J V Forrester

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. Forrester J, McMenamin P, Dando S. CNS infection and immune privilege. Nat Rev Neurosci. 2018;19:655-671 pubmed publisher
    ..We review the consequences of immune privilege in the context of CNS infections and ask whether immune privilege may provide protection for certain pathogens and promote their latency. ..
  2. Forrester J, Xu H, Kuffova L, Dick A, McMenamin P. Dendritic cell physiology and function in the eye. Immunol Rev. 2010;234:282-304 pubmed publisher
    ..This approach has considerable potential for use in translational clinical therapy to prevent sight-threatening disease caused by ocular inflammation. ..
  3. Forrester J. Bowman lecture on the role of inflammation in degenerative disease of the eye. Eye (Lond). 2013;27:340-52 pubmed publisher
    ..In this review, the range of inflammatory processes in the eye is evaluated in the context of how these processes impact upon retinal degenerative disease, particularly diabetic retinopathy and age-related macular degeneration. ..
  4. request reprint
    Klaska I, Forrester J. Mouse models of autoimmune uveitis. Curr Pharm Des. 2015;21:2453-67 pubmed
  5. Forrester J, Kuffova L, Dick A. Autoimmunity, Autoinflammation, and Infection in Uveitis. Am J Ophthalmol. 2018;189:77-85 pubmed publisher
    ..An uncontrolled, overexuberant host immune response may cause continuing irreversible tissue damage even after the infection has been cleared. ..
  6. Liu Y, Corbett C, Klaska I, Makinen K, Nickerson J, Cornall R, et al. Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3). Exp Eye Res. 2018;172:54-65 pubmed publisher
  7. Chen X, Kezic J, Forrester J, Goldberg G, Wicks I, Bernard C, et al. In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression. J Neuroinflammation. 2015;12:17 pubmed publisher
    ..This approach acts as a valuable adjunct to other methods of studying the clinical course of EAU. ..
  8. Leiper L, Walczysko P, Kucerova R, Ou J, Shanley L, Lawson D, et al. The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay. BMC Biol. 2006;4:27 pubmed
    ..A model is presented whereby minor abrasions, which are quickly healed in normal corneas, transiently persist in aniridic patients, compromising the corneal stroma. ..
  9. Stoppelkamp S, Reid D, Yeoh J, Taylor J, McKenzie E, Brown G, et al. Murine pattern recognition receptor dectin-1 is essential in the development of experimental autoimmune uveoretinitis. Mol Immunol. 2015;67:398-406 pubmed publisher
    ..Thus dectin-1 plays a critical role in the ability of complete Freund's adjuvant to induce EAU in mice. ..

More Information

Publications12

  1. request reprint
    Forrester J. Intermediate and posterior uveitis. Chem Immunol Allergy. 2007;92:228-43 pubmed
    ..Importantly, this has led to the development of new treatments with novel immunosuppressants and 'biologics' and the promise of cell-based therapies which may allow customized therapies tailored to the individual's inflammatory profile...
  2. Forrester J, Klaska I, Yu T, Kuffova L. Uveitis in mouse and man. Int Rev Immunol. 2013;32:76-96 pubmed publisher
  3. Voigt V, Wikstrom M, Kezic J, Schuster I, Fleming P, Makinen K, et al. Ocular antigen does not cause disease unless presented in the context of inflammation. Sci Rep. 2017;7:14226 pubmed publisher
    ..However, when the same antigen is presented during viral infection, antigen-specific T cells access the retina and autoimmune uveitis ensues. ..