Klaus Futterer

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2
    Rana Roy
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
    ACS Chem Biol 8:2245-55. 2013
  2. pmc The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module
    Luke J Alderwick
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    PLoS Pathog 7:e1001299. 2011
  3. ncbi request reprint "Wunder" F-BAR domains: going from pits to vesicles
    Klaus Futterer
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Cell 129:655-7. 2007
  4. doi request reprint Differential specific radiation damage in the Cu II-bound and Pd II-bound forms of an alpha-helical foldamer: a case study of crystallographic phasing by RIP and SAD
    Klaus Futterer
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England
    Acta Crystallogr D Biol Crystallogr 64:264-72. 2008
  5. pmc Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+
    Alistair K Brown
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Struct Biol 7:55. 2007
  6. pmc Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
    Sarah M Batt
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 109:11354-9. 2012
  7. ncbi request reprint Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c)
    Rosalind A Wilson
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, England
    Acta Crystallogr D Biol Crystallogr 59:2303-5. 2003
  8. doi request reprint Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis
    Veeraraghavan Usha
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England
    Acta Crystallogr D Biol Crystallogr 65:383-7. 2009
  9. pmc Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
    Luke J Alderwick
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 103:2558-63. 2006
  10. ncbi request reprint Regulation of cell wall synthesis and growth
    Lynn G Dover
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Curr Mol Med 7:247-76. 2007

Collaborators

Detail Information

Publications22

  1. pmc Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2
    Rana Roy
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
    ACS Chem Biol 8:2245-55. 2013
    ..Thus, complex formation may act as part of a regulatory mechanism of the GlgE pathway, which overall must avoid accumulation of toxic pathway intermediates, such as maltose-1-phosphate, and optimize the use of scarce nutrients. ..
  2. pmc The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module
    Luke J Alderwick
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    PLoS Pathog 7:e1001299. 2011
    ..This work provides the first step towards unravelling the structure and function of a GT-C-type glycosyltransferase that is essential in M. tuberculosis...
  3. ncbi request reprint "Wunder" F-BAR domains: going from pits to vesicles
    Klaus Futterer
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Cell 129:655-7. 2007
    ..In this issue, Shimada et al. (2007) reveal the mode of action of the F-BAR domain, which deepens the initial membrane pit that forms during clathrin-mediated endocytosis...
  4. doi request reprint Differential specific radiation damage in the Cu II-bound and Pd II-bound forms of an alpha-helical foldamer: a case study of crystallographic phasing by RIP and SAD
    Klaus Futterer
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England
    Acta Crystallogr D Biol Crystallogr 64:264-72. 2008
    ....
  5. pmc Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+
    Alistair K Brown
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Struct Biol 7:55. 2007
    ..Human IMPase, the putative target of lithium therapy, has been studied extensively, but the function of four IMPase-like genes in M. tuberculosis is unclear...
  6. pmc Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
    Sarah M Batt
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 109:11354-9. 2012
    ..These results mark a significant step forward in the characterization of a key TB drug target...
  7. ncbi request reprint Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c)
    Rosalind A Wilson
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, England
    Acta Crystallogr D Biol Crystallogr 59:2303-5. 2003
    ..9, b = 108.9, c = 109.9 A). Diffraction data complete to 1.7 A resolution were recorded at 100 K at the synchrotron...
  8. doi request reprint Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis
    Veeraraghavan Usha
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England
    Acta Crystallogr D Biol Crystallogr 65:383-7. 2009
    ..Despite a highly conserved active-site architecture, the model indicates that stabilization of the DAP backbone occurs in MtDapF through a tyrosine residue that is specific to mycobacterial DAP epimerases...
  9. pmc Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
    Luke J Alderwick
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 103:2558-63. 2006
    ....
  10. ncbi request reprint Regulation of cell wall synthesis and growth
    Lynn G Dover
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Curr Mol Med 7:247-76. 2007
    ....
  11. doi request reprint Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53
    Man Yeung Heung
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur J Cell Biol 87:699-708. 2008
    ..Furthermore, the tyrosine phosphorylation status does not appear to affect the cell morphology and production of filopod-like structures upon expression of IRSp53...
  12. ncbi request reprint The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases
    Rosalind A Wilson
    School of Biosciences, The University of Birmingham, Edgabston, Birmingham B15 2TT, UK
    J Mol Biol 335:519-30. 2004
    ....
  13. pmc Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT)
    Hemza Ghadbane
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:831-5. 2007
    ..0 A resolution by multi-wavelength anomalous dispersion. Phasing was facilitated by Ni2+ ions bound to the 20-residue N-terminal affinity tag, which packed between the two independent copies of mtFabD...
  14. pmc Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'
    Sarah M Batt
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 285:37741-52. 2010
    ....
  15. pmc Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases
    Alistair K Brown
    School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    PLoS ONE 4:e6306. 2009
    ..Herein, we have examined the susceptibility of mycobacteria to the natural product platensimycin...
  16. pmc Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase
    Guoyu Meng
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    BMC Struct Biol 8:16. 2008
    ..Still, the structural determinants of the fructosyl transfer reaction thus far have been only partially defined...
  17. pmc Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
    Thomas H Millard
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, UK
    EMBO J 24:240-50. 2005
    ..This study promotes an expanded view of IRSp53 as an actin regulator that integrates scaffolding and effector functions...
  18. ncbi request reprint Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance
    Lynn G Dover
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Mol Biol 340:1095-105. 2004
    ....
  19. doi request reprint Bacterial flagellar diversity and evolution: seek simplicity and distrust it?
    Lori A S Snyder
    University of Birmingham, Birmingham, B15 2TT, UK
    Trends Microbiol 17:1-5. 2009
    ..However, a fresh examination of the phylogenetic distribution of flagellar genes warns against a simplistic model of early flagellar evolution...
  20. ncbi request reprint Structural framework of fructosyl transfer in Bacillus subtilis levansucrase
    Guoyu Meng
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Nat Struct Biol 10:935-41. 2003
    ..1 A, strongly suggest that three conserved acidic side chains in the central pocket are critical for catalysis, and presumably function as nucleophile (Asp86) and general acid (Glu342), or stabilize the transition state (Asp247)...
  21. pmc Replacement of the essential Dictyostelium Arp2 gene by its Entamoeba homologue using parasexual genetics
    Mehreen Zaki
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Genet 8:28. 2007
    ..However, little is known about the physiological roles, interactions and regulation of the proteins of the Entamoeba cytoskeleton...
  22. ncbi request reprint Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators
    Mark J Pallen
    Division of Immunity and Infection, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    FEMS Microbiol Lett 223:53-60. 2003
    ....