Genomes and Genes
Affiliation: University of Oxford
- Identity-by-descent approach to gene localisation in eight individuals affected by keratoconus from north-west Tasmania, AustraliaJan Fullerton
Gene Discovery Laboratory, The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne 3052, Australia
Hum Genet 110:462-70. 2002..Identification of a conserved minimal chromosomal haplotype around D20S119 in related Tasmanian patients suggests association with this locus, however association with the nearby candidate gene MMP-9 has been excluded...
- New approaches to the genetic analysis of neuroticism and anxietyJan Fullerton
The Wellcome Trust Centre for Human Genetics, The University of Oxford, Roosevelt Drive, OX37BN, UK
Behav Genet 36:147-61. 2006..As new genetic techniques and statistical approaches arise, we are getting closer to identifying those long sought after QTNs...
- Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in miceBinnaz Yalcin
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 36:1197-202. 2004..We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait...
- The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticismSaffron A G Willis-Owen
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
Biol Psychiatry 58:738-42. 2005..The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness...
- Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticismJan Fullerton
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Am J Hum Genet 72:879-90. 2003..One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous...
- Fine scale mapping of a genetic locus for conditioned fearChristopher J Talbot
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Mamm Genome 14:223-30. 2003..The region containing a gene or genes that influence variation in conditioned fear is approximately 1 megabase in size and contains only one gene of known function, a pre-B cell leukaemia factor...