1243-7. 2013
    ..The aim of this study was to investigate whether the time to presentation with colorectal liver metastases (CRLM) has changed over time. This information, which is currently unknown, may inform future decisions regarding follow-up...
  52. ncbi request reprint Women presenting with lower abdominal pain: a missed opportunity for chlamydia screening?
    T D R Lloyd
    Department of Surgery, University Hospitals of Leicester, The Leicester General Hospital, UK
    Surgeon 4:15-9. 2006
    ..Therefore, are general surgeons considering this as a diagnosis for lower abdominal pain in women?..
  53. ncbi request reprint Major resection of hepatic colorectal liver metastases in elderly patients - an aggressive approach is justified
    C D Mann
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, University Hospitals of Leicester, Gwendolen Road, Leicester, LE5 4PW, UK
    Eur J Surg Oncol 34:428-32. 2008
    ..The aim of this study was to assess the safety of hepatic resection in patients over 70 years of age by comparing outcomes with those of a younger cohort of patients...
  54. ncbi request reprint Surgical therapy in chronic pancreatitis
    C P Neal
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    Minerva Gastroenterol Dietol 58:377-400. 2012
    ..Furthermore, the expansion of islet cell autotransplantation to a wider range of pancreatic resections has the potential to even further improve the outcomes of surgical treatment for this problematic yet increasingly common disease...
  55. doi request reprint Imaging of indeterminate pancreatic cystic lesions: a systematic review
    M J Jones
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Gwendolen Road, Leicester LE5 4PW, UK
    Pancreatology 13:436-42. 2013
    ..This review was undertaken to determine the present reliability of the characterisation, assessment of malignant potential and diagnosis of pancreatic cystic lesions using available imaging modalities...
  56. doi request reprint Justifying the expense of the cancer Clinical Nurse Specialist
    C A Pollard
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    Eur J Cancer Care (Engl) 19:72-9. 2010
    ..This renders evaluation of the CNS problematic and fraught with difficulties. However, a thorough assessment can still be made using carefully constructed audit looking at each task of the CNS...
  57. pmc Factors predicting significant pathology on ultrasonography in women presenting with non-specific lower abdominal pain
    D K Bilku
    University Hospitals of Leicester NHS Trust, UK
    Ann R Coll Surg Engl 94:155-8. 2012
    ..This study examined parameters that predicted the likelihood of significant findings on ultrasonography. These results could be used to select patients for priority imaging or identify those who could be managed with no ultrasonography...
  58. doi request reprint The inguinal release procedure for groin pain: initial experience in 73 sportsmen/women
    C D Mann
    Department of Surgery, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK
    Br J Sports Med 43:579-83. 2009
    ..To assess the impact of the laparoscopic inguinal release procedure with mesh reinforcement on athletes with groin pain...
  59. ncbi request reprint The introduction of a nutrition clinical nurse specialist results in a reduction in the rate of catheter sepsis
    C D Sutton
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Clin Nutr 24:220-3. 2005
    ..Furthermore, the cost of providing such a service was examined to see if it was offset from the savings obtained from reducing venous access infection...
  60. doi request reprint Patient perception of laparoscopic versus open mesh repair of inguinal hernia, the hard sell
    M Patel
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK
    Hernia 16:411-5. 2012
    ..This study examined the adequacy of the consent process for inguinal hernia repair focusing on the patients' understanding of the relative risks and benefits of laparoscopic versus open repair...
  61. ncbi request reprint Prospective comparison of POSSUM and P-POSSUM with clinical assessment of mortality following emergency surgery
    S A Hobson
    Department of General and Colorectal Surgery, The Leicester General Hospital, Leicester, UK
    Acta Anaesthesiol Scand 51:94-100. 2007
    ....
  62. ncbi request reprint Chemoprevention of pancreatic cancer: a review of the molecular pathways involved, and evidence for the potential for chemoprevention
    H Doucas
    Department of Cancer Studies and Molecular Medicine, Biocentre, Leicester, UK
    Pancreatology 6:429-39. 2006
    ..Pancreatic cancer has a poor prognosis. The use of drugs or natural agents which inhibit or slow down tumour growth therefore has important potential in the development of future therapies...
  63. ncbi request reprint Clinical aspects of natural anti-angiogenic drugs
    C P Neal
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester, UK
    Curr Drug Targets 7:371-83. 2006
    ..This review discusses evidence for the efficacy of this drug class and key issues in the translation of pre-clinical results into the development of efficacious drugs for clinical use...
  64. doi request reprint Enhanced recovery programmes in hepatobiliary and pancreatic surgery: a systematic review
    T C Hall
    University Hospitals of Leicester NHS Trust, UK
    Ann R Coll Surg Engl 94:318-26. 2012
    ..The aim of this systematic review was to appraise the current evidence for ERP in HPB surgery...
  65. doi request reprint Management of acute non-cirrhotic and non-malignant portal vein thrombosis: a systematic review
    T C Hall
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, LE5 4PW, UK
    World J Surg 35:2510-20. 2011
    ..This review examines the impact of such treatment, its outcomes, and the complications resulting from the resultant portal hypertension...
  66. ncbi request reprint Augmenting the ablative effect of liver electrolysis: using two electrodes and the pringle maneuver
    D P Berry
    Hepatobiliary Unit, Leicester General Hospital, Leicester, United Kingdom
    J Invest Surg 17:105-12. 2004
    ..The time delay in achieving tumor ablation via electrolysis can be overcome by using two electrodes combined with the Pringle maneuver to increase the volume of the lesion produced...
  67. doi request reprint Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Biomed Chromatogr 25:660-3. 2011
    ..This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption...
  68. doi request reprint Preoperative systemic inflammation and infectious complications after resection of colorectal liver metastases
    Christopher P Neal
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, United Kingdom
    Arch Surg 146:471-8. 2011
    ..The preoperative systemic inflammatory response, itself a predictor of poor survival, was recently shown to independently predict postoperative infectious complications after primary colorectal cancer resection...
  69. ncbi request reprint Management of benign rectal strictures: a review of present therapeutic procedures
    G Garcea
    Colorectal Department, The Leicester General Hospital, and the dagger Colorectal Department, Glenfield Hospital, Leicester, United Kingdom
    Dis Colon Rectum 46:1451-60. 2003
    ..Case reports detailing a particular treatment option abound in the surgical literature. An overall précis of the different techniques available is presented, with a comparison of their relative strengths and weaknesses...
  70. ncbi request reprint Migration of endoscopic biliary stent and small bowel perforation within an incisional hernia
    F Akimboye
    Department of Surgery, Pilgrim Hospital, Sibsey Road, Boston, Lincs, PE21 9QS, UK
    Surg Laparosc Endosc Percutan Tech 16:39-40. 2006
    ..Patients with comorbid abdominal pathologies, including colonic diverticulae or abdominal herniae, may be at increased risk of perforation from migrated stents...
  71. ncbi request reprint Acute colonic pseudo-obstruction following major orthopaedic surgery
    M G A Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Colorectal Dis 7:496-9. 2005
    ..We aim to assess the incidence of ACPO in patients undergoing elective orthopaedic procedures, and to examine for potential exacerbating factors...
  72. doi request reprint Pancreaticogastric fistula secondary to intraductal papillary mucinous neoplasia: a case report and review of the literature
    T C Hall
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, UK
    Ann R Coll Surg Engl 93:e32-4. 2011
    ..An occasional feature of IPMNs is fistula formation to surrounding organs. This report describes a case of a pancreaticogastric fistula from a main duct IPMN that produced the complete resolution of the patient's symptoms...
  73. ncbi request reprint A snapshot of MDT working and patient mapping in the UK colorectal cancer centres in 2002
    M J Kelly
    Department of Surgery, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
    Colorectal Dis 5:577-81. 2003
    ..To ascertain the position nationally of Colorectal Multi-Disciplinary Team (MDT) implementation as part of the NHS cancer plan. Also to define nationally patterns of 'bottlenecks' in the patient journey from referral to treatment...
  74. doi request reprint The incidence and success of treatment for severe chronic groin pain after open, transabdominal preperitoneal, and totally extraperitoneal hernia repair
    Elizabeth Bright
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK
    World J Surg 34:692-6. 2010
    ..The aim of this study was to compare the frequency of attendance at a chronic pain clinic (CPC) for CGP after open, TAPP or TEP repair...
  75. doi request reprint Pilot study of oral anthocyanins for colorectal cancer chemoprevention
    Sarah Thomasset
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    Cancer Prev Res (Phila) 2:625-33. 2009
    ..Studies of doses containing <0.5 gram bilberry anthocyanins are necessary to adjudge whether they may be appropriate for development as colorectal cancer chemopreventive agents...
  76. ncbi request reprint Laparoscopic repair of direct inguinal hernia: a new technique that reduces the development of postoperative seroma
    V M Reddy
    Department of General Surgery, Leicester Royal Infirmary, Infirmary Square, Leicester, LE1 5WW, UK
    Hernia 11:393-6. 2007
    ..We undertook a study to investigate whether TF inversion in this way reduces the incidence of postoperative seroma...
  77. doi request reprint Incarcerated small bowel within a spontaneous lumbar hernia
    K A T Teo
    Department of Hepatobiliary and Pancreatic Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Hernia 14:539-41. 2010
    ....
  78. doi request reprint Laparoscopic inguinal ligament tenotomy and mesh reinforcement of the anterior abdominal wall: a new approach for the management of chronic groin pain
    David M Lloyd
    Department of Laparoscopic and Upper Gastrointestinal Surgery, The Leicester Royal Infirmary, Leicester
    Surg Laparosc Endosc Percutan Tech 18:363-8. 2008
    ..We describe a new technique, which combines laparoscopic inguinal ligament tenotomy in conjunction with a mesh repair...
  79. doi request reprint Ultrasound changes within the liver after total pancreatectomy and intrahepatic islet cell autotransplantation
    Seok L Ong
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
    Transplantation 85:1773-7. 2008
    ..Awareness of the potential changes in the appearance of the liver on ultrasonography (USS), together with an assessment of liver function, is important in the postoperative surveillance of these patients...
  80. ncbi request reprint Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis
    Christopher D Sutton
    Department of Surgery, University Hospitals of Leicester, Leicester, UK
    Clin Cancer Res 11:6567-73. 2005
    ....
  81. ncbi request reprint Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
    Carmen Hoh
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies, University of Leicester, United Kingdom
    Clin Cancer Res 12:2944-50. 2006
    ..The high silibinin levels achieved in the human colorectal mucosa after consumption of safe silibinin doses support its further exploration as a potential human colorectal cancer chemopreventive agent...
  82. doi request reprint Branch-type intraductal papillary mucinous neoplasms: an update
    G Garcea
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, UK gg43 le ac uk
    Pancreatology 11:336-42. 2011
    ..Selected BT-IPMNs can be managed conservatively by surveillance because of their lower malignant potential. This review aims to update the reader on advances in our knowledge of BT-IPMNs since the consensus guidelines published in 2006...
  83. pmc Sclerosing haemangiomas of the liver: two cases of mistaken identity
    C Lauder
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, 28 Woodville Road, Adelaide, SA 5011, Australia
    HPB Surg 2009:473591. 2009
    ..The typical radiological and histological appearances of these lesions are discussed...
  84. doi request reprint Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis
    Christopher D Mann
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Biocentre, University of Leicester, Leicester, UK
    Eur J Cancer Prev 18:13-25. 2009
    ..Problems regarding validation of biomarkers, agent delivery, side effects and patient selection are barriers that need to be overcome to determine the potential of such agents in clinical practice...
  85. ncbi request reprint Prognostic molecular markers in hepatocellular carcinoma: a systematic review
    Christopher D Mann
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    Eur J Cancer 43:979-92. 2007
    ..Not only might these molecules allow more accurate prediction of prognosis for patients with HCC, but they may also provide targets for potential therapeutic agents...
  86. doi request reprint Inaccuracy of fine-needle biopsy in the diagnosis of solitary fibrous tumour of the liver
    Jane Jingyao Chen
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK
    Asian J Surg 31:195-8. 2008
    ..We report a case of SFT of the liver and highlight the potential inaccuracy of percutaneous biopsy in the diagnosis of large solitary liver tumours...
  87. ncbi request reprint Isolated Roux-loop pancreaticojejunostomy: a series of 61 patients with zero postoperative pancreaticoenteric leaks
    Christopher D Sutton
    Department of Hepatobiliary and Pancreatic Surgery, The Leicester General Hospital, Leicester, England United Kingdom
    J Gastrointest Surg 8:701-5. 2004
    ..There were no PJ anastomotic leaks. This method of pancreatojejunostomy has produced a 0% leak rate in this center...
  88. ncbi request reprint Systematic reaction to electrolytic treatment of pig livers in vivo
    David Berry
    Department of Hepatobiliary Surgery, Leicester General Hospital, Leicester, Leicestershire, England, UK
    ANZ J Surg 74:586-90. 2004
    ..The aim of the present study was to determine if a systemic reaction occurred following electrolytic treatment of pig livers in vivo, by measuring biochemical indices of liver function and cytokines such as IL-8 and TNF-alpha...
  89. ncbi request reprint An unusual case of concurrent insulinoma and nesidioblastosis
    Elizabeth Bright
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
    JOP 9:649-53. 2008
    ..Adult nesidioblastosis is rarely reported. To the best of our knowledge the presence of both insulinoma and nesidioblastosis has not been reported before...
  90. ncbi request reprint Dietary polyphenolic phytochemicals--promising cancer chemopreventive agents in humans? A review of their clinical properties
    Sarah C Thomasset
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Int J Cancer 120:451-8. 2007
    ....
  91. doi request reprint Predictive factors for unanticipated admission following day case surgery
    Giuseppe Garcea
    J Eval Clin Pract 14:175-7. 2008