N Freemantle

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Real-world trials to answer real-world questions
    Nick Freemantle
    University of Birmingham, Birmingham, UK
    Pharmacoeconomics 23:747-54. 2005
  2. pmc What factors predict differences in infant and perinatal mortality in primary care trusts in England? A prognostic model
    Nick Freemantle
    School of Health and Population Sciences, University of Birmingham, Birmingham B15 2TT
    BMJ 339:b2892. 2009
  3. pmc Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF
    Magnus Edner
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
    Cardiovasc Ultrasound 7:1. 2009
  4. pmc Access to interpreting services in England: secondary analysis of national data
    Paramjit S Gill
    School of Health and Population Sciences, University of Birmingham, Birmingham, UK
    BMC Public Health 9:12. 2009
  5. pmc The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias
    Puvan Tharmanathan
    Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
    BMC Med Res Methodol 8:12. 2008
  6. pmc Design of the BiRmingham Early Detection In untREated psyChosis Trial (REDIRECT): cluster randomised controlled trial of general practitioner education in detection of first episode psychosis [ISRCTN87898421]
    Lynda Tait
    Department of Primary Care and General Practice, The University of Birmingham, UK
    BMC Health Serv Res 5:19. 2005
  7. pmc Rationale and study design of a cross sectional study documenting the prevalence of Heart Failure amongst the minority ethnic communities in the UK: the E-ECHOES Study (Ethnic--Echocardiographic Heart of England Screening Study)
    Paramjit S Gill
    Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Cardiovasc Disord 9:47. 2009
  8. pmc Protocol for Past BP: a randomised controlled trial of different blood pressure targets for people with a history of stroke of transient ischaemic attack (TIA) in primary care
    Kate Fletcher
    Primary Care Clinical Sciences, Clinical Sciences Building University of Birmingham, Edgbaston, Birmingham, UK
    BMC Cardiovasc Disord 10:37. 2010
  9. pmc A randomised controlled trial of the effect of educational outreach by community pharmacists on prescribing in UK general practice
    Nick Freemantle
    Department of Primary Care and General Practice, The Medical School, University of Birmingham, Edgbaston
    Br J Gen Pract 52:290-5. 2002
  10. ncbi Availability of inhaled insulin promotes greater perceived acceptance of insulin therapy in patients with type 2 diabetes
    Nick Freemantle
    Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham Edgbaston, Birmingham B15 2TT UK
    Diabetes Care 28:427-8. 2005

Detail Information

Publications87

  1. ncbi Real-world trials to answer real-world questions
    Nick Freemantle
    University of Birmingham, Birmingham, UK
    Pharmacoeconomics 23:747-54. 2005
    ..As an example, a real-world trial currently underway that examines scenarios of introducing inhaled insulin into clinical practice is described...
  2. pmc What factors predict differences in infant and perinatal mortality in primary care trusts in England? A prognostic model
    Nick Freemantle
    School of Health and Population Sciences, University of Birmingham, Birmingham B15 2TT
    BMJ 339:b2892. 2009
    ..To identify predictors of perinatal and infant mortality variations between primary care trusts (PCTs) and identify outlier trusts where outcomes were worse than expected...
  3. pmc Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF
    Magnus Edner
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
    Cardiovasc Ultrasound 7:1. 2009
    ..Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT...
  4. pmc Access to interpreting services in England: secondary analysis of national data
    Paramjit S Gill
    School of Health and Population Sciences, University of Birmingham, Birmingham, UK
    BMC Public Health 9:12. 2009
    ..The aim was to estimate the number of people requiring language support amongst the minority ethnic communities in England...
  5. pmc The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias
    Puvan Tharmanathan
    Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
    BMC Med Res Methodol 8:12. 2008
    ..Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results...
  6. pmc Design of the BiRmingham Early Detection In untREated psyChosis Trial (REDIRECT): cluster randomised controlled trial of general practitioner education in detection of first episode psychosis [ISRCTN87898421]
    Lynda Tait
    Department of Primary Care and General Practice, The University of Birmingham, UK
    BMC Health Serv Res 5:19. 2005
    ....
  7. pmc Rationale and study design of a cross sectional study documenting the prevalence of Heart Failure amongst the minority ethnic communities in the UK: the E-ECHOES Study (Ethnic--Echocardiographic Heart of England Screening Study)
    Paramjit S Gill
    Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Cardiovasc Disord 9:47. 2009
    ....
  8. pmc Protocol for Past BP: a randomised controlled trial of different blood pressure targets for people with a history of stroke of transient ischaemic attack (TIA) in primary care
    Kate Fletcher
    Primary Care Clinical Sciences, Clinical Sciences Building University of Birmingham, Edgbaston, Birmingham, UK
    BMC Cardiovasc Disord 10:37. 2010
    ..PAST BP will determine whether more intensive BP targets can be achieved in a primary care setting, and whether more intensive therapy is associated with adverse effects on quality of life...
  9. pmc A randomised controlled trial of the effect of educational outreach by community pharmacists on prescribing in UK general practice
    Nick Freemantle
    Department of Primary Care and General Practice, The Medical School, University of Birmingham, Edgbaston
    Br J Gen Pract 52:290-5. 2002
    ..Educational outreach visits are commonly used to promote changes in prescribing in family practice. However, the effectiveness of outreach visits has not been evaluated across a range of settings...
  10. ncbi Availability of inhaled insulin promotes greater perceived acceptance of insulin therapy in patients with type 2 diabetes
    Nick Freemantle
    Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham Edgbaston, Birmingham B15 2TT UK
    Diabetes Care 28:427-8. 2005
  11. doi Biostatistical aspects for the use of evidence based medicine in health technology assessment
    Nick Freemantle
    University of Birmingham, UK
    Eur J Health Econ 9:31-43. 2008
    ..In this article, I consider aspects of the statistical synthesis of evidence intended to support decisions on pharmaceutical reimbursement...
  12. pmc How strong is the association between abdominal obesity and the incidence of type 2 diabetes?
    N Freemantle
    School of Primary Care, Occupational and Public Health, University of Birmingham, Birmingham, UK
    Int J Clin Pract 62:1391-6. 2008
    ..Quantitative evidence on the strength of the association between abdominal obesity and the incidence of type 2 diabetes was assessed...
  13. doi Systematic review and mixed treatment comparison of randomized evidence for empirical, pre-emptive and directed treatment strategies for invasive mould disease
    Nick Freemantle
    School of Health and Population Sciences, University of Birmingham, Birmingham, UK
    J Antimicrob Chemother 66:i25-35. 2011
    ..While limited to some degree by the availability of RCTs, the MTCs reported here provide the best available evidence of relative therapeutic success for different available treatment strategies...
  14. pmc Is NICE delivering the goods?
    Nick Freemantle
    University of Birmingham, Birmingham B15 2TT
    BMJ 329:1003-4. 2004
  15. ncbi Cardiac resynchronisation for patients with heart failure due to left ventricular systolic dysfunction -- a systematic review and meta-analysis
    N Freemantle
    Clinical Epidemiology and Biostatistics, Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur J Heart Fail 8:433-40. 2006
    ..Our objective was to provide a valid synthesis of the effects of CRT on mortality, major morbidity, quality of life and implantation success rates...
  16. pmc The Reverend Bayes--was he really a prophet?
    Nick Freemantle
    Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J R Soc Med 98:546. 2005
  17. pmc How well does the evidence on pioglitazone back up researchers' claims for a reduction in macrovascular events?
    Nick Freemantle
    University of Birmingham, Birmingham B15 2TT
    BMJ 331:836-8. 2005
  18. ncbi Composite outcomes in randomized trials: greater precision but with greater uncertainty?
    Nick Freemantle
    Department of Primary Care and General Practice, University of Birmingham, Birmingham, England
    JAMA 289:2554-9. 2003
    ..Current guidelines for the undertaking and reporting of clinical trials could be revised to reflect the common use of composite outcomes in clinical trials...
  19. doi Real-world effectiveness of new medicines should be evaluated by appropriately designed clinical trials
    Nick Freemantle
    School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Clin Epidemiol 63:1053-8. 2010
    ....
  20. doi The applicability and generalizability of findings from clinical trials for health-policy decisions
    Nick Freemantle
    University of Birmingham, Birmingham, UK
    Pharmacoeconomics 27:5-10. 2009
    ..Health policy may be informed by the combination of randomized and observational data in decision-analytic models...
  21. ncbi A fair innings for NICE?
    Nick Freemantle
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Pharmacoeconomics 20:389-91. 2002
  22. ncbi [Real-world studies for answering real-world questions]
    N Freemantle
    Clinical Epidemiology and Biostatistics, University of Birmingham
    Dtsch Med Wochenschr 130:S77-81. 2005
  23. ncbi Use of health-related quality of life in prescribing research. Part 2: methodological considerations for the assessment of health-related quality of life in clinical trials
    M J Calvert
    Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
    J Clin Pharm Ther 29:85-94. 2004
    ..In addition we consider ways to minimize bias within the trial through optimization of compliance and timing of assessments...
  24. ncbi Cost-effectiveness of cardiac resynchronization therapy: results from the CARE-HF trial
    Melanie J Calvert
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, UK
    Eur Heart J 26:2681-8. 2005
    ..The aim of this study was to evaluate the incremental cost per quality adjusted life year (QALY) gained and incremental cost per life year gained of CRT plus medical therapy compared to medical therapy alone...
  25. ncbi Using effectiveness studies for prescribing research, part 2
    N Freemantle
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston Birmingham, UK
    J Clin Pharm Ther 27:469-73. 2002
    ..We also discuss the appropriateness of some specific outcomes in relation to these trials...
  26. pmc Modelling prognostic factors in advanced pancreatic cancer
    D D Stocken
    Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
    Br J Cancer 99:883-93. 2008
    ..The functional form of the relationship between continuous covariates and survival should always be assessed. Our model should aid individual patient risk stratification and the design and analysis of future trials in pancreatic cancer...
  27. doi Evaluation of the management of heart failure in primary care
    Melanie J Calvert
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham, UK
    Fam Pract 26:145-53. 2009
    ..The extent to which guidelines for the treatment of heart failure are currently followed in primary care in the UK is unclear...
  28. ncbi The development and implementation of an educational intervention on first episode psychosis for primary care
    Helen Lester
    Department of Primary Care, University of Birmingham, Birmingham, UK
    Med Educ 39:1006-14. 2005
    ..This paper describes the development and implementation of an educational intervention to help general practitioners (GPs) recognise young people with first episode psychosis...
  29. pmc Management of type 2 diabetes with multiple oral hypoglycaemic agents or insulin in primary care: retrospective cohort study
    Melanie J Calvert
    Department of Primary Care and General Practice, University of Birmingham, Birmingham
    Br J Gen Pract 57:455-60. 2007
    ..Intensive glycaemic control can reduce the risk of microvascular complications in people with type 2 diabetes...
  30. pmc Cluster randomised controlled trial of the effectiveness of primary care mental health workers
    Helen Lester
    Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
    Br J Gen Pract 57:196-203. 2007
    ..Mental health issues are a core part of the work of primary care and are the second most common reason for consultations. There is some evidence that the quality of primary care mental health provision is variable...
  31. pmc Examination performance of graduate entry medical students compared with mainstream students
    Melanie J Calvert
    University of Birmingham Birmingham B15 2TT, UK
    J R Soc Med 102:425-30. 2009
    ..To assess whether medical students on graduate entry/fast- track programmes perform as well as students on standard courses...
  32. ncbi The management of people with type 2 diabetes with hypoglycaemic agents in primary care: retrospective cohort study
    Melanie J Calvert
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Fam Pract 24:224-9. 2007
    ..Oral hypoglycaemic agents are typically the first pharmacological intervention used to improve glycaemic control...
  33. pmc Effect of the quality and outcomes framework on diabetes care in the United Kingdom: retrospective cohort study
    Melanie Calvert
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT
    BMJ 338:b1870. 2009
    ....
  34. ncbi The long-term cost-effectiveness of cardiac resynchronization therapy with or without an implantable cardioverter-defibrillator
    Guiqing Yao
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur Heart J 28:42-51. 2007
    ....
  35. ncbi The diagnosis of heart failure in European primary care: The IMPROVEMENT Programme survey of perception and practice
    F D Richard Hobbs
    Primary Care Clinical Sciences Building, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Eur J Heart Fail 7:768-79. 2005
    ..To examine European primary care physicians (PCPs) views on diagnosis of heart failure and compare perceptions with actual practice...
  36. ncbi The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study
    Melanie J Calvert
    Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur J Heart Fail 7:243-51. 2005
    ....
  37. ncbi Striding forward or getting too big for their boots? The developing role of data monitoring committees in clinical trials
    P Tharmanathan
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Clin Pharm Ther 31:111-8. 2006
  38. doi Bleeding in cardiac surgery: the use of aprotinin does not affect survival
    Domenico Pagano
    Department of Cardiothoracic Surgery, University Hospital Birmingham, Birmingham, United Kingdom
    J Thorac Cardiovasc Surg 135:495-502. 2008
    ..However, 2 recent reports from a single database have implicated the use of aprotinin as a risk for postoperative complications and reduced long-term survival...
  39. ncbi Long-term cost-effectiveness analysis of nebivolol compared with standard care in elderly patients with heart failure: an individual patient-based simulation model
    Guiqing Yao
    University of Birmingham, Birmingham, UK
    Pharmacoeconomics 26:879-89. 2008
    ..The SENIORS trial demonstrated that nebivolol is effective in the treatment of heart failure in elderly patients (e.g. > or = 70 years). This analysis evaluates the cost effectiveness of nebivolol compared with standard treatment...
  40. ncbi Use of health-related quality of life in prescribing research. Part 1: why evaluate health-related quality of life?
    M J Calvert
    Department of Primary Care and General Practice, University of Birmingham, Birmingham, UK
    J Clin Pharm Ther 28:513-21. 2003
    ..In addition we consider the potential role of HRQoL assessment in routine clinical practice, and its use in licensing and health technology appraisal...
  41. ncbi Highlighting the need for better patient care in stable angina: results of the international Angina Treatment Patterns (ATP) Survey in 7074 patients
    Joanne L Eastaugh
    Department of Primary Care and General Practice, Primary Care and Clinical Sciences Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Fam Pract 22:43-50. 2005
    ..Stable angina is a growing problem worldwide. Diagnostic methods and treatment regimens are established but data on actual practice are sparse and pre-date current guidance...
  42. ncbi Standardised patient assessments on consecutive days during high-stakes GP training interviews: is there any evidence of candidates sharing information?
    Adam Fraser
    Wand Medical Centre, Birmingham, UK
    Educ Prim Care 20:285-90. 2009
    ..We were concerned that candidates later in the week may receive information from their colleagues and potentially gain an unfair advantage by discovering the content of the exercise...
  43. ncbi Changing doctor prescribing behaviour
    P S Gill
    Department of Primary Care and General Practice, University of Birmingham, UK
    Pharm World Sci 21:158-67. 1999
    ..Of these interventions, 49 (51%, 41%-61%) showed a positive significant change compared to the control group but interpretation of specific interventions is limited due to wide and overlapping confidence intervals...
  44. ncbi Using effectiveness studies for prescribing research, part 1
    N Freemantle
    Department of Primary Care and General Practice, University of Birmingham, UK
    J Clin Pharm Ther 27:383-9. 2002
    ..This includes open rather than blind assessments and greater emphasis on qualitative issues during development of interventions followed by quantitative appraisal of their impact...
  45. ncbi What is the place of beta-blockade in patients who have experienced a myocardial infarction with preserved left ventricular function? Evidence and (mis)interpretation
    Nick Freemantle
    Department of Primary Care and General Practice, School of Medicine, University of Birmingham, Edgbaston, UK
    Prog Cardiovasc Dis 44:243-50. 2002
    ..In this article we address a series of questions related to the important and continuing role of beta blockade after myocardial infarction...
  46. ncbi Predictors and treatment response with cardiac resynchronization therapy in patients with heart failure characterized by dyssynchrony: a pre-defined analysis from the CARE-HF trial
    Matthew Richardson
    Health Care Evaluation Group, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur Heart J 28:1827-34. 2007
    ....
  47. pmc Antenatal peer support workers and initiation of breast feeding: cluster randomised controlled trial
    Christine MacArthur
    School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT
    BMJ 338:b131. 2009
    ..To assess the effectiveness of an antenatal service using community based breastfeeding peer support workers on initiation of breast feeding...
  48. pmc Commentary on the EBOR trial report
    Nick Freemantle
    Br J Gen Pract 52:587-8. 2002
  49. ncbi Clinical trials update from the American College of Cardiology meeting: CARE-HF and the remission of heart failure, Women's Health Study, TNT, COMPASS-HF, VERITAS, CANPAP, PEECH and PREMIER
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 7:931-6. 2005
    ..In the PREMIER study the matrix metalloproteinase inhibitor PG-116800 failed to prevent LV remodelling following myocardial infarction...
  50. ncbi Clinical trials update from the European Society of Cardiology Heart Failure meeting: SHAPE, BRING-UP 2 VAS, COLA II, FOSIDIAL, BETACAR, CASINO and meta-analysis of cardiac resynchronisation therapy
    Alison P Coletta
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 6:673-6. 2004
    ..1% and +12.0%, respectively). Revised mortality data for the CASINO study and a meta-analysis of the effects of cardiac resynchronisation therapy on mortality in the light of the recently published COMPANION study are reported...
  51. ncbi Comment and reply on: Relative efficacy/effectiveness and relative costs of treatment with insulin glargine and insulin detemir
    Nick Freemantle
    Curr Med Res Opin 23:1761-2; author reply 1762-4. 2007
  52. doi Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up study
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Technol Ther 10:25-38. 2008
    ....
  53. pmc Challenges for the National Institute for Clinical Excellence
    Alan Maynard
    Department of Health Sciences, University of York, York YO10 5DD
    BMJ 329:227-9. 2004
  54. ncbi Updating evidence-based clinical guidelines
    Martin Eccles
    Centre for Health Services Research, University of Newcastle upon Tyne, UK
    J Health Serv Res Policy 7:98-103. 2002
    ..To report on the updating of two evidence-based guidelines...
  55. ncbi Variation in activity rates of consultant surgeons and the influence of reward structures in the English NHS
    Karen Bloor
    Department of Health Sciences, Alcuin College, University of York, York, UK
    J Health Serv Res Policy 9:76-84. 2004
    ....
  56. ncbi Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM
    Alison P Coletta
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull HU15 5JQ, UK
    Eur J Heart Fail 5:697-704. 2003
    ..The ESTEEM study showed that the oral thrombin inhibitor ximelagatran plus aspirin was more effective than aspirin alone in the prophylaxis of major cardiovascular events following MI...
  57. ncbi Evaluation of a complex intervention for changing professional behaviour: the Evidence Based Out Reach (EBOR) Trial
    Irwin Nazareth
    Department of Primary Care and Population Science, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2NF, UK
    J Health Serv Res Policy 7:230-8. 2002
    ....
  58. ncbi Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trial
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 6:787-91. 2004
    ..The primary outcome measure is death or hospitalisation for any reason...
  59. ncbi Effect of cardiac resynchronization on morbidity and mortality of diabetic patients with severe heart failure
    Uta C Hoppe
    Internal Medicine III, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Diabetes Care 30:722-4. 2007
  60. ncbi Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]
    John G F Cleland
    Academic Unit of Cardiology, Department of Cardiology, Castle Hill Hospital, University of Hull, Castle Road, Cottingham, Kingston upon Hull, East Yorkshire, UK
    Eur Heart J 27:1928-32. 2006
    ..4 months [median 29.6, interquartile range (IQR) 23.6-34.6]. Prior to study closure, an extension phase lasting a further 8 months (allowing time for data analysis and presentation) was declared during which cross-over was discouraged...
  61. ncbi NICE says no to inhaled insulin: what lessons should we learn?
    Nick Freemantle
    Pharmacoeconomics 24:627-9. 2006
  62. ncbi Specialist nurse-led clinics to improve control of hypertension and hyperlipidemia in diabetes: economic analysis of the SPLINT trial
    James M Mason
    School for Health, University of Durham, Stockton on Tees, UK
    Diabetes Care 28:40-6. 2005
    ..To determine the cost-effectiveness of specialist nurse-led clinics provided to improve lipid and blood pressure control in diabetic patients receiving hospital-based care...
  63. ncbi PROactive study
    John S Yudkin
    Lancet 367:24-5; author reply 26-7. 2006
  64. pmc Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England
    Arch Gen Psychiatry 63:1217-23. 2006
    ..Selective serotonin reuptake inhibitors (SSRIs) are often described as having a delayed onset of effect in the treatment of depression. However, some trials have reported clinical improvement as early as the first week of treatment...
  65. ncbi Baseline echocardiographic characteristics of heart failure patients enrolled in a large European multicentre trial (CArdiac REsynchronisation Heart Failure study)
    Stefano Ghio
    Division of Cardiology, IRCCS Policlinico S Matteo, University Hospital, Pavia, Italy
    Eur J Echocardiogr 7:373-8. 2006
    ..The CARE-HF trial provides the opportunity to address these issues in a large population of patients with advanced HF...
  66. ncbi Prevalence of ECG abnormalities in an international survey of patients with suspected or confirmed heart failure at death or discharge
    Nasrin K Khan
    University of Hull, Kingston upon Hull, United Kingdom
    Eur J Heart Fail 9:491-501. 2007
    ..Most patients suspected of having heart failure (HF) will get a 12-lead electrocardiogram (ECG) but its utility for excluding HF or assisting in its management has rarely been investigated...
  67. ncbi Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin E meta-analysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness study
    Rhidian J Shelton
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 7:127-35. 2005
    ..Analysis of data from SCD-HeFT supports the cost-effectiveness of ICDs in heart failure, although overall cost implications may be prohibitive...
  68. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  69. ncbi Development and validation of the Economic Assessment of Glycemic Control and Long-Term Effects of diabetes (EAGLE) model
    Elvira Mueller
    Analytica International, Loerrach, Germany
    Diabetes Technol Ther 8:219-36. 2006
    ....
  70. ncbi The clinical impact of implantable loop recorders in patients with syncope
    David J Farwell
    Department of Cardiology, Eastbourne District General Hospital, King s Drive, Eastbourne, East Sussex, UK
    Eur Heart J 27:351-6. 2006
    ..Initial follow-up (at least 6 months) did not demonstrate a reduction in syncopal events or an improvement in quality of life. We report the planned extension of follow-up to 18 months...
  71. ncbi The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis
    Simon Thackray
    Department of Academic Cardiology, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 4:515-29. 2002
    ..To review systematically the use of intravenous (IV) inotropic agents acting through the adrenergic signalling pathway, compared with placebo or an active agent, in patients with heart failure...
  72. pmc Representation of South Asian people in randomised trials: ethnic origin need not be a barrier to participation
    Hannah Cooper
    BMJ 327:394-5. 2003
  73. ncbi Cardiac resynchronization therapy in heart failure
    Melanie Calvert
    Ann Intern Med 142:305-7; author reply 307-8. 2005
  74. pmc Composite and surrogate outcomes in randomised controlled trials
    Nick Freemantle
    BMJ 334:756-7. 2007
  75. ncbi Early and sustained effects of cardiac resynchronization therapy on N-terminal pro-B-type natriuretic peptide in patients with moderate to severe heart failure and cardiac dyssynchrony
    Friedrich M Fruhwald
    Division of Cardiology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Eur Heart J 28:1592-7. 2007
    ..The purpose of this analysis was to investigate the effect of CRT on plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-pro-BNP), a powerful marker of cardiac dysfunction and prognosis...
  76. ncbi Clinical trials update from the American Heart Association meeting: Omega-3 fatty acids and arrhythmia risk in patients with an implantable defibrillator, ACTIV in CHF, VALIANT, the Hanover autologous bone marrow transplantation study, SPORTIF V, ORBIT an
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 6:109-15. 2004
    ..ORBIT and PAD showed public access defibrillators saved lives but questioned their cost effectiveness. DEFINITE supported a role for ICDs in patients with non-ischemic cardiomyopathy, although cost-effectiveness remains in doubt...
  77. ncbi Is medication review by pharmacists of any use?
    Arnold G Zermansky
    Pharmacoeconomics 25:91-2. 2007
  78. ncbi Clinical trials update from the American Heart Association 2006: OAT, SALT 1 and 2, MAGIC, ABCD, PABA-CHF, IMPROVE-CHF, and percutaneous mitral annuloplasty
    John G F Cleland
    Department of Cardiology, Postgraduate Medical Institute, Division of Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 9:92-7. 2007
    ..In IMPROVE-CHF, an NT-pro BNP guided treatment strategy was found to reduce the cost of managing patients with acute breathlessness...
  79. ncbi Relation of sex, age and concomitant diseases to drug prescription for heart failure in primary care in Europe
    Jorg Muntwyler
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Eur J Heart Fail 6:663-8. 2004
    ..To study the role of sex, age and concomitant diseases for prescription of cardiovascular drugs among patients with heart failure cared for in the community...
  80. ncbi Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 8:105-10. 2006
    ..The PROACTIVE study showed encouraging results for the use of pioglitazone in post-myocardial infarction patients with concomitant type 2 diabetes...
  81. pmc Gender and variation in activity rates of hospital consultants
    Karen Bloor
    Department of Health Sciences, University of York, UK
    J R Soc Med 101:27-33. 2008
    ..To explore whether or not gender predicts consultant activity rates...
  82. ncbi Answering important questions reliably--GISSI Heart Failure, a factorially designed trial with composite (co)primary outcome measures
    Nick Freemantle
    Eur J Heart Fail 6:531-3. 2004
  83. ncbi The perindopril in elderly people with chronic heart failure (PEP-CHF) study
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur Heart J 27:2338-45. 2006
    ..Few substantial randomized controlled trials have been conducted in this population, none has focussed on patients with evidence of diastolic dysfunction and none has shown clear benefit on symptoms, morbidity, or mortality...
  84. ncbi Clinical trials update and cumulative meta-analyses from the American College of Cardiology: WATCH, SCD-HeFT, DINAMIT, CASINO, INSPIRE, STRATUS-US, RIO-Lipids and cardiac resynchronisation therapy in heart failure
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 6:501-8. 2004
    ..Rimonabant was shown to be safe and effective in treating the combined cardiovascular risk factors of smoking and obesity. An overview of new developments in cardiac resynchronisation therapy (CRT) in heart failure is also reported...
  85. doi Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response a report from the CARE-HF (Cardiac Resynchronization in Heart Failure) Trial
    John Cleland
    Department of Cardiology, University of Hull, Hull, United Kingdom
    J Am Coll Cardiol 52:438-45. 2008
    ..This study was designed to investigate whether selected baseline variables and early response markers predict the effects of cardiac resynchronization therapy (CRT) on long-term mortality...
  86. ncbi Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failure
    Uta C Hoppe
    Department of Internal Medicine III, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany
    Circulation 114:18-25. 2006
    ..Atrial fibrillation/flutter (AF) and heart failure often coexist; however, the effect of cardiac resynchronization therapy (CRT) on the incidence of AF and on the outcome of patients with new-onset AF remains undefined...
  87. ncbi Relation between mild renal dysfunction and outcomes after coronary artery bypass grafting
    Rosita Zakeri
    University Hospital Birmingham, Edgbaston B15 2TH, United Kingdom
    Circulation 112:I270-5. 2005
    ..47 to 2.25 mg/dL), which may impact mortality and morbidity after CABG...