R J Franklin

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia
    Robin J M Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Brain Res Bull 57:827-32. 2002
  2. ncbi request reprint Why does remyelination fail in multiple sclerosis?
    Robin J M Franklin
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Nat Rev Neurosci 3:705-14. 2002
  3. ncbi request reprint Neuroprotection and repair in multiple sclerosis
    Robin J M Franklin
    Wellcome Trust and MRC Stem Cell Institute, University of Cambridge, UK
    Nat Rev Neurol 8:624-34. 2012
  4. doi request reprint Do your glial cells make you clever?
    Robin J M Franklin
    Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Cell Stem Cell 12:265-6. 2013
  5. pmc Quantification of deficits in lateral paw positioning after spinal cord injury in dogs
    Lindsay Hamilton
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    BMC Vet Res 4:47. 2008
  6. pmc Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis
    Lindsay Hamilton
    Brain Repair Centre and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    BMC Neurosci 8:77. 2007
  7. pmc Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures
    Perrine Barraud
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    BMC Neurosci 9:24. 2008
  8. ncbi request reprint Remyelination by transplanted olfactory ensheathing cells
    Robin J M Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Anat Rec B New Anat 271:71-6. 2003
  9. ncbi request reprint Do olfactory glia have advantages over Schwann cells for CNS repair?
    R J Franklin
    MRC Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, United Kingdom
    J Neurosci Res 50:665-72. 1997
  10. doi request reprint The biology of CNS remyelination: the key to therapeutic advances
    Robin J M Franklin
    Dept of Veterinary Medicine, University of Cambridge, Madingely Road, Cambridge, CB3 0ES
    J Neurol 255:19-25. 2008

Detail Information

Publications80

  1. ncbi request reprint Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia
    Robin J M Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Brain Res Bull 57:827-32. 2002
    ..This article considers some of the properties that would be required of a transplanted myelinogenic cell and assesses the advantages and disadvantages of the currently available cell types...
  2. ncbi request reprint Why does remyelination fail in multiple sclerosis?
    Robin J M Franklin
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Nat Rev Neurosci 3:705-14. 2002
    ..Understanding why remyelination fails is crucial for devising effective methods by which to enhance it...
  3. ncbi request reprint Neuroprotection and repair in multiple sclerosis
    Robin J M Franklin
    Wellcome Trust and MRC Stem Cell Institute, University of Cambridge, UK
    Nat Rev Neurol 8:624-34. 2012
    ..An understanding of these processes could lead to better strategies for the prevention and treatment of axonal loss, which will ultimately benefit patients with MS...
  4. doi request reprint Do your glial cells make you clever?
    Robin J M Franklin
    Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Cell Stem Cell 12:265-6. 2013
    ..In this issue of Cell Stem Cell, Han et al. (2013) transplant human glial progenitors into mouse brains and thereby improve their learning and memory and implicate a previously unknown role for glial cells in contributing to cognition...
  5. pmc Quantification of deficits in lateral paw positioning after spinal cord injury in dogs
    Lindsay Hamilton
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    BMC Vet Res 4:47. 2008
    ..Dogs have a high centre of mass thereby facilitating recognition of lateral instability...
  6. pmc Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis
    Lindsay Hamilton
    Brain Repair Centre and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    BMC Neurosci 8:77. 2007
    ..To achieve this potential a robust method of functional analysis is required so that statistical comparison of numerical data derived from treated and control animals can be achieved...
  7. pmc Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures
    Perrine Barraud
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    BMC Neurosci 9:24. 2008
    ..However, olfactory stem and progenitor cells expand very slowly when grown as free-floating spheres (olfactory-spheres) under growth factor stimulation in a neurosphere assay...
  8. ncbi request reprint Remyelination by transplanted olfactory ensheathing cells
    Robin J M Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Anat Rec B New Anat 271:71-6. 2003
    ....
  9. ncbi request reprint Do olfactory glia have advantages over Schwann cells for CNS repair?
    R J Franklin
    MRC Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, United Kingdom
    J Neurosci Res 50:665-72. 1997
    ..In this article we review the repair properties of olfactory glia and identify the areas in which their use for repairing the CNS may have advantages over Schwann cells...
  10. doi request reprint The biology of CNS remyelination: the key to therapeutic advances
    Robin J M Franklin
    Dept of Veterinary Medicine, University of Cambridge, Madingely Road, Cambridge, CB3 0ES
    J Neurol 255:19-25. 2008
    ..This may represent a promising therapeutic target for promoting remyelination in multiple sclerosis and thus limiting the accumulation of irreversible neurological disability...
  11. ncbi request reprint Understanding CNS remyelination: clues from developmental and regeneration biology
    R J Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    J Neurosci Res 58:207-13. 1999
    ....
  12. doi request reprint Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
    ..The mechanisms of remyelination therefore provide critical clues for regeneration biologists that help them to determine why remyelination fails in MS and in other demyelinating diseases and how it might be enhanced therapeutically...
  13. ncbi request reprint Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination
    M R Kotter
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Glia 35:204-12. 2001
    ....
  14. ncbi request reprint Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS
    Jacques Penderis
    Cambridge Centre for Brain Repair and Centre for Veterinary Sciences, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Eur J Neurosci 18:2253-64. 2003
    ....
  15. ncbi request reprint Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS
    G L Hinks
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Neuropathol Appl Neurobiol 27:59-67. 2001
    ....
  16. pmc CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination
    Malgorzata Zawadzka
    MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cell Stem Cell 6:578-90. 2010
    ....
  17. ncbi request reprint Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system
    Chrystelle Ibanez
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Glia 55:144-51. 2007
    ..These data, supported by Western blotting, indicate that calponin can not be used to distinguish adult OECs and Schwann cells...
  18. ncbi request reprint Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression
    Mark R Kotter
    Cambridge Centre for Brain Repair, and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Neurobiol Dis 18:166-75. 2005
    ..These data suggest that the macrophage response to toxin-induced demyelination influences the growth factor environment, thereby affecting the behavior of OPCs and hence the efficiency of remyelination...
  19. ncbi request reprint Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination
    Mark F Stidworthy
    Cambridge Centre for Brain Repair and Centre for Veterinary Sciences, University of Cambridge, UK
    Brain 127:1928-41. 2004
    ..More generally, the re-expression of developmentally expressed genes following injury in the adult does not per se imply similar function...
  20. ncbi request reprint The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 22:2451-9. 2002
    ....
  21. doi request reprint Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination
    Chao Zhao
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Neurobiol Dis 31:209-17. 2008
    ..There was no difference in the rate of remyelination between the two groups indicating that OPN is not a critical component of remyelination...
  22. ncbi request reprint The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination
    P M Smith
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, UK
    J Neuroimmunol 119:261-8. 2001
    ..These results demonstrate that cyclophosphamide is deleterious to oligodendrocyte remyelination and for this reason should be used with caution in patients with demyelinating disease...
  23. ncbi request reprint Bridging the divide: spinal cord repair by cellular transplantation--from research laboratory to therapeutic application
    N D Jeffery
    Department of Clinical Veterinary Medicine, University of Cambridge
    J Small Anim Pract 42:428-32. 2001
    ..This article describes the experiments which have generated this optimism and considers the steps that will be required to make the transition from laboratory experiments to clinical application...
  24. ncbi request reprint Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    Chao Zhao
    Cambridge Center for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Neurobiol Aging 27:1298-307. 2006
    ..These data relate the age-associated delay in remyelination efficiency to changes in the macrophage and inflammatory mediator response to demyelination...
  25. ncbi request reprint Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system
    Jacques Penderis
    Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Brain 126:1382-91. 2003
    ..These results indicate that repeated CNS demyelination, which has the opportunity to repair in the intervening period, is not characterized by impaired remyelination or depletion of OPCs...
  26. ncbi request reprint Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination
    Wen Wu Li
    Cambridge Centre for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Neuroimmunol 158:58-66. 2005
    ..These results indicate that microglia/macrophage activation is an important process for remyelination and further support the concept that suppression of inflammatory response may impair remyelination...
  27. ncbi request reprint Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS
    Mark D Dunning
    Cambridge Center for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 24:9799-810. 2004
    ..These studies demonstrate the feasibility of noninvasive imaging of transplanted SCs and OECs and represent a significant step toward the clinical application of promising experimental approaches...
  28. ncbi request reprint SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells
    P M Smith
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Glia 36:342-53. 2001
    ....
  29. ncbi request reprint Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres
    Mark D Dunning
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Neuroimage 31:172-80. 2006
    ....
  30. ncbi request reprint Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology
    Malgorzata Zawadzka
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Curr Opin Neurol 20:294-8. 2007
    ..The following article reviews recent advances in remyelination biology and its presentation in demyelinating diseases such as multiple sclerosis. It is based primarily on articles published during 2006...
  31. doi request reprint Transplanted oligodendrocyte precursor cells reduce neurodegeneration in a model of glaucoma
    Natalie D Bull
    Centre for Brain Repair and National Institute for Health Research Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 50:4244-53. 2009
    ..The purpose of our investigation was to determine whether oligodendrocyte precursor cells (OPCs), a type of neural stem cell, can protect retinal ganglion cells (RGCs) from glaucomatous damage in vivo...
  32. ncbi request reprint Mechanisms of CNS remyelination--the key to therapeutic advances
    Chao Zhao
    Cambridge Centre for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, Madingley Road, University of Cambridge, Cambridge CB3 0ES, UK
    J Neurol Sci 233:87-91. 2005
    ....
  33. ncbi request reprint Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells
    Andras Lakatos
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Brain 126:598-609. 2003
    ..These results highlight the important concept that the regenerative properties of OECs are profoundly influenced by the cells with which they are transplanted...
  34. ncbi request reprint Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells
    Anna Setzu
    Cambridge Centre for Brain Repair and MS Society Cambridge Centre for Myelin Repair, University of Cambridge, Cambridge, United Kingdom
    Glia 54:297-303. 2006
    ..Our results have important implications for the development of immunomodulatory treatments for acute demyelinating disease and for the therapeutic creation of proremyelination environments in chronic demyelinating disease...
  35. ncbi request reprint Transplant mediated repair of the central nervous system: an imminent solution?
    Andras Lakatos
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Curr Opin Neurol 15:701-5. 2002
    ..This article reviews recent advances in the use of cell transplantation to promote recovery from traumatic injury of the CNS, focusing on axonal regeneration in the spinal cord...
  36. ncbi request reprint Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    Mark R Kotter
    Cambridge Centre for Brain Repair, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 26:328-32. 2006
    ..These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration...
  37. ncbi request reprint Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS
    Wen Wu Li
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Exp Neurol 202:250-4. 2006
    ..These results indicate a sex-associated divergence in remyelination efficiency that occurs with ageing that is unaffected by the removal of gonadal sources of sex steroid hormones...
  38. ncbi request reprint Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter
    Andras Lakatos
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, UK
    Exp Neurol 184:237-46. 2003
    ....
  39. ncbi request reprint Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS
    Stephen P J Fancy
    Cambridge Centre for Brain Repair and Centre for Veterinary Sciences, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    Mol Cell Neurosci 27:247-54. 2004
    ..2 and Olig2 plays a critically important role in the differentiation of adult OPCs into remyelinating oligodendrocytes and that these genes may present novel targets for therapeutic manipulation in cases where remyelination is impaired...
  40. ncbi request reprint The Brown Animal Sanatory Institution--historical lessons for the present?
    R J Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Vet J 159:231-7. 2000
    ..Many of its aspirations, achievements and difficulties are relevant and comparable to those faced by the profession today...
  41. doi request reprint An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss
    David W Hampton
    Cambridge Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 2PY UK
    J Neuroimmunol 201:200-11. 2008
    ..Together with the clinical pattern, our findings identify chronic EAE as an excellent model of secondary progressive multiple sclerosis...
  42. doi request reprint Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects
    Clare E Buckley
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Neuropharmacology 59:149-59. 2010
    ....
  43. ncbi request reprint Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs
    Barbara J Skelly
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet J 174:652-4. 2007
    ....
  44. pmc Myelin repair: the role of stem and precursor cells in multiple sclerosis
    Siddharthan Chandran
    Cambridge Centre for Brain Repair, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK
    Philos Trans R Soc Lond B Biol Sci 363:171-83. 2008
    ..This review considers the basic and clinical biology of remyelination and the potential contribution of stem and precursor cells to enhance and supplement spontaneous remyelination...
  45. doi request reprint Remyelination - An effective means of neuroprotection
    Charlotte C Bruce
    Cambridge Centre for Brain Repair, University of Cambridge, UK
    Horm Behav 57:56-62. 2010
    ..This has created a compelling case for developing therapies that promote remyelination: evidence from experimental animal models suggests that hormones may have a beneficial role to play in this regard...
  46. ncbi request reprint Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
    Mol Cell Neurosci 20:669-82. 2002
    ....
  47. ncbi request reprint Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury
    Nick D Jeffery
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Neurotrauma 22:1282-93. 2005
    ..Of this population, 72% were p75(+) OGC, 20% were meningeal cells, and the remainder mainly astrocytes. Intraspinal transplantation was not associated with any observable long- or short-term complications...
  48. ncbi request reprint Recognition and diagnosis of lysosomal storage diseases in the cat and dog
    Barbara J Skelly
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    J Vet Intern Med 16:133-41. 2002
    ..Many features of storage diseases make them difficult to recognize and diagnose. In this review, we summarize the clinical features of these diseases and outline the steps required to confirm a diagnosis...
  49. ncbi request reprint Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells
    Perrine Barraud
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Eur J Neurosci 26:3345-57. 2007
    ..In contrast, EGF appears to be primarily a survival factor for both the olfactory stem and precursor cells...
  50. ncbi request reprint CNS axons retain their competence for myelination throughout life
    Anna Setzu
    Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Glia 45:307-11. 2004
    ..This finding suggests that chronically demyelinated regions of axons such as those in seen in multiple sclerosis are likely to remain competent to be remyelinated...
  51. ncbi request reprint Neuroscience. The mysteries of myelin unwrapped
    Charles ffrench-Constant
    Department of Pathology, University of Cambridge, UK
    Science 304:688-9. 2004
  52. doi request reprint Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination
    Chao Zhao
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    J Neurosci Res 87:3447-55. 2009
    ....
  53. ncbi request reprint Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system
    Divya M Chari
    Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    J Neurosci Res 83:594-605. 2006
    ..The potential consequences of delayed remyelination in inflammatory lesions are discussed...
  54. ncbi request reprint Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS
    Divya M Chari
    Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Exp Neurol 198:145-53. 2006
    ..Transplanted OPCs could only be established in tissue that had been exposed to > or =20 Gy. Since 20 Gy is close to the ED50 for radiation necrosis, our findings demonstrate the limitation of OPC replacement strategies...
  55. ncbi request reprint Quantifying the early stages of remyelination following cuprizone-induced demyelination
    Mark F Stidworthy
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Brain Pathol 13:329-39. 2003
    ..We also noted axonal pathology that persisted for at least 2 weeks after cuprizone withdrawal...
  56. ncbi request reprint Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture
    Daisuke Ito
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Cell Transplant 16:1021-7. 2008
    ....
  57. doi request reprint Temporal dynamics of myelination in the zebrafish spinal cord
    Clare E Buckley
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Glia 58:802-12. 2010
    ..This study confirms the use of the zebrafish larvae as a versatile and efficient in vivo model of myelination and provides a platform on which future myelination screening studies can be based...
  58. doi request reprint FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures
    Perrine Barraud
    MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Exp Cell Res 316:1489-99. 2010
    ..These data demonstrate that FGF2 but not EGF permit the maintenance of a subset of cells responsive to FGF2 and EGF, whereas EGF induces unresponsive to either growth factor possibly via intrinsic mechanisms of regulation...
  59. pmc Stem cells, progenitors and myelin repair
    Chao Zhao
    Cambridge Centre for Brain Repair and The Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, UK
    J Anat 207:251-8. 2005
    ....
  60. ncbi request reprint Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: defining cellular targets
    Chao Zhao
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Neurol Sci 265:12-6. 2008
    ....
  61. ncbi request reprint Lentiviral vectors for gene delivery to normal and demyelinated white matter
    Chao Zhao
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Glia 42:59-67. 2003
    ....
  62. doi request reprint Taking ageing into account in remyelination-based therapies for multiple sclerosis
    Julia M Rist
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Neurol Sci 274:64-7. 2008
    ....
  63. ncbi request reprint Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination
    J B Relvas
    Department of Medical Genetics and Cambridge Centre for Brain Repair, University Forvie Site, Robinson Way, CB2 2PY, Cambridge, United Kingdom
    Curr Biol 11:1039-43. 2001
    ....
  64. ncbi request reprint Progressive encephalomyelopathy and cerebellar degeneration in 10 captive-bred cheetahs
    A C Palmer
    Department of Clinical Veterinary Medicine, University of Cambridge
    Vet Rec 149:49-54. 2001
    ..The olivary nucleus was necrotic. There were foci of inflammatory cells in the molecular layer of the cerebellum and in the medulla. The cause of the disease remains unknown...
  65. ncbi request reprint Comparison of cell populations derived from canine olfactory bulb and olfactory mucosal cultures
    Daisuke Ito
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Am J Vet Res 67:1050-6. 2006
    ..To evaluate the numbers and proportions of olfactory ensheathing cells (OECs) in cell cultures derived from the olfactory bulb (OB) and olfactory mucosa of dogs...
  66. ncbi request reprint Ageing and CNS remyelination
    Robin J M Franklin
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Neuroreport 13:923-8. 2002
    ..Based on these differences, a conceptual framework is proposed to explain the age-associated effects on remyelination, which we have called the dysregulation hypothesis, and the feasibility of reversing these effects is discussed...
  67. ncbi request reprint Myelination and behaviour of tenascin-C null transgenic mice
    B W Kiernan
    Wellcome CRC Institute of Developmental Biology and Cancer, Cambridge, UK
    Eur J Neurosci 11:3082-92. 1999
    ..The effects on coordination are, however, not seen on a 129 genetic background. Taken together, these results significantly extend the phenotype associated with tenascin-C deficiency but argue against a role in myelination...
  68. pmc Zebrafish myelination: a transparent model for remyelination?
    Clare E Buckley
    Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK
    Dis Model Mech 1:221-8. 2008
    ..However, experimental outputs must be designed carefully for such visual and temporal techniques...
  69. doi request reprint Cellular responses in the spinal cord during development of hypomyelination in the mv rat
    Takeshi Izawa
    Department of Veterinary Sciences, Osaka Prefecture University, Gakuencho 1 1, Nakaku, Sakai, Osaka 599 8531, Japan
    Brain Res 1195:120-9. 2008
    ..The data suggest that attractin may be directly involved in the function of oligodendrocytes in CNS myelination...
  70. ncbi request reprint Tyrosine kinases: maiming myelin in leprosy
    Robin J M Franklin
    Nat Med 12:889-90. 2006
  71. ncbi request reprint Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins
    Sarah K Williams
    Division of Clinical Neuroscience, University of Glasgow, Beatson Laboratories, Glasgow G61 1BD, United Kingdom
    J Comp Neurol 470:50-62. 2004
    ....
  72. ncbi request reprint Olig gene function in CNS development and disease
    Keith L Ligon
    Department of Pathology, Division of Neuropathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Glia 54:1-10. 2006
    ..Studies of Olig expression in human brain tumors and repair of demyelinating lesions suggest the possibility of additional functions in a variety of neurological diseases...
  73. ncbi request reprint Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination
    Rachel H Woodruff
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, UK
    Mol Cell Neurosci 25:252-62. 2004
    ..Nevertheless, our experiments show that it is possible to increase OPC population density in demyelinated areas by artificially increasing the supply of PDGF...
  74. ncbi request reprint bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS
    Heather A Arnett
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 306:2111-5. 2004
    ..Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis...
  75. ncbi request reprint Obtaining olfactory ensheathing cells from extra-cranial sources a step closer to clinical transplant-mediated repair of the CNS?
    Robin J M Franklin
    Brain 125:2-3. 2002
  76. ncbi request reprint Enhancing central nervous system remyelination in multiple sclerosis
    Monique Dubois-Dalcq
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 48:9-12. 2005
    ..Here we raise issues highlighted by prior experimental and human work that should be considered lest these studies become "lost in translation."..
  77. ncbi request reprint Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination
    Yves Benninger
    Institute for Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Neurosci 26:7665-73. 2006
    ..We conclude that, although beta1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS...
  78. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    ..Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles...
  79. ncbi request reprint Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS
    Tina Thurnherr
    Institute for Cell Biology, Department of Biology, Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 26:10110-9. 2006
    ....
  80. ncbi request reprint The phagocytic capacity of neurones
    Samantha Bowen
    Neuroscience Centre and Pathology Group, Queen Mary s School of Medicine and Dentistry, Institute of Pathology, Royal London Hospital, London, UK
    Eur J Neurosci 25:2947-55. 2007
    ....