Margaret C Frame

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. Frame M, Patel H, Serrels B, Lietha D, Eck M. The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol. 2010;11:802-14 pubmed publisher
    ..Importantly, the FAK FERM domain might act as a paradigm for the actions of other FERM domain-containing proteins. ..
  2. Serrels B, McGivern N, Canel M, Byron A, Johnson S, McSorley H, et al. IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks. Sci Signal. 2017;10: pubmed publisher
    ..Our data provide mechanistic insight into how FAK controls the tumor immune environment, namely, through a transcriptional regulatory network mediated by nuclear IL-33. Targeting this axis may boost antitumor immunity in patients. ..
  3. Frame M, Serrels A. FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling. Cancer Cell. 2015;27:429-31 pubmed publisher
  4. Sandilands E, Schoenherr C, Frame M. p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy. Cell Signal. 2015;27:1816-23 pubmed publisher
    ..We therefore deduce that the FAK-regulated signalling module PDK1-Akt-p70S6K that controls Src's intracellular trafficking operates at Src-containing autophagosomes. ..
  5. Serrels A, Lund T, Serrels B, Byron A, McPherson R, von Kriegsheim A, et al. Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity. Cell. 2015;163:160-73 pubmed publisher
    ..Therefore, FAK inhibitors may trigger immune-mediated tumor regression, providing previously unrecognized therapeutic opportunities. ..
  6. Kanellos G, Zhou J, Patel H, Ridgway R, Huels D, Gurniak C, et al. ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival. Cell Rep. 2015;13:1949-64 pubmed publisher
  7. Frame M, Norman J. A tal(in) of cell spreading. Nat Cell Biol. 2008;10:1017-9 pubmed publisher
    ..New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function. ..
  8. Schoenherr C, Serrels B, Proby C, Cunningham D, Findlay J, Baillie G, et al. Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells. J Cell Sci. 2014;127:5303-16 pubmed publisher