Research Topics
| Peter GallagherSummaryAffiliation: University of Newcastle Country: UK Publications
| Collaborators
|
Detail Information
Publications
Neuropsychological functioning in health and mood disorder: Modulation by glucocorticoids and their receptorsPeter Gallagher
Institute of Neuroscience, Newcastle University, UK
Psychoneuroendocrinology 34:S196-207. 2009..Finally we examine the neuropsychological effects of drugs that specifically target glucocorticoid receptor function...- Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophreniaPeter Gallagher
School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
J Psychiatr Res 42:1037-41. 2008..This may in part underlie the putative therapeutic effects of such drugs... 
Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorderPeter Gallagher
School of Neurology, Neurobiology and Psychiatry, Newcastle University, UK
Schizophr Res 90:258-65. 2007..These data suggest that afternoon hypercortisolaemia is evident in symptomatic bipolar and schizophrenic patients compared to controls. However, an elevation in DHEA levels may represent a specific endocrine marker in schizophrenia...- Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophreniaPeter Gallagher
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
Biol Psychiatry 57:155-61. 2005..Future studies in schizophrenia should examine patients with demonstrable hypothalmic-pituitary-adrenal axis dysfunction... - Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorderAllan H Young
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
Neuropsychopharmacology 29:1538-45. 2004..These data require replication but provide preliminary evidence that glucocorticoid receptor antagonists may have useful cognitive-enhancing and possibly antidepressant properties in bipolar disorder... - Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophreniaPaul Mackin
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
Aust N Z J Psychiatry 41:321-6. 2007..The aim of the present study was to investigate BDNF levels in patients with bipolar disorder and schizophrenia before and after treatment with the glucocorticoid receptor antagonist mifepristone... - Lithium, arginine vasopressin and the dex/CRH test in mood disordered patientsStuart Watson
The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
Psychoneuroendocrinology 32:464-9. 2007..These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium... - Neurocognitive impairment in euthymic patients with bipolar affective disorderJill M Thompson
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
Br J Psychiatry 186:32-40. 2005..CONCLUSIONS: Neurocognitive impairment persists in patients whose bipolar disorder is in remission. This may represent a trait abnormality and be a marker of underlying neurobiological dysfunction... - Effect of aspirin on hypothalamic-pituitary-adrenal function and on neuropsychological performance in healthy adults: a pilot studyStuart Watson
Institute of Neuroscience, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle University, Newcastle, UK
Psychopharmacology (Berl) 205:151-5. 2009..Aspirin has been shown to attenuate the adrenocorticotropic hormone (ACTH) and cortisol response to physiological challenge suggesting its potential to act as an augmenting agent in depression... - The dex/CRH test--is it better than the DST?Stuart Watson
School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
Psychoneuroendocrinology 31:889-94. 2006..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility... - Neurocognitive function following remission in major depressive disorder: potential objective marker of response?Peter Gallagher
School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
Aust N Z J Psychiatry 41:54-61. 2007..Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated... - Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteersAndrea J Hearn
Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle, UK
Psychopharmacology (Berl) 171:458-64. 2004..This suggests that this model of DA function is not affected by this regimen of corticosteroid administration... - Effects of intrinsic and extrinsic motivation on attention and memoryLucy J Robinson
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
Acta Psychol (Amst) 141:243-9. 2012..The effects of motivational factors should not be overlooked when interpreting absolute levels of performance in neuropsychological processes... - A meta-analysis of cognitive deficits in euthymic patients with bipolar disorderLucy J Robinson
School of Neurology, Neurobiology and Psychiatry (Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
J Affect Disord 93:105-15. 2006..Future investigations should clarify the functional significance of deficits and indicate whether patients will benefit from ameliorative interventions... - Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection methodPeter Gallagher
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
J Psychopharmacol 20:643-9. 2006..2;R(2) 0.04). It is crucial that future studies are aware of these issues and are cognizant of the effects of the method of collection when examining steroid levels in saliva... 
Effects of acute tryptophan depletion on executive function in healthy male volunteersPeter Gallagher
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
BMC Psychiatry 3:10. 2003....- Post-dexamethasone arginine vasopressin levels in patients with severe mood disordersStuart Watson
Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle NE1 4LP, UK
J Psychiatr Res 40:353-9. 2006.... - Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patientsAllan H Young
Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
Am J Psychiatry 159:1237-9. 2002..The authors examined the ratio of cortisol to DHEA in drug-free depressed patients and a matched comparison group... - Metabolic disease and cardiovascular risk in people treated with antipsychotics in the communityPaul Mackin
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
Br J Psychiatry 191:23-9. 2007..Prevalence of physical comorbidity in severe mental illness is a significant public health concern, but comparative data in people with diagnoses other than schizophrenia are sparse... - Effects of acute tryptophan depletion on cognitive function in euthymic bipolar patientsJohn H Hughes
Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle-upon-Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle-upon-Tyne NE1 4LP, UK
Eur Neuropsychopharmacol 12:123-8. 2002..Effects on specific 'executive' functions are less clear, and should be the focus for future research... - Facial expression perception: an objective outcome measure for treatment studies in mood disorders?Helen R Venn
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
Int J Neuropsychopharmacol 9:229-45. 2006..This review suggests that measurement of facial expression perception may prove to be a useful experimental tool for assessing efficacy of antidepressant treatments... - White matter microstructural abnormalities in euthymic bipolar disorderKarine A N Macritchie
Psychobiology Research Group, Institute of Neuroscience, Newcastle University, UK
Br J Psychiatry 196:52-8. 2010..Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder... - Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderlyRichard J Porter
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand, and Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
J Psychopharmacol 21:71-5. 2007..However, they demonstrated reduced reactivity of the HPA axis compared to healthy subjects... - Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorderStuart Watson
The Stanley Research Centre, University of Newcastle upon Tyne, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
Br J Psychiatry 184:496-502. 2004..This measure of HPA axis dysfunction is a potential trait marker in bipolar disorder and thus possibly indicative of the core pathophysiological process in this illness... - Brain-derived neurotrophic factor in patients with remitted depressionPaul Mackin
Am J Psychiatry 162:2399; author reply 2399-400. 2005 - Neuropsychological impairment in major depression: its nature, origin and clinical significanceRichard J Porter
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
Aust N Z J Psychiatry 41:115-28. 2007..Classification based on neuropsychological profile may, in fact, be useful. Further research should examine further the clinical importance of patterns of neuropsychological impairment... - Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patientsRichard J Porter
Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
Psychopharmacology (Berl) 169:77-83. 2003..The greater prolactin response to l-tryptophan infusion in depressed subjects may be the result of an increase in dopamine receptor sensitivity, secondary to reduced dopamine levels... - The effects of sub-chronic administration of hydrocortisone on hormonal and psychological responses to L-tryptophan in normal male volunteersRichard J Porter
Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
Psychopharmacology (Berl) 163:68-75. 2002..More precise, non-neuroendocrine models of 5-HT(1A) receptor function are necessary to clarify this... - The effects of acute tryptophan depletion on neuropsychological functionJohn H Hughes
University of Newcastle upon Tyne, Department of Psychiatry, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
J Psychopharmacol 17:300-9. 2003.... - Corticosteroid-serotonin interactions in depression: a review of the human evidenceRichard J Porter
Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
Psychopharmacology (Berl) 173:1-17. 2004..It has been suggested that corticosteroid-serotonin interactions are central to the pathophysiology of depression. These interactions have been investigated in healthy and depressed humans, primarily using neuroendocrine techniques... - Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjectsRichard J Porter
Dept of Psychological Medicine, P O Box 4345, Christchurch, New Zealand
Am J Geriatr Psychiatry 13:607-15. 2005..These risk factors are frequent in older recovered depressed people. The authors investigated the effects of ATD on mood and cognitive functioning in this group... - Neuropsychological dysfunction, soft neurological signs and social disability in euthymic patients with bipolar disorderUtpal Goswami
Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
Br J Psychiatry 188:366-73. 2006..CONCLUSIONS: Cognitive dysfunction, social dysfunction and soft signs occur in euthymic patients with bipolar disorder and may represent trait deficits... - Phenytoin, an anti-bipolar anticonvulsant: a potential anti-glucocorticoid mechanism?Peter Gallagher
Int J Neuropsychopharmacol 9:627-8. 2006 - Cortisol/DHEA ratios in depressionPeter Gallagher
Neuropsychopharmacology 26:410. 2002