Dilys J Freeman

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring
    Malini G Kanagalingam
    Reproductive and Maternal Medicine, University of Glasgow, Glasgow, United Kingdom
    Atherosclerosis 205:244-50. 2009
  2. pmc Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
    Eleanor Jarvie
    Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, U K
    Clin Sci (Lond) 119:123-9. 2010
  3. ncbi Short- and long-term changes in plasma inflammatory markers associated with preeclampsia
    Dilys J Freeman
    Division of Developmental Medicine, University of Glasgow, Glasgow, United Kingdom
    Hypertension 44:708-14. 2004
  4. ncbi C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
  5. ncbi A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
  6. doi Effects of maternal obesity on fetal growth and body composition: implications for programming and future health
    Dilys J Freeman
    Developmental Medicine, Faculty of Medicine, University of Glasgow, 2nd Floor McGregor Building, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Semin Fetal Neonatal Med 15:113-8. 2010
  7. doi Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia
    D J Freeman
    Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:421-7. 2008
  8. ncbi Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    Diabetes 56:2697-704. 2007
  9. doi Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes
    Scott M Nelson
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Diabetes Care 31:1123-5. 2008
  10. doi Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
    Naveed Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 371:1927-35. 2008

Detail Information

Publications28

  1. doi Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring
    Malini G Kanagalingam
    Reproductive and Maternal Medicine, University of Glasgow, Glasgow, United Kingdom
    Atherosclerosis 205:244-50. 2009
    ..However, whether established or putative novel cardiovascular risk factors including vascular and metabolic function are disrupted in women who delivered small for gestational age (SGA) offspring is unknown...
  2. pmc Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
    Eleanor Jarvie
    Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, U K
    Clin Sci (Lond) 119:123-9. 2010
    ..The combination of excess/altered lipid nutrient supply, suboptimal in utero metabolic environment and alterations in placental gene expression, inflammation and metabolism may also induce obesity in the offspring...
  3. ncbi Short- and long-term changes in plasma inflammatory markers associated with preeclampsia
    Dilys J Freeman
    Division of Developmental Medicine, University of Glasgow, Glasgow, United Kingdom
    Hypertension 44:708-14. 2004
    ..In conclusion, preeclampsia is associated with short- and long-term changes in inflammatory status...
  4. ncbi C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
    ..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
  5. ncbi A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
    ..Gene-smoking and gene-treatment interactions were investigated...
  6. doi Effects of maternal obesity on fetal growth and body composition: implications for programming and future health
    Dilys J Freeman
    Developmental Medicine, Faculty of Medicine, University of Glasgow, 2nd Floor McGregor Building, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Semin Fetal Neonatal Med 15:113-8. 2010
    ....
  7. doi Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia
    D J Freeman
    Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:421-7. 2008
    ..Pre-eclampsia is associated with increased placental debris circulating in maternal plasma...
  8. ncbi Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    Diabetes 56:2697-704. 2007
    ..We examined whether these biomarkers were elevated at birth in offspring of type 1 diabetic mothers (OT1DM)...
  9. doi Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes
    Scott M Nelson
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Diabetes Care 31:1123-5. 2008
    ..To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes...
  10. doi Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
    Naveed Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 371:1927-35. 2008
    ..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
  11. ncbi Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers
    Frances M Stewart
    Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Royal Infirmary Glasgow, United Kingdom
    J Clin Endocrinol Metab 92:969-75. 2007
    ..Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. In the nonpregnant, obesity is associated with dyslipidemia, vascular dysfunction, and low-grade chronic inflammation...
  12. pmc Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester
    Barbara J Meyer
    Metabolic Research Centre, School of Health Sciences, University of Wollongong, Wollongong, New South Wales 2500, Australia
    J Clin Endocrinol Metab 98:643-52. 2013
    ..In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL)...
  13. doi Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    Naveed Sattar
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 375:735-42. 2010
    ..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
  14. pmc Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Dilys J Freeman
    Centre of Population and Health Sciences, University of Glasgow, Glasgow, UK
    BMC Geriatr 11:8. 2011
    ..We aimed to determine the effect of pravastatin on incident VTE in older people; we also studied the impact of clinical and plasma risk variables...
  15. doi Early pregnancy soluble E-selectin concentrations and risk of preeclampsia
    David M Carty
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK
    J Hypertens 30:954-9. 2012
    ..We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia...
  16. ncbi The G-to-T point mutation in codon 34 of the factor XIII gene and the risk of pre-eclampsia
    Peter Clark
    Department of Transfusion Medicine, Ninewells Hospital Dundee, Glasgow, UK
    Blood Coagul Fibrinolysis 14:155-7. 2003
    ..7 (CI95 0.4-1.1). We conclude that the presence of leucine at this site is not associated with a protection against pre-eclampsia to the magnitude of that reported in other thrombotic disease...
  17. doi Longitudinal assessment of antim├╝llerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin
    Scott M Nelson
    Reproductive and Maternal Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, United Kingdom
    Fertil Steril 93:1356-8. 2010
    ....
  18. doi Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients
    Judith Madigan
    Division of Immunology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom
    J Immunol 184:3202-12. 2010
    ..These data support the view that trophoblast D6 scavenges maternal chemokines at the fetomaternal interface and that, in some circumstances, this can help to ensure fetal survival...
  19. ncbi IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes
    Scott M Nelson
    Department of Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 ER, UK
    Diabetes 56:2705-9. 2007
    ..We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures...
  20. ncbi Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?
    Vanessa A Rodie
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, UK
    Atherosclerosis 175:189-202. 2004
    ..These women may be an appropriate cohort for CVD risk screening and for possible intervention...
  21. ncbi Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partum
    Frances Stewart
    Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, G31 2ER, UK
    Lipids 42:335-44. 2007
    ..The correlation between maternal 22:6n3 and 24:1n9 suggests that mobilisation of these fatty acids may be coordinated. The inverse relationship between 16:1n7 and maternal central obesity warrants further investigation...
  22. doi Erythrocytosis in offspring of mothers with Type 1 diabetes--are factors other than insulin critical determinants?
    S M Nelson
    Faculty of Medicine, University of Glasgow, Glasgow, G31 ER, UK
    Diabet Med 26:887-92. 2009
    ..We assessed the association of maternal glycaemic control, birthweight and fetal hormones with haematological indices in pregnancies complicated by maternal diabetes...
  23. doi Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly
    N Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK
    Diabetologia 52:235-9. 2009
    ....
  24. pmc Preeclampsia is associated with compromised maternal synthesis of long-chain polyunsaturated fatty acids, leading to offspring deficiency
    Vanessa A Mackay
    School of Medicine, Institute of Cardiovascular and Medical Sciences, McGregor Building Level 2, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    Hypertension 60:1078-85. 2012
    ..001; 0.40 [0.81] versus 0.00 [0.00], P=0.038 expression relative to control gene [square root]). Low maternal and fetal long-chain polyunsaturated fatty acid concentrations in PE may be the result of decreased maternal synthesis...
  25. doi Short- and long-term strategies for the management of hypertensive disorders of pregnancy
    Shahzya S Huda
    Clinical Lecturer, Section of Reproductive and Maternal Medicine, University of Glasgow, Level 2 McGregor Building, Western Infirmary, Glasgow G11 6NT, UK
    Expert Rev Cardiovasc Ther 7:1581-94. 2009
    ..We also explore the evidence relating adverse pregnancy outcome to an increased future risk of cardiovascular disease and potential strategies to minimize this risk...
  26. ncbi Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction
    V A Rodie
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER, UK
    Atherosclerosis 176:181-7. 2004
    ..Our findings are potentially pertinent to understanding the future cardiovascular health of the offspring...
  27. ncbi Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction
    Vanessa A Rodie
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom
    J Soc Gynecol Investig 12:320-9. 2005
    ..We studied placental PPARdelta, PPARgamma, and retinoid X receptor alpha (RXRalpha) expression in healthy pregnancy and in preeclampsia (PET) and intrauterine growth restriction (IUGR)...
  28. ncbi Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study
    D J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Circulation 103:357-62. 2001
    ....