K A Fox

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Resuscitation from out-of-hospital cardiac arrest: implications for cardiac enzyme estimation
    N R Grubb
    Cardiovascular Research Unit, University of Edinburgh, UK
    Resuscitation 33:35-41. 1996
  2. pmc Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction--a hospital registry-primary care linked cohort (MINAP-GPRD)
    Rachael Boggon
    General Practice Research Database, Medicines and Healthcare products Regulatory Agency, 151 Buckingham Palace Road, London SW1W 9SZ, UK
    Eur Heart J 32:2376-86. 2011
  3. doi European Society of Cardiology Congress 2013 highlights
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Future Cardiol 10:23-6. 2014
  4. doi A profile of Keith AA Fox, cardiologist and researcher
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Future Cardiol 10:27-9. 2014
  5. ncbi What's new for ESC congress 2013? (Amsterdam 30th august - 4th September 2013)
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
    Acta Cardiol 68:345-6. 2013
  6. pmc What's new for ESC Congress 2013? (Amsterdam 30 August - 4 September 2013)
    K A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Neth Heart J 21:304-6. 2013
  7. doi A European perspective on improving acute systems of care in STEMI: we know what to do, but how can we do it?
    Keith A A Fox
    Division of Medical and Radiological Sciences at Edinburgh University, Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 5:708-14. 2008
  8. ncbi Time course of events in acute coronary syndromes: implications for clinical practice from the GRACE registry
    Keith A A Fox
    Cardiovascular Research, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    Nat Clin Pract Cardiovasc Med 5:580-9. 2008
  9. ncbi Comparison of enoxaparin versus unfractionated heparin in patients with unstable angina pectoris/non-ST-segment elevation acute myocardial infarction having subsequent percutaneous coronary intervention
    Keith A A Fox
    Edinburgh Royal Infirmary, Edinburgh, United Kingdom
    Am J Cardiol 90:477-82. 2002
  10. doi Does abdominal obesity have a similar impact on cardiovascular disease and diabetes? A study of 91,246 ambulant patients in 27 European countries
    Keith A A Fox
    Department of Cardiovascular Research, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 30:3055-63. 2009

Detail Information

Publications124 found, 100 shown here

  1. ncbi Resuscitation from out-of-hospital cardiac arrest: implications for cardiac enzyme estimation
    N R Grubb
    Cardiovascular Research Unit, University of Edinburgh, UK
    Resuscitation 33:35-41. 1996
    ..The use of MB-CK fraction leads to greater diagnostic error because of the variability of muscle CK release after resuscitation...
  2. pmc Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction--a hospital registry-primary care linked cohort (MINAP-GPRD)
    Rachael Boggon
    General Practice Research Database, Medicines and Healthcare products Regulatory Agency, 151 Buckingham Palace Road, London SW1W 9SZ, UK
    Eur Heart J 32:2376-86. 2011
    ..We examined the extent to which clopidogrel treatment initiated in hospital is continued in primary care; the factors predictive of clopidogrel discontinuation and the hazard of death or recurrent MI...
  3. doi European Society of Cardiology Congress 2013 highlights
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Future Cardiol 10:23-6. 2014
    ..In addition, innovative new approaches linked basic science and clinical science and the new ‘hubs of the congress’ allowed excellent interaction and exchange of ideas...
  4. doi A profile of Keith AA Fox, cardiologist and researcher
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Future Cardiol 10:27-9. 2014
    ..His current areas of research include the inhibition of coronary thrombosis and the role of platelets and inflammation in acute coronary syndromes...
  5. ncbi What's new for ESC congress 2013? (Amsterdam 30th august - 4th September 2013)
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
    Acta Cardiol 68:345-6. 2013
    ..Related specialty areas have much to learn from each other and the ESC Congress 2013 will attract specialists from other organ systems to help understand disease mechanisms and improve the management of our patients...
  6. pmc What's new for ESC Congress 2013? (Amsterdam 30 August - 4 September 2013)
    K A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Neth Heart J 21:304-6. 2013
    ..Related specialty areas have much to learn from each other and the ESC Congress 2013 will attract specialists from other organ systems to help understand disease mechanisms and improve the management of our patients...
  7. doi A European perspective on improving acute systems of care in STEMI: we know what to do, but how can we do it?
    Keith A A Fox
    Division of Medical and Radiological Sciences at Edinburgh University, Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 5:708-14. 2008
    ..Third, greater emphasis on quality improvement, collaboration among health professionals, and achieving high-quality care for all is required from funding bodies, regulatory agencies and professional societies...
  8. ncbi Time course of events in acute coronary syndromes: implications for clinical practice from the GRACE registry
    Keith A A Fox
    Cardiovascular Research, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    Nat Clin Pract Cardiovasc Med 5:580-9. 2008
    ..The time course of events after acute coronary syndromes might influence the timing and duration of therapeutic interventions. We investigated the impact of risk status and ST-segment category at presentation...
  9. ncbi Comparison of enoxaparin versus unfractionated heparin in patients with unstable angina pectoris/non-ST-segment elevation acute myocardial infarction having subsequent percutaneous coronary intervention
    Keith A A Fox
    Edinburgh Royal Infirmary, Edinburgh, United Kingdom
    Am J Cardiol 90:477-82. 2002
    ..Nevertheless, in the absence of large clinical trials, this study suggests that treatment with enoxaparin was well tolerated, and exhibited a similar risk of major hemorrhage to UFH in patients who underwent PCI...
  10. doi Does abdominal obesity have a similar impact on cardiovascular disease and diabetes? A study of 91,246 ambulant patients in 27 European countries
    Keith A A Fox
    Department of Cardiovascular Research, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 30:3055-63. 2009
    ..Differences in cardiovascular risk factors across Europe provide an opportunity to examine the impact of adiposity on the frequency of diabetes and cardiovascular disease (CVD)...
  11. ncbi Influence of renal function on the efficacy and safety of fondaparinux relative to enoxaparin in non ST-segment elevation acute coronary syndromes
    Keith A A Fox
    Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom
    Ann Intern Med 147:304-10. 2007
    ..Renal dysfunction increases the risk for major bleeding...
  12. pmc British Cardiac Society Working Group on the definition of myocardial infarction
    K A A Fox
    University of Edinburgh, Edinburgh, UK
    Heart 90:603-9. 2004
    ..A revision process has been initiated under the guidance of the ESC, the ACC, and the American Heart Association (AHA). The purpose of this report is to help inform the next revision of the ESC/ACC/AHA guidelines for the diagnosis of MI...
  13. pmc Management of acute coronary syndromes: an update
    Keith A A Fox
    Cardiovascular Research Unit, Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Heart 90:698-706. 2004
  14. ncbi British Cardiac Society Working Group on the definition of myocardial infarction
    K A A Fox
    Chancellor s Building, 49 Little France Crescent, University of Edinburgh, Edinburgh EH16 4SB, Scotland, UK
    Ann Clin Biochem 41:263-71. 2004
    ..A revision process has been initiated under the guidance of the ESC, the ACC, and the American Heart Association (AHA). The purpose of this report is to help inform the next revision of the ESC/ACC/AHA guidelines for the diagnosis of MI...
  15. ncbi From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE)
    Keith A A Fox
    Department of Cardiology, The Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh EH3 9YW, Scotland, UK
    Eur Heart J 24:1414-24. 2003
    ..The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are modifiable, remain uncertain...
  16. ncbi Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial
    Keith A A Fox
    Royal Infirmary of Edinburgh, Edinburgh, UK
    Circulation 110:1202-8. 2004
    ..Antiplatelet therapy and antithrombin therapy have been demonstrated to reduce the risk of cardiac events in patients presenting with acute coronary syndrome, yet all effective therapies also increase the risk of bleeding...
  17. ncbi 5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial
    K A A Fox
    Centre for Cardiovascular Science, Department of Medical and Radiological Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK
    Lancet 366:914-20. 2005
    ..We tested whether an interventional strategy (routine angiography followed by revascularisation) was better than a conservative strategy (ischaemia-driven or symptom-driven angiography) over 5 years' follow-up...
  18. pmc Intervention in acute coronary syndromes: do patients undergo intervention on the basis of their risk characteristics? The Global Registry of Acute Coronary Events (GRACE)
    K A A Fox
    Cardiovascular Research, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK
    Heart 93:177-82. 2007
    ..To determine whether revascularisation is more likely to be performed in higher-risk patients and whether the findings are influenced by hospitals adopting more or less aggressive revascularisation strategies...
  19. pmc Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)
    Keith A A Fox
    Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB
    BMJ 333:1091. 2006
    ..To develop a clinical risk prediction tool for estimating the cumulative six month risk of death and death or myocardial infarction to facilitate triage and management of patients with acute coronary syndrome...
  20. ncbi Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006
    Keith A A Fox
    Cardiovascular Research, Division of Medical and Radiological Sciences, The University of Edinburgh, Edinburgh, Scotland
    JAMA 297:1892-900. 2007
    ....
  21. ncbi Long-term outcome of a routine versus selective invasive strategy in patients with non-ST-segment elevation acute coronary syndrome a meta-analysis of individual patient data
    Keith A A Fox
    British Heart Foundation Professor of Cardiology, Centre for Cardiovascular Science, University and Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Am Coll Cardiol 55:2435-45. 2010
    ....
  22. ncbi Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Randomized Intervention Trial of unstable Angina
    K A A Fox
    Cardiovascular Research, Department of Medical and Radiological Sciences, Royal Infirmary, Edinburgh EH3 9YW, UK
    Lancet 360:743-51. 2002
    ..We aimed to test the hypothesis that an interventional strategy is better than a conservative strategy in such patients...
  23. doi The Global Registry of Acute Coronary Events, 1999 to 2009--GRACE
    K A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Heart 96:1095-101. 2010
    ..Six-month follow-up was 85% complete. Publications and risk scores are available at http://www.outcome.org/grace. Proposals for specific analyses were considered, in competition, by an independent publications committee...
  24. doi Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study)
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 31:2755-64. 2010
    ....
  25. doi Acute coronary syndromes in 2010: progress from trials to practice
    Keith A A Fox
    University BHF Centre for Cardiovascular Science, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh UK
    Nat Rev Cardiol 8:68-70. 2011
    ..Key publications in 2010 have addressed this issue and questioned whether specific acs therapies should be targeted according to clinical and genetic characteristics...
  26. ncbi An international perspective on acute coronary syndrome care: insights from the Global Registry of Acute Coronary Events
    Keith A A Fox
    University and the Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom
    Am Heart J 148:S40-5. 2004
    ....
  27. doi Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 32:2387-94. 2011
    ..Rivaroxaban, an oral, direct factor Xa inhibitor metabolized predominantly by the liver, preserves the benefit of warfarin for stroke prevention while causing fewer intracranial and fatal haemorrhages...
  28. pmc Has the frequency of bleeding changed over time for patients presenting with an acute coronary syndrome? The global registry of acute coronary events
    Keith A A Fox
    Cardiovascular Research, Division of Medical and Radiological Sciences, The University of Edinburgh, Edinburgh, UK
    Eur Heart J 31:667-75. 2010
    ..To determine whether changes in practice, over time, are associated with altered rates of major bleeding in acute coronary syndromes (ACS)...
  29. ncbi An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Scotland, UK
    Thromb Haemost 78:1242-8. 1997
    ..This model should provide a useful and selective method of assessing the in vivo capacity of the forearm endothelium to release t-PA acutely...
  30. ncbi The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, UK
    Cardiovasc Res 38:485-92. 1998
    ..Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man...
  31. ncbi Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
    Circulation 99:1411-5. 1999
    ..Smoking is a known risk factor for arterial thrombosis and myocardial infarction, and it causes endothelial dysfunction. We therefore examined the effects of cigarette smoking on substance P-induced tPA release in vivo in humans...
  32. ncbi Reduced responsiveness to endothelin-1 in peripheral resistance vessels of patients with syndrome X
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Scotland, United Kingdom
    J Am Coll Cardiol 31:1585-90. 1998
    ..This study sought to assess the contribution and action of nitric oxide and endothelin-1 in peripheral resistance vessels of patients with syndrome X...
  33. ncbi Intra-arterial tumor necrosis factor-alpha impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans
    Stanley Chia
    Department of Cardiology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Arterioscler Thromb Vasc Biol 23:695-701. 2003
    ..We assessed the direct effects of local intra-arterial tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and endotoxin on blood flow and endogenous tissue plasminogen activator (t-PA) release in vivo in humans...
  34. ncbi Effect of DC shock on serum levels of total creatine kinase, MB-creatine kinase mass and troponin T
    N R Grubb
    Cardiovascular Research Unit, University of Edinburgh, Lauriston Place, UK
    Resuscitation 36:193-9. 1998
    ..Electrical injury is not likely to account for the elevated troponin T levels seen after out-of-hospital resuscitation in patients without myocardial infarction...
  35. ncbi Characterisation of atherosclerotic plaque by spectral analysis of intravascular ultrasound: an in vitro methodology
    T Spencer
    Department of Medical Physics, Edinburgh University, Western General Hospital, Scotland, UK
    Ultrasound Med Biol 23:191-203. 1997
    ..However, the greatest discriminative power was given by the y-axis (0 Hz) intercept of the spectral slope: LFT/DFT (p = 0.001); LFT/CA (p = 0.0001); and DFT/CA (p = 0.089)...
  36. ncbi Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, UK
    Thromb Haemost 84:195-203. 2000
    ..Patients with type 3 vWD appear to have a generalised failure to release t-PA acutely despite a normal interleukin-6 response to desmopressin infusion...
  37. pmc Regulation of peripheral vascular tone in patients with heart failure: contribution of angiotensin II
    D E Newby
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, UK
    Heart 80:134-40. 1998
    ..To determine directly the contribution of angiotensin II to basal and sympathetically stimulated peripheral arteriolar tone in patients with heart failure...
  38. ncbi Unstable angina: the first 48 hours and later in-hospital management
    D E Newby
    Department of Cardiology, Edinburgh Royal Infirmary, Edinburgh, UK
    Br Med Bull 59:69-87. 2001
    ..Moreover, rapid and intensive management of associated risk factors, such as hypercholesterolaemia, would appear to have potentially substantial benefits even within the acute in-hospital phase of unstable angina...
  39. ncbi Antithrombotic therapy in acute coronary syndromes: key notes from ESSENCE and TIMI 11B
    K A Fox
    Department of Medical and Radiological Sciences, Cardiology, The Royal Infirmary, Edinburgh, Scotland, UK
    Semin Hematol 38:67-74. 2001
    ..In contrast, studies with other LMWHs have not shown consistent superiority over unfractionated heparin. This may reflect the pharmacologic heterogeneity of LMWH and/or differences in trial design...
  40. ncbi A 'same day' direct-access chest pain clinic: improved management and reduced hospitalization
    D E Newby
    Department of Cardiology, Royal Infirmary, Edinburgh, UK
    QJM 91:333-7. 1998
    ....
  41. ncbi Clopidogrel in acute coronary heart disease
    Jehangir N Din
    Centre for Cardiovascular Sciences, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland
    Am Heart Hosp J 3:234-42. 2005
    ..The optimal loading dose and length of treatment, however, are yet to be firmly established, and there is a need to clearly identify those patients who will benefit most from additional glycoprotein IIb/IIIa inhibition...
  42. ncbi The safety of anistreplase from the placebo-controlled AIMS study (anistreplase Intervention Mortality Study). The AIMS Study Group
    K A Fox
    Department of Cardiology, University of Edinburgh, Scotland
    Clin Cardiol . 1990
    ..The frequency of in-hospital reinfarction was higher in anistreplase-treated patients compared with patients given placebo.(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis
    D E Newby
    Departments of Cardiology, University of Edinburgh, Royal Infirmary, United Kingdom
    Circulation 103:1936-41. 2001
    ..The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart...
  44. ncbi Memory impairment in out-of-hospital cardiac arrest survivors is associated with global reduction in brain volume, not focal hippocampal injury
    N R Grubb
    Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
    Stroke 31:1509-14. 2000
    ..The hippocampus may be vulnerable to hypoxic injury during cardiac arrest. The purpose of this study was to determine whether selective hippocampal injury is the substrate for this memory impairment...
  45. ncbi Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure
    Mark T Kearney
    Department of Cardiology, GKT School of Medicine, King s College London, Bessemer Road, Denmark Hill, London SE5 9PJ, United Kingdom
    J Am Coll Cardiol 40:1801-8. 2002
    ..The aim of this study was to explore the value of noninvasive predictors of death/mode of death in ambulant outpatients with chronic heart failure (HF)...
  46. ncbi The impact of renal dysfunction on outcomes in the ExTRACT-TIMI 25 trial
    Keith A A Fox
    University of Edinburgh, Edinburgh, United Kingdom
    J Am Coll Cardiol 49:2249-55. 2007
    ....
  47. ncbi Bradykinin receptor antagonism and endothelial tissue plasminogen activator release in humans
    Fraser N Witherow
    Cardiovascular Research, University of Edinburgh, University of Edinburgh, Royal Infirmary of Edinburgh, UK
    Arterioscler Thromb Vasc Biol 23:1667-70. 2003
    ..We sought to assess pharmacodynamic responses to the bradykinin antagonist B9340 and to determine the contribution of the endothelial bradykinin receptor to stimulated tissue plasminogen activator (t-PA) release in humans...
  48. ncbi Influence of differential vascular remodeling on the coronary vasomotor response
    Andrew L McLeod
    Department of Cardiology, Royal Infirmary, 51 Little France Crescent, Little France, Edinburgh EH16 4SA, UK
    Cardiovasc Res 59:520-6. 2003
    ..The study aims were to assess whether the pattern of vascular remodeling influences the physical and vasomotor responses of the coronary arteries in vivo in man...
  49. ncbi Vitamin C and the risk of acute myocardial infarction
    R A Riemersma
    British Heart Foundation Cardiovascular Research Unit, the Department of Cardiology and Medicine, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Am J Clin Nutr 71:1181-6. 2000
    ..Low-fat soluble-antioxidant status is associated with an increased risk of heart disease...
  50. ncbi B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, EH16 4SB
    Arterioscler Thromb Vasc Biol 25:772-7. 2005
    ..We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure...
  51. pmc Invasive assessment of the coronary circulation: intravascular ultrasound and Doppler
    David E Newby
    Cardiovascular Research, Department of Cardiology, Royal Infirmary, 1 Lauriston Place, Edinburgh EH3 9YW
    Br J Clin Pharmacol 53:561-75. 2002
  52. ncbi Marked bradykinin-induced tissue plasminogen activator release in patients with heart failure maintained on long-term angiotensin-converting enzyme inhibitor therapy
    Fraser N Witherow
    Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Am Coll Cardiol 40:961-6. 2002
    ....
  53. ncbi Laser Doppler anemometry measurements of the shear stresses on ultrasonic contrast agent microbubbles attached to agar
    Mairead B Butler
    Department of Medical Physics, University of Edinburgh, Edinburgh EH16 4SB, UK
    Ultrasound Med Biol 31:545-52. 2005
    ..The bubbles were found to remain attached to the agar for shear stresses of up to 3.4 Pa. This compares with mean physiological arterial shear stresses of less than 1.5 Pa for pulsatile flow...
  54. ncbi Seven-year outcome in the RITA-2 trial: coronary angioplasty versus medical therapy
    Robert A Henderson
    Department of Cardiology, Nottingham City Hospital, Nottingham, United Kingdom
    J Am Coll Cardiol 42:1161-70. 2003
    ..This study was designed to compare the long-term consequences of percutaneous transluminal coronary angioplasty (PTCA) and continued medical treatment...
  55. ncbi Clopidogrel: an updated and comprehensive review
    Keith A A Fox
    The University of Edinburgh, SU305 Chancellor s Building, Little France Crescent, Edinburgh, EH16 4SA, UK
    Expert Opin Drug Metab Toxicol 3:621-31. 2007
    ..Clopidogrel has changed the way in which patients with non-ST-elevation and, more recently, ST elevation acute coronary syndromes are treated...
  56. ncbi Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans
    Ingibjörg J Gudmundsdóttir
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Circulation 114:1625-32. 2006
    ..The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans...
  57. ncbi Plasma TAFI and soluble CD40 ligand do not predict reperfusion following thrombolysis for acute myocardial infarction
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, UK
    Thromb Res 118:189-97. 2006
    ....
  58. ncbi Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men
    Stanley Chia
    Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom
    J Am Coll Cardiol 41:333-9. 2003
    ..The purpose of this study was to investigate in vivo the effects of acute systemic inflammation on the endogenous fibrinolytic capacity in men...
  59. ncbi Evaluation of vascular injury following percutaneous transluminal coronary angioplasty: a comparison of the accuracy of two- and three-dimensional intracoronary ultrasound imaging
    Nicholas D Palmer
    Departments of Cardiology and Pathology, Western General Hospital, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Coron Artery Dis 14:255-62. 2003
    ..This study compares conventional two-dimensional ICUS imaging to combined two- and three-dimensional ICUS information in the assessment of vascular injury following PTCA...
  60. doi Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
    ..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
  61. ncbi Increased platelet binding to circulating monocytes in acute coronary syndromes
    Jaydeep Sarma
    Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK
    Circulation 105:2166-71. 2002
    ..Recent studies suggest that prevention of platelet-leukocyte binding via P-selectin glycoprotein ligand-1 (PSGL-1) may be beneficial in animal models of vascular injury...
  62. ncbi Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, EH16 4SB
    Hypertension 44:913-8. 2004
    ....
  63. ncbi Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom EH16 4SB
    Arterioscler Thromb Vasc Biol 24:1043-8. 2004
    ..Using B9340, a bradykinin receptor antagonist, we determined the contribution of bradykinin to the systemic hemodynamic effects of long-term ACE inhibition in patients with chronic heart failure...
  64. doi Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome
    Nicholas L Mills
    University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Bldg, Edinburgh EH16 4SB, Scotland
    JAMA 305:1210-6. 2011
    ....
  65. ncbi Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure
    John P LeMaitre
    Cardiology Department, Centre for Cardiovascular Research, Edinburgh, United Kingdom
    Am Heart J 147:100-5. 2004
    ..Training is known to improve symptoms in heart failure but less is known about the effects of specific forms of training on the proinflammatory state...
  66. ncbi Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure
    Anna R Dover
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Clin Sci (Lond) 111:275-80. 2006
    ..We conclude that iNOS activity does not contribute to peripheral vascular tone in patients with symptomatic heart failure...
  67. doi Diesel exhaust inhalation does not affect heart rhythm or heart rate variability
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 97:544-50. 2011
    ..This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease...
  68. ncbi Effects of a brief course of azithromycin on soluble cell adhesion molecules and markers of inflammation in survivors of an acute coronary syndrome: A double-blind, randomized, placebo-controlled study
    Graham S Hillis
    Department of Cardiology the Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Am Heart J 148:72-9. 2004
    ....
  69. doi Randomized controlled trial of dual antiplatelet therapy in patients undergoing surgery for critical limb ischemia
    Anne Burdess
    Departments of Clinical and Surgical Sciences, The University of Edinburgh, Edinburgh, United Kingdom
    Ann Surg 252:37-42. 2010
    ..We hypothesized that perioperative dual antiplatelet therapy would improve biomarkers of atherothrombosis without causing unacceptable bleeding in patients undergoing surgery for critical limb ischemia...
  70. ncbi Memory function in patients with stable, moderate to severe cardiac failure
    N R Grubb
    Cardiovascular Research Unit, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom
    Am Heart J 140:E1-5. 2000
    ..The prevalence of cognitive dysfunction in patients with stable, moderately severe cardiac failure is not known. The purpose of this study was to evaluate the prevalence of memory dysfunction in that population...
  71. ncbi Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    F N Witherow
    Department of Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, UK
    Circulation 104:2177-81. 2001
    ....
  72. ncbi Chronicity of memory impairment in long-term out-of-hospital cardiac arrest survivors
    E E Drysdale
    Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, EH10 4NZ, Edinburgh, UK
    Resuscitation 47:27-32. 2000
    ..We conclude that the memory deficits that we previously observed in cardiac arrest victims are persistent. Both recall and recognition memory are affected, implying that non-selective brain injury may be the mechanism...
  73. doi Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status
    Stylianos Bournazos
    The University of Edinburgh MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Arterioscler Thromb Vasc Biol 28:1491-8. 2008
    ....
  74. ncbi A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors
    Mark T Kearney
    Department of Cardiology, GKT School of Medicine, King s College, Bessemer Road, Denmark Hill, SE5 9PJ, London, UK
    Eur J Heart Fail 5:489-97. 2003
    ..Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term...
  75. pmc Prediction of cognitive dysfunction after resuscitation from out-of-hospital cardiac arrest using serum neuron-specific enolase and protein S-100
    Neil R Grubb
    Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, UK
    Heart 93:1268-73. 2007
    ..More than 50% of patients initially resuscitated from out-of-hospital cardiac arrest die in hospital...
  76. ncbi A randomised study of home-based electrical stimulation of the legs and conventional bicycle exercise training for patients with chronic heart failure
    Stuart Harris
    Cardiology, Centre for Cardiovascular Research, University of Edinburgh, Edinburgh, UK
    Eur Heart J 24:871-8. 2003
    ..This study was designed to compare the safety and efficacy of conventional bicycle exercise and functional electrical stimulation (FES) of the legs as forms of home-based exercise training for patients with stable CHF...
  77. ncbi Assessment of skeletal muscle ventricle function using tissue velocity imaging
    N R Grubb
    Cardiovascular Research Unit, University of Edinburgh, United Kingdom
    J Card Surg 12:420-30. 1997
    ....
  78. ncbi Classification of arterial plaque by spectral analysis of in vitro radio frequency intravascular ultrasound data
    R J Watson
    Department of Medical Physics and Medical Engineering, University of Edinburgh, UK
    Ultrasound Med Biol 26:73-80. 2000
    ..The total correctly classified was 86%. Using "leave-one-out" cross-validation, the classification rates were 48% for seven tissue subgroups and 83% for three broader categories of tissue type...
  79. ncbi Thyroid disease and increased cardiovascular risk
    Moffat J Nyirenda
    Endocrine Clinic, Royal Infirmary of Edinburgh, Edinburgh, Scotland
    Thyroid 15:718-24. 2005
    ..003). Thus, different forms of thyroid disease were associated with increased long-term vascular risk despite restoration of euthyroidism. The mechanisms that mediate this risk are unclear but may not involve thyroid hormone abnormality...
  80. ncbi Three-dimensional forward-viewing intravascular ultrasound imaging of human arteries in vitro
    L Gatzoulis
    Department of Medical Physics and Medical Engineering, Royal Infirmary of Edinburgh, Edinburgh, UK
    Ultrasound Med Biol 27:969-82. 2001
    ..A rotating-sector forward-viewing IVUS system is suitable for anatomical assessment of severely diseased vessels in three dimensions...
  81. ncbi Cardiac size, autonomic function, and 5-year follow-up of chronic heart failure patients with severe prolongation of ventricular activation
    Mark T Kearney
    Department of Cardiology, King s College, London, United Kingdom
    J Card Fail 9:93-9. 2003
    ..We tested the hypotheses that in patients with chronic heart failure, QRS > 150 ms is a risk factor for additional abnormalities of ventricular morphology, heart rate variability, and increased mortality...
  82. ncbi Maximum oxygen uptake corrected for skeletal muscle mass accurately predicts functional improvements following exercise training in chronic heart failure
    John P LeMaitre
    Cardiology, Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
    Eur J Heart Fail 8:243-8. 2006
    ..Skeletal muscle mass and peak oxygen uptake are important predictors of functional status and outcome in patients with stable chronic heart failure...
  83. ncbi Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial
    Shamir R Mehta
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, General Division, 237 Barton St E, Hamilton, Ontario, Canada L6K 1B8
    Circulation 111:1390-7. 2005
    ..We performed a randomized trial to determine the safety and feasibility of fondaparinux in the percutaneous coronary intervention (PCI) setting...
  84. ncbi Benefit of clopidogrel in patients with acute coronary syndromes without ST-segment elevation in various risk groups
    Andrzej Budaj
    Postgraduate Medical School, Grochowski Hospital Warsaw, Poland
    Circulation 106:1622-6. 2002
    ..The purpose of the present analysis was to estimate the treatment effect Zof clopidogrel in patients who were stratified according to their risk of future cardiovascular events...
  85. doi Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis
    Michelle O'Donoghue
    TIMI Study Group, Brigham and Women s Hospital, 350 Longwood Ave, First Floor, Boston, MA 02115, USA
    JAMA 300:71-80. 2008
    ..Although an invasive strategy is frequently used in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS), data from some trials suggest that this strategy may not benefit women...
  86. ncbi Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study
    Ron J G Peters
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 108:1682-7. 2003
    ..We studied the benefits and risks of adding clopidogrel to different doses of aspirin in the treatment of patients with acute coronary syndrome (ACS)...
  87. ncbi Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE)
    Alvaro Avezum
    Dante Pazzanese Cardiology Institute, Research Division, Sao Paulo, Brazil
    Am Heart J 149:67-73. 2005
    ..Evidence-based cardiac therapies are underutilized in elderly patients. We assessed differences in practice patterns, comorbidities, and in-hospital event rates, by age and type of acute coronary syndrome (ACS)...
  88. ncbi Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST-elevation myocardial infarction. Design and rationale for the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thro
    Elliott M Antman
    TIMI Study Group, Boston, MA 02115, USA
    Am Heart J 149:217-26. 2005
  89. doi Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go
    Kim A Eagle
    University of Michigan Cardiovascular Center, Ann Arbor, MI 48109 0477, USA
    Eur Heart J 29:609-17. 2008
    ..Many patients who are eligible for acute reperfusion therapy receive it after substantial delays or not at all. We wanted to determine whether over the years more patients are receiving reperfusion therapy...
  90. ncbi Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A-to-Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, 5323 Harry Hines Blvd, Rm HA 9 133, UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Eur Heart J 25:1688-94. 2004
    ..However, less is known about the relative merits of these two forms of heparin in patients receiving concomitant glycoprotein IIb/IIIa inhibitors...
  91. ncbi Costs and cost effectiveness of low molecular weight heparins and platelet glycoprotein IIb/IIIa inhibitors: in the management of acute coronary syndromes
    Nick Bosanquet
    Department of Bioengineering, Imperial College School of Science, Technology and Medicine, London, UK
    Pharmacoeconomics 21:1135-52. 2003
    ..However, more comprehensive economic data on the GP IIb/IIIa inhibitors are needed...
  92. ncbi Global patterns of use of antithrombotic and antiplatelet therapies in patients with acute coronary syndromes: insights from the Global Registry of Acute Coronary Events (GRACE)
    Andrzej Budaj
    Postgraduate Medical School, Grochowski Hospital Warsaw, Poland
    Am Heart J 146:999-1006. 2003
    ..The objective of this report was to describe patterns of use of antithrombotic and antiplatelet therapies in patients with the spectrum of ACS through the use of data from the Global Registry of Acute Coronary Events (GRACE)...
  93. ncbi Six-month outcomes in a multinational registry of patients hospitalized with an acute coronary syndrome (the Global Registry of Acute Coronary Events [GRACE])
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 93:288-93. 2004
    ..These data suggest the need for better long-term medical management and more intense follow-up of patients with an ACS to improve their long-term outlook...
  94. ncbi Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction
    Rajendra H Mehta
    University of Michigan, Ann Arbor, Mich, USA
    Am Heart J 147:253-9. 2004
    ....
  95. ncbi Patterns of use of heparins in ACS. Correlates and hospital outcomes: the Global Registry of Acute Coronary Events (GRACE)
    Werner Klein
    Medizinische Universitätsklinik Graz, Klinische Abteilung für Kardiologie, Auenbruggerplatz 5, Graz, Styria 8036, Austria
    Thromb Haemost 90:519-27. 2003
    ..We can conclude that UFH tends to be used more frequently than LMWH, but hospital outcomes appeared to be better with LMWH after adjusting for covariables...
  96. ncbi A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry
    Kim A Eagle
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA
    JAMA 291:2727-33. 2004
    ..Accurate estimation of risk for untoward outcomes after patients have been hospitalized for an acute coronary syndrome (ACS) may help clinicians guide the type and intensity of therapy...
  97. ncbi Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study
    Frederick A Spencer
    Department of Medicine Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Ann Intern Med 140:857-66. 2004
    ..Statins administered early in patients with acute coronary syndromes may lead to modest reductions in recurrent ischemic events...
  98. ncbi Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial
    Michael A Blazing
    Duke Clinical Research Institute, Durham, NC, USA
    JAMA 292:55-64. 2004
    ..It is not clear if combining enoxaparin with glycoprotein IIb/IIIa inhibitors is as safe or as effective as the current standard combination of unfractionated heparin with glycoprotein IIb/IIIa inhibitors...
  99. ncbi Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment
    Jonas Oldgren
    Uppsala Clinical Research Center, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Eur Heart J 29:315-23. 2008
    ..We evaluated fondaparinux treatment vs. usual care, i.e. placebo or unfractionated (UF) heparin, in a pre-specified subgroup of 2867 (out of 12 092) patients not receiving reperfusion treatment in the OASIS-6 trial...
  100. ncbi Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction?
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences, 1200 Main St W, Hamilton, Canada, L8N 3Z5
    Circulation 116:2793-801. 2007
    ..Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world" setting...