Russell G Foster

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc The evolution of irradiance detection: melanopsin and the non-visual opsins
    Stuart N Peirson
    Nuffield Laboratory of Ophthalmology, University of Oxford, The John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Philos Trans R Soc Lond B Biol Sci 364:2849-65. 2009
  2. pmc Sleep and circadian rhythm disruption in schizophrenia
    Katharina Wulff
    Nuffield Laboratory of Ophthalmology, University of Oxford, The John Radcliffe Hospital, Headley Way, Oxford, UK
    Br J Psychiatry 200:308-16. 2012
  3. pmc Vertebrate ancient opsin photopigment spectra and the avian photoperiodic response
    Wayne I L Davies
    Nuffield Laboratory of Ophthalmology, Oxford University, Oxford, UK
    Biol Lett 8:291-4. 2012
  4. ncbi request reprint The rhythms of life: what your body clock means to you!
    Russell G Foster
    Nuffield Department of Clinical Neurosciences Nuffield Laboratory of Ophthalmology, Level 5 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford, UK
    Exp Physiol 99:599-606. 2014
  5. pmc The effects of using cognitive behavioural therapy to improve sleep for patients with delusions and hallucinations (the BEST study): study protocol for a randomized controlled trial
    Daniel Freeman
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Trials 14:214. 2013
  6. pmc Ultraviolet light provides a major input to non-image-forming light detection in mice
    Floor van Oosterhout
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Curr Biol 22:1397-402. 2012
  7. doi request reprint Biological clocks: who in this place set up a sundial?
    Russell G Foster
    Nuffield Laboratory of Ophthalmology, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, UK
    Curr Biol 22:R405-7. 2012
  8. pmc Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina
    Farhan H Zaidi
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London W6 8RF, United Kingdom
    Curr Biol 17:2122-8. 2007
  9. ncbi request reprint Circadian vision
    Russell G Foster
    Department of Ophthalmology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Curr Biol 17:R746-51. 2007
  10. doi request reprint Human responses to the geophysical daily, annual and lunar cycles
    Russell G Foster
    Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 and 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 7BN, UK
    Curr Biol 18:R784-R794. 2008

Detail Information

Publications71

  1. pmc The evolution of irradiance detection: melanopsin and the non-visual opsins
    Stuart N Peirson
    Nuffield Laboratory of Ophthalmology, University of Oxford, The John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Philos Trans R Soc Lond B Biol Sci 364:2849-65. 2009
    ....
  2. pmc Sleep and circadian rhythm disruption in schizophrenia
    Katharina Wulff
    Nuffield Laboratory of Ophthalmology, University of Oxford, The John Radcliffe Hospital, Headley Way, Oxford, UK
    Br J Psychiatry 200:308-16. 2012
    ..Sleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions...
  3. pmc Vertebrate ancient opsin photopigment spectra and the avian photoperiodic response
    Wayne I L Davies
    Nuffield Laboratory of Ophthalmology, Oxford University, Oxford, UK
    Biol Lett 8:291-4. 2012
    ..Such a correspondence argues strongly that VA opsin plays a key role in regulating seasonal reproduction in birds...
  4. ncbi request reprint The rhythms of life: what your body clock means to you!
    Russell G Foster
    Nuffield Department of Clinical Neurosciences Nuffield Laboratory of Ophthalmology, Level 5 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford, UK
    Exp Physiol 99:599-606. 2014
    ..This short review considers how 24 h rhythms are generated and regulated, the consequences of working against our body clock and the emerging relationship between SCRD and mental illness...
  5. pmc The effects of using cognitive behavioural therapy to improve sleep for patients with delusions and hallucinations (the BEST study): study protocol for a randomized controlled trial
    Daniel Freeman
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Trials 14:214. 2013
    ..The clear next step is a pilot randomized controlled test. The clinical aim is to test whether CBT-I can reduce both insomnia and psychotic symptoms. The trial will inform decisions for a definitive large-scale evaluation...
  6. pmc Ultraviolet light provides a major input to non-image-forming light detection in mice
    Floor van Oosterhout
    Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Curr Biol 22:1397-402. 2012
    ..Our data show that UVS cones play an important role in circadian and sleep regulation in mice...
  7. doi request reprint Biological clocks: who in this place set up a sundial?
    Russell G Foster
    Nuffield Laboratory of Ophthalmology, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, UK
    Curr Biol 22:R405-7. 2012
    ..How do circadian rhythms, alarm clocks and the light/dark cycle interact? The concept of social jetlag is informing our appreciation of the tensions and consequences of imposing an artificial temporal order upon our biology...
  8. pmc Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina
    Farhan H Zaidi
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London W6 8RF, United Kingdom
    Curr Biol 17:2122-8. 2007
    ....
  9. ncbi request reprint Circadian vision
    Russell G Foster
    Department of Ophthalmology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Curr Biol 17:R746-51. 2007
  10. doi request reprint Human responses to the geophysical daily, annual and lunar cycles
    Russell G Foster
    Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 and 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 7BN, UK
    Curr Biol 18:R784-R794. 2008
    ....
  11. ncbi request reprint Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit
    Alun R Barnard
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, London, UK
    Vis Neurosci 21:675-83. 2004
    ..Thus, it seems that non-rod non-cone photoreceptors can drive many, but not all, non-image-forming light responses...
  12. doi request reprint VA opsin-based photoreceptors in the hypothalamus of birds
    Stephanie Halford
    Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Curr Biol 19:1396-402. 2009
    ..These results provide the most complete cellular and molecular description of a deep brain photoreceptor in any vertebrate and strongly implicate VA opsin in mediating the avian photoperiodic response...
  13. ncbi request reprint Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice
    Ma ayan Semo
    Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Eur J Neurosci 18:3007-17. 2003
    ..Collectively, our data suggest that melanopsin RGCs form a heterogeneous population of neurons, and that most of the light-induced c-fos expression within these cells is associated with the endogenous photosensitivity of these neurons...
  14. doi request reprint The acute light-induction of sleep is mediated by OPN4-based photoreception
    Daniela Lupi
    Circadian and Visual Neuroscience Group, Nuffield Laboratory of Ophthalmology, Levels 5 and 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Nat Neurosci 11:1068-73. 2008
    ..Collectively, our findings describe a previously unknown pathway in sleep regulation and identify the pRGC/OPN4 signaling system as a potentially new pharmacological target for the selective manipulation of sleep and arousal states...
  15. ncbi request reprint Light-evoked FOS induction within the suprachiasmatic nuclei (SCN) of melanopsin knockout (Opn4-/-) mice: a developmental study
    Daniela Lupi
    Department of Visual Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital Campus, London, UK
    Chronobiol Int 23:167-79. 2006
    ..These results are related to the broader context of recent findings and the potential role(s) of a neonatal photoreceptor...
  16. ncbi request reprint Microarray analysis and functional genomics identify novel components of melanopsin signaling
    Stuart N Peirson
    Circadian and Visual Neuroscience Group, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 17:1363-72. 2007
    ..Here, we use a microarray-based approach, which we term transcriptional recalibration, coupled with functional genomics to identify downstream targets of melanopsin signaling...
  17. pmc The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate
    Stewart Thompson
    Nuffield Laboratory of Ophthalmology, The John Radcliffe Hospital, Headley Way, University of Oxford, Roosevelt Drive, Oxford OX3 9DU, UK
    Eur J Neurosci 28:724-9. 2008
    ..Surprisingly, this irradiance detection response is dependent upon rod and cone photoreceptors, with no apparent contribution from melanopsin pRGCs...
  18. pmc Differential expression of melanopsin isoforms Opn4L and Opn4S during postnatal development of the mouse retina
    Steven Hughes
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e34531. 2012
    ..We suggest that the distinct functions associated with these cell types will develop at different times during postnatal development...
  19. pmc Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina
    Susana S Pires
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 29:12332-42. 2009
    ....
  20. pmc Isolation and characterization of melanopsin (Opn4) from the Australian marsupial Sminthopsis crassicaudata (fat-tailed dunnart)
    Susana S Pires
    Circadian and Visual Neuroscience, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Proc Biol Sci 274:2791-9. 2007
    ..This approach reveals that the two marsupials show a higher sequence identity than that seen between rodents and primates, despite separating at approximately the same point in time, some 65-85 Myr ago...
  21. ncbi request reprint The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: a case report
    Katharina Wulff
    Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK
    Chronobiol Int 23:485-95. 2006
    ..These circadian abnormalities may reinforce the altered sleep patterns and the problems of cognitive function and social engagement associated with schizophrenic...
  22. doi request reprint Rapid assessment of sleep-wake behavior in mice
    Simon P Fisher
    Nuffield Laboratory of Ophthalmology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom
    J Biol Rhythms 27:48-58. 2012
    ..This approach is robust yet relatively inexpensive to implement and can be easily incorporated into ongoing screening programs to provide a powerful first-pass screen for assessing sleep and allied behaviors...
  23. pmc Disrupted circadian rhythms in a mouse model of schizophrenia
    Peter L Oliver
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Curr Biol 22:314-9. 2012
    ..Collectively, our data provide a link between disruption of circadian activity cycles and synaptic dysfunction in a model of neuropsychiatric disease...
  24. ncbi request reprint Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice
    Ma ayan Semo
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Eur J Neurosci 17:1793-801. 2003
    ..These findings, together with recent studies on melanopsin knockout mice, are consistent with the hypothesis that melanopsin-expressing ganglion cells are photosensitive and mediate a range of irradiance-detection tasks...
  25. ncbi request reprint Long-term constant light induces constitutive elevated expression of mPER2 protein in the murine SCN: a molecular basis for Aschoff's rule?
    Marta Muñoz
    Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College, Charing Cross Hospital, London, UK
    J Biol Rhythms 20:3-14. 2005
    ....
  26. doi request reprint Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception
    Steven Hughes
    The Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 5 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Eur J Neurosci 35:34-43. 2012
    ..Expression of TRPM3 is detected in Muller cells and the ciliary body but is absent from pRGCs, and thus our data support an indirect role for TRPM3 in pupillary light responses...
  27. ncbi request reprint Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epithelium
    Stuart N Peirson
    Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Brain Res Mol Brain Res 123:132-5. 2004
    ..Our results raise questions about the presumed function of melanopsin, and highlight the need for biochemical studies on this protein...
  28. doi request reprint Functional diversity of melanopsins and their global expression in the teleost retina
    Wayne I L Davies
    Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, Levels 5 6 West Wing, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Cell Mol Life Sci 68:4115-32. 2011
    ....
  29. ncbi request reprint Melanopsin: an exciting photopigment
    Mark W Hankins
    Circadian and Visual Neuroscience Group, Nuffield Laboratory of Ophthalmology, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Trends Neurosci 31:27-36. 2008
    ..Here we outline the discovery of this remarkable new photoreceptor system, review the structure of melanopsin and conclude with a working model of melanopsin phototransduction...
  30. ncbi request reprint Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?
    James Bellingham
    Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, United Kingdom
    J Exp Zool B Mol Dev Evol 297:1-10. 2003
    ....
  31. ncbi request reprint Melanopsin (Opn4) positive cells in the cat retina are randomly distributed across the ganglion cell layer
    Ma ayan Semo
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK
    Vis Neurosci 22:111-6. 2005
    ..Melanopsin containing cells showed no clear center-to-periphery gradient in their distribution and were comprised of a relatively uniform cellular population...
  32. ncbi request reprint 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo
    Sumathi Sekaran
    Circadian and Visual Neuroscience Group, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    J Neurosci 27:3981-6. 2007
    ..Collectively, our data further elucidate the phototransduction pathway in the photosensitive RGCs and demonstrate that 2-APB can be used to silence activity in these cells both in vitro and in vivo...
  33. ncbi request reprint Expression of opsin genes early in ocular development of humans and mice
    Emma E Tarttelin
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London W6 8RP, UK
    Exp Eye Res 76:393-6. 2003
    ..Human non-rod, non-cone opsins are also all expressed early, by 8.6 weeks post-conception. The implications of these observations are discussed with regard to the possible functions of these opsins at early stages of ocular development...
  34. doi request reprint Impact of age and retinal degeneration on the light input to circadian brain structures
    Daniela Lupi
    University of Oxford, Circadian and Visual Neuroscience Group, Nuffield Laboratory of Ophthalmology, Level 5 and 6, West Wing, The John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Neurobiol Aging 33:383-92. 2012
    ..Furthermore, we show light-induced Fos within the vLGN and IGL is predominantly subserved by rods and cones, and once again aging reduces the amplitude of this response...
  35. ncbi request reprint Comparison of clock gene expression in SCN, retina, heart, and liver of mice
    Stuart N Peirson
    Circadian and Visual Neuroscience Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem Biophys Res Commun 351:800-7. 2006
    ..In this study, we examine the molecular profile of clock genes within the central SCN pacemaker and peripheral oscillators, identifying differences in phasing, amplitude, waveform, and basal expression levels...
  36. doi request reprint Sleep and circadian rhythm disruption in social jetlag and mental illness
    Russell G Foster
    Nuffield Department of Clinical Neurosciences, Nuffield Laboratory of Ophthalmology, Oxford, United Kingdom
    Prog Mol Biol Transl Sci 119:325-46. 2013
    ....
  37. pmc The CRTC1-SIK1 pathway regulates entrainment of the circadian clock
    Aarti Jagannath
    Nuffield Department of Clinical Neurosciences Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Cell 154:1100-11. 2013
    ..Thus SIK1 provides negative feedback, acting to suppress the effects of light on the clock. This pathway provides a potential target for the regulation of circadian rhythms. ..
  38. ncbi request reprint Light, photoreceptors, and circadian clocks
    Russell G Foster
    Division of Circadian and Visual Neuroscience, University of Oxford, UK
    Methods Mol Biol 362:3-28. 2007
    ..The aims of this chapter are to provide an accessible introduction to photobiological methods and explain why these approaches need to be applied to the study of circadian systems...
  39. pmc Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina
    Steven Hughes
    Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Curr Biol 23:1696-701. 2013
    ..These data illustrate the importance of classical photoreceptors in providing spectral tuning of pRGC light responses and have important implications for the complexity of non-image-forming responses to light...
  40. ncbi request reprint Non-rod, non-cone photoreception in rodents and teleost fish
    Russell G Foster
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Novartis Found Symp 253:3-23; discussion 23-30, 52-5, 102-9. 2003
    ..We compare non-rod, non-cone ocular photoreceptors in mammals and fish, and examine the criteria used to place candidate photopigment molecules into a functional context...
  41. doi request reprint Irradiance encoding in the suprachiasmatic nuclei by rod and cone photoreceptors
    Hester C van Diepen
    1J H M, Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, P O Box 9600 Mailbox S5 P, 2300 RC, Leiden, The Netherlands
    FASEB J 27:4204-12. 2013
    ..8%). Collectively, our data demonstrate a role for classical photoreceptors in illuminance detection by the SCN...
  42. ncbi request reprint Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neurons
    Sumathi Sekaran
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital, London, United Kingdom
    Curr Biol 13:1290-8. 2003
    ..These data are consistent with the presence of a novel inner-retinal photoreceptor mediating non-image-forming irradiance detection...
  43. ncbi request reprint Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue
    Emma E Tarttelin
    Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London W6 8RP, UK
    FEBS Lett 554:410-6. 2003
    ..Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord...
  44. doi request reprint Next-generation sequencing in health-care delivery: lessons from the functional analysis of rhodopsin
    Wayne I L Davies
    Nuffield Department of Clinical Neuroscience, Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, University of Oxford, UK
    Genet Med 14:891-9. 2012
    ..We exemplify this issue with reference to human rhodopsin, in which pathogenic mutations can lead to autosomal dominant retinitis pigmentosa...
  45. doi request reprint Sleep and circadian rhythm disruption in neuropsychiatric illness
    Aarti Jagannath
    Department of Clinical Neurosciences Nuffield Laboratory of Ophthalmology, University of Oxford, Level 5 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, United Kingdom F Hoffmann La Roche AG, Pharma Research and Early Development, DTA Neuroscience pRED Grenzacherstrasse 124, Basel CH4070, Switzerland
    Curr Opin Neurobiol 23:888-94. 2013
    ..A deeper understanding of these links will provide not only a greater understanding of disease mechanisms, but also holds the promise of novel avenues for therapeutic intervention. ..
  46. ncbi request reprint Melanopsin: another way of signaling light
    Stuart Peirson
    Division of Neuroscience and Mental Health, Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London W6 8RF, United Kingdom
    Neuron 49:331-9. 2006
    ..This review discusses the signaling pathways that may underlie melanopsin-dependent phototransduction in native pRGCs, as well as the many exciting challenges ahead...
  47. doi request reprint Melanopsin phototransduction: slowly emerging from the dark
    Steven Hughes
    Nuffield Department of Clinical Neuroscience, Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom
    Prog Brain Res 199:19-40. 2012
    ....
  48. doi request reprint Vertebrate ancient opsin and melanopsin: divergent irradiance detectors
    Wayne L Davies
    Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford, UK OX3 9DU
    Photochem Photobiol Sci 9:1444-57. 2010
    ..g. va opsin) simply do not fit neatly within this scheme. Thus, the review concludes with a discussion of these anomalies and their context regarding the phylogeny of photoreceptor and photopigment development...
  49. ncbi request reprint Blue light-filtering intraocular lenses: review of potential benefits and side effects
    Fiona M Cuthbertson
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford Eye Hospital, Oxford, United Kingdom
    J Cataract Refract Surg 35:1281-97. 2009
    ..We place this information in context with regard to patients having cataract surgery and the day-to-day conditions in which they live...
  50. doi request reprint Sleep and circadian rhythm disturbances: multiple genes and multiple phenotypes
    Katharina Wulff
    Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Curr Opin Genet Dev 19:237-46. 2009
    ..Here we attempt to summarise what recent progress has been made, and what will be needed in the future to gain a more complete understanding of this fundamental aspect of physiology...
  51. ncbi request reprint Evaluating the links between schizophrenia and sleep and circadian rhythm disruption
    David Pritchett
    Nuffield Department of Clinical Neurosciences Nuffield Laboratory of Ophthalmology, University of Oxford, John Radcliffe Hospital, Level 5 6 West Wing, Headley Way, Oxford OX3 9DU, UK
    J Neural Transm 119:1061-75. 2012
    ....
  52. ncbi request reprint Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
    Katharina Wulff
    Circadian and Visual Neuroscience Group, Nuffield Laboratory of Ophthalmology, University of Oxford, Headley Way, Oxford, OX3 9DU, UK
    Nat Rev Neurosci 11:589-99. 2010
    ..The stabilization of sleep may be a means by which to reduce the symptoms of--and permit early intervention of--psychiatric and neurodegenerative disease...
  53. ncbi request reprint Non-rod, non-cone photoreception in the vertebrates
    Russell G Foster
    Department of Integrative and Molecular Neuroscience, Faculty of Medicine, Imperial College of Science, Engineering and Medicine, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
    Prog Retin Eye Res 21:507-27. 2002
    ..We also hope to convince the more casual reader that there is much more to vertebrate photoreceptors than the study of retinal rods and cones...
  54. ncbi request reprint The rhythm of rest and excess
    Russell G Foster
    Department of Visual Neuroscience, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Nat Rev Neurosci 6:407-14. 2005
    ..Our occupation of the night is having unanticipated costs for both our physical and mental health, which, if continued, might condemn whole sectors of our society to a dismal future...
  55. pmc Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii)
    Wayne I L Davies
    School of Animal Biology, University of Western Australia Oceans Institute and Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e51276. 2012
    ....
  56. pmc In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution
    James Bellingham
    Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, UK
    BMC Genomics 4:3. 2003
    ..Exceptions to this are RGR-opsin and melanopsin, whose genes have very different intron insertion positions. The gene structure of another opsin, peropsin (retinal pigment epithelium-derived rhodopsin homologue, RRH) is unknown...
  57. ncbi request reprint Keeping an eye on the time: the Cogan Lecture
    Russell G Foster
    Department of Integrative and Molecular Neuroscience, Faculty of Medicine, Imperial College of Science, Engineering, and Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom
    Invest Ophthalmol Vis Sci 43:1286-98. 2002
  58. pmc Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis
    Stuart N Peirson
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Nucleic Acids Res 31:e73. 2003
    ..We have automated this method to provide a means of streamlining the real-time PCR process, enabling analysis of experimental samples based upon their own reaction kinetics rather than those of artificial standards...
  59. pmc The nocturnal bottleneck and the evolution of activity patterns in mammals
    Menno P Gerkema
    Centre for Behaviour and Neuroscience, Department of Chronobiology, University of Groningen, Groningen, The Netherlands
    Proc Biol Sci 280:20130508. 2013
    ..Our conclusion presently is that arguments in favour of the nocturnal bottleneck hypothesis in eutherians prevail...
  60. ncbi request reprint Opsins and mammalian photoentrainment
    James Bellingham
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK
    Cell Tissue Res 309:57-71. 2002
    ....
  61. pmc Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by light
    Stewart Thompson
    Howard Hughes Medical Institute, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242, USA
    Eur J Neurosci 27:1973-9. 2008
    ..Together the evidence demonstrates a pronounced and sustained classical photoreceptor input to irradiance detection for negative masking, and suggests one role of classical photoreceptor input is to constrain dynamic range...
  62. ncbi request reprint Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position
    James Bellingham
    Department of Integrative and Molecular Neuroscience, Imperial College Faculty of Medicine, Charing Cross Hospital, London, UK
    Brain Res Mol Brain Res 107:128-36. 2002
    ..They might represent a separate branch of photopigment evolution in the vertebrates or they may have a non-direct photosensory function, perhaps as a photoisomerase, in non-rod, non-cone light detection...
  63. ncbi request reprint Seeing the light...in a new way
    Russell G Foster
    Department of Visual Neuroscience, Imperial College Faculty of Medicine, London, UK
    J Neuroendocrinol 16:179-80. 2004
    ..These receptors may even help modulate our mood and sense of well-being...
  64. ncbi request reprint Neurobiology: bright blue times
    Russell G Foster
    Imperial Coll, London, UK
    Nature 433:698-9. 2005
  65. ncbi request reprint VA opsin, melanopsin, and an inherent light response within retinal interneurons
    Aaron Jenkins
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom
    Curr Biol 13:1269-78. 2003
    ..As yet, there has been little more than speculation as to the physiological function of these opsins within local retinal circuit neurons...
  66. ncbi request reprint Inner retinal photoreceptors (IRPs) in mammals and teleost fish
    Russell G Foster
    Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Engineering and Medicine, Charing Cross Hospital, Fulham Palace Road, London, UK W6 8RF
    Photochem Photobiol Sci 3:617-27. 2004
    ..The discovery of IRPs in the vertebrates tells us that despite 150 years of research, we still have much to learn about how the eye processes light...
  67. ncbi request reprint Teleost multiple tissue (tmt) opsin: a candidate photopigment regulating the peripheral clocks of zebrafish?
    Paraskevi Moutsaki
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
    Brain Res Mol Brain Res 112:135-45. 2003
    ..Collectively the data suggest that tmt-opsin is a strong candidate for the photic regulation of zebrafish peripheral clocks...
  68. ncbi request reprint Placing ocular mutants into a functional context: a chronobiological approach
    Urs Albrecht
    Division of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musee 5, Switzerland
    Methods 28:465-77. 2002
    ..Such measurements have, and continue to provide, a remarkably powerful assay of how light is detected and transduced to regulate circadian rhythms. The methods used for such measurements in mice are described in the following article...
  69. ncbi request reprint Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cells
    Simon N Archer
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Eur J Neurosci 19:2923-30. 2004
    ..We hypothesize that the unique metabolic needs of photoreceptors justify this trade-off...
  70. ncbi request reprint A green cone-like pigment in the 'blind' mole-rat Spalax ehrenbergi: functional expression and photochemical characterization
    Jannie W H Janssen
    Department of Biochemistry UMC 160, Nijmegen Center for Molecular Lift, Sciences, University of Nijmegen Medical School, PO Box 9101, Nijmegen, The Netherlands
    Photochem Photobiol Sci 2:1287-91. 2003
    ..Finally, the slow part of the photocascade deviates in some aspects from that of sighted mammals. The possible relevance of these findings for the evolutionary adaptation of Spalax to a subterranean ecotope is discussed...
  71. ncbi request reprint Visual pigments and oil droplets in diurnal lizards: a comparative study of Caribbean anoles
    Ellis R Loew
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    J Exp Biol 205:927-38. 2002
    ..These findings suggest that anoline visual pigments, as far as they determine visual system spectral sensitivity, are not necessarily adapted to the photic environment or to the color of significant visual targets (e.g. dewlaps)...