N C Fox

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study
    N C Fox
    The National Hospital for Neurology and Neurosurgery, London, UK
    Brain 121:1631-9. 1998
  2. doi request reprint A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neuroimage 40:1655-71. 2008
  3. ncbi request reprint Early onset familial Alzheimer's disease: Mutation frequency in 31 families
    J C Janssen
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 60:235-9. 2003
  4. ncbi request reprint Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
    D Chan
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Ann Neurol 49:433-42. 2001
  5. ncbi request reprint A decade of pre-diagnostic assessment in a case of familial Alzheimer's disease: tracking progression from asymptomatic to MCI and dementia
    A K Godbolt
    Dementia Research Group, Institute of Neurology, Queen Square, London, UK
    Neurocase 11:56-64. 2005
  6. doi request reprint Onset and progression of pathologic atrophy in Huntington disease: a longitudinal MR imaging study
    N Z Hobbs
    Dementia Research Centre and Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, UK
    AJNR Am J Neuroradiol 31:1036-41. 2010
  7. ncbi request reprint Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testing
    D C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
    Neurocase 11:274-82. 2005
  8. ncbi request reprint Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    N C Fox
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 358:201-5. 2001
  9. ncbi request reprint Knight's move thinking? Mild cognitive impairment in a chess player
    H A Archer
    The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurocase 11:26-31. 2005
  10. doi request reprint Neuropsychological correlates of whole brain atrophy in Alzheimer's disease
    J M Schott
    Dementia Research Centre National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropsychologia 46:1732-7. 2008

Detail Information

Publications56

  1. ncbi request reprint Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study
    N C Fox
    The National Hospital for Neurology and Neurosurgery, London, UK
    Brain 121:1631-9. 1998
    ..This may have implications for the detection and treatment of Alzheimer's disease at an early stage...
  2. doi request reprint A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neuroimage 40:1655-71. 2008
    ..The change over time can then be calculated automatically using boundary shift or fluid measures, with boundary shift giving most similar results to manual...
  3. ncbi request reprint Early onset familial Alzheimer's disease: Mutation frequency in 31 families
    J C Janssen
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 60:235-9. 2003
    ..Three causative genes have been identified for autosomal dominant AD...
  4. ncbi request reprint Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
    D Chan
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Ann Neurol 49:433-42. 2001
    ..In addition, the pattern of atrophy in semantic dementia suggests that semantic memory is subserved by anterior temporal lobe structures, within which the middle and inferior temporal gyri may play a key role...
  5. ncbi request reprint A decade of pre-diagnostic assessment in a case of familial Alzheimer's disease: tracking progression from asymptomatic to MCI and dementia
    A K Godbolt
    Dementia Research Group, Institute of Neurology, Queen Square, London, UK
    Neurocase 11:56-64. 2005
    ..Longitudinal MRI, neuropsychological and clinical data are presented over the decade preceding this man's diagnosis, through the asymptomatic and prodromal preludes to his presentation with MCI and on to eventual conversion to AD...
  6. doi request reprint Onset and progression of pathologic atrophy in Huntington disease: a longitudinal MR imaging study
    N Z Hobbs
    Dementia Research Centre and Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, UK
    AJNR Am J Neuroradiol 31:1036-41. 2010
    ..This may prove useful in assessing disease-modifying treatments. We investigated how caudate and global volumes change as HD progresses from premanifest to early disease...
  7. ncbi request reprint Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testing
    D C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
    Neurocase 11:274-82. 2005
    ..These results suggest that the FAB is a valid and easily applicable bedside test to discriminate executive dysfunction in these three frequently confused bradykinetic rigid syndromes...
  8. ncbi request reprint Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    N C Fox
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Lancet 358:201-5. 2001
    ..We used an imaging technique known as voxel-compression mapping to localise progressive atrophy in patients with preclinical Alzheimer's disease...
  9. ncbi request reprint Knight's move thinking? Mild cognitive impairment in a chess player
    H A Archer
    The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurocase 11:26-31. 2005
    ....
  10. doi request reprint Neuropsychological correlates of whole brain atrophy in Alzheimer's disease
    J M Schott
    Dementia Research Centre National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropsychologia 46:1732-7. 2008
    ..This methodology whereby data from patients falling to floor on a given test may be included and accounted for, rather than discarded, may find broader application in clinical studies incorporating neuropsychometric outcomes...
  11. doi request reprint Distinct neuropsychological profiles correspond to distribution of cortical thinning in inherited prion disease caused by insertional mutation
    K Alner
    National Prion Clinic, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 83:109-14. 2012
    ..Here we report for the first time the neuropsychological and clinical assessments in these two groups...
  12. ncbi request reprint Rates of global and regional cerebral atrophy in AD and frontotemporal dementia
    D Chan
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, London, UK
    Neurology 57:1756-63. 2001
    ..Increased rates of whole-brain atrophy did not discriminate AD from FTD, but analysis of regional atrophy rates revealed marked differences between patient groups...
  13. ncbi request reprint A second family with familial AD and the V717L APP mutation has a later age at onset
    A K Godbolt
    Dementia Research Centre, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neurology 66:611-2. 2006
  14. ncbi request reprint Brain biopsy in dementia
    J D Warren
    Dementia Research Centre, Institute of Neurology, London, UK
    Brain 128:2016-25. 2005
    ....
  15. pmc Brain-water diffusion coefficients reflect the severity of inherited prion disease
    H Hyare
    National Prion Clinic, Box 98, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, WC1N 3BG
    Neurology 74:658-65. 2010
    ..We wished to assess the potential of diffusion-weighted MRI as a biomarker of disease severity in inherited prion diseases...
  16. ncbi request reprint A presenilin 1 R278I mutation presenting with language impairment
    A K Godbolt
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    Neurology 63:1702-4. 2004
    ..Screening for PSEN1 mutations may be appropriate in cases of familial dementia even where the clinical phenotype is not typical of AD...
  17. ncbi request reprint MRS shows abnormalities before symptoms in familial Alzheimer disease
    A K Godbolt
    Dementia Research Centre, Institute of Neurology, University College of London, London, UK
    Neurology 66:718-22. 2006
    ..Presenilin 1 (PS1) and amyloid precursor protein (APP) mutation carriers have a nearly 100% risk of developing AD and may be studied prior to symptom onset...
  18. ncbi request reprint Automatic calculation of hippocampal atrophy rates using a hippocampal template and the boundary shift integral
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neurobiol Aging 28:1657-63. 2007
    ..4 GHz Intel Xeon server, whereas manual delineation of each hippocampal pair took approximately 90 min of operator-intensive labour. This method may be useful diagnostically or in studies where analysis of many scans may be required...
  19. ncbi request reprint Combining short interval MRI in Alzheimer's disease: Implications for therapeutic trials
    J M Schott
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, Box 16, WC1N 3BG, London, UK
    J Neurol 253:1147-53. 2006
    ..We conclude that sample sizes required in short interval therapeutic trials using cerebral atrophy as an outcome measure may be reduced if multiple serial MRI is performed...
  20. doi request reprint Memory complaints and increased rates of brain atrophy: risk factors for mild cognitive impairment and Alzheimer's disease
    H A Archer
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Int J Geriatr Psychiatry 25:1119-26. 2010
    ..To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline...
  21. ncbi request reprint Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online
    M S Palmer
    Molecular Genetics, Biomedical Sciences Division, Imperial College School of Medicine, London, UK
    Hum Mutat 13:256. 1999
    ..I143F shows incomplete penetration within the affected family. P436S is the most carboxy-terminal presenilin 1 mutation reported to date...
  22. doi request reprint Familial Alzheimer's disease and inherited prion disease in the UK are poorly ascertained
    J C Stevens
    Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:1054-7. 2011
    ..By comparison with frequencies predicted from published population studies, to estimate the proportion of patients with these conditions who are being accurately diagnosed...
  23. doi request reprint Acceleration of cortical thinning in familial Alzheimer's disease
    W D Knight
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1765-73. 2011
    ..We used automated cortical thickness (CTh) measurement to compare the grey matter of such a group with cognitively normal controls...
  24. ncbi request reprint Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsy
    D C Paviour
    Dementia Research Centre UCL, Institute of Neurology UCL, London, UK
    Neurology 64:675-9. 2005
    ..It is not clear whether MRI-based measurements can differentiate this relative atrophy of the SCP during life...
  25. ncbi request reprint Vulnerability to neuroleptic side effects in frontotemporal lobar degeneration
    Y A L Pijnenburg
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Int J Geriatr Psychiatry 18:67-72. 2003
    ..Frontotemporal lobar degeneration (FTLD) is commonly associated with behavioural disturbances such as disinhibition and aggression; these often result in the use of neuroleptic medication...
  26. ncbi request reprint Increased rate of whole-brain atrophy over 6 months in early Huntington disease
    S M D Henley
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Neurology 67:694-6. 2006
    ..10 [0.88]%/year; controls, 0.26 [0.54]%/year). The measurement of cerebral change over short time periods (e.g., 6 months) may be relevant for trials designed to assess effects on neurodegeneration or atrophy...
  27. ncbi request reprint Magnetization transfer ratio in Alzheimer disease: comparison with volumetric measurements
    B H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    AJNR Am J Neuroradiol 28:965-70. 2007
    ..This study assessed the value of measuring MTR in addition to volumetric MR in differentiating patients with AD from control subjects...
  28. ncbi request reprint Epilepsy presenting as AD: neuroimaging, electroclinical features, and response to treatment
    P Høgh
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK
    Neurology 58:298-301. 2002
    ..Memory functions improved with antiepileptic medication in all three patients. The demonstration of temporal lobe spike activity in patients with progressive memory impairment is an indication for a trial of antiepileptic medication...
  29. ncbi request reprint Normalization of cerebral volumes by use of intracranial volume: implications for longitudinal quantitative MR imaging
    J L Whitwell
    Dementia Research Group, Institute of Neurology, London, UK
    AJNR Am J Neuroradiol 22:1483-9. 2001
    ..This may have important implications in progression studies...
  30. ncbi request reprint Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    N C Fox
    Dementia Research Centre, Institute of Neurology, London, UK
    Neurology 64:1563-72. 2005
    ..Reported are MRI findings of a Phase IIa immunotherapy trial in AD prematurely terminated owing to meningoencephalitis in a subset of patients...
  31. pmc Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsy
    D C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology UCL, London, UK
    J Neurol Neurosurg Psychiatry 75:1772-5. 2004
    ..MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken...
  32. pmc Genetics of the dementias
    J M Schott
    Dementia Research Group, National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 73:II27-31. 2002
  33. ncbi request reprint Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation
    J C Janssen
    Dementia Research Group, Institute of Neurology, London, UK
    Neurology 58:1161-8. 2002
    ..To describe the clinical features of nine British families with neuropathologically verified frontotemporal dementia (FTD) due to the intronic tau exon 10(+16) mutation...
  34. ncbi request reprint Haemodialysis and cerebral oedema
    R J Walters
    Department of Clinical Neurology, St. Mary's Hospital, London, UK
    Nephron 87:143-7. 2001
    ..Modifications to dialysis may help. Common problems which increase cerebral volume, e.g. acute stroke, require careful appraisal in these patients. These observations need consideration when quantifying atrophy in dialysis patients...
  35. pmc Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene
    R J Harvey
    Dementia Research Group, The National Hospital for Neurology and Neurosurgery and Imperial College School of Medicine at St Mary s, London, UK
    J Neurol Neurosurg Psychiatry 64:44-9. 1998
    ....
  36. ncbi request reprint Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment
    L A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, The Netherlands
    Neurology 69:1491-7. 2007
    ..We compared baseline clinical, neuropsychological, and MRI measures to characterize these MCI subgroups...
  37. pmc Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis
    C M Dalton
    NMR Research Unit, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 73:141-7. 2002
    ..Cerebral atrophy is recognised in established MS, but its time of onset and whether, in early disease, it is related to MRI lesion load or clinical outcome is less certain...
  38. doi request reprint Longitudinal imaging in dementia
    R I Scahill
    Dementia Research Centre, 8 11 Queen Square, London WC1N 3BG, UK
    Br J Radiol 80:S92-8. 2007
    ....
  39. doi request reprint Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors
    J D Sluimer
    Department of Radiology and Alzheimer Centre, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 70:1836-41. 2008
    ..To assess which baseline clinical and MRI measures influence whole-brain atrophy rates, measured from serial MR imaging...
  40. doi request reprint An alternative method for estimating efficacy of the AN1792 vaccine for Alzheimer disease
    M Grundman
    Neurology 71:697; author reply 697-8. 2008
  41. ncbi request reprint Automated hippocampal segmentation by regional fluid registration of serial MRI: validation and application in Alzheimer's disease
    W R Crum
    Dementia Research Group, Institute of Neurology, 8-11 Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 13:847-55. 2001
    ..7%. Fluid registration has potential importance for tracking longitudinal structural changes in brain particularly in the context of the clinical trial where large numbers of subjects may have multiple MR scans...
  42. pmc Mapping the onset and progression of atrophy in familial frontotemporal lobar degeneration
    J C Janssen
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:162-8. 2005
    ..Frontotemporal lobar degeneration (FTLD) may be inherited as an autosomal dominant disease. Studying patients "at risk" for developing FTLD can provide insights into the earliest onset and evolution of the disease...
  43. ncbi request reprint Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    Neurobiol Aging 29:1199-203. 2008
    ..This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial...
  44. ncbi request reprint Improved reliability of hippocampal atrophy rate measurement in mild cognitive impairment using fluid registration
    L A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 34:1036-41. 2007
    ..This method may be useful to quantify hippocampal volume change, given the reduction in operator time and improved precision...
  45. ncbi request reprint Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease
    G B Karas
    Department of Diagnostic Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 23:708-16. 2004
    ..Mild cognitive impairment (MCI) is thought to be the prodromal phase to Alzheimer's disease (AD). We analyzed patterns of gray matter (GM) loss to examine what characterizes MCI and what determines the difference with AD...
  46. ncbi request reprint Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    S Gilman
    Department of Neurology, University of Michigan, 300 N Ingalls 3D15, Ann Arbor, MI 48109 0489, USA
    Neurology 64:1553-62. 2005
    ..The authors report the results of a phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of meningoencephalitis in 6% of immunized patients...
  47. pmc Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 74:1371-81. 2003
    ....
  48. ncbi request reprint Measuring atrophy in Alzheimer disease: a serial MRI study over 6 and 12 months
    J M Schott
    Dementia Research Centre, Institute of Neurology, University College London, UK
    Neurology 65:119-24. 2005
    ..Global brain atrophy rate calculated from serial MRI scans may be a surrogate marker of Alzheimer disease (AD) progression. Few studies have assessed atrophy in AD over short intervals...
  49. pmc Development of selective verbal memory impairment secondary to a left thalamic infarct: a longitudinal case study
    J M Schott
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 74:255-7. 2003
    ..High resolution volumetric MRI may be helpful in demonstrating small subcortical infarcts that may not be seen using computed tomography or conventional MRI...
  50. ncbi request reprint The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia
    S M Paling
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Med Image Anal 8:69-79. 2004
    ..001) compared to controls. In general the analysis technique is shown to be a robust, accurate and transferable tool of potential value for future studies of dementia and related neuro-degenerative disorders...
  51. pmc Transient ischaemic attacks are associated with increased rates of global cerebral atrophy
    R J L Walters
    Department of Clinical Neurology, St Mary s Hospital, London W2 1NY, UK
    J Neurol Neurosurg Psychiatry 74:213-6. 2003
    ....
  52. ncbi request reprint Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease
    A Petzold
    Institute of Neurology, Department of Neuroinflammation, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 336:167-70. 2003
    ..53, P<0.001). No such correlation was found for FTLD patients. This study supports the concept that S100B is of pathological relevance for degeneration of the central nervous system in AD...
  53. ncbi request reprint Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort
    H A Archer
    Institute of Neurology, Dementia Research Centre, London, WC1N 3BG
    Int J Geriatr Psychiatry 21:1206-12. 2006
    ....
  54. ncbi request reprint The effect of APOE genotype on clinical phenotype in Alzheimer disease
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 67:526-7. 2006
    ..2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele...
  55. ncbi request reprint Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation
    J C Janssen
    Dementia Research Group, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, England
    Arch Neurol 58:953-8. 2001
    ..CONCLUSIONS: The PSEN1 L153V mutation lies in the main mutation cluster of PSEN1 in the second transmembrane domain. It causes early-onset FAD with clinical features similar to those of other reported FAD pedigrees...
  56. ncbi request reprint Presenilin-1 mutation (E280G), spastic paraparesis, and cranial MRI white-matter abnormalities
    S O'Riordan
    St Vincent s University Hospital, Dublin, Ireland
    Neurology 59:1108-10. 2002
    ..Another affected sibling also had MRI white matter abnormalities. The MRI findings may reflect an ischemic leukoencephalopathy due to amyloid angiopathy affecting meningocortical vessels...