J A Franklyn

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi request reprint Thyrotoxicosis
    Jayne A Franklyn
    Centre for Diabetes, Endocrinology and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Lancet 379:1155-66. 2012
  2. doi request reprint Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine
    Kristien Boelaert
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:1869-82. 2013
  3. doi request reprint The thyroid--too much and too little across the ages. The consequences of subclinical thyroid dysfunction
    Jayne A Franklyn
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Clin Endocrinol (Oxf) 78:1-8. 2013
  4. ncbi request reprint Subclinical thyroid disorders--consequences and implications for treatment
    J A Franklyn
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Ann Endocrinol (Paris) 68:229-30. 2007
  5. ncbi request reprint Treatment of amiodarone-associated thyrotoxicosis
    Jayne A Franklyn
    Institute of Biomedical Research, The Medical School, University of Birmingham, UK
    Nat Clin Pract Endocrinol Metab 3:662-6. 2007
  6. ncbi request reprint Should we treat subclinical hyperthyroidism?
    Jayne A Franklyn
    Institute ofBiomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Nat Clin Pract Endocrinol Metab 4:550-1. 2008
  7. ncbi request reprint Thyroid disease and its treatment: short- and long-term consequences
    J A Franklyn
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston
    J R Coll Physicians Lond 33:564-7. 1999
  8. ncbi request reprint Age and gender predict the outcome of treatment for Graves' hyperthyroidism
    A Allahabadia
    Division of Medical Sciences, University of Birmingham, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 85:1038-42. 2000
  9. doi request reprint Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors
    V E Smith
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:2876-86. 2013
  10. doi request reprint Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease
    A A Zeitlin
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Genes Immun 9:358-63. 2008

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint Thyrotoxicosis
    Jayne A Franklyn
    Centre for Diabetes, Endocrinology and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Lancet 379:1155-66. 2012
    ..Total thyroidectomy is an option in selected cases. Future efforts are likely to concentrate on novel and safe ways to modulate the underlying disease process rather than stopping excess thyroid hormone production...
  2. doi request reprint Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine
    Kristien Boelaert
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:1869-82. 2013
    ..Hyperthyroidism is common, but opinions regarding optimal therapy with antithyroid drugs or radioiodine (131-I) differ. There are no randomized trials comparing these options in terms of mortality...
  3. doi request reprint The thyroid--too much and too little across the ages. The consequences of subclinical thyroid dysfunction
    Jayne A Franklyn
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Clin Endocrinol (Oxf) 78:1-8. 2013
    ..There is, however, much to learn about these disorders and, given their prevalence, their impact on health...
  4. ncbi request reprint Subclinical thyroid disorders--consequences and implications for treatment
    J A Franklyn
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Ann Endocrinol (Paris) 68:229-30. 2007
    ..Subclinical hypothyroidism is characterized by high serum TSH concentrations, together with normal free T4 values...
  5. ncbi request reprint Treatment of amiodarone-associated thyrotoxicosis
    Jayne A Franklyn
    Institute of Biomedical Research, The Medical School, University of Birmingham, UK
    Nat Clin Pract Endocrinol Metab 3:662-6. 2007
    ..A 75-year-old man had a myocardial infarction complicated by poor left ventricular function and non-sustained ventricular tachycardia. He began treatment with amiodarone and 12 months later developed symptoms of thyrotoxicosis...
  6. ncbi request reprint Should we treat subclinical hyperthyroidism?
    Jayne A Franklyn
    Institute ofBiomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Nat Clin Pract Endocrinol Metab 4:550-1. 2008
  7. ncbi request reprint Thyroid disease and its treatment: short- and long-term consequences
    J A Franklyn
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston
    J R Coll Physicians Lond 33:564-7. 1999
    ..Our own studies reveal no increase in cancer diagnoses or deaths, apart from a small increase in thyroid cancer risk which may be associated with the underlying thyroid disease...
  8. ncbi request reprint Age and gender predict the outcome of treatment for Graves' hyperthyroidism
    A Allahabadia
    Division of Medical Sciences, University of Birmingham, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 85:1038-42. 2000
    ....
  9. doi request reprint Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors
    V E Smith
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:2876-86. 2013
    ....
  10. doi request reprint Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease
    A A Zeitlin
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Genes Immun 9:358-63. 2008
    ....
  11. pmc The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation
    S Y Chan
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Floor 3, Birmingham Women s Hospital, Edgbaston, Birmingham B15 2TG, UK
    J Physiol 589:2827-45. 2011
    ..However, human NT2 neurodifferentiation is not dependent upon T3 or MCT8 and there were no compensatory changes to promote T3 uptake in a T3-depleted environment...
  12. ncbi request reprint Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom
    J E Collins
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Clin Endocrinol Metab 89:6336-9. 2004
    ....
  13. ncbi request reprint Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians
    J E Collins
    Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Birmingham, UK
    Clin Endocrinol (Oxf) 60:618-24. 2004
    ..The aim of this study was to test for association of polymorphisms of the VDR gene in the genetic susceptibility to GD in UK Caucasians...
  14. ncbi request reprint Pituitary tumor transforming gene and fibroblast growth factor-2 expression: potential prognostic indicators in differentiated thyroid cancer
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 88:2341-7. 2003
    ..64; P = 0.003). We conclude that PTTG and FGF-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer...
  15. ncbi request reprint Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway
    D S Kim
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:4603-11. 2006
    ..We recently reported that the proangiogenic pituitary tumor transforming gene (PTTG) stimulates VEGF and up-regulates inhibitor of DNA binding-3 (ID3), an important gene in VEGF-dependent angiogenesis...
  16. pmc Monocarboxylate transporter 8 expression in the human placenta: the effects of severe intrauterine growth restriction
    S Y Chan
    Department of Fetal Medicine, Division of Reproductive and Child Health, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
    J Endocrinol 189:465-71. 2006
    ..Altered expression in placenta associated with IUGR may reflect a compensatory mechanism attempting to increase T3 uptake by trophoblast cells...
  17. ncbi request reprint A potential role for PTTG/securin in the developing human fetal brain
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    FASEB J 17:1631-9. 2003
    ..We propose a potential role for human PTTG/securin in modulating cell proliferation and FGF-2 expression during human neurogenesis...
  18. ncbi request reprint Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease
    M J Simmonds
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:1056-61. 2006
    ....
  19. doi request reprint Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism
    K Boelaert
    Division of Medical Sciences, University Hospital Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 70:129-38. 2009
    ..There is little consensus regarding the most appropriate dose of radioiodine ((131)I) to be administered to patients with hyperthyroidism...
  20. ncbi request reprint PTTG and PBF repress the human sodium iodide symporter
    K Boelaert
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Oncogene 26:4344-56. 2007
    ....
  21. pmc Differential triiodothyronine responsiveness and transport by human cytotrophoblasts from normal and growth-restricted pregnancies
    E Vasilopoulou
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    J Clin Endocrinol Metab 95:4762-70. 2010
    ..We postulate that altered TH bioavailability to trophoblasts may contribute to the pathogenesis of IUGR...
  22. ncbi request reprint Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer
    D S Kim
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 91:1119-28. 2006
    ..PTTG has been shown to promote angiogenesis, a key rate-limiting step in tumor progression, by up-regulation of fibroblast growth factor-2 and vascular endothelial growth factor...
  23. ncbi request reprint Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74
    M J Simmonds
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 65:429-32. 2006
    ..The aim of this study was to investigate the association rs2076530 with disease in a large UK Caucasian Graves' disease (GD) dataset...
  24. ncbi request reprint Tag SNP screening of the PDCD1 gene for association with Graves' disease
    P R Newby
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 67:125-8. 2007
    ..The objective of our study was to investigate eight tag SNPs representing the majority of common variation in PDCD1 within a well-characterized large UK Caucasian GD dataset...
  25. doi request reprint Older subjects with hyperthyroidism present with a paucity of symptoms and signs: a large cross-sectional study
    K Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 95:2715-26. 2010
    ..The absence of classical symptoms and signs of hyperthyroidism often results in delayed diagnosis and treatment...
  26. ncbi request reprint Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour
    C J McCabe
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 58:141-50. 2003
    ....
  27. ncbi request reprint Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy
    A A Syed
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 67:663-7. 2007
    ....
  28. ncbi request reprint Radioiodine treatment of hyperthyroidism-prognostic factors for outcome
    A Allahabadia
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    J Clin Endocrinol Metab 86:3611-7. 2001
    ....
  29. ncbi request reprint Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies
    S Chan
    Department of Fetal Medicine, Division of Reproductive and Child Health, University of Birmingham, Birmingham, United Kingdom B15 2TG
    J Clin Endocrinol Metab 88:4488-95. 2003
    ..The lack of difference in deiodinase expression in normal placentas and those found in IUGR argues against placental deiodinases being responsible for the hypothyroxemia in circulating fetal thyroid hormones observed in this condition...
  30. ncbi request reprint Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype
    N Manji
    Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Second Floor, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:4873-80. 2006
    ..Both genetic and environmental factors contribute to susceptibility to Graves' disease (GD) and Hashimoto's thyroiditis (HT), as well as disease manifestations...
  31. doi request reprint Expression and function of thyroid hormone transporters in the microvillous plasma membrane of human term placental syncytiotrophoblast
    L S Loubière
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Endocrinology 153:6126-35. 2012
    ..Our data demonstrate that syncytiotrophoblast may control the quantity and forms of THs taken up by the human placenta. Thus, syncytiotrophoblast could be critical in regulating transplacental TH supply from the mother to the fetus...
  32. ncbi request reprint Circulating thyroid hormone concentrations and placental thyroid hormone receptor expression in normal human pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR)
    M D Kilby
    Department of Fetal Medicine, University of Birmingham, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 83:2964-71. 1998
    ....
  33. ncbi request reprint Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects
    N Manji
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 64:125-8. 2006
    ..Overt thyroid dysfunction is well recognized to affect weight, but the influence of minor perturbations of thyroid function remains unclear...
  34. ncbi request reprint Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease
    A A Zeitlin
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Clin Endocrinol (Oxf) 65:380-4. 2006
    ..The aim of this study was to determine whether PTPN21 is acting as a GD susceptibility locus in UK Caucasian subjects...
  35. ncbi request reprint Separase, securin and Rad21 in neural cell growth
    H N Pemberton
    Divisions of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    J Cell Physiol 213:45-53. 2007
    ..Our data suggest that the co-ordinated expression of separase, securin and Rad21 is fundamental for the developing brain...
  36. ncbi request reprint Thyroid hormone and estrogen receptor expression in normal pituitary and nonfunctioning tumors of the anterior pituitary
    N J Gittoes
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 82:1960-7. 1997
    ..We suggest that reduced expression of TRs and ER may account for inappropriate expression of the glycoprotein hormone alpha-subunit gene in some NFTs and may contribute to uncontrolled tumor growth...
  37. ncbi request reprint No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies
    J M Heward
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Clin Endocrinol (Oxf) 49:331-4. 1998
    ....
  38. ncbi request reprint Weight gain following treatment of hyperthyroidism
    J Dale
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 55:233-9. 2001
    ..Pre-existing obesity, a diagnosis of Graves' disease and prior weight loss independently predicted weight gain and weight continued to rise with time. Patients who became hypothyroid, despite T4 replacement, gained most weight...
  39. doi request reprint Monocarboxylate transporter 8 in neuronal cell growth
    S R James
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Endocrinology 150:1961-9. 2009
    ....
  40. ncbi request reprint Estrogen receptor beta mRNA expression in normal and adenomatous pituitaries
    N J Gittoes
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    Pituitary 1:99-104. 1999
    ..56 +/- 0.21; mean +/- SE; n = 5; p < 0.05 Student's t-test). Studies of ER beta protein expression are required to determine the functional significance of reduced ER beta mRNA expression in NFTs...
  41. doi request reprint Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction
    L S Loubière
    School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Placenta 31:295-304. 2010
    ..Increased MCT8 and decreased MCT10 expression within placentae of pregnancies complicated by IUGR may contribute to aberrant development of the fetoplacental unit...
  42. ncbi request reprint Association between serum free thyroxine concentration and atrial fibrillation
    M D Gammage
    Department of Cardiovascular Medicine, University of Birmingham, Birmingham, England
    Arch Intern Med 167:928-34. 2007
    ..Our objective was to determine the relationship between thyroid function and presence of atrial fibrillation (AF) in older subjects...
  43. ncbi request reprint Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity
    D S Kim
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham B15 2TH, UK
    Carcinogenesis 28:749-59. 2007
    ..Our data suggest that, by repressing Ku70 activity and inhibiting the non-homologous end-joining dsDNA repair pathway, securin may be a critical gene in the development of GI in colorectal cancer...
  44. ncbi request reprint Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors
    C J McCabe
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    J Clin Endocrinol Metab 87:4238-44. 2002
    ....
  45. ncbi request reprint Thyroid hormones and fetal brain development
    H N Pemberton
    Department of Fetal Medicine, Birmingham Women s Hospital, University of Birmingham, Birmingham, UK
    Minerva Ginecol 57:367-78. 2005
    ..Understanding these molecular mechanisms further will have profound implications in the clinical management of individuals affected by abnormal maternal of fetal thyroid status...
  46. ncbi request reprint Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 91:4295-301. 2006
    ..Thyroid nodules and goiter are common, and fine-needle aspiration biopsy (FNAB) is the first investigation of choice in distinguishing benign from malignant disease...
  47. ncbi request reprint The in vitro effects of triiodothyronine on epidermal growth factor-induced trophoblast function
    K J Barber
    Department of Maternal and Fetal Medicine, Division of Reproductive and Child Health, 3rd Floor, Birmingham Women s Hospital, Edgbaston, Birmingham B15 2TG, United Kingdom
    J Clin Endocrinol Metab 90:1655-61. 2005
    ..Both T(3) and EGF also significantly enhanced SGHPL-4 motility. These results suggest that EGF and T(3) may act synergistically to regulate both proliferation and differentiated function of human trophoblast...
  48. ncbi request reprint Thyroid hormone responsiveness in N-Tera-2 cells
    S Chan
    Division of Reproductive and Child Health, University of Birmingham, Birmingham Women s Hospital, Edgbaston, Birmingham B15 2TG, UK
    J Endocrinol 178:159-67. 2003
    ..Undifferentiated NT2 and differentiated hNT cells show differing patterns of T(3)-responsiveness, suggesting that there are different regulatory factors operating within these cell types...
  49. ncbi request reprint A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease
    M J Simmonds
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    Genes Immun 5:267-73. 2004
    ..This study has established accurate allele frequencies of TNF-alpha SNPs in a UK population and provides preliminary evidence for association of the TNF-alpha gene with GD...
  50. ncbi request reprint Retinoid X receptor expression in the normal pituitary and clinically 'non-functioning' pituitary tumours
    N J Gittoes
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK
    Clin Endocrinol (Oxf) 48:425-33. 1998
    ....
  51. ncbi request reprint Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth restriction
    M D Kilby
    Department of Fetal Medicine, Division of Human Reproduction and Childhealth, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Clin Endocrinol (Oxf) 53:469-77. 2000
    ....
  52. ncbi request reprint PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    J Mol Endocrinol 33:663-77. 2004
    ..Taken together, our data suggest that PXXP structure and phosphorylation are likely to exert independent and critical influences upon PTTG's diverse actions in vitro...
  53. ncbi request reprint Tissue-specific regulation of thyroid hormone receptor mRNA isoforms and target gene proteins in domestic ducks
    C M Bishop
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Endocrinol 165:607-15. 2000
    ..098+/-0.019, 0.822+/-0.297 and 0. 38+/-0.202 TR:beta-actin respectively). Only the pituitary gland expressed significant levels of TR beta 2 mRNA...
  54. ncbi request reprint Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity
    K F Tait
    Division of Medical Sciences, University of Birmingham, UK
    Diabet Med 21:267-70. 2004
    ..The aim of this study was to investigate whether the INS VNTR region is a Type 1 diabetes-specific locus or acting as a general autoimmunity gene...
  55. ncbi request reprint Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease
    J E Collins
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Endocrinol Metab 88:5039-42. 2003
    ..Although these findings may represent a random chance event, in view of previous reports of linkage and association of this gene region to AITD, this may be an example of a rare causal variant of a complex disease...
  56. ncbi request reprint HLA class II DNA genotypes in Graves' disease: clues to inheritance of the HLA-linked component of susceptibility
    J Fletcher
    Department of Medicine, Birmingham University, UK
    Clin Endocrinol (Oxf) 29:539-47. 1988
    ..01). The implications of these findings are discussed with reference to models for the inheritance of the HLA-linked component of Graves' disease susceptibility...
  57. ncbi request reprint Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' disease
    L Harper
    Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 60:671-5. 2004
    ..We aimed to investigate whether carbimazole therapy was also associated with increased risk of ANCA...
  58. ncbi request reprint Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study
    J V Parle
    Division of Primary Care, Public and Occupational Health, Birmingham, UK
    Lancet 358:861-5. 2001
    ..2). INTERPRETATION: A single measurement of low serum thyrotropin in individuals aged 60 years or older is associated with increased mortality from all causes, and in particular mortality due to circulatory and cardiovascular diseases...
  59. ncbi request reprint An audit of management of differentiated thyroid cancer in specialist and non-specialist clinic settings
    H Kumar
    Divisions of Medical Sciences and Mathematics and Statistics, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Clin Endocrinol (Oxf) 54:719-23. 2001
    ....
  60. ncbi request reprint The use of laser capture microdissection (LCM) and quantitative polymerase chain reaction to define thyroid hormone receptor expression in human 'term' placenta
    S Chan
    Department of Fetal Medicine, Division of Reproductive and Child Health, Floor 3, Birmingham Women s Hospital, University of Birmingham, Edgbaston, Birmingham B15 2TG, UK
    Placenta 25:758-62. 2004
    ..05) and TRbeta1 (40%; p = 0.03) in the trophoblast layer compared to the heterogeneous stromal cells. However, there was no significant difference in TRalpha2 mRNA expression between the two groups of cells...
  61. ncbi request reprint The significance of TSH values measured in a sensitive assay in the follow-up of hyperthyroid patients treated with radioiodine
    P H Davies
    Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 74:1189-94. 1992
    ....
  62. ncbi request reprint Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    Oliver J Brand
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Clin Endocrinol (Oxf) 66:508-12. 2007
    ..Because certain autoimmune diseases, such as autoimmune thyroid disease (AITD) and T1D cluster together in certain families, we sought to determine if the TID-associated CD25 region was also associated with Graves' disease (GD)...
  63. ncbi request reprint A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians
    Joanne M Heward
    Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Edgbaston, Birmingham, UK, B15 2TT
    Clin Endocrinol (Oxf) 61:269-72. 2004
    ..The aim of this study was to determine whether this SNP of the CD40 gene confers susceptibility to GD in UK Caucasians...
  64. ncbi request reprint Thyroid disease and its treatment: short-term and long-term cardiovascular consequences
    F Osman
    Department of Cardiology, Queen Elizabeth Hospital, Birmingham, UK
    Curr Opin Pharmacol 1:626-31. 2001
    ..Increasing evidence suggests that long-term vascular morbidity and mortality occurs in both overt and subclinical thyroid disease...
  65. ncbi request reprint Successful treatment of amiodarone-induced thyrotoxicosis
    Faizel Osman
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Circulation 105:1275-7. 2002
    ..Amiodarone-induced thyrotoxicosis (AIT) is a difficult management problem about which there are little published data. We examined whether continuing amiodarone or differentiating AIT into 2 subtypes affected outcome...
  66. doi request reprint PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8
    V E Smith
    School of Clinical and Experimental Medicine, Institute for Biomedical Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Endocrinology 153:3526-36. 2012
    ..Furthermore, alongside NIS repression, PBF may thus represent a new regulator of TH biosynthesis and secretion...
  67. ncbi request reprint Thyroid hormone in health and disease
    K Boelaert
    Division of Medical Sciences, IBR Building, 2nd Floor, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    J Endocrinol 187:1-15. 2005
    ..Furthermore we will describe some recent developments in our understanding of the relationship between thyroid status and health...
  68. doi request reprint Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease
    Oliver J Brand
    Institute of Biomedical Research, University of Birmingham, Edgbaston, West Midlands, UK
    Hum Mol Genet 18:1704-13. 2009
    ..8 x 10(-4)). In addition, we provide preliminary evidence that the disease-associated genotypes of rs179247 (AA) and rs12101255 (TT) show reduced mRNA expression ratios of flTSHR relative to two alternate TSHR mRNA splice variants...
  69. ncbi request reprint Association of PTPN22 haplotypes with Graves' disease
    Joanne M Heward
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 92:685-90. 2007
    ..A recent study reported associations of a series of single nucleotide polymorphisms (SNPs) within PTPN22, including rs2476601, with rheumatoid arthritis...
  70. ncbi request reprint Prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community-based cross-sectional survey
    Sue Wilson
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:4809-16. 2006
    ..Population-based screening has been advocated for subclinical thyroid dysfunction in the elderly because the disorder is perceived to be common, and health benefits may be accrued by detection and treatment...
  71. doi request reprint Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease
    Kristien Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Med 123:183.e1-9. 2010
    ..Common autoimmune disorders tend to coexist in the same subjects and to cluster in families...
  72. ncbi request reprint Thyroid function and mortality in patients treated for hyperthyroidism
    Jayne A Franklyn
    Division of Medical Sciences, University of Birmingham, England
    JAMA 294:71-80. 2005
    ..Hyperthyroidism has been reported to cause excess all-cause and circulatory mortality. Whether this can be reversed is unknown, as is the influence of mild persisting thyroid dysfunction and treatment-induced hypothyroidism...
  73. ncbi request reprint Levothyroxine treatment and occurrence of fracture of the hip
    Michael C Sheppard
    Department of Medicine, The University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    Arch Intern Med 162:338-43. 2002
    ..Levothyroxine sodium is widely prescribed and has been implicated as a cause of reduction in bone mineral density and, therefore, suggested to be a major contributor to the risk of osteoporotic fractures...
  74. ncbi request reprint Thyroid hormone action in the placenta
    M D Kilby
    Department of Fetal Medicine, Division of Reproduction and Child Health, Birmingham Women s Hospital, University of Birmingham, Edgbaston B15 2TT, United Kingdom
    Placenta 26:105-13. 2005
  75. ncbi request reprint No association of an interleukin 4 gene promoter polymorphism with Graves' disease in the United Kingdom
    J M Heward
    Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 86:3861-3. 2001
    ..Our data support the hypothesis that the C-T promoter polymorphism of the interleukin 4 gene does not confer protection against the development of GD in Caucasians in the United Kingdom...
  76. ncbi request reprint Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment
    Faizel Osman
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
    Am J Cardiol 94:465-9. 2004
    ..This study is the first to evaluate HRT in overt and treated hyperthyroidism...
  77. ncbi request reprint Polymorphisms of interleukin 4 receptor gene and interleukin 10 gene are not associated with Graves' disease in the UK
    Karen F Tait
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Autoimmunity 37:189-94. 2004
    ..We conclude these polymorphisms of IL-10 and IL-4R previously associated with other immune mediated diseases, do not confer susceptibility to GD in white Caucasians in the United Kingdom...
  78. doi request reprint Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease
    Matthew J Simmonds
    Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Thyroid 20:413-7. 2010
    ..We sought to confirm this association in a large Caucasian U.K. GD cohort...
  79. doi request reprint Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression
    Kadija Yesmin
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 73:119-25. 2010
    ..This study aimed to determine whether FcGRIIa is associated with Graves' disease (GD) in the UK Caucasian population by Tag SNP screening common polymorphisms within the FcGRIIa region...
  80. ncbi request reprint Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy: a matched case-control study
    Faizel Osman
    Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, England
    J Am Coll Cardiol 49:71-81. 2007
    ..This study sought to prospectively evaluate the prevalence of cardiovascular abnormalities in patients with overt hyperthyroidism before and after antithyroid therapy...
  81. ncbi request reprint Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours
    L A Tannahill
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    Clin Endocrinol (Oxf) 56:735-43. 2002
    ..We hypothesized that aberrant expression of deiodinase enzymes and/or altered enzyme activity in pituitary tumours may change tissue concentrations of THs and influence their growth and secretory characteristics...
  82. ncbi request reprint Thyroid receptor alpha1 and alpha2 mutations in nonfunctioning pituitary tumors
    C J McCabe
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Clin Endocrinol Metab 84:649-53. 1999
    ..The functional significance of the novel TRalpha mutations is unknown; definition of mutant TR action may provide insight into the role of TRs in the growth control of pituitary cells...
  83. ncbi request reprint Adenovirus-mediated expression of dominant negative fibroblast growth factor (FGF) receptor 1 in thyroid cells blocks FGF effects and reduces goitrogenesis in mice
    Emma L Davies
    Division of Medical Sciences, University of Birmingham, United Kingdom B15 2TT
    J Clin Endocrinol Metab 88:4472-80. 2003
    ..We conclude that the FGF axis is important in thyroid growth and that RAdDN-FGFR1 effectively blocks FGF actions, offering a means to control goitrogenesis...
  84. ncbi request reprint Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom
    Ratnasingam Nithiyananthan
    Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, United Kingdom
    Thyroid 12:3-6. 2002
    ..8.8% and 50% vs. 46% respectively; chi2 = 11.7, p = 0.003). These results suggest that the CTLA-4 gene region on chromosome 2q33 is a susceptibility locus for autoimmune hypothyroidism in the United Kingdom...
  85. ncbi request reprint Sodium iodide symporter: a novel strategy to target breast, prostate, and other cancers?
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, B15 2TH, Birmingham, UK
    Lancet 361:796-7. 2003
  86. pmc Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study
    Paul R Newby
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, West Midlands, UK
    Eur J Hum Genet 18:1021-6. 2010
    ..Our study confirms the need for large data sets and stringent analysis criteria when searching for susceptibility loci in common diseases...
  87. ncbi request reprint Clinical review 142: cardiac dysrhythmias and thyroid dysfunction: the hidden menace?
    Faizel Osman
    Division of Medical Sciences, Queen Elizabeth Hospital, University of Birmingham, Birmingham, United Kingdom B15 2TH
    J Clin Endocrinol Metab 87:963-7. 2002
    ..Improved detection of supraventricular dysrhythmias and therapeutic intervention (e.g. anticoagulants, antiarrhythmics) may improve the long-term vascular prognosis, but their role remains to be established in large therapeutic trials...
  88. pmc Regression mapping of association between the human leukocyte antigen region and Graves disease
    Matthew J Simmonds
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, and Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom
    Am J Hum Genet 76:157-63. 2005
    ..However, we cannot yet exclude a primary role for DQA1 or for other polymorphisms that affect DRB1 function or expression...
  89. ncbi request reprint Hyperthyroidism and cardiovascular morbidity and mortality
    Faizel Osman
    Department of Cardiovascular Medicine, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham, England
    Thyroid 12:483-7. 2002
    ....
  90. doi request reprint The effects of acute triiodothyronine therapy on myocardial gene expression in brain stem dead cardiac donors
    Sally R James
    Department of Cardiothoracic Surgery, University Hospitals Birmingham, National Health Service Foundation Trust, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 95:1338-43. 2010
    ..5 and SERCA2a, but not ADRB1 or PLB and is not associated with any improvement in hemodynamic performance...
  91. ncbi request reprint How does glucose insulin potassium improve hemodynamic performance? Evidence for altered expression of beta-adrenoreceptor and calcium handling genes
    Aaron M Ranasinghe
    Department of Cardiothoracic Surgery, University Hospital Birmingham, Birmingham, UK
    Circulation 114:I239-44. 2006
    ..We investigated whether this is associated with changes in gene expression of beta1-adrenergic receptor (ADRB1) or other calcium handling proteins...
  92. ncbi request reprint Role and regulation of the fibroblast growth factor axis in human thyroid follicular cells
    Helen C Cocks
    University of Birmingham, Birmingham B15 2TT, UK
    Am J Physiol Endocrinol Metab 285:E460-9. 2003
    ..We conclude that TSH stimulates FGFR1 but not FGF-2 expression. PKC activation stimulates FGF-2 synthesis and secretion, and TSH synergizes with PKC activators. Increases in FGFR1 or FGF-2 or in both may contribute to goitrogenesis...
  93. ncbi request reprint Placental transport of thyroid hormone
    Sally R James
    Division of Reproductive and Child Health, University of Birmingham, Birmingham, UK
    Best Pract Res Clin Endocrinol Metab 21:253-64. 2007
    ....
  94. ncbi request reprint A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect
    Matthew J Simmonds
    Division of Medical Sciences, University of Birmingham, UK
    Hum Mol Genet 16:2149-53. 2007
    ..Our results point to a primary role for class I-mediated responses in GD, a condition classically assumed to be a straightforward HLA-class II-restricted autoantibody response to the thyroid stimulating hormone receptor...
  95. ncbi request reprint Association of the TSHR gene with Graves' disease: the first disease specific locus
    Bryan M Dechairo
    Target Discovery, Oxagen Ltd, Abingdon OX14 4RY, UK
    Eur J Hum Genet 13:1223-30. 2005
    ..3; AIH, P=NS). These results in two independent Caucasian data sets suggest that the TSHR is the first replicated GD-specific locus meriting further fine mapping and functional analysis to identify the aetiological variants...
  96. ncbi request reprint Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
    ..The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established...
  97. pmc Thyroid function tests and hypothyroidism. Restoring serum TSH to reference range should be goal of replacement
    Mark P Vanderpump
    BMJ 326:1086-7; author reply 1087. 2003
  98. ncbi request reprint Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    Hironori Ueda
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nature 423:506-11. 2003
    ..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction...
  99. ncbi request reprint A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al
    Matthew J Simmonds
    Arthritis Rheum 46:3109-10. 2002
  100. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  101. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....