Research Topics
| N FreemantleSummaryAffiliation: University of Birmingham Country: UK Publications
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Publications
Real-world trials to answer real-world questionsNick Freemantle
University of Birmingham, Birmingham, UK
Pharmacoeconomics 23:747-54. 2005..As an example, a real-world trial currently underway that examines scenarios of introducing inhaled insulin into clinical practice is described...
What factors predict differences in infant and perinatal mortality in primary care trusts in England? A prognostic modelNick Freemantle
School of Health and Population Sciences, University of Birmingham, Birmingham B15 2TT
BMJ 339:b2892. 2009..To identify predictors of perinatal and infant mortality variations between primary care trusts (PCTs) and identify outlier trusts where outcomes were worse than expected...- Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HFMagnus Edner
Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
Cardiovasc Ultrasound 7:1. 2009..Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT... - Access to interpreting services in England: secondary analysis of national dataParamjit S Gill
School of Health and Population Sciences, University of Birmingham, Birmingham, UK
BMC Public Health 9:12. 2009..The aim was to estimate the number of people requiring language support amongst the minority ethnic communities in England... - The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of biasPuvan Tharmanathan
Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
BMC Med Res Methodol 8:12. 2008..Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results... - Design of the BiRmingham Early Detection In untREated psyChosis Trial (REDIRECT): cluster randomised controlled trial of general practitioner education in detection of first episode psychosis [ISRCTN87898421]Lynda Tait
Department of Primary Care and General Practice, The University of Birmingham, UK
BMC Health Serv Res 5:19. 2005.... - Rationale and study design of a cross sectional study documenting the prevalence of Heart Failure amongst the minority ethnic communities in the UK: the E-ECHOES Study (Ethnic--Echocardiographic Heart of England Screening Study)Paramjit S Gill
Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
BMC Cardiovasc Disord 9:47. 2009.... - Protocol for Past BP: a randomised controlled trial of different blood pressure targets for people with a history of stroke of transient ischaemic attack (TIA) in primary careKate Fletcher
Primary Care Clinical Sciences, Clinical Sciences Building University of Birmingham, Edgbaston, Birmingham, UK
BMC Cardiovasc Disord 10:37. 2010..PAST BP will determine whether more intensive BP targets can be achieved in a primary care setting, and whether more intensive therapy is associated with adverse effects on quality of life... - A randomised controlled trial of the effect of educational outreach by community pharmacists on prescribing in UK general practiceNick Freemantle
Department of Primary Care and General Practice, The Medical School, University of Birmingham, Edgbaston
Br J Gen Pract 52:290-5. 2002..Educational outreach visits are commonly used to promote changes in prescribing in family practice. However, the effectiveness of outreach visits has not been evaluated across a range of settings... - Availability of inhaled insulin promotes greater perceived acceptance of insulin therapy in patients with type 2 diabetesNick Freemantle
Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham Edgbaston, Birmingham B15 2TT UK
Diabetes Care 28:427-8. 2005 
Biostatistical aspects for the use of evidence based medicine in health technology assessmentNick Freemantle
University of Birmingham, UK
Eur J Health Econ 9:31-43. 2008..In this article, I consider aspects of the statistical synthesis of evidence intended to support decisions on pharmaceutical reimbursement...- How strong is the association between abdominal obesity and the incidence of type 2 diabetes?N Freemantle
School of Primary Care, Occupational and Public Health, University of Birmingham, Birmingham, UK
Int J Clin Pract 62:1391-6. 2008..Quantitative evidence on the strength of the association between abdominal obesity and the incidence of type 2 diabetes was assessed... - Systematic review and mixed treatment comparison of randomized evidence for empirical, pre-emptive and directed treatment strategies for invasive mould diseaseNick Freemantle
School of Health and Population Sciences, University of Birmingham, Birmingham, UK
J Antimicrob Chemother 66:i25-35. 2011..While limited to some degree by the availability of RCTs, the MTCs reported here provide the best available evidence of relative therapeutic success for different available treatment strategies... - Is NICE delivering the goods?Nick Freemantle
University of Birmingham, Birmingham B15 2TT
BMJ 329:1003-4. 2004 - Cardiac resynchronisation for patients with heart failure due to left ventricular systolic dysfunction -- a systematic review and meta-analysisN Freemantle
Clinical Epidemiology and Biostatistics, Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur J Heart Fail 8:433-40. 2006..Our objective was to provide a valid synthesis of the effects of CRT on mortality, major morbidity, quality of life and implantation success rates... - The Reverend Bayes--was he really a prophet?Nick Freemantle
Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J R Soc Med 98:546. 2005 - How well does the evidence on pioglitazone back up researchers' claims for a reduction in macrovascular events?Nick Freemantle
University of Birmingham, Birmingham B15 2TT
BMJ 331:836-8. 2005 - Composite outcomes in randomized trials: greater precision but with greater uncertainty?Nick Freemantle
Department of Primary Care and General Practice, University of Birmingham, Birmingham, England
JAMA 289:2554-9. 2003..Current guidelines for the undertaking and reporting of clinical trials could be revised to reflect the common use of composite outcomes in clinical trials... - Real-world effectiveness of new medicines should be evaluated by appropriately designed clinical trialsNick Freemantle
School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Clin Epidemiol 63:1053-8. 2010.... - The applicability and generalizability of findings from clinical trials for health-policy decisionsNick Freemantle
University of Birmingham, Birmingham, UK
Pharmacoeconomics 27:5-10. 2009..Health policy may be informed by the combination of randomized and observational data in decision-analytic models... - A fair innings for NICE?Nick Freemantle
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Pharmacoeconomics 20:389-91. 2002 - [Real-world studies for answering real-world questions]N Freemantle
Clinical Epidemiology and Biostatistics, University of Birmingham
Dtsch Med Wochenschr 130:S77-81. 2005 - Use of health-related quality of life in prescribing research. Part 2: methodological considerations for the assessment of health-related quality of life in clinical trialsM J Calvert
Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
J Clin Pharm Ther 29:85-94. 2004..In addition we consider ways to minimize bias within the trial through optimization of compliance and timing of assessments... - Cost-effectiveness of cardiac resynchronization therapy: results from the CARE-HF trialMelanie J Calvert
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, UK
Eur Heart J 26:2681-8. 2005..CONCLUSION: Treatment with CRT appears cost-effective at the notional willingness to pay threshold of 29 400 (20,000 pounds sterlings) per QALY gained... - Using effectiveness studies for prescribing research, part 2N Freemantle
Department of Primary Care and General Practice, University of Birmingham, Edgbaston Birmingham, UK
J Clin Pharm Ther 27:469-73. 2002..We also discuss the appropriateness of some specific outcomes in relation to these trials... - Modelling prognostic factors in advanced pancreatic cancerD D Stocken
Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
Br J Cancer 99:883-93. 2008..The functional form of the relationship between continuous covariates and survival should always be assessed. Our model should aid individual patient risk stratification and the design and analysis of future trials in pancreatic cancer... - Evaluation of the management of heart failure in primary careMelanie J Calvert
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham, UK
Fam Pract 26:145-53. 2009..The extent to which guidelines for the treatment of heart failure are currently followed in primary care in the UK is unclear... - The development and implementation of an educational intervention on first episode psychosis for primary careHelen Lester
Department of Primary Care, University of Birmingham, Birmingham, UK
Med Educ 39:1006-14. 2005..This paper describes the development and implementation of an educational intervention to help general practitioners (GPs) recognise young people with first episode psychosis... - Management of type 2 diabetes with multiple oral hypoglycaemic agents or insulin in primary care: retrospective cohort studyMelanie J Calvert
Department of Primary Care and General Practice, University of Birmingham, Birmingham
Br J Gen Pract 57:455-60. 2007..Intensive glycaemic control can reduce the risk of microvascular complications in people with type 2 diabetes... - Cluster randomised controlled trial of the effectiveness of primary care mental health workersHelen Lester
Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
Br J Gen Pract 57:196-203. 2007..Mental health issues are a core part of the work of primary care and are the second most common reason for consultations. There is some evidence that the quality of primary care mental health provision is variable... - Examination performance of graduate entry medical students compared with mainstream studentsMelanie J Calvert
University of Birmingham Birmingham B15 2TT, UK
J R Soc Med 102:425-30. 2009..To assess whether medical students on graduate entry/fast- track programmes perform as well as students on standard courses... - The management of people with type 2 diabetes with hypoglycaemic agents in primary care: retrospective cohort studyMelanie J Calvert
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Fam Pract 24:224-9. 2007..Oral hypoglycaemic agents are typically the first pharmacological intervention used to improve glycaemic control... - Effect of the quality and outcomes framework on diabetes care in the United Kingdom: retrospective cohort studyMelanie Calvert
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT
BMJ 338:b1870. 2009.... - The long-term cost-effectiveness of cardiac resynchronization therapy with or without an implantable cardioverter-defibrillatorGuiqing Yao
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur Heart J 28:42-51. 2007.... - The diagnosis of heart failure in European primary care: The IMPROVEMENT Programme survey of perception and practiceF D Richard Hobbs
Primary Care Clinical Sciences Building, University of Birmingham, Birmingham B15 2TT, United Kingdom
Eur J Heart Fail 7:768-79. 2005..To examine European primary care physicians (PCPs) views on diagnosis of heart failure and compare perceptions with actual practice... - The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF studyMelanie J Calvert
Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur J Heart Fail 7:243-51. 2005.... - Striding forward or getting too big for their boots? The developing role of data monitoring committees in clinical trialsP Tharmanathan
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Clin Pharm Ther 31:111-8. 2006 - Bleeding in cardiac surgery: the use of aprotinin does not affect survivalDomenico Pagano
Department of Cardiothoracic Surgery, University Hospital Birmingham, Birmingham, United Kingdom
J Thorac Cardiovasc Surg 135:495-502. 2008..However, 2 recent reports from a single database have implicated the use of aprotinin as a risk for postoperative complications and reduced long-term survival... - Long-term cost-effectiveness analysis of nebivolol compared with standard care in elderly patients with heart failure: an individual patient-based simulation modelGuiqing Yao
University of Birmingham, Birmingham, UK
Pharmacoeconomics 26:879-89. 2008..The SENIORS trial demonstrated that nebivolol is effective in the treatment of heart failure in elderly patients (e.g. > or = 70 years). This analysis evaluates the cost effectiveness of nebivolol compared with standard treatment... - Use of health-related quality of life in prescribing research. Part 1: why evaluate health-related quality of life?M J Calvert
Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
J Clin Pharm Ther 28:513-21. 2003..In addition we consider the potential role of HRQoL assessment in routine clinical practice, and its use in licensing and health technology appraisal... - Highlighting the need for better patient care in stable angina: results of the international Angina Treatment Patterns (ATP) Survey in 7074 patientsJoanne L Eastaugh
Department of Primary Care and General Practice, Primary Care and Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Fam Pract 22:43-50. 2005..Stable angina is a growing problem worldwide. Diagnostic methods and treatment regimens are established but data on actual practice are sparse and pre-date current guidance... - Standardised patient assessments on consecutive days during high-stakes GP training interviews: is there any evidence of candidates sharing information?Adam Fraser
Wand Medical Centre, Birmingham, UK
Educ Prim Care 20:285-90. 2009..We were concerned that candidates later in the week may receive information from their colleagues and potentially gain an unfair advantage by discovering the content of the exercise... - Changing doctor prescribing behaviourP S Gill
Department of Primary Care and General Practice, University of Birmingham, UK
Pharm World Sci 21:158-67. 1999..Of these interventions, 49 (51%, 41%-61%) showed a positive significant change compared to the control group but interpretation of specific interventions is limited due to wide and overlapping confidence intervals... - Using effectiveness studies for prescribing research, part 1N Freemantle
Department of Primary Care and General Practice, University of Birmingham, UK
J Clin Pharm Ther 27:383-9. 2002..This includes open rather than blind assessments and greater emphasis on qualitative issues during development of interventions followed by quantitative appraisal of their impact... - What is the place of beta-blockade in patients who have experienced a myocardial infarction with preserved left ventricular function? Evidence and (mis)interpretationNick Freemantle
Department of Primary Care and General Practice, School of Medicine, University of Birmingham, Edgbaston, UK
Prog Cardiovasc Dis 44:243-50. 2002..In this article we address a series of questions related to the important and continuing role of beta blockade after myocardial infarction... - Predictors and treatment response with cardiac resynchronization therapy in patients with heart failure characterized by dyssynchrony: a pre-defined analysis from the CARE-HF trialMatthew Richardson
Health Care Evaluation Group, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur Heart J 28:1827-34. 2007.... - Antenatal peer support workers and initiation of breast feeding: cluster randomised controlled trialChristine MacArthur
School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT
BMJ 338:b131. 2009..To assess the effectiveness of an antenatal service using community based breastfeeding peer support workers on initiation of breast feeding... - Commentary on the EBOR trial reportNick Freemantle
Br J Gen Pract 52:587-8. 2002 - Clinical trials update from the American College of Cardiology meeting: CARE-HF and the remission of heart failure, Women's Health Study, TNT, COMPASS-HF, VERITAS, CANPAP, PEECH and PREMIERJohn G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU15 5JQ, UK
Eur J Heart Fail 7:931-6. 2005..In the PREMIER study the matrix metalloproteinase inhibitor PG-116800 failed to prevent LV remodelling following myocardial infarction... - Clinical trials update from the European Society of Cardiology Heart Failure meeting: SHAPE, BRING-UP 2 VAS, COLA II, FOSIDIAL, BETACAR, CASINO and meta-analysis of cardiac resynchronisation therapyAlison P Coletta
Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
Eur J Heart Fail 6:673-6. 2004..1% and +12.0%, respectively). Revised mortality data for the CASINO study and a meta-analysis of the effects of cardiac resynchronisation therapy on mortality in the light of the recently published COMPANION study are reported... - Comment and reply on: Relative efficacy/effectiveness and relative costs of treatment with insulin glargine and insulin detemirNick Freemantle
Curr Med Res Opin 23:1761-2; author reply 1762-4. 2007 - Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up studyWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Diabetes Technol Ther 10:25-38. 2008.... - Challenges for the National Institute for Clinical ExcellenceAlan Maynard
Department of Health Sciences, University of York, York YO10 5DD
BMJ 329:227-9. 2004 - Updating evidence-based clinical guidelinesMartin Eccles
Centre for Health Services Research, University of Newcastle upon Tyne, UK
J Health Serv Res Policy 7:98-103. 2002..There is a need for further sharing of experiences and the development of explicit methods for informing decisions on when and how to update evidence-based guidelines... - Variation in activity rates of consultant surgeons and the influence of reward structures in the English NHSKaren Bloor
Department of Health Sciences, Alcuin College, University of York, York, UK
J Health Serv Res Policy 9:76-84. 2004..Rich data sources like HES merit careful exploration and increased use as an essential first step in measuring and managing variations in specialists' performance... - Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEMAlison P Coletta
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull HU15 5JQ, UK
Eur J Heart Fail 5:697-704. 2003..The ESTEEM study showed that the oral thrombin inhibitor ximelagatran plus aspirin was more effective than aspirin alone in the prophylaxis of major cardiovascular events following MI... - Evaluation of a complex intervention for changing professional behaviour: the Evidence Based Out Reach (EBOR) TrialIrwin Nazareth
Department of Primary Care and Population Science, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2NF, UK
J Health Serv Res Policy 7:230-8. 2002.... - Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trialJohn G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU16 5JQ, UK
Eur J Heart Fail 6:787-91. 2004..The primary outcome measure is death or hospitalisation for any reason... - Effect of cardiac resynchronization on morbidity and mortality of diabetic patients with severe heart failureUta C Hoppe
Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany
Diabetes Care 30:722-4. 2007 - Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]John G F Cleland
Academic Unit of Cardiology, Department of Cardiology, Castle Hill Hospital, University of Hull, Castle Road, Cottingham, Kingston upon Hull, East Yorkshire, UK
Eur Heart J 27:1928-32. 2006..4 months [median 29.6, interquartile range (IQR) 23.6-34.6]. Prior to study closure, an extension phase lasting a further 8 months (allowing time for data analysis and presentation) was declared during which cross-over was discouraged... - NICE says no to inhaled insulin: what lessons should we learn?Nick Freemantle
Pharmacoeconomics 24:627-9. 2006 - Specialist nurse-led clinics to improve control of hypertension and hyperlipidemia in diabetes: economic analysis of the SPLINT trialJames M Mason
School for Health, University of Durham, Stockton on Tees, UK
Diabetes Care 28:40-6. 2005..To determine the cost-effectiveness of specialist nurse-led clinics provided to improve lipid and blood pressure control in diabetic patients receiving hospital-based care... - PROactive studyJohn S Yudkin
Lancet 367:24-5; author reply 26-7. 2006 - Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysisMatthew J Taylor
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England
Arch Gen Psychiatry 63:1217-23. 2006..Selective serotonin reuptake inhibitors (SSRIs) are often described as having a delayed onset of effect in the treatment of depression. However, some trials have reported clinical improvement as early as the first week of treatment... - Baseline echocardiographic characteristics of heart failure patients enrolled in a large European multicentre trial (CArdiac REsynchronisation Heart Failure study)Stefano Ghio
Division of Cardiology, IRCCS Policlinico S Matteo, University Hospital, Pavia, Italy
Eur J Echocardiogr 7:373-8. 2006..The CARE-HF trial provides the opportunity to address these issues in a large population of patients with advanced HF... - Prevalence of ECG abnormalities in an international survey of patients with suspected or confirmed heart failure at death or dischargeNasrin K Khan
University of Hull, Kingston upon Hull, United Kingdom
Eur J Heart Fail 9:491-501. 2007..Most patients suspected of having heart failure (HF) will get a 12-lead electrocardiogram (ECG) but its utility for excluding HF or assisting in its management has rarely been investigated... - Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin E meta-analysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness studyRhidian J Shelton
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU15 5JQ, UK
Eur J Heart Fail 7:127-35. 2005..Analysis of data from SCD-HeFT supports the cost-effectiveness of ICDs in heart failure, although overall cost implications may be prohibitive... - The effect of cardiac resynchronization on morbidity and mortality in heart failureJohn G F Cleland
Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
N Engl J Med 352:1539-49. 2005..We evaluated its effects on morbidity and mortality... - Development and validation of the Economic Assessment of Glycemic Control and Long-Term Effects of diabetes (EAGLE) modelElvira Mueller
Analytica International, Loerrach, Germany
Diabetes Technol Ther 8:219-36. 2006.... - The clinical impact of implantable loop recorders in patients with syncopeDavid J Farwell
Department of Cardiology, Eastbourne District General Hospital, King s Drive, Eastbourne, East Sussex, UK
Eur Heart J 27:351-6. 2006..Initial follow-up (at least 6 months) did not demonstrate a reduction in syncopal events or an improvement in quality of life. We report the planned extension of follow-up to 18 months... - The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysisSimon Thackray
Department of Academic Cardiology, University of Hull, Kingston upon Hull, UK
Eur J Heart Fail 4:515-29. 2002..To review systematically the use of intravenous (IV) inotropic agents acting through the adrenergic signalling pathway, compared with placebo or an active agent, in patients with heart failure... - Representation of South Asian people in randomised trials: ethnic origin need not be a barrier to participationHannah Cooper
BMJ 327:394-5. 2003 - Cardiac resynchronization therapy in heart failureMelanie Calvert
Ann Intern Med 142:305-7; author reply 307-8. 2005 - Composite and surrogate outcomes in randomised controlled trialsNick Freemantle
BMJ 334:756-7. 2007 - Early and sustained effects of cardiac resynchronization therapy on N-terminal pro-B-type natriuretic peptide in patients with moderate to severe heart failure and cardiac dyssynchronyFriedrich M Fruhwald
Division of Cardiology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria
Eur Heart J 28:1592-7. 2007..The purpose of this analysis was to investigate the effect of CRT on plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-pro-BNP), a powerful marker of cardiac dysfunction and prognosis... - Clinical trials update from the American Heart Association meeting: Omega-3 fatty acids and arrhythmia risk in patients with an implantable defibrillator, ACTIV in CHF, VALIANT, the Hanover autologous bone marrow transplantation study, SPORTIF V, ORBIT anJohn G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU15 5JQ, UK
Eur J Heart Fail 6:109-15. 2004..ORBIT and PAD showed public access defibrillators saved lives but questioned their cost effectiveness. DEFINITE supported a role for ICDs in patients with non-ischemic cardiomyopathy, although cost-effectiveness remains in doubt... - Is medication review by pharmacists of any use?Arnold G Zermansky
Pharmacoeconomics 25:91-2. 2007 - Clinical trials update from the American Heart Association 2006: OAT, SALT 1 and 2, MAGIC, ABCD, PABA-CHF, IMPROVE-CHF, and percutaneous mitral annuloplastyJohn G F Cleland
Department of Cardiology, Postgraduate Medical Institute, Division of Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
Eur J Heart Fail 9:92-7. 2007..In IMPROVE-CHF, an NT-pro BNP guided treatment strategy was found to reduce the cost of managing patients with acute breathlessness... - Relation of sex, age and concomitant diseases to drug prescription for heart failure in primary care in EuropeJorg Muntwyler
Department of Internal Medicine, University Hospital, Zurich, Switzerland
Eur J Heart Fail 6:663-8. 2004..To study the role of sex, age and concomitant diseases for prescription of cardiovascular drugs among patients with heart failure cared for in the community... - Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVEJohn G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU15 5JQ, UK
Eur J Heart Fail 8:105-10. 2006..The PROACTIVE study showed encouraging results for the use of pioglitazone in post-myocardial infarction patients with concomitant type 2 diabetes... - Gender and variation in activity rates of hospital consultantsKaren Bloor
Department of Health Sciences, University of York, UK
J R Soc Med 101:27-33. 2008..To explore whether or not gender predicts consultant activity rates... - Answering important questions reliably--GISSI Heart Failure, a factorially designed trial with composite (co)primary outcome measuresNick Freemantle
Eur J Heart Fail 6:531-3. 2004 - The perindopril in elderly people with chronic heart failure (PEP-CHF) studyJohn G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
Eur Heart J 27:2338-45. 2006..Few substantial randomized controlled trials have been conducted in this population, none has focussed on patients with evidence of diastolic dysfunction and none has shown clear benefit on symptoms, morbidity, or mortality... - Clinical trials update and cumulative meta-analyses from the American College of Cardiology: WATCH, SCD-HeFT, DINAMIT, CASINO, INSPIRE, STRATUS-US, RIO-Lipids and cardiac resynchronisation therapy in heart failureJohn G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull HU16 5JQ, UK
Eur J Heart Fail 6:501-8. 2004..Rimonabant was shown to be safe and effective in treating the combined cardiovascular risk factors of smoking and obesity. An overview of new developments in cardiac resynchronisation therapy (CRT) in heart failure is also reported... - Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response a report from the CARE-HF (Cardiac Resynchronization in Heart Failure) TrialJohn Cleland
Department of Cardiology, University of Hull, Hull, United Kingdom
J Am Coll Cardiol 52:438-45. 2008..This study was designed to investigate whether selected baseline variables and early response markers predict the effects of cardiac resynchronization therapy (CRT) on long-term mortality... - Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failureUta C Hoppe
Department of Internal Medicine III, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany
Circulation 114:18-25. 2006..Atrial fibrillation/flutter (AF) and heart failure often coexist; however, the effect of cardiac resynchronization therapy (CRT) on the incidence of AF and on the outcome of patients with new-onset AF remains undefined... - Relation between mild renal dysfunction and outcomes after coronary artery bypass graftingRosita Zakeri
University Hospital Birmingham, Edgbaston B15 2TH, United Kingdom
Circulation 112:I270-5. 2005..001). CONCLUSIONS: Mild renal dysfunction is an important predictor of outcome in terms of in-hospital mortality, morbidity, and midterm survival in patients undergoing CABG...