Stephen B Fox

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers
    J Chakrabarti
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Br J Cancer 91:954-8. 2004
  2. ncbi request reprint CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha
    Stephen B Fox
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital and Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, UK
    Cancer Res 64:6075-81. 2004
  3. ncbi request reprint Histological quantitation of tumour angiogenesis
    Stephen B Fox
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    APMIS 112:413-30. 2004
  4. ncbi request reprint Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus
    Stephen B Fox
    CRUK Tumour Pathology Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Pathol 202:313-20. 2004
  5. ncbi request reprint Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas
    Stephen B Fox
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Clin Cancer Res 10:3521-7. 2004
  6. pmc Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer
    Ern Yu Tan
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Breast Cancer Res 9:R89. 2007
  7. ncbi request reprint Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival
    Leticia Campo
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    J Pathol 205:585-91. 2005
  8. ncbi request reprint BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer
    Ern Yu Tan
    Nuffield Department of Clinical Laboratory Sciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Clin Cancer Res 13:467-74. 2007
  9. ncbi request reprint Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas
    Gaynor J Bates
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
    Breast Cancer Res Treat 111:453-9. 2008
  10. ncbi request reprint Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer
    Daniele Generali
    Weatherall Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Endocr Relat Cancer 13:921-30. 2006

Collaborators

Detail Information

Publications40

  1. pmc The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers
    J Chakrabarti
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Br J Cancer 91:954-8. 2004
    ..Reversing this phenotype may alter the biological behaviour of individual tumours...
  2. ncbi request reprint CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha
    Stephen B Fox
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital and Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, UK
    Cancer Res 64:6075-81. 2004
    ..This may be an important mechanism by which tumors enhance hypoxia-inducible factor expression and result in an aggressive phenotype...
  3. ncbi request reprint Histological quantitation of tumour angiogenesis
    Stephen B Fox
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    APMIS 112:413-30. 2004
    ..Gene arrays may be able to provide an angiogenesis profile. Continued study into the processes involved in generating a tumour blood supply is likely to identify new markers that may be more accurate measures...
  4. ncbi request reprint Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus
    Stephen B Fox
    CRUK Tumour Pathology Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Pathol 202:313-20. 2004
    ..It further suggests that cells traffic pKDR depending on the precise KDR tyrosines that are autophosphorylated in a manner that enables receptor activation to result in different functions...
  5. ncbi request reprint Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas
    Stephen B Fox
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Clin Cancer Res 10:3521-7. 2004
    ..The FOXP1 gene, which maps to 3p14, shows common loss of heterozygosity in breast tumors and is a candidate tumor suppressor gene. However, its role in breast cancer is unknown...
  6. pmc Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer
    Ern Yu Tan
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Breast Cancer Res 9:R89. 2007
    ..The present study investigates the role of FIH-1 in invasive breast carcinoma and its correlation with hypoxia...
  7. ncbi request reprint Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival
    Leticia Campo
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    J Pathol 205:585-91. 2005
    ..63) survival was observed in patients stratified by angiogenin expression. This study suggests that angiogenin may be important in breast cancer progression and that, through its relationship with ER, it may be a target for tamoxifen...
  8. ncbi request reprint BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer
    Ern Yu Tan
    Nuffield Department of Clinical Laboratory Sciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Clin Cancer Res 13:467-74. 2007
    ..Its perinecrotic localization within ductal carcinoma in situ (DCIS) suggests an involvement in neoplastic cellular adaptation to low oxygen tension. This study has investigated the role of BNIP3 in normal and neoplastic breast...
  9. ncbi request reprint Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas
    Gaynor J Bates
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
    Breast Cancer Res Treat 111:453-9. 2008
    ..FOXP1 is not estrogen regulated and silencing FOXP1 expression, using siRNA, did not affect ERalpha, ERbeta or progesterone receptor expression, suggesting ER and FOXP1 co-expression may reflect a common regulatory mechanism...
  10. ncbi request reprint Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer
    Daniele Generali
    Weatherall Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Endocr Relat Cancer 13:921-30. 2006
    ..Studies investigating the effects of pH on tamoxifen uptake and the effects of therapy with CA inhibitors are planned...
  11. doi request reprint Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer
    Daniele Generali
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Clin Oncol 27:227-34. 2009
    ..We aimed to identify signaling pathways involved in the response and resistance to aromatase inhibitor therapy in patients with breast cancer...
  12. ncbi request reprint Regulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer
    Daniele Generali
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Cancer Res 13:550-8. 2007
    ..The HAI-2 predictive role was assessed in T(2-4) N(0-1) breast cancers (n = 177) enrolled in a neoadjuvant randomized trial comparing epirubicin versus epirubicin + tamoxifen...
  13. doi request reprint Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
    Daniele Generali
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Cancer Res 14:2673-80. 2008
    ..However, the effects of endocrine therapy with aromatase inhibitors on in vivo expression of this signaling cascade, and its relation to tumor response and patient outcome, is unknown...
  14. doi request reprint Immunomodulation of FOXP3+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients
    Daniele Generali
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Cancer Res 15:1046-51. 2009
    ....
  15. ncbi request reprint Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia
    Alison H Banham
    Nuffield Department Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Prostate 67:1091-8. 2007
    ..This study investigated whether FOXP1 has a similar relationship to the androgen receptor (AR) in prostate cancer and how these factors relate to the presence of hypoxia...
  16. ncbi request reprint Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    Gaynor J Bates
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    J Clin Oncol 24:5373-80. 2006
    ..To assess the clinical significance of tumor-infiltrating FOXP3-positive regulatory T cells (TR) in breast cancer patients with long-term follow-up...
  17. ncbi request reprint Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
    Daniele Generali
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Cancer Res 12:4562-8. 2006
    ....
  18. doi request reprint Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival
    John Q Davies
    Sir William Dunn School of Pathology, University of Oxford, The Nuffield Department of Clinical Laboratory Sciences and Molecular Oncology, John Radcliffe Hospital, Oxford, UK
    Oncol Rep 25:619-27. 2011
    ..The association of improved patient survival with higher nuclear expression levels identifies EMR2 as a potential biomarker in patients with invasive breast cancer...
  19. pmc The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis
    Leonid L Nikitenko
    Authors Affiliations Cancer Research UK Viral Oncology Group and Sarcoma Biology Group, UCL Cancer Institute, University College London, London Keble College, Linacre College, Nuffield Department of Clinical Laboratory Sciences Cancer Research UK Oncology Laboratory, Weatherall Institute of Molecular Medicine Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom Scientific Centre of the Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences, Irkutsk, Russia Unità di Patologia Mammaria Senologia e Breast, Unit Centro di Medicina Molecolare, Istituti Ospitalieri di Cremona, Cremona, Italy Department of Pathology, Cancer Society Tissue Bank, University of Otago, Christchurch, New Zealand Department of Pathology, University of Melbourne, Parkville and Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Clin Cancer Res 19:5740-8. 2013
    ..We therefore investigated the diagnostic/prognostic use for CLR in human tumor types that may rely on adrenomedullin signaling and in clear cell renal cell carcinoma (RCC), a highly vascular tumor, in particular...
  20. ncbi request reprint Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade
    Heidi Michelle Sowter
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    J Pathol 201:573-80. 2003
    ..BNip3 was present in tumour-associated macrophages and in apocrine metaplastic lesions. Expression of NIX did not correlate with any of the parameters investigated...
  21. ncbi request reprint c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism
    Ulrike E Knies-Bamforth
    Molecular Oncology Laboratory, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Cancer Res 64:6563-70. 2004
    ..Blocking VEGF signaling in vivo significantly reduced dermal angiogenesis, demonstrating the importance of VEGF as a mediating factor for the c-Myc-induced angiogenic phenotype...
  22. ncbi request reprint Quantitative angiogenesis in breast cancer
    Stephen B Fox
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, UK
    Methods Mol Med 120:161-87. 2006
    ....
  23. ncbi request reprint Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection
    Scott M Ward
    Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, South Parks Road, Oxford, UK
    J Hepatol 47:316-24. 2007
    ..We wished to address to what extent regulatory T cells exist in the livers of HCV+ individuals, and what the role of such cells might be in disease progression...
  24. ncbi request reprint Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing
    Stephen Atkinson
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    J Pathol 203:721-8. 2004
    ..VEGF may synergize with PDGF in inducing the stromal and vascular changes present in digital clubbing...
  25. ncbi request reprint Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms
    Leonid L Nikitenko
    Nuffield Department of Obstetrics and Gynaecology, The University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Cell Sci 119:910-22. 2006
    ..These novel findings regarding regulation of EndoCL function in endothelial cells are likely to be of importance in conditions where AM or CGRP levels are elevated, such as cardiovascular disease, diabetes and inflammation...
  26. pmc Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients
    Khoon Lin Ling
    Tumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Cancer Immun 7:7. 2007
    ....
  27. ncbi request reprint The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis
    Cecile G Colpaert
    Department of Pathology, University Hospital Antwerp, University of Antwerp, Edegem, Belgium
    Breast Cancer Res Treat 81:137-47. 2003
    ..FF is useful as a surrogate marker of hypoxia-driven ongoing angiogenesis and is associated with a higher relapse rate and a worse overall survival...
  28. ncbi request reprint The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression
    Vickie Hanrahan
    Angiogenesis Research Group, Department of Pathology, Christchurch School of Medicine Health Sciences, Christchurch, New Zealand
    J Pathol 200:183-94. 2003
    ....
  29. ncbi request reprint Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia
    Margaret J Currie
    Pathology Department, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand
    J Pathol 198:502-10. 2002
    ..These data suggest that it is endothelial induction of Ang-2 in tumours that regulates vessel stability and supports targeting Tie2 as an effective novel anti-angiogenic therapy in clear cell RCCs...
  30. pmc Breast tumour angiogenesis
    Stephen B Fox
    Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, 3002, Australia
    Breast Cancer Res 9:216. 2007
    ..The regulation of angiogenesis and the antivascular agents that are used in an antiangiogenic dosing schedule, both novel and conventional, are also summarized...
  31. doi request reprint Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines
    Nadeem Shaida
    Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, United Kingdom
    Prostate 68:336-43. 2008
    ..BNIP3 is a hypoxia-induced protein involved in cell death and survival but its role in human tumors is unclear. This study investigated the role of BNIP3 in prostate cancer...
  32. ncbi request reprint Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility
    Karl Rodins
    Anatomical Pathology, Canterbury Health Laboratories, Christchurch Hospital, Christchurch, New Zealand 8001
    Clin Cancer Res 8:1075-81. 2002
    ..The Mcm proteins are essential for initiating eukaryotic DNA replication and serve as useful markers of proliferating cells...
  33. ncbi request reprint Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification
    Ilse Van der Auwera
    Translational Cancer Research Group Antwerp Lab Pathology University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Clin Cancer Res 10:7965-71. 2004
    ..The aim of this study was to confirm the angiogenic phenotype of inflammatory breast cancer and to investigate its potential to induce lymphangiogenesis...
  34. ncbi request reprint The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2alpha but not HIF-1alpha
    Stephen B Fox
    Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Australia
    Prostate 67:623-9. 2007
    ..Regulatory T cells (T(R)) mediate peripheral immunological tolerance and are implicated in tumor progression. Because prostate cancer is being investigated for treatment by immunotherapy, we have assessed tumor T(R) in prostate cancers...
  35. ncbi request reprint Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis
    Steven Van Laere
    Translational Cancer Research Group, Lab Pathology, University of Antwerp University Hospital Antwerp, Edegem and General Hospital, Sint Augustinus, Wilrijk, Belgium
    Breast Cancer Res Treat 93:237-46. 2005
    ..The results of our study provide potential targets for the treatment of patients with IBC...
  36. ncbi request reprint The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
    Jane L Boddy
    Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK
    Clin Cancer Res 11:7658-63. 2005
    ..The study aimed to assess whether a relationship exists in human prostate cancer between expression of the androgen receptor, HIFs, and the key angiogenesis factor, vascular endothelial growth factor (VEGF)...
  37. pmc High resolution melting for mutation scanning of TP53 exons 5-8
    Michael Krypuy
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    BMC Cancer 7:168. 2007
    ..We therefore evaluated the use of high resolution melting (HRM) as a rapid mutation scanning tool for TP53 in tumour samples...
  38. pmc Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis
    Elena A Takano
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    BMC Cancer 8:59. 2008
    ....
  39. ncbi request reprint Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    Richard W Tothill
    Peter MacCallum Cancer Center, University of Melbourne, Melbourne, Australia
    Clin Cancer Res 14:5198-208. 2008
    ..The study aim to identify novel molecular subtypes of ovarian cancer by gene expression profiling with linkage to clinical and pathologic features...
  40. ncbi request reprint Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients
    Alberto Bottini
    Breast Unit and Anatomia Patologica, Azienda Ospedaliera Istituti Ospitalieri Cremona, Italy
    J Clin Oncol 24:3623-8. 2006
    ..To investigate the activity of letrozole plus/minus oral metronomic cyclophosphamide as primary systemic treatment (PST) in elderly breast cancer patients...