Ian Galea

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. doi request reprint CNS inflammation other than multiple sclerosis: How likely is diagnosis?
    Duncan Street
    From Clinical Neurosciences D S, I G, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and Wessex Neurological Centre C A H, I G, University Hospital Southampton NHS Foundation Trust, UK
    Neurology 82:1187-9. 2014
  2. doi request reprint A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis
    I Galea
    University of Southampton, Southampton, UK
    Eur J Neurol 20:1107-9. 2013
  3. pmc The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage
    James Galea
    Brain Injury Research Group, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, Manchester, UK
    J Neurochem 121:785-92. 2012
  4. doi request reprint Immune-to-brain signalling: the role of cerebral CD163-positive macrophages
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Neurosci Lett 448:41-6. 2008
  5. pmc An antigen-specific pathway for CD8 T cells across the blood-brain barrier
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    J Exp Med 204:2023-30. 2007
  6. ncbi request reprint What is immune privilege (not)?
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, SO16 7PX, UK
    Trends Immunol 28:12-8. 2007
  7. ncbi request reprint Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Glia 49:375-84. 2005
  8. pmc CD8+ T-cell cross-competition is governed by peptide-MHC class I stability
    Ian Galea
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Immunol 42:256-63. 2012
  9. ncbi request reprint Blood-derived dendritic cells in an acute brain injury
    Tracey A Newman
    CNS Inflammation Group, University of Southampton, UK
    J Neuroimmunol 166:167-72. 2005
  10. doi request reprint Cognitive and behavioural correlates of different domains of psychological adjustment in early-stage multiple sclerosis
    Laura Dennison
    Centre for the Clinical Applications of Health Psychology, University of Southampton, Southampton, UK
    J Psychosom Res 69:353-61. 2010

Detail Information

Publications12

  1. doi request reprint CNS inflammation other than multiple sclerosis: How likely is diagnosis?
    Duncan Street
    From Clinical Neurosciences D S, I G, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and Wessex Neurological Centre C A H, I G, University Hospital Southampton NHS Foundation Trust, UK
    Neurology 82:1187-9. 2014
    ..Undiagnosed CIDOMS patients represented the largest workload of the neurology center. ..
  2. doi request reprint A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis
    I Galea
    University of Southampton, Southampton, UK
    Eur J Neurol 20:1107-9. 2013
    ..It has recently been extended to provide long-term predictions based on the data from a large natural history cohort...
  3. pmc The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage
    James Galea
    Brain Injury Research Group, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, Manchester, UK
    J Neurochem 121:785-92. 2012
    ....
  4. doi request reprint Immune-to-brain signalling: the role of cerebral CD163-positive macrophages
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Neurosci Lett 448:41-6. 2008
    ..Cerebral endothelial cells outnumber CD163-positive macrophages and are arguably better situated to signal circulating inflammatory stimuli to the brain...
  5. pmc An antigen-specific pathway for CD8 T cells across the blood-brain barrier
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    J Exp Med 204:2023-30. 2007
    ..This has implications for a variety of diseases in which antigen-specific CD8 T cell traffic into the brain is a beneficial or deleterious feature...
  6. ncbi request reprint What is immune privilege (not)?
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, SO16 7PX, UK
    Trends Immunol 28:12-8. 2007
    ..It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment...
  7. ncbi request reprint Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Glia 49:375-84. 2005
    ....
  8. pmc CD8+ T-cell cross-competition is governed by peptide-MHC class I stability
    Ian Galea
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Immunol 42:256-63. 2012
    ..They also provide an insight into factors that facilitate CD8(+) T-cell coexistence, with important implications for vaccine design and delivery...
  9. ncbi request reprint Blood-derived dendritic cells in an acute brain injury
    Tracey A Newman
    CNS Inflammation Group, University of Southampton, UK
    J Neuroimmunol 166:167-72. 2005
    ..We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment...
  10. doi request reprint Cognitive and behavioural correlates of different domains of psychological adjustment in early-stage multiple sclerosis
    Laura Dennison
    Centre for the Clinical Applications of Health Psychology, University of Southampton, Southampton, UK
    J Psychosom Res 69:353-61. 2010
    ..Psychological distress was hypothesised to be most strongly related to more general unhelpful cognitions about the self and emotions...
  11. ncbi request reprint CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation
    Babs O Fabriek
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Glia 51:297-305. 2005
    ..Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS...
  12. ncbi request reprint What is the blood-brain barrier (not)?
    Ingo Bechmann
    Dr Senckenbergische Anatomie, Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60 590 Frankfurt, Germany
    Trends Immunol 28:5-11. 2007
    ..We propose that the second step frequently involves perivascular antigen-recognition and the induction of ectoenzymes, for example matrix metalloproteinases (MMPs)...