Nick C Fox

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    N C Fox
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 358:201-5. 2001
  2. ncbi Imaging cerebral atrophy: normal ageing to Alzheimer's disease
    Nick C Fox
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Lancet 363:392-4. 2004
  3. ncbi The analysis of repeated 'direct' measures of change illustrated with an application in longitudinal imaging
    Chris Frost
    Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Stat Med 23:3275-86. 2004
  4. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
  5. pmc Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Alzheimers Res Ther 3:1. 2011
  6. ncbi Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    N C Fox
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurology 64:1563-72. 2005
  7. doi Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trials
    Nick C Fox
    The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 57:15-8. 2011
  8. pmc Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
  9. doi An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
  10. ncbi Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008

Detail Information

Publications123 found, 100 shown here

  1. ncbi Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    N C Fox
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 358:201-5. 2001
    ..We used an imaging technique known as voxel-compression mapping to localise progressive atrophy in patients with preclinical Alzheimer's disease...
  2. ncbi Imaging cerebral atrophy: normal ageing to Alzheimer's disease
    Nick C Fox
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Lancet 363:392-4. 2004
    ..Such use of MRI requires accurate understanding of how brain changes in normal ageing differ from those in dementia...
  3. ncbi The analysis of repeated 'direct' measures of change illustrated with an application in longitudinal imaging
    Chris Frost
    Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Stat Med 23:3275-86. 2004
    ..We illustrate the use of our models with data from a cohort of patients with Alzheimer's disease...
  4. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  5. pmc Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Alzheimers Res Ther 3:1. 2011
    ..Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention...
  6. ncbi Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    N C Fox
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurology 64:1563-72. 2005
    ..Reported are MRI findings of a Phase IIa immunotherapy trial in AD prematurely terminated owing to meningoencephalitis in a subset of patients...
  7. doi Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trials
    Nick C Fox
    The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 57:15-8. 2011
    ..In the absence of a "gold standard", we discuss a number of steps against which methodologies designed to quantify atrophy from serial scans can be assessed...
  8. pmc Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
    ..To describe the clinical, neuropsychologic, and radiologic features of a family with a C31LfsX35 mutation in the progranulin gene CCDS11483.1)...
  9. doi An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
    ..The model and its formulation extend naturally to a wide range of other diseases and developmental processes and accommodate cross-sectional and longitudinal input data...
  10. ncbi Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008
    ..Both cognitive tests and MRI-based measures have been suggested as outcomes in trials assessing disease-modifying therapies in Alzheimer's disease (AD)...
  11. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
    ..MAPS-HBSI required the lowest sample sizes (78 subjects) for a hypothetical trial. In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD...
  12. ncbi Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College, London, UK
    J Neurol 256:203-12. 2009
    ..Overall we have demonstrated that increased CAG repeat length is associated with atrophy in extra-striatal as well as striatal regions, which has implications for the monitoring of disease-modifying therapies in the condition...
  13. ncbi Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  14. ncbi Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, UK
    Neuroimage 47:1659-65. 2009
    ..We describe and evaluate an automated technique based on a local registration and boundary shift integral (BSI) approach at the caudate-CSF and caudate-white matter boundaries; caudate boundary shift integral (CBSI)...
  15. ncbi The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
    ..They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and early HD compared with controls...
  16. ncbi Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
    ..We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs...
  17. ncbi Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal data
    Oscar Camara
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 10:785-92. 2007
    ..Mean absolute error differences between volume changes given by the FFD-based technique and the gold standard were: sulcal CSF < 2.49%; lateral ventricles < 2.25%; brain < 0.36%; hippocampi < 1.42%...
  18. ncbi Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, England
    Arch Neurol 62:1402-8. 2005
    ..The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo...
  19. pmc Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
    ..The findings suggest that the effects of GRN and MAPT mutations are expressed in partly overlapping but distinct anatomical networks that link specific molecular dysfunction with clinical phenotype...
  20. ncbi Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
    Sarah J Tabrizi
    UCL Institute of Neurology, University College London, Department of Neurodegenerative Disease, Queen Square, London, UK
    Lancet Neurol 10:31-42. 2011
    ..We report 12-month longitudinal changes, building on baseline findings...
  21. pmc Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
    ..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
  22. pmc Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
    Sarah J Tabrizi
    UCL Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 8:791-801. 2009
    ..Our aim was to identify sensitive and reliable biomarkers in premanifest carriers of mutated HTT and in individuals with early HD that could provide essential methodology for the assessment of therapeutic interventions...
  23. pmc Mapping the progression of progranulin-associated frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Clin Pract Neurol 4:455-60. 2008
    ..The patient was initially asymptomatic but developed progressive behavioral and cognitive decline characterized by apathy, impaired emotion recognition, mixed aphasia and parietal lobe dysfunction...
  24. pmc The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study
    David M Cash
    From the Dementia Research Centre D M C, Y L, N S R, K M K, T Y, I B M, M N R, S O, N C F and Wellcome Trust Centre for Neuroimaging G R R, UCL Institute of Neurology, London, UK Washington University School of Medicine T L S B, N J C, D S M, C X, R J B, J C M, St Louis, MO Mayo Clinic C R J, Rochester, MN Imaging Genetics Center P M T, Laboratory of Neuroimaging, Department of Neurology and Psychiatry, UCLA School of Medicine, Los Angeles, CA Indiana University School of Medicine B F G, A J S, Indianapolis Mental Health Research Institute C L M, The University of Melbourne, Victoria, Australia Mary S Easton Center for Alzheimer s Disease J M R, UCLA Department of Neurology, Los Angeles, CA Butler Hospital S P S, Providence, RI Neuroscience Research Australia P R S, Sydney and the Center for Alzheimer Research and Treatment R A S, Japan
    Neurology 81:1425-33. 2013
    ..To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers...
  25. ncbi Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  26. doi An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, UCL Institute of Neurology, London, UK Centre for Medical Image Computing CMIC, University College London, UK
    Neuroimage 72:153-63. 2013
    ..Tensor-based registration for longitudinal processing of DTI data in clinical studies may be of particular value in studies assessing disease progression...
  27. doi Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:73-82. 2013
    ..These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns...
  28. doi Visualizing the emergence of posterior cortical atrophy
    Jonathan Kennedy
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurocase 18:248-57. 2012
    ..Based on the clinical, neuropsychological and neuroimaging features, a diagnosis of PCA was made. The present case represents a unique opportunity to study and visualize the evolution of PCA from the very earliest symptomatic stages...
  29. ncbi Clinical application of measurement of hippocampal atrophy in degenerative dementias
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Hippocampus 19:510-6. 2009
    ..This article details the progress in using MRI to understand hippocampal changes in the degenerative dementias and also describes attempts to automate hippocampal segmentation in these diseases...
  30. ncbi Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  31. ncbi The clinical profile of right temporal lobe atrophy
    Dennis Chan
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, London, UK
    Brain 132:1287-98. 2009
    ....
  32. ncbi Rate and acceleration of whole-brain atrophy in premanifest and early Huntington's disease
    Edward J Wild
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 25:888-95. 2010
    ..We conclude that the study of whole-brain atrophy has the potential to inform our understanding of the neurobiology of HD and warrants further study as one means of assessing the outcomes of future clinical trials...
  33. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
    ..There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages...
  34. pmc Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features
    Colin J Mahoney
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 135:736-50. 2012
    ....
  35. ncbi Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom
    Mov Disord 24:932-6. 2009
    ..Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD...
  36. ncbi Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal Alzheimer's disease images
    Oscar Camara
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, UK
    Neuroimage 42:696-709. 2008
    ....
  37. pmc Comparison of phantom and registration scaling corrections using the ADNI cohort
    Matthew J Clarkson
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Neuroimage 47:1506-13. 2009
    ..Furthermore, based upon the atrophy rates in the AD subjects in this study, sample size requirements would be approximately 10-12% lower with (either) correction for voxel scaling than if no correction was used...
  38. ncbi Pure progressive amnesia and the APPV717G mutation
    William D Knight
    Department of Neurodegenerative Diseases, Dementia Research Centre, Institute of Neurology, University College London, UK
    Alzheimer Dis Assoc Disord 23:410-4. 2009
    ..The mean annual hippocampal atrophy rate, determined by volumetric magnetic resonance imaging was intermediate between values previously associated with cognitively normal individuals and those with sporadic Alzheimer disease...
  39. ncbi An event-based disease progression model and its application to familial Alzheimer's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, Department of Computer Science, University College London, UK
    Inf Process Med Imaging 22:748-59. 2011
    ..We show progression of neuronal atrophy on a much finer level than previous studies, while confirming progression patterns from pathological studies, and integrate clinical events into the model...
  40. ncbi Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, London, England
    Arch Neurol 63:1434-9. 2006
    ..Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis...
  41. ncbi Shining a light on posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimers Dement 9:463-5. 2013
    ....
  42. doi Rates of hemispheric and lobar atrophy in the language variants of frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    J Alzheimers Dis 30:407-11. 2012
    ..These patterns provide information about disease evolution in the FTLD language variants that is of both clinical and neurobiological relevance...
  43. ncbi Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
    ..We investigate the issues related to mask construction, and recommend the use of alternative strategies which greatly decrease this danger of false negatives...
  44. ncbi Atrophy rates of the cingulate gyrus and hippocampus in AD and FTLD
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 28:20-8. 2007
    ..Significantly better discrimination between AD and controls was obtained by hippocampal rather than cingulate rates. In conclusion, cingulate atrophy is as significant a feature of AD and FTLD as hippocampal atrophy...
  45. pmc Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
    ..In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy...
  46. ncbi Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study
    Dennis Chan
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 362:1121-2. 2003
    ..8% (95% CI 2.3-3.3), which rose by 0.32% per year (0.15-0.50). Our findings reinforce the need for early diagnosis and therapeutic intervention in Alzheimer's disease...
  47. ncbi Detecting treatment effects on brain atrophy in relapsing remitting multiple sclerosis: sample size estimates
    Valerie M Anderson
    MS NMR Research Unit, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 254:1588-94. 2007
    ....
  48. doi STEPS: Similarity and Truth Estimation for Propagated Segmentations and its application to hippocampal segmentation and brain parcelation
    M Jorge Cardoso
    Centre for Medical Image Computing CMIC, University College London, UK
    Med Image Anal 17:671-84. 2013
    ..Comparisons of STEPS with state-of-the-art multi-label fusion algorithms showed statistically significant segmentation accuracy improvements (p<10(-4)) in several key structures...
  49. pmc Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population
    Jon Beck
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK
    Am J Hum Genet 92:345-53. 2013
    ..C9orf72-related disease might mimic several neurodegenerative disorders and, with potentially 90,000 carriers in the United Kingdom, is more common than previously realized...
  50. pmc Gray matter atrophy rate as a marker of disease progression in AD
    Valerie M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:1194-202. 2012
    ..Jacobian integration could be useful for measuring GM atrophy rate in Alzheimer's disease as a marker of disease progression and treatment efficacy...
  51. doi Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  52. pmc The importance of group-wise registration in tract based spatial statistics study of neurodegeneration: a simulation study in Alzheimer's disease
    Shiva Keihaninejad
    Dementia Research Centre, University College London Institute of Neurology, London, United Kingdom
    PLoS ONE 7:e45996. 2012
    ..Using a group-wise average atlas as the reference outperformed other references in the TBSS pipeline in all evaluations...
  53. pmc Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:648-54. 2013
    ..To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD)...
  54. doi Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  55. ncbi Differentiating AD from aging using semiautomated measurement of hippocampal atrophy rates
    Josephine Barnes
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, WCIN 3BG, London, UK
    Neuroimage 23:574-81. 2004
    ..We conclude that HBSI-derived atrophy rates reduce operator time and error, and are at least as effective as the manual equivalent as a diagnostic marker and are a potential marker of progression in longitudinal studies and trials...
  56. ncbi Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI study
    Josephine Barnes
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 19:338-44. 2005
    ..To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus...
  57. ncbi Defective emotion recognition in early HD is neuropsychologically and anatomically generic
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Neuropsychologia 46:2152-60. 2008
    ..Even in early HD there is a wide-ranging impairment in recognition of negative emotions denoting 'threat'. Our findings implicate a generic fronto-subcortical network in the pathogenesis of these emotion recognition deficits...
  58. ncbi Sporadic and familial dementia with ubiquitin-positive tau-negative inclusions: clinical features of one histopathological abnormality underlying frontotemporal lobar degeneration
    Alison K Godbolt
    Dementia Research Centre, Institute of Neurology, University College London, England
    Arch Neurol 62:1097-101. 2005
    ..Familial disease occurs in up to 50% of frontotemporal lobar degeneration cases. One of several underlying histopathological abnormalities is of ubiquitin-positive tau-negative inclusions, similar to those in motor neuron disease...
  59. pmc A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series
    Jonathan Beck
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 131:706-20. 2008
    ..Finally, we confirmed a modifying effect of APOE-E4 genotype on clinical phenotype with a later onset in the GRN carriers suggesting that this gene has distinct phenotypic effects in different neurodegenerative diseases...
  60. ncbi A framework for using diffusion weighted imaging to improve cortical parcellation
    Matthew J Clarkson
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:534-41. 2010
    ..This work introduces a framework to investigate the relationship between structure and function, with no a-priori knowledge of specific regions of interest...
  61. ncbi Application of automated medial temporal lobe atrophy scale to Alzheimer disease
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, WC1N 3BG, England
    Arch Neurol 64:849-54. 2007
    ..To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods...
  62. ncbi Voxel-based morphometry in tau-positive and tau-negative frontotemporal lobar degenerations
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurodegener Dis 1:225-30. 2004
    ..Correlations between regional patterns of tissue loss and specific proteinopathies have not been established...
  63. ncbi Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controls
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    J Comput Assist Tomogr 31:581-7. 2007
    ..To assess hippocampal atrophy rates calculated from fluid registration methods...
  64. ncbi Improved maximum a posteriori cortical segmentation by iterative relaxation of priors
    Manuel Jorge Cardoso
    Centre for Medical Image Computing, University College London, UK
    Med Image Comput Comput Assist Interv 12:441-9. 2009
    ....
  65. pmc Automatic classification of MR scans in Alzheimer's disease
    Stefan Kloppel
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Brain 131:681-9. 2008
    ..Thirdly, the method is robust and can be generalized across different centres. This suggests an important role for computer based diagnostic image analysis for clinical practice...
  66. doi Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    ..To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy...
  67. ncbi A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's disease
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 20:238-44. 2005
    ..Despite an overlap between clinical and radiological features of FTLD and AD, marked amygdala atrophy points towards a diagnosis of FTLD, with left greater than right atrophy suggestive of one of the language variants...
  68. pmc Posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Lancet Neurol 11:170-8. 2012
    ..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies...
  69. pmc LoAd: a locally adaptive cortical segmentation algorithm
    M Jorge Cardoso
    Centre for Medical Image Computing CMIC, University College London, London, UK
    Neuroimage 56:1386-97. 2011
    ....
  70. doi Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers
    William D Knight
    Department of Neurodegeneration, UCL Institute of Neurology, University College London, Dementia Research Centre, Queen Square, London WC1N 3BG, UK
    Brain 134:293-300. 2011
    ..A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease...
  71. ncbi Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  72. ncbi Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
    ..Division of all volumes by head size is unlikely to be adequate owing to their non-proportional relationship...
  73. doi A comparison of voxel and surface based cortical thickness estimation methods
    Matthew J Clarkson
    Centre for Medical Image Computing, The Engineering Front Building, University College London, London WC1E 6BT, UK
    Neuroimage 57:856-65. 2011
    ..Finally we assessed longitudinal performance and concluded that currently FreeSurfer provides the most plausible measure of change over time, with further work required for voxel based methods...
  74. pmc Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection
    Kelvin K Leung
    Dementia Research Centre DRC, Institute of Neurology, University College London, London, UK
    Neuroimage 50:516-23. 2010
    ..001) when using KN-BSI instead of classic-BSI. We concluded that KN-BSI offers more robust brain atrophy measurement than classic-BSI and substantially reduces sample sizes needed in clinical trials...
  75. ncbi Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations
    Matthew C Evans
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Eur Radiol 20:674-82. 2010
    ..To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects...
  76. ncbi Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study
    Basil H Ridha
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Lancet Neurol 5:828-34. 2006
    ..We used hierarchical modelling to assess how hippocampal and whole-brain volumes change as familial Alzheimer's disease progresses from the presymptomatic stage through to diagnosis...
  77. ncbi Atrophy patterns in Alzheimer's disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 49:2264-74. 2010
    ....
  78. pmc A meta-analysis of hippocampal atrophy rates in Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 30:1711-23. 2009
    ..Mean (95% CIs) annualised hippocampal atrophy rates were found to be 4.66% (95% CI 3.92, 5.40) for AD subjects and 1.41% (0.52, 2.30) for controls. The difference between AD and control subject in this rate was 3.33% (1.73, 4.94)...
  79. ncbi Phenomenological model of diffuse global and regional atrophy using finite-element methods
    Oscar Camara
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, Department of Computer Science, University College London, London WCEI 6BT, UK
    IEEE Trans Med Imaging 25:1417-30. 2006
    ..Results confirm the potential of the proposed methodology...
  80. ncbi Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Group, Institute of Neurology, University College London and Imperial College London, London, UK
    Dement Geriatr Cogn Disord 17:307-10. 2004
    ..The different FTLD syndromes displayed different patterns of change. This technique gives an insight into disease evolution over time in these disorders and may be useful as a method of tracking change in clinical trials...
  81. pmc Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils
    Richard G Boyes
    Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London, UK
    Neuroimage 39:1752-62. 2008
    ....
  82. ncbi VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Neuroimage 35:207-13. 2007
    ..In accord with emerging evidence in humans and other species, our findings implicate distinct components of a multi-component brain network in the control of specific aspects of eating behaviour...
  83. pmc Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:2565-81. 2011
    ....
  84. ncbi Fast free-form deformation using graphics processing units
    Marc Modat
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
    Comput Methods Programs Biomed 98:278-84. 2010
    ..This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets...
  85. ncbi The natural history of Alzheimer disease: a longitudinal presymptomatic and symptomatic study of a familial cohort
    Alison K Godbolt
    Dementia Research Group, Institute of Neurology, London, England
    Arch Neurol 61:1743-8. 2004
    ..Knowledge of the evolution of cognitive deficits in Alzheimer disease is important for our understanding of disease progression. Previous reports, however, have either lacked detail or have not covered the presymptomatic stages...
  86. ncbi Computer-assisted imaging to assess brain structure in healthy and diseased brains
    John Ashburner
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Lancet Neurol 2:79-88. 2003
    ....
  87. ncbi Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias
    Catriona D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 17:29-46. 2002
    ....
  88. ncbi Simulation of local and global atrophy in Alzheimer's disease studies
    Oscar Camara-Rey
    Center of Medical Image Computing, Unviersity College of London, UK
    Med Image Comput Comput Assist Interv 9:937-45. 2006
    ..An example of simulated data is shown and a visual evaluation protocol used by experts has been developed to assess the degree of realism of the simulated images. First results demonstrate the potential of the proposed methodology...
  89. ncbi Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI
    Jonathan M Schott
    Dementia Research Group, Institute of Neurology, London, United Kingdom
    Mov Disord 18:955-8. 2003
    ..The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA...
  90. pmc Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia
    Colin J Mahoney
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1274-8. 2011
    ..Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined...
  91. ncbi Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
    Mov Disord 21:989-96. 2006
    ..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls...
  92. ncbi Magnetic resonance imaging measures of brain atrophy in multiple sclerosis
    Valerie M Anderson
    Department of Neuroinflammation, Institute of Neurology, University College of London, London, United Kingdom
    J Magn Reson Imaging 23:605-18. 2006
    ....
  93. ncbi Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
    Brain 129:1040-9. 2006
    ..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies...
  94. ncbi Simulation of acquisition artefacts in MR scans: effects on automatic measures of brain atrophy
    Oscar Camara-Rey
    Center of Medical Image Computing, University College of London, UK
    Med Image Comput Comput Assist Interv 9:272-80. 2006
    ..We investigate the effect of the simulated acquisition artefacts in atrophy measurements provided by an automatic technique, SIENA...
  95. ncbi MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effects
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, 1 Wakefield Street, London WC1N, UK
    J Neurol 254:478-81. 2007
    ..Regional rather than whole brain atrophy rates calculated from volumetric serial MRI brain scans in PSP and MSA-P provide a more practical and powerful means of monitoring disease progression in clinical trials...
  96. ncbi A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
    Arch Neurol 60:989-94. 2003
    ..To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data...
  97. ncbi New developments in mild cognitive impairment and Alzheimer's disease
    Jonathan M Schott
    Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 19:552-8. 2006
    ....
  98. ncbi Symptoms of memory loss as predictors of cognitive impairment?: the use and reliability of memory ratings in a clinic population
    Hilary A Archer
    Institute of Neurology, Dementia Research Centre, London School of Hygiene and Tropical Medicine, Keppel St, London, UK
    Alzheimer Dis Assoc Disord 21:101-6. 2007
    ..The relative importance of different aspects of the clinical history in predicting cognitive impairment is uncertain...
  99. pmc Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point study
    Jonathan M Schott
    Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 133:3315-22. 2010
    ....
  100. ncbi Quantitative magnetization transfer imaging in Alzheimer disease
    Basil H Ridha
    Dementia Research Centre, NMR Research Unit, and Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, England
    Radiology 244:832-7. 2007
    ..To prospectively measure magnetization transfer (MT) parameters, along with established atrophy parameters, in patients with Alzheimer disease (AD) and in age- and sex-matched control subjects...
  101. doi Does registration of serial MRI improve diagnosis of dementia?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neuroradiology 52:987-95. 2010
    ..We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia...