D Forman

..Active treatment was strongly associated with improved survival, especially in non-small cell lung cancer...

..There is evidence for a small benefit of eradicating H. pylori in nonulcer dyspepsia, and this is confirmed by updating the Cochrane systematic review...

..In conclusion, outcomes of breast cancer treatment in South Asian patients were similar to non-Asian patients. Asian patients presented later to their GPs, with larger primary tumours and more frequently had mastectomy...

..A cross-sectional survey was performed to evaluate the association between H. pylori and adult height...

..Evidence relating the aetiology of gastric cancer to Helicobacter pylori infection, dietary factors, smoking, occupation, physical activity and anthropometry is presented...

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..Our results would suggest that in the clinical isolates investigated dupA is not associated with IL-8 induction in vitro...

..This study aimed to describe the changes in and predictors of length of stay (LOS) in hospital after surgery for breast cancer between 1997/98 and 2004/05 in two regions of England...

..The development of molecular biomarkers to identify Barrett's oesophagus patients with high rates of malignant transformation would represent a significant advance...

..pylori infections without risk of a symptomatic outcome, therefore screening represents a rational strategy for cancer prevention. Adoption of such a policy will require carefully balancing the costs of the programme with its benefits...

..Cancer incidence, mortality and survival statistics for the UK are routinely available; however, data on prevalence, which is generally regarded as an important measure for health planning and resource allocation, are relatively scarce...

..Decisive evidence concerning all the risks and benefits of a screen-and-treat strategy will be derived only from large, long-term, randomized, controlled trials...

..In the absence of such routine information, useful insights can be obtained from analysis of appropriate clinical datasets that exist in Japan...

..Its main recommendation was to concentrate care into the hands of site-specialist multidisciplinary teams. This study aimed to determine whether these teams improved processes and outcomes of care for breast cancer patients...

..84-1.03, P=0.15). In conclusion, the extent of implementation of the Calman-Hine report has been variable and its recommendations are associated with improvements in processes and outcomes of care for colorectal cancer patients...

..This study compared treatment and outcome information between the Medical Research Council Conventional versus Laparoscopic-Assisted Surgery in Colorectal Cancer (CLASICC) trial and the NCDR...

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..This population-based study investigated the frequency of hepatic resections for colorectal cancer metastases across England and their outcome...

..08; 95% CI 1.05-1.11). These effects may operate through several pathways, such as later presentation leading to advanced disease...

..All variables within the Royal College of Pathologists MPD are of prognostic significance. High-quality pathology reports are essential in providing accurate prognostic information and guiding optimal patient management...

..To examine the association between gastric atrophy, Helicobacter pylori and CagA status, and ratio of oesophageal squamous cell carcinoma to oesophageal adenocarcinoma (OSCC:OAC) amongst international heterogeneous populations...

..Previous analyses have, however, been confounded by failure to adjust for the location of the tumour within the rectum. This population-based study sought to examine whether variations in tumour height explained differences in APE use...

..This study aimed to examine the introduction of laparoscopic surgery in the English National Health Service...

..This study compared treatment and outcome information between the Medical Research Council Conventional versus Laparoscopic-Assisted Surgery in Colorectal Cancer (CLASICC) trial and the NCDR...

..There are few studies examining the stability of gastrointestinal symptoms during prolonged periods of follow-up...

..However, there is a need for studies of ethnicity that include indicators of individual living standards or socioeconomic status...

..Mortality, in contrast, appears to be levelling off, indicating that secondary prevention has been more effective...

..Potential aetiological causes for the increased rates include hypertension, smoking, a diet lacking fruit and vegetables, analgesic use and, particularly, obesity...

..Continuing declines in mortality can be expected in the current decade, as a result of the long-term effects of both mammography screening and increased use of systemic therapy...

..In addition, we sought to determine how variations in surgical management relate to the degree of specialisation and caseload of the managing consultant...

..Our objective was to analyse variation in non-metastatic prostate cancer management in the Northern and Yorkshire region of England...

..It is important to establish why male Barrett's esophagus and ERD patients are at increased risk of malignancy compared with females...

..Gastro-oesophageal reflux symptoms (GERS) are common in the community. However, few studies have examined their long-term natural history, or impact on survival...

..The data were analysed using path analysis to account for the complex variable interrelationships within the data...

..The degree of surgical site specialization varied considerably across hospital Trusts. In both cancer sites, the move towards surgical site specialization began prior to the publication of the Calman-Hine report...

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..Screening for Helicobacter pylori reduces dyspepsia and dyspepsia-related costs in positive individuals...

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..We report the outcome of this cohort 10 years after the original study ended...

..pylori) is acquired mainly in childhood, with studies demonstrating this is related to living conditions. Effects of sibling number and birth order on prevalence of infection have not been extensively studied...

..Such studies are necessary in order to understand the overall risks of cancer and death experienced by patients with BE...

..36 (95% CI 1.20-1.53) to 1.11 (95% CI 0.99-1.23). Differences in tumour thickness appeared to be the most important factor...

..The influence of adult socioeconomic status, co-habitation, gender, smoking, coffee and alcohol intake on risk of Helicobacter pylori infection is uncertain...

..The natural history of the condition has been studied extensively, but few studies have examined factors that predict its new onset or health care-seeking behavior...

..pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains...

..89; 95% CI: 0.77-1.03). CONCLUSIONS: There were significant reductions in total dyspepsia-related health care costs. The savings made were greater than the initial cost of H pylori screening and treatment...

..Trends in seminoma and nonseminoma conform to largely the same temporal patterns on this scale, implying that they share important etiologic factors...

..During the 1990s, there were moves to establish more specialised care of gynaecological cancers, with referral to multidisciplinary teams. The trends observed in this study are consistent with the goals of policy...

..To investigate the hypothesis that biological aging, as measured by age at diagnosis of some common cancers, is socioeconomically patterned...

..There is a need to improve completeness and standardization of detailed information collected on gastric cancer patients to allow detailed comparative analyses and interpretation...

..Grade decreased but stage increased with increasing age in women with breast cancer. The chances of data on stage and grade at diagnosis being unavailable increased with age in all cases...

..35) and of higher socioeconomic status (adjusted OR=1.58, 95% CI: 1.16, 2.15 (top tertile vs. bottom tertile)). White Caucasian ethnicity, male gender, and higher socioeconomic status are independent risk factors for Barrett's esophagus...

..This data suggests that heterocyclic amines do not play an important role in the aetiology of colorectal cancer but that exposure to other carcinogens such as polycyclic aromatic hydrocarbons may be important determinants of cancer risk...

..pylori CagA seronegative subjects. In conclusion, S. japonicum co-infection with H. pylori is associated with alterations in IgG responses to H. pylori and less gastric atrophy...

..However, few have reported the effect of quality of life on the development of dyspepsia. A 10-year longitudinal follow-up study examining the effect of quality of life on subsequent dyspepsia was performed...

..This study sought to determine what patient, tumor, and management factors influence the number of nodes retrieved and to determine if the extent of lymphadenectomy affects stage allocation and influences survival...

..06), GSTP1 (p=0.16, with p=0.02 after adjustment for potential confounders) and NQO1 predicted phenotype (p=0.01). Because of the multiple hypotheses tested in our study, these findings require independent confirmation...

..To identify by routine pathology which Dukes B colorectal cancer patients may benefit from chemotherapy...

..High conservation of ssrA in H. pylori was observed. The annotated ORF HP0784 in H. pylori, which largely overlaps ssrA, is unlikely to be functional. H. pylori ssrA interestingly expressed a large and a small tmRNA molecule...

..This systematic review and meta-analysis investigated whether increasing BMI is associated with Barrett's esophagus as compared to general population and GERD controls...

..Dyspepsia is common, and the condition is often chronic, with a relapsing and remitting nature. Factors influencing the decision to consult a physician with symptoms remain unclear...

..Significantly higher than reference HRs in Estonia and Poland suggest inadequacy or unavailability of treatments...

..CONCLUSIONS: H. pylori eradication therapy reduces the recurrence of peptic ulcer disease and is cost-effective...

..57; 95% CI, 1.81-3.64). Our data suggest that dietary folate intake may be an important determinant for premalignant colorectal disease development but not colorectal cancer, an association that is modified by MTHFR genotype...