D G Gadian

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Developmental amnesia associated with early hypoxic-ischaemic injury
    D G Gadian
    Radiology and Physics Unit, Institute of Child Health, London, UK
    Brain 123:499-507. 2000
  2. ncbi request reprint Diffusion and perfusion magnetic resonance imaging in childhood stroke
    D G Gadian
    Radiology and Physics Unit, Institute of Child Health, University College London Medical School, UK
    J Child Neurol 15:279-83. 2000
  3. ncbi request reprint Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T
    F Calamante
    Royal College of Surgeons, Institute of Child Health, University College London Medical School, United Kingdom
    Magn Reson Med 41:479-85. 1999
  4. ncbi request reprint Differential effects of early hippocampal pathology on episodic and semantic memory
    F Vargha-Khadem
    Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
    Science 277:376-80. 1997
  5. doi request reprint Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus
    M Choy
    Radiology and Physics Unit, UCL Institute of Child Health, University College London, London, UK
    Exp Neurol 225:196-201. 2010
  6. ncbi request reprint The role of the medial temporal lobe in autistic spectrum disorders
    C H Salmond
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, UK
    Eur J Neurosci 22:764-72. 2005
  7. ncbi request reprint MR perfusion imaging in Moyamoya Syndrome: potential implications for clinical evaluation of occlusive cerebrovascular disease
    F Calamante
    Radiology and Physics Units, Institute of Child Health, University College London, UK
    Stroke 32:2810-6. 2001
  8. ncbi request reprint Acute changes in MRI diffusion, perfusion, T(1), and T(2) in a rat model of oligemia produced by partial occlusion of the middle cerebral artery
    M F Lythgoe
    Royal College of Surgeons Unit of Biophysics, Institute of Child Health, University College London, London, UK
    Magn Reson Med 44:706-12. 2000
  9. ncbi request reprint MRI analysis of an inherited speech and language disorder: structural brain abnormalities
    K E Watkins
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, London, UK
    Brain 125:465-78. 2002
  10. ncbi request reprint Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
    F Liegeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, UCL, 4th Floor, 30 Guilford Street, London WC1N 1EH, UK
    Brain 127:1229-36. 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Developmental amnesia associated with early hypoxic-ischaemic injury
    D G Gadian
    Radiology and Physics Unit, Institute of Child Health, London, UK
    Brain 123:499-507. 2000
    ....
  2. ncbi request reprint Diffusion and perfusion magnetic resonance imaging in childhood stroke
    D G Gadian
    Radiology and Physics Unit, Institute of Child Health, University College London Medical School, UK
    J Child Neurol 15:279-83. 2000
    ..These magnetic resonance methods therefore should play an important role in investigation of children with stroke and could be of particular value in studies of at-risk populations of children such as those with sickle cell disease...
  3. ncbi request reprint Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T
    F Calamante
    Royal College of Surgeons, Institute of Child Health, University College London Medical School, United Kingdom
    Magn Reson Med 41:479-85. 1999
    ....
  4. ncbi request reprint Differential effects of early hippocampal pathology on episodic and semantic memory
    F Vargha-Khadem
    Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
    Science 277:376-80. 1997
    ..The findings provide support for the view that the episodic and semantic components of cognitive memory are partly dissociable, with only the episodic component being fully dependent on the hippocampus...
  5. doi request reprint Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus
    M Choy
    Radiology and Physics Unit, UCL Institute of Child Health, University College London, London, UK
    Exp Neurol 225:196-201. 2010
    ..In this study we investigated CBF changes using perfusion MRI during SE in the pilocarpine rat...
  6. ncbi request reprint The role of the medial temporal lobe in autistic spectrum disorders
    C H Salmond
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, UK
    Eur J Neurosci 22:764-72. 2005
    ..The structural imaging data highlight abnormalities in several brain regions previously implicated in ASD, including the medial temporal lobes...
  7. ncbi request reprint MR perfusion imaging in Moyamoya Syndrome: potential implications for clinical evaluation of occlusive cerebrovascular disease
    F Calamante
    Radiology and Physics Units, Institute of Child Health, University College London, UK
    Stroke 32:2810-6. 2001
    ..This study investigates the scope and limitations of perfusion MRI in the clinical evaluation of such patients...
  8. ncbi request reprint Acute changes in MRI diffusion, perfusion, T(1), and T(2) in a rat model of oligemia produced by partial occlusion of the middle cerebral artery
    M F Lythgoe
    Royal College of Surgeons Unit of Biophysics, Institute of Child Health, University College London, London, UK
    Magn Reson Med 44:706-12. 2000
    ..These changes occur before the onset of vasogenic edema. We attribute the acute change in T(2) to increased amounts of deoxyhemoglobin; the mechanisms underlying the change in T(1) require further investigation...
  9. ncbi request reprint MRI analysis of an inherited speech and language disorder: structural brain abnormalities
    K E Watkins
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, London, UK
    Brain 125:465-78. 2002
    ..These results thus provide further evidence of a relationship between the abnormal development of this nucleus and the impairments in oromotor control and articulation reported in the KE family...
  10. ncbi request reprint Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
    F Liegeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, UCL, 4th Floor, 30 Guilford Street, London WC1N 1EH, UK
    Brain 127:1229-36. 2004
    ..In conclusion, it is difficult to infer intra- versus inter-hemispheric language reorganization on the basis of clinical observations in the presence of early pathology to the left hemisphere...
  11. ncbi request reprint Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition
    F Calamante
    Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
    Magn Reson Med 44:466-73. 2000
    ..While the error introduced by the delay can be corrected by using the information of the arrival time of the bolus, the correction for the dispersion is less straightforward and requires a model for the vasculature...
  12. ncbi request reprint Correction for eddy current induced Bo shifts in diffusion-weighted echo-planar imaging
    F Calamante
    Radiology and Physics Unit, Institute of Child Health, University College London Medical School, England
    Magn Reson Med 41:95-102. 1999
    ..The method uses a non-phase-encoded reference scan to correct the phase of each echo in the echo train, and can provide ADC maps that are free of misregistration artifacts, without the need for off-line postprocessing...
  13. ncbi request reprint q-Space imaging of the brain
    M D King
    Royal College of Surgeons Unit Biophysics, Institute of Child Health, London, United Kingdom
    Magn Reson Med 32:707-13. 1994
    ..The displacement profile changes that occur subsequent to an interruption of the forebrain blood supply are consistent with the hyperintensity changes seen in diffusion-weighted imaging...
  14. ncbi request reprint A direct test for lateralization of language activation using fMRI: comparison with invasive assessments in children with epilepsy
    F Liegeois
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 2AP, United Kingdom
    Neuroimage 17:1861-7. 2002
    ..It is suggested that the direct method could be used in future fMRI studies to establish hemispheric lateralization for cognitive functions...
  15. ncbi request reprint Simultaneous noninvasive measurement of CBF and CBV using double-echo FAIR (DEFAIR)
    D L Thomas
    RCS Unit of Biophysics, Institute of Child Health, University College London, London, UK
    Magn Reson Med 45:853-63. 2001
    ..However, the technique can be used repetitively in longer-term time course studies due to its noninvasive and quantitative nature...
  16. ncbi request reprint Distributional assumptions in voxel-based morphometry
    C H Salmond
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London, United Kingdom
    Neuroimage 17:1027-30. 2002
    ..This is despite the fact that conventional group comparisons appear to be robust, remaining valid even with no smoothing. The implications of the results for researchers using voxel-based morphometry are discussed...
  17. ncbi request reprint Magnetic resonance imaging findings within 5 days of status epilepticus in childhood
    Rod C Scott
    Great Ormond Street Hospital for Children NHS Trust, Institute of Child Health, University College London, London, UK
    Brain 125:1951-9. 2002
    ..A systematic longitudinal study is required to characterize the evolution of these abnormalities and to determine whether any patient develops MTS...
  18. pmc Dissociations in cognitive memory: the syndrome of developmental amnesia
    F Vargha-Khadem
    Cognitive Neuroscience Unit, Institute of Child Health, University College London, London WC1N 2PA, UK
    Philos Trans R Soc Lond B Biol Sci 356:1435-40. 2001
    ..These findings are discussed in terms of the locus and extent of neuropathology associated with hypoxic ischaemic damage, the neural basis of 'remembering' versus 'knowing', and a hierarchical model of cognitive memory...
  19. ncbi request reprint Calculation difficulties in children of very low birthweight: a neural correlate
    E B Isaacs
    MRC Childhood Nutrition Research Centre and Radiology and Physics Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Brain 124:1701-7. 2001
    ..To our knowledge, this is the first report establishing a structural neural correlate of calculation ability in a group of neurologically normal individuals...
  20. ncbi request reprint Quantitative magnetic resonance characterization of mesial temporal sclerosis in childhood
    R C Scott
    Neurosciences Unit, Institute of Child Health, University College London, UK
    Neurology 56:1659-65. 2001
    ..To investigate whether quantitative MR techniques can be used to distinguish between mesial temporal sclerosis in patients with a history of prolonged febrile convulsion and in patients without such a history...
  21. pmc Investigating individual differences in brain abnormalities in autism
    C H Salmond
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, Mecklenburgh Square, London WC1N 2AP, UK
    Philos Trans R Soc Lond B Biol Sci 358:405-13. 2003
    ..Surprisingly, there were no significant differences between the patterns of emotional modulation of the startle response in the autistic group compared with the controls...
  22. ncbi request reprint Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical use
    F Calamante
    Radiology and Physics Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children National Health Service Trust, London, UK
    Stroke 33:1146-51. 2002
    ..The purpose of this article is to discuss some of the issues involved and the potential implications for absolute cerebral blood flow measurements in clinical use...
  23. ncbi request reprint MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia
    D A West
    Royal College of Surgeons Unit of Biophysics, Institute of Child Health, University College London, London WC1N 1EH, UK
    Neuroscience 127:333-9. 2004
    ..There is limited information on the role of STAT-1 following stroke. In this study we use MRI measurements of cerebral perfusion and bioenergetic status to target measurements of regional STAT-1 activity...
  24. pmc Neural basis of an inherited speech and language disorder
    F Vargha-Khadem
    Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenbourgh Square, London WC1N 2AP, United Kingdom
    Proc Natl Acad Sci U S A 95:12695-700. 1998
    ....
  25. ncbi request reprint Limitations and requirements of diffusion tensor fiber tracking: an assessment using simulations
    J D Tournier
    Radiology and Physics Unit, Institute of Child Health, University College London, London, UK
    Magn Reson Med 47:701-8. 2002
    ..The results derived from real data show similar trends and thus support the findings of the simulations. These simulations may therefore help to determine which structures can be tracked for a given image quality...
  26. ncbi request reprint Brain morphometry and IQ measurements in preterm children
    E B Isaacs
    MRC Childhood Nutrition Research Centre, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Brain 127:2595-607. 2004
    ..Whether this is true of children born at >30 weeks gestation and what other factors predispose to this decline have yet to be determined...
  27. pmc Developmental amnesia and its relationship to degree of hippocampal atrophy
    E B Isaacs
    Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    Proc Natl Acad Sci U S A 100:13060-3. 2003
    ..Whether this is a sufficient condition for the disorder or whether abnormality in other brain regions is also necessary remains to be determined...
  28. pmc Developmental amnesia: effect of age at injury
    F Vargha-Khadem
    Institute of Child Health and Institute of Neurology, University College London, London WC1N 3JH, UK
    Proc Natl Acad Sci U S A 100:10055-60. 2003
    ..It thus appears that, if this selective memory disorder is a special syndrome related to the early occurrence of hypoxia-induced damage, then the effective age at injury for this syndrome extends from birth to puberty...
  29. ncbi request reprint The precision of anatomical normalization in the medial temporal lobe using spatial basis functions
    C H Salmond
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, 30 Guilford Street, London WCIN 1EM, United Kingdom
    Neuroimage 17:507-12. 2002
    ..quot; The implications of our results, for users of voxel-based morphometry, are discussed...