Research Topics
| Ian GaleaSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhageJames Galea
Brain Injury Research Group, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, Manchester, UK
J Neurochem 121:785-92. 2012....
Immune-to-brain signalling: the role of cerebral CD163-positive macrophagesIan Galea
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Neurosci Lett 448:41-6. 2008..Cerebral endothelial cells outnumber CD163-positive macrophages and are arguably better situated to signal circulating inflammatory stimuli to the brain...
An antigen-specific pathway for CD8 T cells across the blood-brain barrierIan Galea
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
J Exp Med 204:2023-30. 2007..This has implications for a variety of diseases in which antigen-specific CD8 T cell traffic into the brain is a beneficial or deleterious feature...
What is immune privilege (not)?Ian Galea
CNS Inflammation Group, School of Biological Sciences, University of Southampton, SO16 7PX, UK
Trends Immunol 28:12-8. 2007..It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment...- Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brainIan Galea
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Glia 49:375-84. 2005.... - Cognitive and behavioural correlates of different domains of psychological adjustment in early-stage multiple sclerosisLaura Dennison
Centre for the Clinical Applications of Health Psychology, University of Southampton, Southampton, UK
J Psychosom Res 69:353-61. 2010..Psychological distress was hypothesised to be most strongly related to more general unhelpful cognitions about the self and emotions... - CD8+ T-cell cross-competition is governed by peptide-MHC class I stabilityIan Galea
Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
Eur J Immunol 42:256-63. 2012..They also provide an insight into factors that facilitate CD8(+) T-cell coexistence, with important implications for vaccine design and delivery... - Blood-derived dendritic cells in an acute brain injuryTracey A Newman
CNS Inflammation Group, University of Southampton, UK
J Neuroimmunol 166:167-72. 2005..We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment... - CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentationBabs O Fabriek
Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
Glia 51:297-305. 2005..Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS... - What is the blood-brain barrier (not)?Ingo Bechmann
Dr Senckenbergische Anatomie, Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60 590 Frankfurt, Germany
Trends Immunol 28:5-11. 2007..We propose that the second step frequently involves perivascular antigen-recognition and the induction of ectoenzymes, for example matrix metalloproteinases (MMPs)...