A J Forhead

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Plasma leptin concentration in fetal sheep during late gestation: ontogeny and effect of glucocorticoids
    A J Forhead
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Endocrinology 143:1166-73. 2002
  2. pmc Effects of cortisol and dexamethasone on insulin signalling pathways in skeletal muscle of the ovine fetus during late gestation
    Juanita K Jellyman
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e52363. 2012
  3. ncbi request reprint Developmental changes in plasma angiotensin-converting enzyme concentration in fetal and neonatal lambs
    A J Forhead
    Department of Physiology, University of Cambridge, UK
    Reprod Fertil Dev 10:393-8. 1998
  4. doi request reprint Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheep
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Endocrinol 208:137-45. 2011
  5. ncbi request reprint Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term
    Alison J Forhead
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 147:5988-94. 2006
  6. pmc Developmental regulation of hepatic and renal gluconeogenic enzymes by thyroid hormones in fetal sheep during late gestation
    Alison J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 548:941-7. 2003
  7. doi request reprint Role of thyroid hormones in the developmental control of tissue glycogen in fetal sheep near term
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Exp Physiol 94:1079-87. 2009
  8. pmc The hungry fetus? Role of leptin as a nutritional signal before birth
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 587:1145-52. 2009
  9. ncbi request reprint Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestation
    A J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Exp Physiol 89:323-9. 2004
  10. pmc Role of leptin in the regulation of growth and carbohydrate metabolism in the ovine fetus during late gestation
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23EG, UK
    J Physiol 586:2393-403. 2008

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Plasma leptin concentration in fetal sheep during late gestation: ontogeny and effect of glucocorticoids
    A J Forhead
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Endocrinology 143:1166-73. 2002
    ..Furthermore, fetal treatment with exogenous and endogenous glucocorticoids increases circulating leptin concentration in utero...
  2. pmc Effects of cortisol and dexamethasone on insulin signalling pathways in skeletal muscle of the ovine fetus during late gestation
    Juanita K Jellyman
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e52363. 2012
    ..These findings may provide a mechanism by which elevated concentrations of endogenous glucocorticoids retard fetal growth...
  3. ncbi request reprint Developmental changes in plasma angiotensin-converting enzyme concentration in fetal and neonatal lambs
    A J Forhead
    Department of Physiology, University of Cambridge, UK
    Reprod Fertil Dev 10:393-8. 1998
    ..Therefore, in the sheep fetus, plasma ACE increased towards term in association with the prepartum cortisol surge. Developmental changes in ACE activity may be partly responsible for the ontogenic rise in fetal blood pressure...
  4. doi request reprint Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheep
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Endocrinol 208:137-45. 2011
    ....
  5. ncbi request reprint Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term
    Alison J Forhead
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 147:5988-94. 2006
    ..Some of the maturational effects of cortisol on deiodinase activity may be mediated by T3...
  6. pmc Developmental regulation of hepatic and renal gluconeogenic enzymes by thyroid hormones in fetal sheep during late gestation
    Alison J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 548:941-7. 2003
    ..Therefore, in fetal sheep, thyroid hormones are important for the prepartum rises in G6P and PEPCK activities in the liver and kidney and may mediate, in part, the maturational effects of cortisol...
  7. doi request reprint Role of thyroid hormones in the developmental control of tissue glycogen in fetal sheep near term
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Exp Physiol 94:1079-87. 2009
    ..Therefore, thyroid hormones are important in the developmental control of hepatic and cardiac glycogen content in the ovine fetus near term and may mediate, in part, the maturational effects of cortisol...
  8. pmc The hungry fetus? Role of leptin as a nutritional signal before birth
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 587:1145-52. 2009
    ..Some of these actions are involved in the growth and development of the fetus and others have long-term consequences for the control of energy balance in adult life...
  9. ncbi request reprint Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestation
    A J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Exp Physiol 89:323-9. 2004
    ..Thereafter, Ang II, via the AT(1) receptor, may mediate, in part, the hypertensive effects of cortisol in utero...
  10. pmc Role of leptin in the regulation of growth and carbohydrate metabolism in the ovine fetus during late gestation
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23EG, UK
    J Physiol 586:2393-403. 2008
    ..These actions of leptin in utero may contribute to the development of neonatal hypoglycaemia in macrosomic babies of diabetic mothers...
  11. ncbi request reprint Differential effects of maternal dexamethasone treatment on circulating thyroid hormone concentrations and tissue deiodinase activity in the pregnant ewe and fetus
    Alison J Forhead
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 148:800-5. 2007
    ..Changes in T(3) bioavailability may mediate some of the maturational effects of antenatal glucocorticoid treatment in the preterm fetus...
  12. ncbi request reprint Effects of thyroid hormones on pulmonary and renal angiotensin-converting enzyme concentrations in fetal sheep near term
    A J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Endocrinol 173:143-50. 2002
    ..In addition, the prepartum rise in plasma T(3) appears to mediate, in part, the maturational effect of cortisol on pulmonary ACE concentration...
  13. pmc Role of cortisol in the ontogenic control of pulmonary and renal angiotensin-converting enzyme in fetal sheep near term
    A J Forhead
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 526:409-16. 2000
    ..4. Therefore, these findings suggest that the ontogenic rise in ACE concentration observed in the lungs of the sheep fetus near term is induced, at least in part, by the prepartum cortisol surge...
  14. ncbi request reprint Ontogeny of pulmonary and renal angiotensin-converting enzyme in pigs
    A J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Mol Cell Endocrinol 185:127-33. 2001
    ..Renal ACE increased between 10-12 weeks and 10-12 months. Postnatal changes in tissue ACE may have consequences for cardiovascular, pulmonary and renal function in pigs...
  15. ncbi request reprint Effects of dexamethasone on the glucogenic capacity of fetal, pregnant, and non-pregnant adult sheep
    K L Franko
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    J Endocrinol 192:67-73. 2007
    ..These findings show that maternal dexamethasone treatment increases the glucogenic capacity of both the mother and fetus and has major implications for glucose availability both before and after birth...
  16. ncbi request reprint Pancreatic alpha cell function in the fetal foal during late gestation
    A L Fowden
    Department of Physiology, University of Cambridge, UK
    Exp Physiol 84:697-705. 1999
    ..These observations indicate that equine pancreatic alpha cells are functional in utero but that they are unresponsive to variations in glycaemia until after birth...
  17. ncbi request reprint Regulation of glucogenesis by thyroid hormones in fetal sheep during late gestation
    A L Fowden
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    J Endocrinol 170:461-9. 2001
    ....
  18. ncbi request reprint Maturation of pancreatic beta-cell function in the fetal horse during late gestation
    A L Fowden
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Endocrinol 186:467-73. 2005
    ..Primarily, these prepartum maturational changes were in the mechanisms of glucose-stimulated insulin secretion, which would enable the beta cells to regulate glycaemia at the higher glucose levels observed postnatally...
  19. ncbi request reprint Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero
    A J Forhead
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Am J Physiol Endocrinol Metab 278:E1166-74. 2000
    ....
  20. pmc The effects of birth weight on basal cardiovascular function in pigs at 3 months of age
    K R Poore
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 539:969-78. 2002
    ..These data show that basal MAP in 3-month-old pigs is negatively associated with BW and positively correlated to disproportionate size at birth. This effect was associated with an increase in basal plasma noradrenaline concentrations...
  21. pmc Adrenal glands are essential for activation of glucogenesis during undernutrition in fetal sheep near term
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing St, Cambridge, CB2 3EG, UK
    Am J Physiol Endocrinol Metab 300:E94-102. 2011
    ..They may also be involved in regulating insulin sensitivity in utero...
  22. pmc Control of growth hormone receptor and insulin-like growth factor-I expression by cortisol in ovine fetal skeletal muscle
    J Li
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 541:581-9. 2002
    ..These observations have important implications for muscle development both before and after birth, particularly during conditions which alter intrauterine cortisol exposure...
  23. pmc Ontogenic and nutritionally induced changes in fetal metabolism in the horse
    A L Fowden
    Departments of Physiology and Clinical Veterinary Medicine, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 528:209-19. 2000
    ..Different species therefore adopt different strategies in meeting the nutritional demands of the growing fetus during the second half of gestation...
  24. doi request reprint Effects of maternal dietary manipulation during different periods of pregnancy on hepatic glucogenic capacity in fetal and pregnant rats near term
    K L Franko
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23EG, UK
    Nutr Metab Cardiovasc Dis 19:555-62. 2009
    ..However, whether these abnormalities are present before birth remain unknown...
  25. ncbi request reprint Functional significance and cortisol dependence of the gross morphology of ovine placentomes during late gestation
    J W Ward
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Biol Reprod 74:137-45. 2006
    ..These findings have important implications for the placental control of fetal growth and development, particularly during adverse intrauterine conditions...
  26. doi request reprint Differential effects of prenatal stress and glucocorticoid administration on postnatal growth and glucose metabolism in rats
    K L Franko
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Endocrinol 204:319-29. 2010
    ..Dex and saline treatments of pregnant rats have differential sex-linked effects on the growth and glucose metabolism of their offspring, which indicates that the programming actions of natural and synthetic glucocorticoids may differ...
  27. ncbi request reprint Developmental changes in pulmonary and renal angiotensin-converting enzyme concentration in fetal and neonatal horses
    S J O'Connor
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    Reprod Fertil Dev 14:413-7. 2002
    ..Therefore, premature delivery in this species may interrupt the onset of ACE production in the fetal lungs and circumvent the normal maturation of the renin-angiotensin system...
  28. ncbi request reprint Thyroid hormones and the mRNA of the GH receptor and IGFs in skeletal muscle of fetal sheep
    A J Forhead
    Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, United Kingdom
    Am J Physiol Endocrinol Metab 282:E80-6. 2002
    ..These findings show, in the sheep fetus, that thyroid hormones may influence the growth and development of skeletal muscle via changes in the local activity of the somatotrophic axis...
  29. pmc Programming placental nutrient transport capacity
    A L Fowden
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 572:5-15. 2006
    ....
  30. pmc Effect of cortisol on blood pressure and the renin-angiotensin system in fetal sheep during late gestation
    A J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG
    J Physiol 526:167-76. 2000
    ..These findings show that, in the sheep fetus during late gestation, the RAS becomes more important in the maintenance of resting blood pressure when plasma cortisol concentration is elevated, whether endogenously or exogenously...
  31. ncbi request reprint Effect of dexamethasone on pulmonary and renal angiotensin-converting enzyme concentration in fetal sheep during late gestation
    Heiner Zimmermann
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Am J Obstet Gynecol 189:1467-71. 2003
    ..The effect of dexamethasone on tissue angiotensin-converting enzyme (ACE) was investigated in fetal sheep...
  32. ncbi request reprint Postnatal insulin secretion and sensitivity after manipulation of fetal growth by embryo transfer in the horse
    A J Forhead
    Department of Physiology, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
    J Endocrinol 181:459-67. 2004
    ..More specifically, it is overgrowth, not growth retardation in utero that alters equine beta cell function in the immediate neonatal period...
  33. ncbi request reprint Hypothalamic-pituitary-adrenal axis function in pony foals after neonatal ACTH-induced glucocorticoid overexposure
    J K Jellyman
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Equine Vet J Suppl 44:38-42. 2012
    ..The effects of overexposure to glucocorticoids during early life of the foal on the subsequent HPA programming of the hypothalamic-pituitary-adrenal axis are unknown...
  34. ncbi request reprint Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in ovine placenta by fetal cortisol
    K A Clarke
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    J Endocrinol 172:527-34. 2002
    ..These findings have important implications, not only for glucocorticoid exposure in utero, but also for the local actions of cortisol within the placental tissues that are involved in initiating parturition in the sheep...
  35. ncbi request reprint Effects of pituitary hormone deficiency on growth and glucose metabolism of the sheep fetus
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge, United Kingdom
    Endocrinology 148:4812-20. 2007
    ..They also suggest that fetal metabolism is altered when gestational length is extended...
  36. ncbi request reprint The Endocrinology of equine parturition
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge
    Exp Clin Endocrinol Diabetes 116:393-403. 2008
    ..However, further studies are required to establish the causes and consequences of the rise and fall in maternal progestagens and the extent to which initiation of equine labour depends on the fetal HPA axis...
  37. ncbi request reprint Endocrine mechanisms of intrauterine programming
    A L Fowden
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Reproduction 127:515-26. 2004
    ..Endocrine changes may, therefore, be both the cause and the consequence of intrauterine programming...
  38. ncbi request reprint Cortisol influences the ontogeny of both alpha- and beta-subunits of the cardiac sodium channel in fetal sheep
    A I Fahmi
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, UK
    J Endocrinol 180:449-55. 2004
    ..These findings could have implications for the aetiology of sudden infant death syndrome and for the intrauterine programming of adult cardiovascular disease...
  39. ncbi request reprint Developmental control of plasma leptin and adipose leptin messenger ribonucleic acid in the ovine fetus during late gestation: role of glucocorticoids and thyroid hormones
    Deirdre M O'Connor
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 148:3750-7. 2007
    ..Developmental changes in circulating and PAT leptin may mediate the maturational effects of cortisol in utero and have long-term consequences for appetite regulation and the development of obesity...
  40. ncbi request reprint Developmental programming of the ovine placenta
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Soc Reprod Fertil Suppl 67:41-57. 2010
    ..Thus, the placental epigenome provides both a memory of environmental conditions experienced during development and an index of the future well being of the offspring...
  41. ncbi request reprint Ontogeny of uteroplacental progestagen production in pregnant mares during the second half of gestation
    J C Ousey
    Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, United Kingdom
    Biol Reprod 69:540-8. 2003
    ..These findings demonstrate that uteroplacental progestagen production changes during the second half of gestation, which may have important implications for the maintenance of pregnancy and the onset of labor in the mare...
  42. ncbi request reprint Thyroid hormones in fetal growth and prepartum maturation
    A J Forhead
    Department of PhysiologyDevelopment and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UKDepartment of Biological and Medical SciencesOxford Brookes University, Oxford OX3 0BP, UKDepartment of PhysiologyDevelopment and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UKDepartment of Biological and Medical SciencesOxford Brookes University, Oxford OX3 0BP, UK
    J Endocrinol 221:R87-R103. 2014
    ....
  43. ncbi request reprint The placenta and intrauterine programming
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 20:439-50. 2008
    ....
  44. ncbi request reprint Endocrine regulation of feto-placental growth
    Abigail L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building Downing Street, Cambridge CB2 3EG, UK
    Horm Res 72:257-65. 2009
    ..This review examines the role of hormones in feto-placental growth with particular emphasis on insulin, the insulin-like growth factors and glucocorticoids...
  45. ncbi request reprint Intrauterine programming of physiological systems: causes and consequences
    Abigail L Fowden
    Department of Physiology, University of Cambridge, Cambridge, UK
    Physiology (Bethesda) 21:29-37. 2006
    ..Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age...
  46. ncbi request reprint Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and human
    Gusztav Belteki
    Department of Obstetrics and Gynaecology, University of Cambridge, and Neonatal Intensive Care Unit, Addenbrooke s Hospital, Box 223, Cambridge CB2 0SW, United Kingdom
    J Clin Endocrinol Metab 95:3798-805. 2010
    ..Although prematurity is associated with oxidative stress, no effective antioxidant therapy has yet been identified...
  47. pmc Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine
    Sarah L Kempster
    Dept of Obstetrics and Gynaecology, Univ of Cambridge, Box 223, Cambridge, CB2 0SW, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 300:G253-63. 2011
    ....
  48. ncbi request reprint Hormones as epigenetic signals in developmental programming
    Abigail L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Exp Physiol 94:607-25. 2009
    ....
  49. pmc Development of cardiovascular function in the horse fetus
    Dino A Giussani
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 565:1019-30. 2005
    ....
  50. ncbi request reprint Endocrine and metabolic programming during intrauterine development
    Abigail L Fowden
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    Early Hum Dev 81:723-34. 2005
    ..It also considers how changes in these endocrine systems contribute to the programming of metabolism in later life...
  51. pmc Postnatal cardiovascular function after manipulation of fetal growth by embryo transfer in the horse
    Dino A Giussani
    Department of Physiology and Clinical Veterinary Medicine, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 547:67-76. 2003
    ..These findings suggest that deviations in the pattern and rate of fetal growth both above and below the normal trajectory may influence cardiovascular function in postnatal life...
  52. ncbi request reprint Endocrine adaptations in the foal over the perinatal period
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Equine Vet J Suppl 44:130-9. 2012
    ....
  53. ncbi request reprint Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring
    S J M Lisle
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Br J Nutr 90:33-9. 2003
    ..42, n 28, P<0.05) and 16 months of age (r-0.64, n 28, P<0.05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number...
  54. ncbi request reprint Glucose transporter 1 localisation throughout pregnancy in the carnivore placenta: light and electron microscope studies
    F B P Wooding
    Physiology Department, Cambridge University, Downing Street, Cambridge CB2 3EG, UK
    Placenta 28:453-64. 2007
    ..GT1 is invariably present on both apical and basal surfaces of the cyto- and syncytiotrophoblast in all carnivore species examined and the pattern of development is described from implantation to term...
  55. ncbi request reprint Localization and control of expression of VEGF-A and the VEGFR-2 receptor in fetal sheep intestines
    Katrina Holmes
    Department of Obstetrics and Gynecology, University of Cambridge, Cambridge, CB2 2QQ, UK
    Pediatr Res 63:143-8. 2008
    ..These data show that intestinal VEGF-A is up-regulated with advancing gestation in a glucocorticoid-dependent manner--novel findings consistent with a role for VEGF-A stimulated angiogenesis in preparing the fetal gut for birth...
  56. ncbi request reprint Long-term programming of blood pressure by maternal dietary iron restriction in the rat
    Rohan M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
    Br J Nutr 88:283-90. 2002
    ..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero...
  57. pmc Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation
    Andrew J W Fletcher
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 562:493-505. 2005
    ..These changes in myocardial responsiveness are not solely dependent on preparturient elevations in fetal plasma cortisol concentration...
  58. ncbi request reprint Functional immunocytochemistry of Tragulus placenta: implications for ruminant evolution
    F B P Wooding
    Department of Physiology Development and Neuroscience, Cambridge University, Downing Street, Cambridge CB2 3EG, UK Electronic address
    Placenta 35:305-10. 2014
    ..This immunocytochemical investigation of placental transporters was designed to elucidate possible mechanisms of evolution to the cotyledonary form...
  59. ncbi request reprint Endocrine adaptations in the foal over the perinatal period
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Rossdale and Partners, Beaufort Cottage Stables, High Street, Newmarket, UK
    Equine Vet J 44:130-9. 2012
    ....
  60. ncbi request reprint A light and electron microscopical study of the Tragulid (mouse deer) placenta
    F B P Wooding
    Department of Physiology Development and Neuroscience, Cambridge University, Downing Street, Cambridge CB2 3EG, UK
    Placenta 28:1039-48. 2007
    ..This intimate fetomaternal confrontation has not been shown in any other ruminant, and could be a relic of the evolutionary development of the synepitheliochorial from the original basic eutherian endo- or hemo-chorial placenta...
  61. ncbi request reprint Plasma angiotensin-converting enzyme (ACE) concentration in Thoroughbred racehorses
    R R C Coomer
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 ES, UK
    Equine Vet J 35:96-8. 2003
  62. ncbi request reprint Hypothalamic-pituitary-adrenal axis function in pony foals after neonatal ACTH-induced glucocorticoid overexposure
    J K Jellyman
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Equine Vet J 44:38-42. 2012
    ..The effects of overexposure to glucocorticoids during early life of the foal on the subsequent HPA programming of the hypothalamic-pituitary-adrenal axis are unknown...