Nick C Fox

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
  2. ncbi Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Alzheimers Res Ther 3:1. 2011
  3. ncbi Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    N C Fox
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 358:201-5. 2001
  4. ncbi Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    N C Fox
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurology 64:1563-72. 2005
  5. ncbi Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trials
    Nick C Fox
    The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 57:15-8. 2011
  6. ncbi Imaging cerebral atrophy: normal ageing to Alzheimer's disease
    Nick C Fox
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Lancet 363:392-4. 2004
  7. ncbi Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
  8. ncbi An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
  9. ncbi Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College, London, UK
    J Neurol 256:203-12. 2009
  10. ncbi Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008

Detail Information

Publications113 found, 100 shown here

  1. ncbi Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  2. ncbi Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Alzheimers Res Ther 3:1. 2011
    ..Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention...
  3. ncbi Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    N C Fox
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 358:201-5. 2001
    ..We used an imaging technique known as voxel-compression mapping to localise progressive atrophy in patients with preclinical Alzheimer's disease...
  4. ncbi Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    N C Fox
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurology 64:1563-72. 2005
    ..Reported are MRI findings of a Phase IIa immunotherapy trial in AD prematurely terminated owing to meningoencephalitis in a subset of patients...
  5. ncbi Algorithms, atrophy and Alzheimer's disease: cautionary tales for clinical trials
    Nick C Fox
    The Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neuroimage 57:15-8. 2011
    ..In the absence of a "gold standard", we discuss a number of steps against which methodologies designed to quantify atrophy from serial scans can be assessed...
  6. ncbi Imaging cerebral atrophy: normal ageing to Alzheimer's disease
    Nick C Fox
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Lancet 363:392-4. 2004
    ..As the precision of imaging improves, the ability to distinguish healthy ageing from degenerative dementia should improve...
  7. ncbi Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
    ..To describe the clinical, neuropsychologic, and radiologic features of a family with a C31LfsX35 mutation in the progranulin gene CCDS11483.1)...
  8. ncbi An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
    ..The model and its formulation extend naturally to a wide range of other diseases and developmental processes and accommodate cross-sectional and longitudinal input data...
  9. ncbi Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College, London, UK
    J Neurol 256:203-12. 2009
    ..Overall we have demonstrated that increased CAG repeat length is associated with atrophy in extra-striatal as well as striatal regions, which has implications for the monitoring of disease-modifying therapies in the condition...
  10. ncbi Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008
    ..Both cognitive tests and MRI-based measures have been suggested as outcomes in trials assessing disease-modifying therapies in Alzheimer's disease (AD)...
  11. ncbi Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
    ..MAPS-HBSI required the lowest sample sizes (78 subjects) for a hypothetical trial. In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD...
  12. ncbi Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  13. ncbi Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, UK
    Neuroimage 47:1659-65. 2009
    ..We describe and evaluate an automated technique based on a local registration and boundary shift integral (BSI) approach at the caudate-CSF and caudate-white matter boundaries; caudate boundary shift integral (CBSI)...
  14. ncbi The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
    ..They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and early HD compared with controls...
  15. ncbi Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
    ..The findings suggest that the effects of GRN and MAPT mutations are expressed in partly overlapping but distinct anatomical networks that link specific molecular dysfunction with clinical phenotype...
  16. ncbi Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
    ..We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs...
  17. ncbi Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
    Sarah J Tabrizi
    UCL Institute of Neurology, University College London, Department of Neurodegenerative Disease, Queen Square, London, UK
    Lancet Neurol 10:31-42. 2011
    ..We report 12-month longitudinal changes, building on baseline findings...
  18. ncbi Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal data
    Oscar Camara
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 10:785-92. 2007
    ..Mean absolute error differences between volume changes given by the FFD-based technique and the gold standard were: sulcal CSF < 2.49%; lateral ventricles < 2.25%; brain < 0.36%; hippocampi < 1.42%...
  19. ncbi Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, England
    Arch Neurol 62:1402-8. 2005
    ..The VBM findings were supported by blinded visual assessment. CONCLUSION: These findings suggest that MRI patterns of regional gray matter atrophy constitute signatures of tissue pathology in FTD...
  20. ncbi Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
    ..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
  21. ncbi Mapping the progression of progranulin-associated frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Clin Pract Neurol 4:455-60. 2008
    ..The patient was initially asymptomatic but developed progressive behavioral and cognitive decline characterized by apathy, impaired emotion recognition, mixed aphasia and parietal lobe dysfunction...
  22. ncbi Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
    Sarah J Tabrizi
    UCL Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 8:791-801. 2009
    ..Our aim was to identify sensitive and reliable biomarkers in premanifest carriers of mutated HTT and in individuals with early HD that could provide essential methodology for the assessment of therapeutic interventions...
  23. ncbi Visualizing the emergence of posterior cortical atrophy
    Jonathan Kennedy
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurocase 18:248-57. 2012
    ..Based on the clinical, neuropsychological and neuroimaging features, a diagnosis of PCA was made. The present case represents a unique opportunity to study and visualize the evolution of PCA from the very earliest symptomatic stages...
  24. ncbi Clinical application of measurement of hippocampal atrophy in degenerative dementias
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Hippocampus 19:510-6. 2009
    ..This article details the progress in using MRI to understand hippocampal changes in the degenerative dementias and also describes attempts to automate hippocampal segmentation in these diseases...
  25. ncbi Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  26. ncbi The clinical profile of right temporal lobe atrophy
    Dennis Chan
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, London, UK
    Brain 132:1287-98. 2009
    ....
  27. ncbi Rate and acceleration of whole-brain atrophy in premanifest and early Huntington's disease
    Edward J Wild
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 25:888-95. 2010
    ..We conclude that the study of whole-brain atrophy has the potential to inform our understanding of the neurobiology of HD and warrants further study as one means of assessing the outcomes of future clinical trials...
  28. ncbi Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features
    Colin J Mahoney
    Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 135:736-50. 2012
    ....
  29. ncbi Comparison of phantom and registration scaling corrections using the ADNI cohort
    Matthew J Clarkson
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Neuroimage 47:1506-13. 2009
    ..Furthermore, based upon the atrophy rates in the AD subjects in this study, sample size requirements would be approximately 10-12% lower with (either) correction for voxel scaling than if no correction was used...
  30. ncbi Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom
    Mov Disord 24:932-6. 2009
    ..Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD...
  31. ncbi Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal Alzheimer's disease images
    Oscar Camara
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, UK
    Neuroimage 42:696-709. 2008
    ....
  32. ncbi Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, London, England
    Arch Neurol 63:1434-9. 2006
    ..Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis...
  33. ncbi Pure progressive amnesia and the APPV717G mutation
    William D Knight
    Department of Neurodegenerative Diseases, Dementia Research Centre, Institute of Neurology, University College London, UK
    Alzheimer Dis Assoc Disord 23:410-4. 2009
    ..The mean annual hippocampal atrophy rate, determined by volumetric magnetic resonance imaging was intermediate between values previously associated with cognitively normal individuals and those with sporadic Alzheimer disease...
  34. ncbi An event-based disease progression model and its application to familial Alzheimer's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, Department of Computer Science, University College London, UK
    Inf Process Med Imaging 22:748-59. 2011
    ..We show progression of neuronal atrophy on a much finer level than previous studies, while confirming progression patterns from pathological studies, and integrate clinical events into the model...
  35. ncbi Rates of hemispheric and lobar atrophy in the language variants of frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, UK
    J Alzheimers Dis 30:407-11. 2012
    ..These patterns provide information about disease evolution in the FTLD language variants that is of both clinical and neurobiological relevance...
  36. ncbi Detecting treatment effects on brain atrophy in relapsing remitting multiple sclerosis: sample size estimates
    Valerie M Anderson
    MS NMR Research Unit, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 254:1588-94. 2007
    ....
  37. ncbi Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
    ..We investigate the issues related to mask construction, and recommend the use of alternative strategies which greatly decrease this danger of false negatives...
  38. ncbi Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study
    Dennis Chan
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 362:1121-2. 2003
    ..8% (95% CI 2.3-3.3), which rose by 0.32% per year (0.15-0.50). Our findings reinforce the need for early diagnosis and therapeutic intervention in Alzheimer's disease...
  39. ncbi Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
    ..In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy...
  40. ncbi Atrophy rates of the cingulate gyrus and hippocampus in AD and FTLD
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 28:20-8. 2007
    ..Significantly better discrimination between AD and controls was obtained by hippocampal rather than cingulate rates. In conclusion, cingulate atrophy is as significant a feature of AD and FTLD as hippocampal atrophy...
  41. ncbi Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:648-54. 2013
    ..To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD)...
  42. ncbi Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  43. ncbi Automatic classification of MR scans in Alzheimer's disease
    Stefan Kloppel
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Brain 131:681-9. 2008
    ..Thirdly, the method is robust and can be generalized across different centres. This suggests an important role for computer based diagnostic image analysis for clinical practice...
  44. ncbi A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series
    Jonathan Beck
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 131:706-20. 2008
    ..Finally, we confirmed a modifying effect of APOE-E4 genotype on clinical phenotype with a later onset in the GRN carriers suggesting that this gene has distinct phenotypic effects in different neurodegenerative diseases...
  45. ncbi Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controls
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    J Comput Assist Tomogr 31:581-7. 2007
    ..To assess hippocampal atrophy rates calculated from fluid registration methods...
  46. ncbi Defective emotion recognition in early HD is neuropsychologically and anatomically generic
    Susie M D Henley
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Neuropsychologia 46:2152-60. 2008
    ..Even in early HD there is a wide-ranging impairment in recognition of negative emotions denoting 'threat'. Our findings implicate a generic fronto-subcortical network in the pathogenesis of these emotion recognition deficits...
  47. ncbi Differentiating AD from aging using semiautomated measurement of hippocampal atrophy rates
    Josephine Barnes
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, WCIN 3BG, London, UK
    Neuroimage 23:574-81. 2004
    ..We conclude that HBSI-derived atrophy rates reduce operator time and error, and are at least as effective as the manual equivalent as a diagnostic marker and are a potential marker of progression in longitudinal studies and trials...
  48. ncbi Improved maximum a posteriori cortical segmentation by iterative relaxation of priors
    Manuel Jorge Cardoso
    Centre for Medical Image Computing, University College London, UK
    Med Image Comput Comput Assist Interv 12:441-9. 2009
    ....
  49. ncbi A framework for using diffusion weighted imaging to improve cortical parcellation
    Matthew J Clarkson
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:534-41. 2010
    ..This work introduces a framework to investigate the relationship between structure and function, with no a-priori knowledge of specific regions of interest...
  50. ncbi A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's disease
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 20:238-44. 2005
    ..Despite an overlap between clinical and radiological features of FTLD and AD, marked amygdala atrophy points towards a diagnosis of FTLD, with left greater than right atrophy suggestive of one of the language variants...
  51. ncbi Sporadic and familial dementia with ubiquitin-positive tau-negative inclusions: clinical features of one histopathological abnormality underlying frontotemporal lobar degeneration
    Alison K Godbolt
    Dementia Research Centre, Institute of Neurology, University College London, England
    Arch Neurol 62:1097-101. 2005
    ..CONCLUSIONS: Behavioral features in familial and sporadic cases were similar, but semantic dementia only occurred in sporadic cases. Diagnostic confusion with Alzheimer disease and corticobasal degeneration occurred in some cases...
  52. ncbi Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI study
    Josephine Barnes
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 19:338-44. 2005
    ..To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus...
  53. ncbi Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    ..To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy...
  54. ncbi Application of automated medial temporal lobe atrophy scale to Alzheimer disease
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, WC1N 3BG, England
    Arch Neurol 64:849-54. 2007
    ..To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods...
  55. ncbi Voxel-based morphometry in tau-positive and tau-negative frontotemporal lobar degenerations
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurodegener Dis 1:225-30. 2004
    ....
  56. ncbi Genetic influences on atrophy patterns in familial Alzheimer's Disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  57. ncbi Posterior cortical atrophy
    Sebastian J Crutch
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Lancet Neurol 11:170-8. 2012
    ..Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies...
  58. ncbi Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  59. ncbi Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations
    Matthew C Evans
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Eur Radiol 20:674-82. 2010
    ..To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects...
  60. ncbi Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study
    Basil H Ridha
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Lancet Neurol 5:828-34. 2006
    ..We used hierarchical modelling to assess how hippocampal and whole-brain volumes change as familial Alzheimer's disease progresses from the presymptomatic stage through to diagnosis...
  61. ncbi Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection
    Kelvin K Leung
    Dementia Research Centre DRC, Institute of Neurology, University College London, London, UK
    Neuroimage 50:516-23. 2010
    ..001) when using KN-BSI instead of classic-BSI. We concluded that KN-BSI offers more robust brain atrophy measurement than classic-BSI and substantially reduces sample sizes needed in clinical trials...
  62. ncbi A comparison of voxel and surface based cortical thickness estimation methods
    Matthew J Clarkson
    Centre for Medical Image Computing, The Engineering Front Building, University College London, London WC1E 6BT, UK
    Neuroimage 57:856-65. 2011
    ..Finally we assessed longitudinal performance and concluded that currently FreeSurfer provides the most plausible measure of change over time, with further work required for voxel based methods...
  63. ncbi LoAd: a locally adaptive cortical segmentation algorithm
    M Jorge Cardoso
    Centre for Medical Image Computing CMIC, University College London, London, UK
    Neuroimage 56:1386-97. 2011
    ....
  64. ncbi Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
    ..Division of all volumes by head size is unlikely to be adequate owing to their non-proportional relationship...
  65. ncbi A meta-analysis of hippocampal atrophy rates in Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 30:1711-23. 2009
    ..Mean (95% CIs) annualised hippocampal atrophy rates were found to be 4.66% (95% CI 3.92, 5.40) for AD subjects and 1.41% (0.52, 2.30) for controls. The difference between AD and control subject in this rate was 3.33% (1.73, 4.94)...
  66. ncbi Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers
    William D Knight
    Department of Neurodegeneration, UCL Institute of Neurology, University College London, Dementia Research Centre, Queen Square, London WC1N 3BG, UK
    Brain 134:293-300. 2011
    ..A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease...
  67. ncbi Atrophy patterns in Alzheimer's disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 49:2264-74. 2010
    ....
  68. ncbi VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Centre, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Neuroimage 35:207-13. 2007
    ..In accord with emerging evidence in humans and other species, our findings implicate distinct components of a multi-component brain network in the control of specific aspects of eating behaviour...
  69. ncbi Fast free-form deformation using graphics processing units
    Marc Modat
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
    Comput Methods Programs Biomed 98:278-84. 2010
    ..This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets...
  70. ncbi Phenomenological model of diffuse global and regional atrophy using finite-element methods
    Oscar Camara
    Centre for Medical Image Computing (CMIC, Department of Medical Physics and Bioengineering, Department of Computer Science, University College London, London WCEI 6BT, UK
    IEEE Trans Med Imaging 25:1417-30. 2006
    ..Results confirm the potential of the proposed methodology...
  71. ncbi Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:2565-81. 2011
    ....
  72. ncbi Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils
    Richard G Boyes
    Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London, UK
    Neuroimage 39:1752-62. 2008
    ....
  73. ncbi Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degeneration
    Jennifer L Whitwell
    Dementia Research Group, Institute of Neurology, University College London and Imperial College London, London, UK
    Dement Geriatr Cogn Disord 17:307-10. 2004
    ..The different FTLD syndromes displayed different patterns of change. This technique gives an insight into disease evolution over time in these disorders and may be useful as a method of tracking change in clinical trials...
  74. ncbi The natural history of Alzheimer disease: a longitudinal presymptomatic and symptomatic study of a familial cohort
    Alison K Godbolt
    Dementia Research Group, Institute of Neurology, London, England
    Arch Neurol 61:1743-8. 2004
    ....
  75. ncbi Computer-assisted imaging to assess brain structure in healthy and diseased brains
    John Ashburner
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Lancet Neurol 2:79-88. 2003
    ....
  76. ncbi Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias
    Catriona D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 17:29-46. 2002
    ....
  77. ncbi Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
    Brain 129:1040-9. 2006
    ..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies...
  78. ncbi Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point study
    Jonathan M Schott
    Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 133:3315-22. 2010
    ....
  79. ncbi Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia
    Colin J Mahoney
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1274-8. 2011
    ..Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined...
  80. ncbi The analysis of repeated 'direct' measures of change illustrated with an application in longitudinal imaging
    Chris Frost
    Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Stat Med 23:3275-86. 2004
    ..We illustrate the use of our models with data from a cohort of patients with Alzheimer's disease...
  81. ncbi Magnetic resonance imaging measures of brain atrophy in multiple sclerosis
    Valerie M Anderson
    Department of Neuroinflammation, Institute of Neurology, University College of London, London, United Kingdom
    J Magn Reson Imaging 23:605-18. 2006
    ....
  82. ncbi Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
    Mov Disord 21:989-96. 2006
    ..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls...
  83. ncbi Quantitative magnetization transfer imaging in Alzheimer disease
    Basil H Ridha
    Dementia Research Centre, NMR Research Unit, and Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, England
    Radiology 244:832-7. 2007
    ..To prospectively measure magnetization transfer (MT) parameters, along with established atrophy parameters, in patients with Alzheimer disease (AD) and in age- and sex-matched control subjects...
  84. ncbi Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI
    Jonathan M Schott
    Dementia Research Group, Institute of Neurology, London, United Kingdom
    Mov Disord 18:955-8. 2003
    ..The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA...
  85. ncbi New developments in mild cognitive impairment and Alzheimer's disease
    Jonathan M Schott
    Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 19:552-8. 2006
    ....
  86. ncbi Symptoms of memory loss as predictors of cognitive impairment?: the use and reliability of memory ratings in a clinic population
    Hilary A Archer
    Institute of Neurology, Dementia Research Centre, London School of Hygiene and Tropical Medicine, Keppel St, London, UK
    Alzheimer Dis Assoc Disord 21:101-6. 2007
    ..The relative importance of different aspects of the clinical history in predicting cognitive impairment is uncertain...
  87. ncbi A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
    Arch Neurol 60:989-94. 2003
    ..To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data...
  88. ncbi Simulation of local and global atrophy in Alzheimer's disease studies
    Oscar Camara-Rey
    Center of Medical Image Computing, Unviersity College of London, UK
    Med Image Comput Comput Assist Interv 9:937-45. 2006
    ..An example of simulated data is shown and a visual evaluation protocol used by experts has been developed to assess the degree of realism of the simulated images. First results demonstrate the potential of the proposed methodology...
  89. ncbi MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effects
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, 1 Wakefield Street, London WC1N, UK
    J Neurol 254:478-81. 2007
    ..Regional rather than whole brain atrophy rates calculated from volumetric serial MRI brain scans in PSP and MSA-P provide a more practical and powerful means of monitoring disease progression in clinical trials...
  90. ncbi Simulation of acquisition artefacts in MR scans: effects on automatic measures of brain atrophy
    Oscar Camara-Rey
    Center of Medical Image Computing, University College of London, UK
    Med Image Comput Comput Assist Interv 9:272-80. 2006
    ..We investigate the effect of the simulated acquisition artefacts in atrophy measurements provided by an automatic technique, SIENA...
  91. ncbi Structural magnetic resonance imaging-derived biomarkers for Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Box 16, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Biomark Med 1:79-92. 2007
    ..As such, there has been much research into biomarkers in recent years, with many showing promise in all areas of biomarker utility. This review focuses on the potential of structural imaging as a biomarker in Alzheimer's disease...
  92. ncbi Does registration of serial MRI improve diagnosis of dementia?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neuroradiology 52:987-95. 2010
    ..We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia...
  93. ncbi Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: cross-validation of BSI, SIENA and SIENAX
    Stephen M Smith
    Oxford University Centre for Functional MRI of the Brain FMRIB, Oxford, UK
    Neuroimage 36:1200-6. 2007
    ..We also compare the SIENA longitudinal measure with atrophy state estimated by SIENAX using just the earliest scan taken from each subject. We show strong correspondence and similar sensitivity to atrophy between all 3 measures...
  94. ncbi Assessing the onset of structural change in familial Alzheimer's disease
    Jonathan M Schott
    Dementia Research Group, Institute of Neurology, University College London, Queen Square, United Kingdom
    Ann Neurol 53:181-8. 2003
    ..We conclude that increased medial temporal lobe atrophy rates are an early and distinguishing feature of AD and that pathological atrophy probably is occurring several years before the onset of symptoms...
  95. ncbi Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients
    Jasper D Sluimer
    Department of Diagnostic Radiology, Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Radiology 248:590-8. 2008
    ....
  96. ncbi Neurofilament inclusion body disease: a new proteinopathy?
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Brain 126:2291-303. 2003
    ..We propose the term neurofilament inclusion body disease for this entity...
  97. ncbi Nothing to say, something to sing: primary progressive dynamic aphasia
    Jason D Warren
    Dementia Research Group, Institute of Neurology, Queen Square, London, UK
    Neurocase 9:140-55. 2003
    ..The domain-specificity of dynamic aphasia may result from the disruption of specific cognitive processes necessary for the creation of verbal messages, as well as selective damage of brain regions involved in language production...
  98. ncbi An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's disease
    Kewei Chen
    Positron Emission Tomography Center, Banner Good Samaritan Regional Medical Center, 1111 E McDowell Road, Phoenix, AZ 85006, USA
    Neuroimage 22:134-43. 2004
    ..8 x 10(-4)]). The IPCA could be used in tracking the progression of AD, evaluating the disease-modifying effects of putative treatments, and investigating the course of other normal and pathological changes in brain morphology...
  99. ncbi 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
    Xue Hua
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
    Neuroimage 41:19-34. 2008
    ..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials...
  100. ncbi Word-finding difficulty: a clinical analysis of the progressive aphasias
    Jonathan D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 131:8-38. 2008
    ....
  101. ncbi Magnetic resonance imaging predictors of cognition in mild cognitive impairment
    Laura A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, Vrije Universiteit Amsterdam, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arch Neurol 64:1023-8. 2007
    ..To describe magnetic resonance imaging characteristics in a large sample of subjects with mild cognitive impairment (MCI) and to investigate associations between these characteristics and cognition...