Clyde Francks

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 12:3225-30. 2003
  2. pmc LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
    C Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 12:1129-39, 1057. 2007
  3. pmc A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 75:1046-58. 2004
  4. pmc A genomewide linkage screen for relative hand skill in sibling pairs
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 70:800-5. 2002
  5. ncbi request reprint Familial and genetic effects on motor coordination, laterality, and reading-related cognition
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Am J Psychiatry 160:1970-7. 2003
  6. pmc Use of multivariate linkage analysis for dissection of a complex cognitive trait
    Angela J Marlow
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 72:561-70. 2003
  7. pmc A genomewide scan for loci involved in attention-deficit/hyperactivity disorder
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 70:1183-96. 2002
  8. ncbi request reprint Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Psychiatr Genet 12:35-41. 2002
  9. ncbi request reprint The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
    Silvia Paracchini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 15:1659-66. 2006
  10. ncbi request reprint The genetic basis of dyslexia
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Lancet Neurol 1:483-90. 2002

Detail Information

Publications19

  1. ncbi request reprint Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 12:3225-30. 2003
    ..The linkages may be due to a single maternally imprinted influence on lateralized brain development that contains common functional polymorphisms...
  2. pmc LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
    C Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 12:1129-39, 1057. 2007
    ..LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution...
  3. pmc A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 75:1046-58. 2004
    ..In addition, the QTL effect may be largely limited to the severe range of reading disability...
  4. pmc A genomewide linkage screen for relative hand skill in sibling pairs
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 70:800-5. 2002
    ..13. Relative hand skill therefore is probably a complex multifactorial phenotype with a heterogeneous background, but nevertheless is amenable to QTL-based gene-mapping approaches...
  5. ncbi request reprint Familial and genetic effects on motor coordination, laterality, and reading-related cognition
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Am J Psychiatry 160:1970-7. 2003
    ..With a large sample, the authors aimed to investigate genetic relationships between measures of reading-related cognition, hand motor skill, and hand skill lateralization...
  6. pmc Use of multivariate linkage analysis for dissection of a complex cognitive trait
    Angela J Marlow
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 72:561-70. 2003
    ..The approach employed here may aid positional cloning of susceptibility genes in a wide spectrum of complex traits...
  7. pmc A genomewide scan for loci involved in attention-deficit/hyperactivity disorder
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 70:1183-96. 2002
    ..Two of the regions highlighted in the present study, 2q24 and 16p13, coincided with the top linkage peaks reported by a recent genome-scan study of autistic sib pairs...
  8. ncbi request reprint Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Psychiatr Genet 12:35-41. 2002
    ..Our study outlines the approach necessary for the identification of genetic variants causing dyslexia susceptibility in an epidemiological population of dyslexics...
  9. ncbi request reprint The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
    Silvia Paracchini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 15:1659-66. 2006
    ..2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex...
  10. ncbi request reprint The genetic basis of dyslexia
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Lancet Neurol 1:483-90. 2002
    ..These genomic regions contain tens or hundreds of candidate genes, and studies aimed at the identification of the specific causal genetic variants are underway...
  11. doi request reprint Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity
    Clyde Francks
    University of Oxford, UK
    Laterality 14:11-6. 2009
    ..2007) published a substantial body of evidence implicating LRRTM1 in handedness and schizophrenia. Progress will now be achieved by others trying to validate, refute, or extend those findings, rather than by further armchair discussion...
  12. ncbi request reprint Genes, cognition and dyslexia: learning to read the genome
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Cogn Sci 10:250-7. 2006
    ..Dissection of cognitive mechanisms that subserve reading will ultimately depend on an integrated approach, uniting data from genetic investigations, behavioural studies and neuroimaging...
  13. ncbi request reprint Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Genet 30:86-91. 2002
    ..This is the first report of QTL-based genome-wide scanning for a human cognitive trait...
  14. pmc Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    Jason Z Liu
    Department of Statistics, University of Oxford, Oxford, UK
    Nat Genet 42:436-40. 2010
    ..Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3...
  15. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  16. pmc Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11
    Matthew N Ogdie
    Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
    Am J Hum Genet 75:661-8. 2004
    ..The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size...
  17. pmc A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11
    Matthew N Ogdie
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Hum Genet 72:1268-79. 2003
    ..Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism...
  18. pmc Confirmatory evidence for linkage of relative hand skill to 2p12-q11
    Clyde Francks
    Am J Hum Genet 72:499-502. 2003
  19. pmc Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism
    Susan L Smalley
    Center for Neurobehavioral Genetics and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024USA
    Am J Hum Genet 71:959-63. 2002
    ..These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism...