Peter Gallagher

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, UK
    Schizophr Res 90:258-65. 2007
  2. doi request reprint Neuropsychological functioning in health and mood disorder: Modulation by glucocorticoids and their receptors
    Peter Gallagher
    Institute of Neuroscience, Newcastle University, UK
    Psychoneuroendocrinology 34:S196-207. 2009
  3. doi request reprint Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Psychiatr Res 42:1037-41. 2008
  4. ncbi request reprint Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005
  5. ncbi request reprint Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
  6. ncbi request reprint Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:321-6. 2007
  7. ncbi request reprint Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Psychoneuroendocrinology 32:464-9. 2007
  8. ncbi request reprint Neurocognitive impairment in euthymic patients with bipolar affective disorder
    Jill M Thompson
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 186:32-40. 2005
  9. doi request reprint Effect of aspirin on hypothalamic-pituitary-adrenal function and on neuropsychological performance in healthy adults: a pilot study
    Stuart Watson
    Institute of Neuroscience, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle University, Newcastle, UK
    Psychopharmacology (Berl) 205:151-5. 2009
  10. ncbi request reprint The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, UK
    Schizophr Res 90:258-65. 2007
    ..These data suggest that afternoon hypercortisolaemia is evident in symptomatic bipolar and schizophrenic patients compared to controls. However, an elevation in DHEA levels may represent a specific endocrine marker in schizophrenia...
  2. doi request reprint Neuropsychological functioning in health and mood disorder: Modulation by glucocorticoids and their receptors
    Peter Gallagher
    Institute of Neuroscience, Newcastle University, UK
    Psychoneuroendocrinology 34:S196-207. 2009
    ..Finally we examine the neuropsychological effects of drugs that specifically target glucocorticoid receptor function...
  3. doi request reprint Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Psychiatr Res 42:1037-41. 2008
    ..This may in part underlie the putative therapeutic effects of such drugs...
  4. ncbi request reprint Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005
    ..We hypothesized that antiglucocorticoid treatments, particularly glucocorticoid receptor (GR) antagonists, would improve neurocognitive functioning and clinical symptoms in this disorder...
  5. ncbi request reprint Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
    ..These data require replication but provide preliminary evidence that glucocorticoid receptor antagonists may have useful cognitive-enhancing and possibly antidepressant properties in bipolar disorder...
  6. ncbi request reprint Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:321-6. 2007
    ..The aim of the present study was to investigate BDNF levels in patients with bipolar disorder and schizophrenia before and after treatment with the glucocorticoid receptor antagonist mifepristone...
  7. ncbi request reprint Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Psychoneuroendocrinology 32:464-9. 2007
    ..These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium...
  8. ncbi request reprint Neurocognitive impairment in euthymic patients with bipolar affective disorder
    Jill M Thompson
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 186:32-40. 2005
    ..However, methodological issues such as the effect of residual mood symptoms and hypercortisolaemia may confound such studies...
  9. doi request reprint Effect of aspirin on hypothalamic-pituitary-adrenal function and on neuropsychological performance in healthy adults: a pilot study
    Stuart Watson
    Institute of Neuroscience, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle University, Newcastle, UK
    Psychopharmacology (Berl) 205:151-5. 2009
    ..Aspirin has been shown to attenuate the adrenocorticotropic hormone (ACTH) and cortisol response to physiological challenge suggesting its potential to act as an augmenting agent in depression...
  10. ncbi request reprint The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
    ..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility...
  11. doi request reprint Periventricular white matter integrity and cortisol levels in healthy controls and in euthymic patients with bipolar disorder: an exploratory analysis
    Karine A N Macritchie
    Institute of Neuroscience, Academic Psychiatry, Newcastle University, United Kingdom
    J Affect Disord 148:249-55. 2013
    ..In a post-hoc analysis of diffusion tensor data, the relationship between cortisol levels and white matter structural integrity was explored in healthy controls and in euthymic patients with bipolar disorder...
  12. ncbi request reprint Neurocognitive function following remission in major depressive disorder: potential objective marker of response?
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:54-61. 2007
    ..Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated...
  13. ncbi request reprint Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers
    Andrea J Hearn
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle, UK
    Psychopharmacology (Berl) 171:458-64. 2004
    ..Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse...
  14. doi request reprint Effects of intrinsic and extrinsic motivation on attention and memory
    Lucy J Robinson
    Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Acta Psychol (Amst) 141:243-9. 2012
    ..The effects of motivational factors should not be overlooked when interpreting absolute levels of performance in neuropsychological processes...
  15. ncbi request reprint A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder
    Lucy J Robinson
    School of Neurology, Neurobiology and Psychiatry Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
    J Affect Disord 93:105-15. 2006
    ..This review aims to combine data from available studies to identify the profile of neuropsychological deficits in euthymic bipolar patients and quantify their magnitude...
  16. ncbi request reprint Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Psychopharmacol 20:643-9. 2006
    ..2;R(2) 0.04). It is crucial that future studies are aware of these issues and are cognizant of the effects of the method of collection when examining steroid levels in saliva...
  17. pmc Effects of acute tryptophan depletion on executive function in healthy male volunteers
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
    BMC Psychiatry 3:10. 2003
    ....
  18. ncbi request reprint Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle NE1 4LP, UK
    J Psychiatr Res 40:353-9. 2006
    ....
  19. ncbi request reprint Metabolic disease and cardiovascular risk in people treated with antipsychotics in the community
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 191:23-9. 2007
    ..Prevalence of physical comorbidity in severe mental illness is a significant public health concern, but comparative data in people with diagnoses other than schizophrenia are sparse...
  20. ncbi request reprint Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients
    Allan H Young
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
    Am J Psychiatry 159:1237-9. 2002
    ..The authors examined the ratio of cortisol to DHEA in drug-free depressed patients and a matched comparison group...
  21. ncbi request reprint Effects of acute tryptophan depletion on cognitive function in euthymic bipolar patients
    John H Hughes
    Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Eur Neuropsychopharmacol 12:123-8. 2002
    ..Effects on specific 'executive' functions are less clear, and should be the focus for future research...
  22. doi request reprint White matter microstructural abnormalities in euthymic bipolar disorder
    Karine A N Macritchie
    Psychobiology Research Group, Institute of Neuroscience, Newcastle University, UK
    Br J Psychiatry 196:52-8. 2010
    ..Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder...
  23. ncbi request reprint Facial expression perception: an objective outcome measure for treatment studies in mood disorders?
    Helen R Venn
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
    Int J Neuropsychopharmacol 9:229-45. 2006
    ..This review suggests that measurement of facial expression perception may prove to be a useful experimental tool for assessing efficacy of antidepressant treatments...
  24. ncbi request reprint Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderly
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand, and Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Psychopharmacol 21:71-5. 2007
    ..However, they demonstrated reduced reactivity of the HPA axis compared to healthy subjects...
  25. ncbi request reprint Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder
    Stuart Watson
    The Stanley Research Centre, University of Newcastle upon Tyne, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Psychiatry 184:496-502. 2004
    ....
  26. ncbi request reprint Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Psychopharmacology (Berl) 169:77-83. 2003
    ..Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds...
  27. ncbi request reprint Neuropsychological impairment in major depression: its nature, origin and clinical significance
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Aust N Z J Psychiatry 41:115-28. 2007
    ..Classification based on neuropsychological profile may, in fact, be useful. Further research should examine further the clinical importance of patterns of neuropsychological impairment...
  28. ncbi request reprint Brain-derived neurotrophic factor in patients with remitted depression
    Paul Mackin
    Am J Psychiatry 162:2399; author reply 2399-400. 2005
  29. ncbi request reprint The effects of sub-chronic administration of hydrocortisone on hormonal and psychological responses to L-tryptophan in normal male volunteers
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 163:68-75. 2002
    ..This response has been shown to be reduced following acute administration of hydrocortisone, and we hypothesised that sub-chronic administration of hydrocortisone would also blunt it...
  30. ncbi request reprint The effects of acute tryptophan depletion on neuropsychological function
    John H Hughes
    University of Newcastle upon Tyne, Department of Psychiatry, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 17:300-9. 2003
    ....
  31. ncbi request reprint Corticosteroid-serotonin interactions in depression: a review of the human evidence
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 173:1-17. 2004
    ..It has been suggested that corticosteroid-serotonin interactions are central to the pathophysiology of depression. These interactions have been investigated in healthy and depressed humans, primarily using neuroendocrine techniques...
  32. ncbi request reprint Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjects
    Richard J Porter
    Dept of Psychological Medicine, P O Box 4345, Christchurch, New Zealand
    Am J Geriatr Psychiatry 13:607-15. 2005
    ..These risk factors are frequent in older recovered depressed people. The authors investigated the effects of ATD on mood and cognitive functioning in this group...
  33. ncbi request reprint Neuropsychological dysfunction, soft neurological signs and social disability in euthymic patients with bipolar disorder
    Utpal Goswami
    Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
    Br J Psychiatry 188:366-73. 2006
    ..Neurocognitive deficits exist in euthymic patients with bipolar disorder, but relationships between symptoms, psychosocial and neurological factors remain uncertain...
  34. ncbi request reprint Phenytoin, an anti-bipolar anticonvulsant: a potential anti-glucocorticoid mechanism?
    Peter Gallagher
    Int J Neuropsychopharmacol 9:627-8. 2006
  35. ncbi request reprint Cortisol/DHEA ratios in depression
    Peter Gallagher
    Neuropsychopharmacology 26:410. 2002