Gerry Fowkes

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Atherosclerotic Vascular Disease Conference: Writing Group I: epidemiology
    Richard C Pasternak
    Circulation 109:2605-12. 2004
  2. doi request reprint Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK Electronic address
    Lancet 382:1329-40. 2013
  3. pmc Accrual and drop out in a primary prevention randomised controlled trial: qualitative study
    Helen C Eborall
    Department of Health Sciences, University of Leicester, UK
    Trials 12:7. 2011
  4. pmc A cross-sectional study of vascular risk factors in a rural South African population: data from the Southern African Stroke Prevention Initiative (SASPI)
    Margaret Thorogood
    University of Warwick, Coventry, UK
    BMC Public Health 7:326. 2007
  5. ncbi request reprint Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study
    F G Fowkes
    Department of Public Health Sciences, Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Teviot Place, Edinburgh, UK
    Atherosclerosis 150:179-85. 2000
  6. ncbi request reprint Ankle-brachial index and extent of atherothrombosis in 8891 patients with or at risk of vascular disease: results of the international AGATHA study
    F Gerald R Fowkes
    Department of Public Health Sciences, Wolfson Unit for the Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh EH8 9AG, UK
    Eur Heart J 27:1861-7. 2006
  7. pmc Distribution of a subclinical marker of cardiovascular risk, the ankle brachial index, in a rural African population: SASPI study
    F Gerry R Fowkes
    FRCPE, Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, UK
    Eur J Cardiovasc Prev Rehabil 13:964-9. 2006
  8. ncbi request reprint Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease
    F Gerald R Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 43:474-80. 2006
  9. doi request reprint Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
  10. ncbi request reprint Prevalence and risk factors of chronic venous insufficiency
    F G Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Scotland
    Angiology 52:S5-15. 2001

Detail Information

Publications43

  1. ncbi request reprint Atherosclerotic Vascular Disease Conference: Writing Group I: epidemiology
    Richard C Pasternak
    Circulation 109:2605-12. 2004
  2. doi request reprint Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK Electronic address
    Lancet 382:1329-40. 2013
    ....
  3. pmc Accrual and drop out in a primary prevention randomised controlled trial: qualitative study
    Helen C Eborall
    Department of Health Sciences, University of Leicester, UK
    Trials 12:7. 2011
    ..Limited research on these issues has been conducted on healthy individuals recruited for prevention trials in the community...
  4. pmc A cross-sectional study of vascular risk factors in a rural South African population: data from the Southern African Stroke Prevention Initiative (SASPI)
    Margaret Thorogood
    University of Warwick, Coventry, UK
    BMC Public Health 7:326. 2007
    ..Using a multidisciplinary approach we aimed to assess the prevalence of several vascular risk factors in Agincourt, a rural demographic surveillance site in South Africa...
  5. ncbi request reprint Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study
    F G Fowkes
    Department of Public Health Sciences, Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Teviot Place, Edinburgh, UK
    Atherosclerosis 150:179-85. 2000
    ....
  6. ncbi request reprint Ankle-brachial index and extent of atherothrombosis in 8891 patients with or at risk of vascular disease: results of the international AGATHA study
    F Gerald R Fowkes
    Department of Public Health Sciences, Wolfson Unit for the Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh EH8 9AG, UK
    Eur Heart J 27:1861-7. 2006
    ..The principal hypotheses were that (1) in diseased patients, a low ABI was related to the number and site of vascular beds affected and (2) in at-risk patients without disease, a low ABI was related to the number of risk factors present...
  7. pmc Distribution of a subclinical marker of cardiovascular risk, the ankle brachial index, in a rural African population: SASPI study
    F Gerry R Fowkes
    FRCPE, Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, UK
    Eur J Cardiovasc Prev Rehabil 13:964-9. 2006
    ..The aim of our study was to measure for the first time in an African population the ankle brachial index (ABI), which is known to be a good marker of subclinical atheroma and of the risk of future cardiovascular events...
  8. ncbi request reprint Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease
    F Gerald R Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 43:474-80. 2006
    ..The aim of this study was to determine if these factors accounted for the link between aneurysms and pulmonary disease...
  9. doi request reprint Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
    ..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
  10. ncbi request reprint Prevalence and risk factors of chronic venous insufficiency
    F G Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Scotland
    Angiology 52:S5-15. 2001
    ..Much further research is required to investigate the cause of this common condition in the general population...
  11. pmc Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia
    Riccardo E Marioni
    Centre for Population Health Sciences, Public Health Sciences Section, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK
    Psychosom Med 71:901-6. 2009
    ..To determine whether circulating levels of the biomarkers C-reactive protein (CRP), fibrinogen, plasma viscosity, and hematocrit were associated with cognitive decline in middle-aged to elderly people...
  12. doi request reprint Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
    Riccardo E Marioni
    Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK
    Behav Genet 40:3-11. 2010
    ..038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability...
  13. doi request reprint Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function
    Jennifer L Bolton
    Public Health Sciences, University of Edinburgh, Medical School, Edinburgh EH9 1NN, UK
    Behav Genet 40:630-8. 2010
    ..003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability 'g' (p = 0.007). There was an indication of a potential interaction between the DRD2 SNPs...
  14. doi request reprint Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts
    Riccardo E Marioni
    Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Behav Genet 41:691-9. 2011
    ..These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons...
  15. pmc Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Riccardo E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Diabetes 59:710-3. 2010
    ....
  16. pmc High rates of ischaemic heart disease in Scotland are not explained by conventional risk factors
    Richard Mitchell
    Research Unit in Health, Behaviour and Change, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Epidemiol Community Health 59:565-7. 2005
    ..62 (1.30, 2.02))...
  17. doi request reprint Haemorheological predictors of cognitive decline: the Edinburgh Artery Study
    Snorri Rafnsson
    Public Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Age Ageing 39:217-22. 2010
    ..vascular risk factors and diseases can negatively impact cognitive function. Determinants of blood flow are implicated in thrombogenesis and ischaemic events, yet little is known about their relationship with cognition...
  18. pmc Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 95:1602-8. 2010
    ..People with type 2 diabetes are at increased cardiovascular disease risk and thus are suitable to study associations of plasma cortisol with cardiovascular risk...
  19. pmc Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Jie Ding
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Diabetes 59:2883-9. 2010
    ..A considerable homology exists between the retinal and cerebral microcirculations; a hypothesized association between diabetic retinopathy (DR) and cognitive decline was examined in older people with type 2 diabetes...
  20. ncbi request reprint Cognitive decline and markers of inflammation and hemostasis: the Edinburgh Artery Study
    Snorri B Rafnsson
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK
    J Am Geriatr Soc 55:700-7. 2007
    ..To determine whether circulating markers of activated inflammation and hemostasis are associated with cognitive decline in older people...
  21. doi request reprint Ankle--brachial index predicts level of, but not change in, cognitive function: the Edinburgh Artery Study at the 15-year follow-up
    Wendy Johnson
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Vasc Med 15:91-7. 2010
    ..In conclusion, over long time periods, low ABI may be associated with reduced cognitive function in older adults, at least partly because the associated poor health creates anxiety and depression...
  22. ncbi request reprint Changes in ankle brachial index in symptomatic and asymptomatic subjects in the general population
    Felicity B Smith
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Community Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Vasc Surg 38:1323-30. 2003
    ..To determine changes over time in the ankle brachial index (ABI) among subjects with and without intermittent claudication in the general population...
  23. ncbi request reprint Low ankle-brachial pressure index predicts increased risk of cardiovascular disease independent of the metabolic syndrome and conventional cardiovascular risk factors in the Edinburgh Artery Study
    Sarah H Wild
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland
    Diabetes Care 29:637-42. 2006
    ..To investigate whether a low ankle-brachial pressure index (ABI) predicts increased risk of cardiovascular disease (CVD) independent of the metabolic syndrome and conventional cardiovascular risk factors...
  24. doi request reprint Metabolic syndrome, haemostatic and inflammatory markers, cerebrovascular and peripheral arterial disease: The Edinburgh Artery Study
    Sarah H Wild
    University of Edinburgh, Teviot Place, United Kingdom
    Atherosclerosis 203:604-9. 2009
    ..Improving insulin sensitivity may reduce cerebrovascular disease risk...
  25. pmc Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial
    Jackie F Price
    Division of Community Health Sciences and Centre for Public Health and Primary Care Research, University of Edinburgh, Edinburgh
    BMJ 337:a1198. 2008
    ..To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk...
  26. ncbi request reprint Lifestyle factors and the risk of varicose veins: Edinburgh Vein Study
    Amanda J Lee
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    J Clin Epidemiol 56:171-9. 2003
    ..In addition, no consistent relationship with any lifestyle factor was shown. Self-reported evidence suggested a familial susceptibility, thereby warranting future genetic studies...
  27. ncbi request reprint Ankle brachial index and intima media thickness predict cardiovascular events similarly and increased prediction when combined
    Jackie F Price
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Division of Community Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    J Clin Epidemiol 60:1067-75. 2007
    ..To compare the predictive value of the ankle brachial index (ABI) and carotid intima media thickness (IMT) for cardiovascular events...
  28. ncbi request reprint Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, School of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Epidemiol 163:334-41. 2006
    ..Since D-dimer and fibrinogen are acute phase reactants, these data support the hypothesis that inflammation is more related to atherosclerosis than is hypercoagulation...
  29. ncbi request reprint Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Eur Heart J 28:354-62. 2007
    ..However, their role in peripheral arterial disease (PAD) is not well established and some of them, including the pro-inflammatory cytokine interleukin-6 (IL-6), have not been examined before in prospective epidemiological studies...
  30. ncbi request reprint Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    ....
  31. ncbi request reprint Ankle brachial index as a predictor of cognitive impairment in the general population: ten-year follow-up of the Edinburgh Artery Study
    Jacqueline F Price
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Division of Community Health Sciences, University of Edinburgh, Teviot Place Edinburgh, Scotland
    J Am Geriatr Soc 54:763-9. 2006
    ..To determine whether the ankle brachial index (ABI, a marker of generalized atherosclerosis) is associated with cognitive impairment after 10 years in older people...
  32. ncbi request reprint C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
    Circulation 112:976-83. 2005
    ..We therefore studied inflammatory markers as predictors of peripheral atherosclerotic progression, measured by the ankle-brachial index (ABI) at 3 consecutive time points over 12 years...
  33. ncbi request reprint Cardiovascular diseases and decline in cognitive function in an elderly community population: the Edinburgh Artery Study
    Snorri B Rafnsson
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Medical School, University of Edinburgh, Teviot Place, Edinburgh, UK
    Psychosom Med 69:425-34. 2007
    ..To investigate cognitive performance and 4-year change in cognitive function in relation to different clinical manifestations of atherosclerotic disease in an elderly community population...
  34. doi request reprint Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: Health-related quality of life outcomes, resource utilization, and cost-effectiveness analysis
    John F Forbes
    Centre for Population Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh, United Kingdom
    J Vasc Surg 51:43S-51S. 2010
    ..We now compare the effect on hospital costs and health-related quality of life (HRQOL) of the BSX-first and BAP-first revascularization strategies using a within-trial cost-effectiveness analysis...
  35. doi request reprint Intravenous naftidrofuryl for critical limb ischaemia
    Felicity B Smith
    Department of Public Health Sciences, The University of Edinburgh, Edinburgh, UK
    Cochrane Database Syst Rev 7:CD002070. 2012
    ..Approximately 25% of those affected will develop critical limb ischaemia (rest pain, ulceration and gangrene) within five years. Naftidrofuryl is a vasoactive drug which may be beneficial in the treatment of critical limb ischaemia...
  36. ncbi request reprint Cultural context, older age and smoking in Scotland: qualitative interviews with older smokers with arterial disease
    Odette Parry
    Research Unit in Health, Behaviour and Change, Department of Community Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Health Promot Int 17:309-16. 2002
    ..These data will be necessary to develop appropriate health promotion measures to successfully target aspects of lives that support smoking in later life...
  37. doi request reprint Association of KIBRA and memory
    Timothy C Bates
    Department of Psychology, University of Edinburgh, 7 George Square, EH89JZ, Scotland, UK
    Neurosci Lett 458:140-3. 2009
    ....
  38. ncbi request reprint The relationship between aortic wall distensibility and rupture of infrarenal abdominal aortic aneurysm
    Katie A Wilson
    Vascular Surgery Unit, University Department of Clinical and Surgical Sciences, the Medical Statistics Unit, University of Edinburgh, Royal Infirmary of Edinburgh, UK
    J Vasc Surg 37:112-7. 2003
    ..The purpose of this study was to determine whether AAA wall distensibility can be used to predict time to rupture independently of other recognized risk factors...
  39. ncbi request reprint Relationship between lifetime smoking, smoking status at older age and human cognitive function
    Marlene C W Stewart
    Wolfson Unit for the Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Neuroepidemiology 26:83-92. 2006
    ....
  40. doi request reprint Scottish smoke-free legislation and trends in smoking cessation
    Freya J I Fowkes
    Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Addiction 103:1888-95. 2008
    ..To investigate trends in smoking cessation before and after the introduction of Scottish smoke-free legislation and to assess the perceived influence of the legislation on giving up smoking and perceptions of the legislation in smokers...
  41. ncbi request reprint Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance
    Anthony R Brady
    MRC Clinical Trials Unit, London, UK
    Circulation 110:16-21. 2004
    ..The aim of this study was to characterize AAA growth in a national cohort of patients with AAA both overall and by cardiovascular risk factors...
  42. ncbi request reprint Chronic venous insufficiency: clinical and duplex correlations. The Edinburgh Vein Study of venous disorders in the general population
    C Vaughan Ruckley
    Vascular Surgery Unit and the Department of Medical Imaging, Royal Infirmary of Edinburgh, Scotland
    J Vasc Surg 36:520-5. 2002
    ..The objective of this study was to determine the prevalence of chronic venous insufficiency (CVI) in the general population and to correlate its clinical features with sonographically proven venous reflux...
  43. pmc The health-related quality of life of people with peripheral arterial disease in the community: the Edinburgh Artery Study
    Jo C Dumville
    Department of Health Sciences, York, UK
    Br J Gen Pract 54:826-31. 2004
    ..The health-related quality of life of people with peripheral arterial disease in the general population is unknown...