Peter Simon Friedmann
Affiliation: University of Southampton
- Contact hypersensitivity: quantitative aspects, susceptibility and risk factorsPeter S Friedmann
Dermatopharmacology Unit, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, School of Medicine, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, UK
EXS 104:51-71. 2014..The underlying mechanisms must be elucidated before it will be possible to make reliable predictions of whether a given individual will develop allergic sensitisation by a given chemical. ..
- Quantifying human susceptibility to contact sensitization; risk assessments now and in the futurePeter S Friedmann
Dermatopharmacology Unit, Southampton University Hospital NHS Trust, Southampton, UK
Contact Dermatitis 63:237-47. 2010..We are not yet in a position to predict sensitization by chemicals from a theoretical starting point...
- Patch testing in drug allergyPeter S Friedmann
Dermatopharmacology Unit, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, UK
Curr Opin Allergy Clin Immunol 10:291-6. 2010..It also covers fundamental principles underlying patch test methodology and summarizes clinical patterns and causal drugs for which patch tests have reasonable value to diagnose culprit drugs...
- Drug-induced exanthemata: a source of clinical and intellectual confusionPeter Simon Friedmann
Dermatopharmacology Unit, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
Eur J Dermatol 20:255-9. 2010..The purpose of this article is to try to offer some structure both from the point of view of clinical classification and also of underlying mechanisms...
- The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humansP S Friedmann
Dermatopharmacology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
Br J Dermatol 157:1093-102. 2007..This article reviews the dose-response relationships of human contact sensitization...
- Mite elimination--clinical effect on eczemaP S Friedmann
Dermatopharmacology Unit, Southampton General Hospital, UK
Allergy 53:97-100. 1998..This was associated with clinical improvement in most patients with atopic eczema - the biggest improvements were seen in the most severely affected subjects...
- Second citeP S Friedmann
Clin Exp Dermatol 31:175-7. 2006
- Peroxisome proliferator-activated receptors and their relevance to dermatologyPeter S Friedmann
Dermatopharmacology Unit, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Acta Derm Venereol 85:194-202. 2005..PPARs can also be activated directly by phosphorylation to have ligand-independent effects. This review will discuss the physiology of PPARs relating this to skin pathology and their role as a target for novel therapies...
- Mechanisms in cutaneous drug hypersensitivity reactionsP S Friedmann
Dermatopharmacology Unit, Southampton General Hospital, Southampton, UK
Clin Exp Allergy 33:861-72. 2003..This will also become of great value for prediction of individuals at risk of becoming sensitized by a particular drug...
- Invariant natural killer T cells in asthma and chronic obstructive pulmonary diseasePandurangan Vijayanand
Division of Infection, Inflammation, and Repair, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
N Engl J Med 356:1410-22. 2007..We also studied whether an increased number of these cells is a feature of chronic obstructive pulmonary disease (COPD)...
- The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobioticsChris Pickard
Dermatopharmacology Unit, School of Medicine, Level F South Block 825, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
J Immunol 183:7576-84. 2009....
- Contact sensitisation and allergic contact dermatitis: immunobiological mechanismsPeter S Friedmann
Dermatopharmacology Unit, Level F South Block 825, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Toxicol Lett 162:49-54. 2006..These observations clearly have important implications across the whole field of risk assessment for induction of contact sensitivity...
- Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patientsPandurangan Vijayanand
Division of Infection, Southampton National Institute of Health Research Respiratory Biomedical Research Unit, University of Southampton School of Medicine, Southampton, United Kingdom
J Immunol 184:4568-74. 2010..This study also provides wider proof of concept for using tissue explants to study immunomodulatory drugs for asthma...
- Ultraviolet radiation causes less immunosuppression in patients with polymorphic light eruption than in controlsRoy A Palmer
Department of Dermatopharmacology, Southampton General Hospital, Southampton, UK
J Invest Dermatol 122:291-4. 2004..04 independent samples t test of Sigma DP-Sigma DN). We conclude that induction of sensitization by 2,4-dinitrochlorobenzene is suppressed less by UVR in patients with PLE than in healthy controls...
- The pathogenesis of atopic eczemaPeter S Friedmann
Dermatopharmacology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD
Hosp Med 63:653-6. 2002..Allergic responses to environmental allergens develop and microbes, including staphylococci and pityrosporum yeasts, may contribute to the inflammatory process...
- Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitisAmanda E Semper
Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, United Kingdom
J Allergy Clin Immunol 112:411-9. 2003..Seminal results from studies investigating Langerhans' cell Fc epsilon RI in skin biopsy sections or epidermal cell suspensions demonstrate the highest receptor expression in lesional skin of patients with active atopic dermatitis...
- Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzeneChris Pickard
Dermatopharmacology Unit, Southampton General Hospital, Southampton, UK
J Invest Dermatol 127:630-7. 2007..The results suggest that DNCB forms multiple haptens with intracellular and extracellular proteins leading to Th1 and Tc1 responses in individuals exposed to this compound...
- Activation of human dendritic cells by the PorA protein of Neisseria meningitidisTamara Al-Bader
Dermatopharmacology Unit, Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton SO16 6YD, UK
Cell Microbiol 6:651-62. 2004....
- Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidisTamara Al-Bader
Dermatopharmacology Unit, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
Infect Immun 71:5590-7. 2003..These data demonstrate that components of the OM, other than LPS, are also likely to be involved in determining the levels of DC activation and the nature of the T-helper immune response...
- Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene statusAshley Cooper
Dermatopharmacology Unit, University of Southampton, Southampton, United Kingdom
J Immunol 175:4806-13. 2005....
- Vaccination with DNA encoding a single-chain TCR fusion protein induces anticlonotypic immunity and protects against T-cell lymphomaStephen M Thirdborough
Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton SO16 6YD, United Kingdom
Cancer Res 62:1757-60. 2002..This is the first report of a DNA vaccine able to induce anti-idiotypic immunity against TCL, and it presents a simple strategy for selectively eliminating T-cell clones in vivo...
- Prime-boost with alternating DNA vaccines designed to engage different antigen presentation pathways generates high frequencies of peptide-specific CD8+ T cellsJoanna N Radcliffe
Cancer Sciences, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
J Immunol 177:6626-33. 2006..Taken together, these results demonstrate that vaccination protocols involving different modes of Ag presentation at prime and boost can significantly improve the effectiveness of immunization...
- Neuropeptide alpha-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitroPawan Kumar
Division of Infection, Inflammation and Immunity, Department of Dermatopharmacology, University of Southampton Medical School, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Inflamm Res 59:105-13. 2010..We investigated the therapeutic effects of alpha-MSH administration on Neisseria meningitidis infection of human meningeal cell cultures in vitro...
- MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)Rocio T Martinez-Nunez
Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, and Southampton General Hospital, Southampton, UK
J Biol Chem 284:16334-42. 2009..Thus, our results suggest a mechanism by which miR-155 regulates proteins involved in the cellular immune response against pathogens that could have clinical implications in the way pathogens enter the human organism...
- Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndromeKyu Seon Oh
DNA Repair Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
Hum Mutat 27:1092-103. 2006..The remarkable phenotypic heterogeneity of XPB is associated with partially active missense mutations in milder patients while severe XP/CS complex patients have nonsense mutations in both alleles with low levels of altered XPB proteins...
- A case of conjugal azathioprine-induced contact hypersensitivityHywel L Cooper
N Engl J Med 359:1524-6. 2008
- Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003S G O Johansson
Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
J Allergy Clin Immunol 113:832-6. 2004..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review...
- Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblastsAmy Storey
Department of Medicine, University of Liverpool, Liverpool, UK
J Invest Dermatol 124:248-55. 2005..001). Hence both n-3 PUFA inhibit production of UVB- and TNF-alpha-induced IL-8 in skin cells; this may be important in the photoprotective and other anti-inflammatory effects conferred by these agents...
- Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory responseRebecca C C Brooke
Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal Hospital, Manchester, UK
J Invest Dermatol 126:2296-301. 2006..Thus, two discrete acute inflammatory responses to topical ALA-PDT occur in human skin; histamine mediates the immediate response, but does not appear involved in the delayed phototoxicity...