Alexander Galkin

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi S-nitrosation of mitochondrial complex I depends on its structural conformation
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, London, UK
    J Biol Chem 282:37448-53. 2007
  2. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
  3. ncbi Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica
    Alexander Galkin
    Universitat Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, D 60590 Frankfurt am Main, Germany
    J Biol Chem 280:30129-35. 2005
  4. pmc Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I
    Alexander Galkin
    Molecular Bioenergetics Group, Cluster of Excellence Frankfurt Macromolecular Complexes, Medical School, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, Germany
    J Biol Chem 283:20907-13. 2008
  5. ncbi HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism
    Andrea Eschemann
    Universitat Frankfurt, Fachbereich Medizin, Institut fur Biochemie I, Frankfurt am Main D 60490, Germany
    J Biol Chem 280:3138-42. 2005
  6. ncbi Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes
    Stefan Dröse
    Universitat Frankfurt, Fachbereich Medizin, Molekulare Bioenergetik, Theodor Stern Kai 7, Haus 26, D 60590 Frankfurt am Main, Germany
    Biochim Biophys Acta 1710:87-95. 2005
  7. ncbi The Redox-Bohr group associated with iron-sulfur cluster N2 of complex I
    Klaus Zwicker
    Universitat Frankfurt, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, D 60590 Frankfurt am Main, Germany
    J Biol Chem 281:23013-7. 2006
  8. ncbi The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes
    Alexander Galkin
    Universitat Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Theodor Stern Kai 7, Haus 26, D 60590 Frankfurt am Main, Germany
    Biochim Biophys Acta 1757:1575-81. 2006
  9. ncbi Nitric oxide and hypoxia
    Alexander Galkin
    The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
    Essays Biochem 43:29-42. 2007

Collaborators

Detail Information

Publications9

  1. ncbi S-nitrosation of mitochondrial complex I depends on its structural conformation
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, London, UK
    J Biol Chem 282:37448-53. 2007
    ..The implications of this finding for hypoxic or pathophysiological conditions in vivo are discussed...
  2. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
    ..These observations provide a mechanism to account for the severe cell injury that follows hypoxia and reoxygenation when accompanied by NO generation...
  3. ncbi Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica
    Alexander Galkin
    Universitat Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, D 60590 Frankfurt am Main, Germany
    J Biol Chem 280:30129-35. 2005
    ..From the effect of different ubiquinone derivatives and pH on this side reaction of complex I we concluded that oxygen accepts electrons from FMNH2 or FMN semiquinone either directly or via more hydrophilic ubiquinone derivatives...
  4. pmc Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I
    Alexander Galkin
    Molecular Bioenergetics Group, Cluster of Excellence Frankfurt Macromolecular Complexes, Medical School, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, Germany
    J Biol Chem 283:20907-13. 2008
    ..In fact, mutations in three positions of the loop were previously reported to cause Leigh syndrome with and without dystonia or progressive mitochondrial disease...
  5. ncbi HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism
    Andrea Eschemann
    Universitat Frankfurt, Fachbereich Medizin, Institut fur Biochemie I, Frankfurt am Main D 60490, Germany
    J Biol Chem 280:3138-42. 2005
    ..We found that the kinetics of alternative NADH dehydrogenase follow a ping-pong mechanism. This suggests that NADH and the ubiquinone headgroup interact with the same binding pocket in an alternating fashion...
  6. ncbi Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes
    Stefan Dröse
    Universitat Frankfurt, Fachbereich Medizin, Molekulare Bioenergetik, Theodor Stern Kai 7, Haus 26, D 60590 Frankfurt am Main, Germany
    Biochim Biophys Acta 1710:87-95. 2005
    ..While this study was not specifically designed to demonstrate possible additional sodium translocating properties of complex I, we did not find indications for primary or secondary Na+ translocation by Y. lipolytica complex I...
  7. ncbi The Redox-Bohr group associated with iron-sulfur cluster N2 of complex I
    Klaus Zwicker
    Universitat Frankfurt, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, D 60590 Frankfurt am Main, Germany
    J Biol Chem 281:23013-7. 2006
    ..This finding has significant implications on the discussion about possible proton pumping mechanism for complex I...
  8. ncbi The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes
    Alexander Galkin
    Universitat Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Theodor Stern Kai 7, Haus 26, D 60590 Frankfurt am Main, Germany
    Biochim Biophys Acta 1757:1575-81. 2006
    ..6H(+)/2e . This is the first demonstration that the proton pump of complex I stayed fully functional after purification of the enzyme...
  9. ncbi Nitric oxide and hypoxia
    Alexander Galkin
    The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
    Essays Biochem 43:29-42. 2007
    ..This chapter discusses the physiological and pathophysiological implications of the interactions of NO with the cytochrome c oxidase...