Affiliation: University of Edinburgh
Adutwum Ofosu K, Magnani D, Theil T, Price D, Fotaki V. The molecular and cellular signatures of the mouse eminentia thalami support its role as a signalling centre in the developing forebrain. Brain Struct Funct. 2016;221:3709-27 pubmed publisher
..Altogether, our data support a role of the EmT as a signalling centre in the developing mouse forebrain. ..
Fotaki V, Yu T, Zaki P, Mason J, Price D. Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3. J Neurosci. 2006;26:9282-92 pubmed
..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon. ..
Fotaki V, Price D, Mason J. Newly identified patterns of Pax2 expression in the developing mouse forebrain. BMC Dev Biol. 2008;8:79 pubmed publisher
..It seems especially useful as a marker of the telencephalic septum, because of its early, strong and characteristic expression in this structure. Further, its expression is maintained in the enlarged septum of Pax6Sey/Sey mutants. ..
Fotaki V, Price D, Mason J. Wnt/?-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects. J Comp Neurol. 2011;519:1640-57 pubmed publisher
..Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/?-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate. ..
Fotaki V, Smith R, Pratt T, Price D. Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/?-catenin signalling in the developing nasal retina of the mouse. Dev Biol. 2013;380:299-313 pubmed publisher
..Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification. ..
Smith R, Huang Y, Tian T, Vojtasova D, Mesalles Naranjo O, Pollard S, et al
. The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk. J Neurosci. 2017;37:7975-7993 pubmed publisher
..Our results unravel a new role of Foxg1 in promoting OF closure providing additional knowledge about the molecules and cellular mechanisms underlying coloboma formation. ..