Rosemary E Gale

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    Claire L Green
    Department of Haematology, UCL Cancer Institute, University College London, 72 Huntley St, London, UK
    J Clin Oncol 28:2739-47. 2010
  2. ncbi request reprint The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, University College London, 98 Chenies Mews, London, UK
    Blood 111:2776-84. 2008
  3. ncbi request reprint No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Blood 106:3658-65. 2005
  4. ncbi request reprint Pathogenic markers in essential thrombocythemia
    Rosemary E Gale
    Department of Haematology, University College London, 98 Chenies Mews, London WC1E 6HX, UK
    Curr Hematol Rep 2:242-7. 2003
  5. ncbi request reprint Long-term serial analysis of X-chromosome inactivation patterns and JAK2 V617F mutant levels in patients with essential thrombocythemia show that minor mutant-positive clones can remain stable for many years
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Blood 109:1241-3. 2007
  6. ncbi request reprint FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
    Adam J Mead
    Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
    Blood 110:1262-70. 2007
  7. doi request reprint The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and C
    Alan K Burnett
    Department of Haematology, Cardiff University School of Medicine, Cardiff, UK
    Blood 115:948-56. 2010
  8. doi request reprint The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    Claire L Green
    Department of Haematology, UCL Cancer Institute, London, United Kingdom
    Blood 118:409-12. 2011
  9. doi request reprint Most acute myeloid leukaemia patients with intermediate mutant FLT3/ITD levels do not have detectable bi-allelic disease, indicating that heterozygous disease alone is associated with an adverse outcome
    Claire Green
    Department of Haematology, Cancer Institute, University College London, London, UK
    Br J Haematol 142:423-6. 2008
  10. doi request reprint Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds
    Bradley N Smith
    Department of Haematology, University College London, London, UK
    Br J Haematol 144:762-70. 2009

Collaborators

Detail Information

Publications35

  1. doi request reprint Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    Claire L Green
    Department of Haematology, UCL Cancer Institute, University College London, 72 Huntley St, London, UK
    J Clin Oncol 28:2739-47. 2010
    ..To determine the clinical relevance of mutations in the CCAAT/enhancer binding protein alpha (CEBPA) gene in acute myeloid leukemia (AML) and to examine factors that might modify prognostic impact...
  2. ncbi request reprint The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, University College London, 98 Chenies Mews, London, UK
    Blood 111:2776-84. 2008
    ..Patients with high FLT3/ITD mutant level (greater than 50%) or FLT3/ITD(+) in the absence of an NPM1 mutation may be good candidates for more experimental therapeutic approaches...
  3. ncbi request reprint No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Blood 106:3658-65. 2005
    ..70, CIs = 0.53-0.92; FLT3/ITD(+) OR = 0.59, CIs = 0.40-0.87; test for interaction, P = .5). These results suggest that at present there is no strong evidence that FLT3 status should influence the decision to proceed to transplantation...
  4. ncbi request reprint Pathogenic markers in essential thrombocythemia
    Rosemary E Gale
    Department of Haematology, University College London, 98 Chenies Mews, London WC1E 6HX, UK
    Curr Hematol Rep 2:242-7. 2003
    ..The contribution of these markers to disease pathogenesis is unknown and prospective studies are needed to evaluate their usefulness for predicting clinical outcome and directing patient therapy...
  5. ncbi request reprint Long-term serial analysis of X-chromosome inactivation patterns and JAK2 V617F mutant levels in patients with essential thrombocythemia show that minor mutant-positive clones can remain stable for many years
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Blood 109:1241-3. 2007
    ..These results suggest that, in many cases of ET, a small stable clone containing a JAK2 mutation can be maintained as a subpopulation for many years...
  6. ncbi request reprint FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
    Adam J Mead
    Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
    Blood 110:1262-70. 2007
    ....
  7. doi request reprint The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and C
    Alan K Burnett
    Department of Haematology, Cardiff University School of Medicine, Cardiff, UK
    Blood 115:948-56. 2010
    ..ATRA has no overall effect on treatment outcomes in this group of patients. The study did not identify any subgroup of patients likely to derive a significant survival benefit from the addition of ATRA to chemotherapy...
  8. doi request reprint The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    Claire L Green
    Department of Haematology, UCL Cancer Institute, London, United Kingdom
    Blood 118:409-12. 2011
    ....
  9. doi request reprint Most acute myeloid leukaemia patients with intermediate mutant FLT3/ITD levels do not have detectable bi-allelic disease, indicating that heterozygous disease alone is associated with an adverse outcome
    Claire Green
    Department of Haematology, Cancer Institute, University College London, London, UK
    Br J Haematol 142:423-6. 2008
    ..Only two had evidence of mutant homozygosity; only one had more homozygous than heterozygous mutant cells. Bi-allelic disease in intermediate mutant level cases is uncommon and heterozygous disease is sufficient for adverse outcome...
  10. doi request reprint Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds
    Bradley N Smith
    Department of Haematology, University College London, London, UK
    Br J Haematol 144:762-70. 2009
    ..The low incidence of HAX1 mutations in our study suggests that the frequency may vary between racial groups but suggests that irrespective of inheritance or racial origin, SCN patients should be screened for HAX1 mutations...
  11. doi request reprint The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    Claire L Green
    Department of Haematology, UCL Cancer Institute, London, UK
    Blood 116:2779-82. 2010
    ..008) and a favorable factor in FLT3/ITD(+) patients (P = .02). These results suggest that metabolic changes induced by an IDH1 mutation may influence chemoresistance in a manner that is context-dependent...
  12. ncbi request reprint Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
    Panagiotis D Kottaridis
    Department of Haematology, University College London, London, United Kingdom
    Blood 100:2393-8. 2002
    ..These results indicate that FLT3 mutations are secondary events in leukemogenesis, are unstable, and thus should be used cautiously for the detection of minimal residual disease...
  13. pmc Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol
    Marc R Mansour
    Department of Haematology, University College London, UCL Cancer Institute, WC1E 6BT, United Kingdom
    J Clin Oncol 27:4352-6. 2009
    ..We sought to evaluate the outcome according to mutation status of patients with adult T-ALL treated on the United Kingdom Acute Lymphoblastic Leukaemia XII (UKALLXII)/Eastern Cooperative Oncology Group (ECOG) E2993 protocol...
  14. ncbi request reprint Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia
    Panagiotis D Kottaridis
    Department of Haematology, Royal Free and University College London Medical School, 98 Chenies Mews, London WC1E 6HX, UK
    Leuk Lymphoma 44:905-13. 2003
    ....
  15. ncbi request reprint Flt3 mutations and leukaemia
    Panagiotis D Kottaridis
    Department of Haematology, Royal Free and University College London Medical School, 98 Chenies Mews, London WC1E 6HX, UK
    Br J Haematol 122:523-38. 2003
  16. doi request reprint GATA2 mutations in sporadic and familial acute myeloid leukaemia patients with CEBPA mutations
    Claire L Green
    Department of Haematology, UCL Cancer Institute, London, UK
    Br J Haematol 161:701-5. 2013
    ..CEBPA and GATA2 mutant levels indicated that both mutations were likely to be early events in leukaemogenesis. GATA2 status did not impact on the favourable outcome of CEBPA-double/FLT3-inernal tandem duplication-negative patients...
  17. ncbi request reprint Neutrophil elastase mutations in congenital neutropenia
    Phil J Ancliff
    Department of Haematology, Geat Ormond Street Hospital, Great Ormond Street, London, UK
    Hematology 8:165-71. 2003
    ..Clinically to date, the discovery of an elastase mutation has been of limited value to individual patients. However, it is hoped that further genotype/phenotype studies may improve assessment of patient prognosis...
  18. ncbi request reprint Long-term follow-up of granulocyte colony-stimulating factor receptor mutations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy
    Phil J Ancliff
    Department of Haematology, University College London, London, UK
    Br J Haematol 120:685-90. 2003
    ..Furthermore, the low frequency of G-CSFR mutations in SCN and the importance of regular screening and close clinical and laboratory follow-up if a mutation is found were demonstrated...
  19. doi request reprint In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm
    Jonathan R Lambert
    Department of Haematology, UCL Cancer Institute, London, United Kingdom
    Blood 114:3018-23. 2009
    ..The presence of a JAK2 mutation in ET patients should not, therefore, be equated with a malignant disease...
  20. doi request reprint Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication
    Adam J Mead
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Br J Haematol 141:454-60. 2008
    ..These results suggest that FLT3/TKD+ and FLT3/WT cases should not be differentiated when considering patients for treatment with FLT3 inhibitors...
  21. ncbi request reprint Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia
    Phil J Ancliff
    Department of Haematology and Immunology, University College London and Great Ormond Street Children s Hospital, London, United Kingdom
    Blood 100:707-9. 2002
    ..This is the first in vivo confirmation of the pathogenic nature of elastase mutations in humans. The normal neutrophil count in the father suggests that the mutant elastase does not have paracrine effects...
  22. pmc Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
    Steven J Howe
    Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, University College London, London, United Kingdom
    J Clin Invest 118:3143-50. 2008
    ....
  23. ncbi request reprint An activating mutation in the transmembrane domain of the granulocyte colony-stimulating factor receptor in patients with acute myeloid leukemia
    Louisa V Forbes
    Department of Haematology, University College London, London WC1E 6HX, UK
    Oncogene 21:5981-9. 2002
    ....
  24. pmc G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction
    Bu Hussain Hayee
    Department of Molecular Medicine, University College London, UK
    Glycobiology 21:914-24. 2011
    ..This aberrant neutrophil glycosylation is predicted to have profound effects on the neutrophil function and merit designation of both syndromes as a new class of congenital disorders of glycosylation...
  25. ncbi request reprint Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia
    Marc R Mansour
    Department of Haematology, University College London, UK
    Clin Cancer Res 13:6964-9. 2007
    ..Whether acquisition of Notch-1 mutations is an early initiating event or a secondary event in the pathogenesis of human T-ALL is unclear...
  26. ncbi request reprint Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia
    Phil J Ancliff
    Department of Haematology, Great Ormond Street Hospital, London, WC1N 3JH, United Kingdom
    Blood 108:2182-9. 2006
    ..Furthermore, these results also suggest a novel cause of myelodysplasia and that male children with myelodysplasia and disturbance of immunologic function should be screened for such mutations...
  27. doi request reprint Does BCR/ABL1 positive acute myeloid leukaemia exist?
    Ellie P Nacheva
    UCL Med School, Royal Free Campus, London, UK
    Br J Haematol 161:541-50. 2013
    ....
  28. doi request reprint The production of JAK2 wild-type platelets is not downregulated in patients with JAK2 V617F mutant-positive essential thrombocythaemia
    Jonathan R Lambert
    Department of Haematology, University College London Cancer Institute, London, UK
    Br J Haematol 145:128-30. 2009
    ..When the absolute number of WT platelets was calculated, it was always within or above the normal platelet range, indicating that there is an aberration in the negative feedback to JAK2 WT platelets in ET...
  29. ncbi request reprint Basic sciences of the myeloproliferative diseases: pathogenic mechanisms of ET and PV
    Rosemary E Gale
    Department of Haematology, University College London, UK
    Int J Hematol 76:305-10. 2002
    ..Investigation of their regulation and biological effects may assist in determining the pathobiology of these elusive disorders...
  30. ncbi request reprint Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7
    Stephen E Langabeer
    Department of Haematology, University College London, London, United Kingdom
    Genes Chromosomes Cancer 34:24-32. 2002
    ..The incidence of acquired mutations in AML patients with acute megakaryoblastic leukemia (FAB type M7) was the same as that reported in other non-M0 patients, with only one mutation detected in 20 (5%) patients studied...
  31. ncbi request reprint RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
    David T Bowen
    Division of Pathology and Neuroscience, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Blood 106:2113-9. 2005
    ..RAS mutation did not influence clinical outcome (overall/disease-free survival, complete remission, relapse rate) either for the entire cohort or within cytogenetic risk groups...
  32. ncbi request reprint No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia
    Domenica Gandini
    Haematologica 89:613-5. 2004
    ..We screened this gene in 46 patients with essential thrombocythemia and identified only a common single nucleotide polymorphism that is unlikely to be of pathological significance...
  33. doi request reprint Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease
    Adam J Mead
    Blood 112:444-5; author reply 445. 2008
  34. doi request reprint Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia
    Manu Gupta
    Cancer Genomics Unit, Medical Oncology Centre, Barts and the London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Genes Chromosomes Cancer 47:729-39. 2008
    ..This study demonstrates aUPD is a frequent and significant finding in AML and pinpoints regions that may contain novel mutational targets...
  35. ncbi request reprint Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia
    Rosemary E Gale
    Department of Haematology, University College London Hospitals, United Kingdom
    Blood 106:3768-76. 2005
    ..Furthermore, in the presence of CEP-701, ATRA-induced differentiation was reduced in FLT3/ITD+ cells. These data carry implications for the use of FLT3 inhibitors as frontline therapy for APL...