Christopher H Fry

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders
    Christopher H Fry
    Institute of Urology and Nephrology, University College London, London, United Kingdom
    Urology 59:3-12. 2002
  2. ncbi request reprint Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity?
    Christopher H Fry
    Institute of Urology and Nephrology, London, United Kingdom
    Urology 63:3-10. 2004
  3. ncbi request reprint Experimental models to study the physiology, pathophysiology, and pharmacology of the lower urinary tract
    C H Fry
    The Institute of Urology, 48 Riding House St, London W1W 7EY, UK
    J Pharmacol Toxicol Methods 49:201-10. 2004
  4. ncbi request reprint T-type Ca2+ channels in non-vascular smooth muscles
    C H Fry
    Institute of Urology, University College London, London W1W 7EY, UK
    Cell Calcium 40:231-9. 2006
  5. ncbi request reprint Control of bladder function by peripheral nerves: avenues for novel drug targets
    Christopher H Fry
    Institute of Urology and Nephrology, London, United Kingdom
    Urology 63:24-31. 2004
  6. ncbi request reprint The function of suburothelial myofibroblasts in the bladder
    C H Fry
    Institute of Urology, University College London, London, United Kingdom
    Neurourol Urodyn 26:914-9. 2007
  7. doi request reprint Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms
    Alexander Roosen
    Department of Surgery, University College London, UK
    Cell Calcium 45:11-7. 2009
  8. ncbi request reprint Relationship between connexin expression and gap-junction resistivity in human atrial myocardium
    Paramdeep S Dhillon
    Myocardial Function Section, Imperial College London and Imperial College NHS Trust, London, UK
    Circ Arrhythm Electrophysiol 7:321-9. 2014
  9. ncbi request reprint Radiotelemetered urodynamics of obstructed ovine fetal bladders: correlations with ex vivo cystometry and renal histopathology
    Marie Klaire Farrugia
    Institute of Child Health, University College London, London, UK
    BJU Int 99:1517-22. 2007
  10. ncbi request reprint The influence of changes in extracellular and intracellular sodium concentration on detrusor contractility
    Dler Besarani
    Institute of Urology, University College London, London, UK
    BJU Int 97:1083-6. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders
    Christopher H Fry
    Institute of Urology and Nephrology, University College London, London, United Kingdom
    Urology 59:3-12. 2002
    ..Nevertheless, the identification of specific cellular lesions in bladder dysfunction presents a novel approach to identification of drug targets and potential treatment modalities...
  2. ncbi request reprint Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity?
    Christopher H Fry
    Institute of Urology and Nephrology, London, United Kingdom
    Urology 63:3-10. 2004
    ..The data do imply that myogenic defects can contribute to abnormal bladder function and, thus, suggest several new targeted drug models that should be explored...
  3. ncbi request reprint Experimental models to study the physiology, pathophysiology, and pharmacology of the lower urinary tract
    C H Fry
    The Institute of Urology, 48 Riding House St, London W1W 7EY, UK
    J Pharmacol Toxicol Methods 49:201-10. 2004
    ..These include models of bladder outflow obstruction, bladder ischaemia, bladder denervation, and congenital abnormalities and their influence on foetal development of the lower urinary tract...
  4. ncbi request reprint T-type Ca2+ channels in non-vascular smooth muscles
    C H Fry
    Institute of Urology, University College London, London W1W 7EY, UK
    Cell Calcium 40:231-9. 2006
    ....
  5. ncbi request reprint Control of bladder function by peripheral nerves: avenues for novel drug targets
    Christopher H Fry
    Institute of Urology and Nephrology, London, United Kingdom
    Urology 63:24-31. 2004
    ..In summary, the cellular and molecular regulation of bladder fullness sensation and efferent transmitter release are becoming better understood and represent potential drug targets for the management of detrusor overactivity...
  6. ncbi request reprint The function of suburothelial myofibroblasts in the bladder
    C H Fry
    Institute of Urology, University College London, London, United Kingdom
    Neurourol Urodyn 26:914-9. 2007
    ..A function for suburothelial myofibroblasts is proposed whereby they act as an amplification stage in the sensory response to bladder-wall stretch, as occurs during bladder filling...
  7. doi request reprint Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms
    Alexander Roosen
    Department of Surgery, University College London, UK
    Cell Calcium 45:11-7. 2009
    ..Ca2+-sensitisation of contractile proteins is likely to play a key role in this synergism, particularly for adrenergic activation...
  8. ncbi request reprint Relationship between connexin expression and gap-junction resistivity in human atrial myocardium
    Paramdeep S Dhillon
    Myocardial Function Section, Imperial College London and Imperial College NHS Trust, London, UK
    Circ Arrhythm Electrophysiol 7:321-9. 2014
    ....
  9. ncbi request reprint Radiotelemetered urodynamics of obstructed ovine fetal bladders: correlations with ex vivo cystometry and renal histopathology
    Marie Klaire Farrugia
    Institute of Child Health, University College London, London, UK
    BJU Int 99:1517-22. 2007
    ....
  10. ncbi request reprint The influence of changes in extracellular and intracellular sodium concentration on detrusor contractility
    Dler Besarani
    Institute of Urology, University College London, London, UK
    BJU Int 97:1083-6. 2006
    ..To determine the role of Na+-Ca2+ exchange in the regulation of isolated detrusor smooth muscle contractility...
  11. pmc Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder
    Nikesh Thiruchelvam
    Nephro Urology Unit, Institute of Child Health, University College London, London, United Kingdom
    Am J Pathol 162:1271-82. 2003
    ..Conversely, in the lamina propria, an imbalance between death and proliferation leads to a relative depletion of cells...
  12. ncbi request reprint The association between T-type Ca2+ current and outward current in isolated human detrusor cells from stable and overactive bladders
    Gui Ping Sui
    The Institute of Urology, University College London, UK
    BJU Int 99:436-41. 2007
    ..To determine if bladder overactivity in humans is associated with an altered activity of Ca(2+) channels in detrusor smooth muscle and the consequent activation of other ion channels...
  13. ncbi request reprint Synergistic effects in neuromuscular activation and calcium-sensitization in the bladder trigone
    Alexander Roosen
    Department of Surgery, University College London, London, UK
    BJU Int 101:610-4. 2008
    ....
  14. pmc The role of the L-type Ca(2+) channel in refilling functional intracellular Ca(2+) stores in guinea-pig detrusor smooth muscle
    C Wu
    Department of Medicine, University College London, 48 Riding House Street, London W1W 7EY, UK
    J Physiol 538:357-69. 2002
    ..Ca(2+) influx is regulated by a feedback mechanism whereby a fall of [Ca(2+)](i) reduces the activity of Ca(2+)-activated K(+) channels, causing cell depolarisation and an enhancement of L-type Ca(2+) channel conductance...
  15. ncbi request reprint Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts
    Gui Ping Sui
    Institute of Urology, University College London, London, UK
    BJU Int 97:1327-31. 2006
    ....
  16. doi request reprint Characteristics of spontaneous activity in the bladder trigone
    Alexander Roosen
    Department of Surgery, University College London, London, United Kingdom
    Eur Urol 56:346-53. 2009
    ..The trigone generates spontaneous activity as well as responding to neuromuscular transmitters, but the relationship between these phenomena are unclear...
  17. ncbi request reprint Electromyographic detection of purinergic activity in Guinea pig detrusor smooth muscle
    A Ballaro
    Institute of Urology and Nephrology, London, UK
    J Urol 169:377-81. 2003
    ..We recorded nerve mediated extracellular electrical activity from guinea pig detrusor smooth muscle strips using suction electrodes and determined the electrophysiological origins of this signal and its relationship to contractile activity...
  18. ncbi request reprint Role of the T-type Ca2+ current on the contractile performance of guinea pig detrusor smooth muscle
    K Y Chow
    The Institute of Urology and Nephrology, University College London, United Kingdom
    Neurourol Urodyn 22:77-82. 2003
    ..The importance of the T-type Ca(2+) current in determining detrusor contractile function was investigated by using guinea pig muscle in vitro...
  19. doi request reprint Relationship between gap-junctional conductance and conduction velocity in mammalian myocardium
    Paramdeep S Dhillon
    Imperial Centre for Translational and Experimental Medicine, Myocardial Function Section, Imperial College London and Imperial College NHS Trust, London, United Kingdom
    Circ Arrhythm Electrophysiol 6:1208-14. 2013
    ..We challenged this prevailing concept and addressed the hypothesis that there is a continuous relationship between R(j) and CV, each independently measured in human and guinea-pig myocardium...
  20. ncbi request reprint Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment
    Alexander Roosen
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, UK
    Eur Urol 55:1440-8. 2009
    ..An increasing body of evidence suggests a possible role of suburothelial myofibroblasts (MFs) in bladder mechanosensation and in the pathophysiology of detrusor overactivity (DO)...
  21. ncbi request reprint The role of angiotensin receptor-1 blockade on electromechanical changes induced by left ventricular hypertrophy and its regression
    Rosaire P Gray
    Department of Medicine, University College London, 48 Riding House St, London W1P 7PN, UK
    Cardiovasc Res 73:539-48. 2007
    ....
  22. ncbi request reprint Characterization of the control of intracellular [Ca2+] and the contractile phenotype of cultured human detrusor smooth muscle cells
    D N Wood
    Institute of Urology and Nephrology, and Tissue Repair and Engineering Centre, London, United Kingdom
    J Urol 172:753-7. 2004
    ..We measured the functional properties of cultured human detrusor myocytes with respect to their ability to regulate their intracellular [Ca2+] and generate force in collagen matrices...
  23. ncbi request reprint Intracellular Ca2+ regulation in a human prostate stromal cell culture
    C Wu
    Institute of Urology, University College London, London, United Kingdom
    Neurourol Urodyn 24:81-8. 2005
    ..This study characterized intracellular Ca2+ ([Ca2+]i) regulation in a cultured cell line in comparison to freshly isolated cells, as a background to understanding contractile regulation and cellular proliferation in this tissue...
  24. ncbi request reprint Ca2+ regulation in detrusor smooth muscle from ovine fetal bladder after in utero bladder outflow obstruction
    C Wu
    Department of Medicine, University College London, London, UK
    J Urol 177:776-80. 2007
    ..We characterized intracellular Ca(2+) regulation in fetal bladders following outflow obstruction by examining the Ca(2+) response to agonists in smooth muscle cells...
  25. ncbi request reprint Ca2+ regulation in detrusor smooth muscle from developing fetal sheep bladders
    C Wu
    Department of Medicine, University College London, UK
    Cell Calcium 39:367-74. 2006
    ..Whilst most of Ca(2+) regulators are substantially developed and occur at an early fetal age, a further functional maturation for cholinergic sensitivity and purinergic efficacy continues throughout to adulthood...
  26. ncbi request reprint Neurotransmission and viscoelasticity in the ovine fetal bladder after in utero bladder outflow obstruction
    N Thiruchelvam
    Nephro Urology Unit, Institute of Child Health, London WC1N 1EH, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 284:R1296-305. 2003
    ..In addition to denervation, hypocontractility may result from a reduction in the elastic modulus that may prevent any extramuscular components from sustaining force produced by detrusor smooth muscle...
  27. ncbi request reprint Bladder electrical activity: the elusive electromyogram
    A Ballaro
    The Institute of Urology and Nephrology, London, UK
    BJU Int 92:78-84. 2003
  28. ncbi request reprint Ca2+ currents in smooth muscle cells isolated from human prostate
    G P Sui
    Institute of Urology and Nephrology, 48 Riding House St, London, United Kingdom
    Prostate 59:275-81. 2004
    ..The objective of the investigation was to demonstrate the presence of voltage-dependent Ca2+ current in human prostate smooth muscle cells and to determine their biophysical characteristics...
  29. ncbi request reprint Na(+)/Ca(2+) exchange and its role in intracellular Ca(2+) regulation in guinea pig detrusor smooth muscle
    C Wu
    Department of Medicine, University College London, London W1P 7PN, United Kingdom
    Am J Physiol Cell Physiol 280:C1090-6. 2001
    ..However, a small rise of intracellular Na(+) concentration would be sufficient to generate significant net Ca(2+) influx...
  30. ncbi request reprint The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder
    R A Harvey
    Institute of Urology, London and Discovery Research Pfizer, Sandwich, United Kingdom
    J Urol 168:1235-9. 2002
    ..The different ATP potencies were compared with the ecto-adenosine triphosphatase (ATPase) of these samples...
  31. ncbi request reprint Electrical characteristics of suburothelial cells isolated from the human bladder
    G P Sui
    Institute of Urology and Nephrology, London, United Kingdom
    J Urol 171:938-43. 2004
    ..We measured the membrane electrical characteristics as well as the response to adenosine triphosphate of cells isolated from the suburothelial layer of the bladder...
  32. ncbi request reprint Inward calcium currents in cultured and freshly isolated detrusor muscle cells: evidence of a T-type calcium current
    G P Sui
    Institute of Urology and Nephrology, London, United Kingdom
    J Urol 165:621-6. 2001
    ..CONCLUSIONS: In freshly isolated guinea pig cells T and L-type Ca2+ current is present but T-type current is absent in confluent cultures...
  33. ncbi request reprint Clinical and experimental aspects of Adreno-muscarinic synergy in the bladder base and prostate
    Alexander Roosen
    Institute of Urology, University College London, London, UK
    Neurourol Urodyn 28:938-43. 2009
    ....
  34. ncbi request reprint Electrophysiological effects accompanying regression of left ventricular hypertrophy
    Alfred N Botchway
    Academic Cardiology Unit, Division of the National Heart and Lung Institute, Imperial College School of Medicine at St Mary s, W2 1NY, London, UK
    Cardiovasc Res 60:510-7. 2003
    ..The aim of this study was to investigate changes following regression of left ventricular hypertrophy (LVH)...
  35. doi request reprint Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders
    G Sui
    Institute of Urology, University College London, UK
    Cell Calcium 45:456-64. 2009
    ..Such cellular activity underlies spontaneous muscle contraction and defective Ca(2+) activation contributes to up-regulated contractile activity in overactive bladders...
  36. ncbi request reprint A new approach to recording the electromyographic activity of detrusor smooth muscle
    A Ballaro
    Institute of Urology and Nephrology, London, United Kingdom
    J Urol 166:1957-61. 2001
    ..We hope that development of this technique may enable its application to the in situ human bladder. However, to our knowledge whether electromyographic activity may be recorded from human detrusor remains to be determined...
  37. ncbi request reprint Electrophysiological properties of the bladder
    C H Fry
    Institute of Urology and Nephrology, University College, London, UK
    Int Urogynecol J Pelvic Floor Dysfunct 9:291-8. 1998
    ..In addition, the precise role that electrophysiological phenomena play in the regulation of the contractile state of the smooth muscle cells, as well as the generation of bladder electromyograms, is discussed...
  38. ncbi request reprint The electrophysiological properties of cultured and freshly isolated detrusor smooth muscle cells
    G P Sui
    Institute of Urology and Nephrology, London, United Kingdom
    J Urol 165:627-32. 2001
    ..CONCLUSIONS: Cell culture qualitatively preserves the electrophysiological properties of detrusor smooth muscle cells, although there is some decrease in channel density...
  39. pmc Purinergic regulation of guinea pig suburothelial myofibroblasts
    C Wu
    Department of Medicine, University College London, UK
    J Physiol 559:231-43. 2004
    ..We propose that these cells may play a regulatory step in the sensation of bladder fullness by responding to ATP. The precise mechanism whereby they couple urothelial ATP release to afferent excitation is the next step to be elucidated...
  40. ncbi request reprint Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation
    Peter Nyirady
    Nephro Urology Unit, Institute of Child Health, University College, London, United Kingdom
    J Urol 168:1615-20. 2002
    ..We hypothesized that fetal bladder outflow obstruction perturbs detrusor contractility and innervation and bladder storage volume-pressure relationships...
  41. ncbi request reprint Variation in urine composition in the human urinary tract: evidence of urothelial function in situ?
    Declan J Cahill
    Deparment of Urology, Guy s and St Thomas Hospital and Institute of Urology and Nephrology, University College London, United Kingdom
    J Urol 169:871-4. 2003
    ..An increased awareness of the concept that the urothelium has a significant transport function led us to question whether urine composition changes as it passes along the human lower urinary tract...
  42. ncbi request reprint The action of isoprenaline on the electrophysiological properties of hypertrophied left ventricular myocytes
    W Wallis
    The Institute of Urology and Nephrology, University College London, UK
    Arch Physiol Biochem 109:117-26. 2001
    ..A simple diffusion model for oxygen is constructed to demonstrate the possibility of cellular hypoxia in hypertrophied myocytes...
  43. ncbi request reprint Reduced anisotropy of action potential conduction in left ventricular hypertrophy
    P A Carey
    Division of the National Heart and Lung Institute, Imperial College School of Medicine, St. Mary's Hospital, London, United Kingdom
    J Cardiovasc Electrophysiol 12:830-5. 2001
    ..There was no influence of hypertrophy. CONCLUSION: The decrease of LCV and reduction of the anisotropic conduction ratio suggest remodeling of the tissue in LVH. The consequences for the generation of arrhythmias are discussed...
  44. ncbi request reprint A description of Ca2+ channels in human detrusor smooth muscle
    G P Sui
    The Institute of Urology and Nephrology, University College London, London, UK
    BJU Int 92:476-82. 2003
    ..To characterize the Ca2+ channels in human detrusor smooth muscle and to investigate their contribution to spontaneous electrical activity...
  45. ncbi request reprint Gap junctions and connexin expression in human suburothelial interstitial cells
    G P Sui
    Institute of Urology, London, UK
    BJU Int 90:118-29. 2002
    ..To determine whether suburothelial interstitial cells of the human bladder express gap junctions, and if so, to establish their extent and composition, using immunocytochemistry, confocal microscopy and electron microscopy...
  46. ncbi request reprint Intracellular sodium and contractile function in hypertrophied human and guinea-pig myocardium
    R P Gray
    Institute of Urology and Nephrology, University College London, 48 Riding House Street, London W1W 7EY, UK
    Pflugers Arch 442:117-23. 2001
    ..The recovery of a raised [Na+]i after an acute acidosis was slowed in hypertrophied myocardium and stabilised at a higher level, suggesting that the membrane mechanisms that regulate [Na+]i are reset...
  47. pmc Modulation of bladder myofibroblast activity: implications for bladder function
    Gui Ping Sui
    Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
    Am J Physiol Renal Physiol 295:F688-97. 2008
    ..The action of glivec and its selective suppression of spontaneous activity in SCT rats identifies a possible pathway to attenuate bladder overactivity...
  48. ncbi request reprint Changes to the contractile function of ureter smooth muscle after partial infravesical obstruction in fetal sheep
    Peter Nyirady
    Department of Urology, Semmelweiss University, Budapest, Hungary
    BJU Int 102:490-4. 2008
    ..To measure spontaneous contractile activity, and the responses to agonists using in vitro preparations of sheep ureter after a period of bladder outlet obstruction (BOO) initiated at mid-gestation...
  49. ncbi request reprint Contractile properties of the developing fetal sheep bladder
    Peter Nyirady
    Semmelweis University Department of Urology, Budapest, Hungary
    Neurourol Urodyn 24:276-81. 2005
    ..To characterise the developmental changes to the normal bladder by examining the in vitro contractile properties of the fetal sheep detrusor smooth muscle bladder at different gestational ages...
  50. ncbi request reprint Structural characterization of myofibroblasts in the bladder
    Marcus J Drake
    School of Surgical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    BJU Int 97:29-32. 2006
  51. ncbi request reprint Alterations in cardiac connexin expression in cardiomyopathies
    Nicholas J Severs
    National Heart and Lung Institute, Imperial College London, UK
    Adv Cardiol 42:228-42. 2006
    ....