Research Topics
Species | A J ForheadSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Plasma leptin concentration in fetal sheep during late gestation: ontogeny and effect of glucocorticoidsA J Forhead
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
Endocrinology 143:1166-73. 2002..Furthermore, fetal treatment with exogenous and endogenous glucocorticoids increases circulating leptin concentration in utero...
Developmental changes in plasma angiotensin-converting enzyme concentration in fetal and neonatal lambsA J Forhead
Department of Physiology, University of Cambridge, UK
Reprod Fertil Dev 10:393-8. 1998..Therefore, in the sheep fetus, plasma ACE increased towards term in association with the prepartum cortisol surge. Developmental changes in ACE activity may be partly responsible for the ontogenic rise in fetal blood pressure...
Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestationA J Forhead
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Exp Physiol 89:323-9. 2004..Thereafter, Ang II, via the AT(1) receptor, may mediate, in part, the hypertensive effects of cortisol in utero...
Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near termAlison J Forhead
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
Endocrinology 147:5988-94. 2006..Some of the maturational effects of cortisol on deiodinase activity may be mediated by T3...
Effects of thyroid hormones on pulmonary and renal angiotensin-converting enzyme concentrations in fetal sheep near termA J Forhead
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Endocrinol 173:143-50. 2002..In addition, the prepartum rise in plasma T(3) appears to mediate, in part, the maturational effect of cortisol on pulmonary ACE concentration...
Differential effects of maternal dexamethasone treatment on circulating thyroid hormone concentrations and tissue deiodinase activity in the pregnant ewe and fetusAlison J Forhead
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
Endocrinology 148:800-5. 2007..Changes in T(3) bioavailability may mediate some of the maturational effects of antenatal glucocorticoid treatment in the preterm fetus...
Role of leptin in the regulation of growth and carbohydrate metabolism in the ovine fetus during late gestationAlison J Forhead
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23EG, UK
J Physiol 586:2393-403. 2008..These actions of leptin in utero may contribute to the development of neonatal hypoglycaemia in macrosomic babies of diabetic mothers...
Ontogeny of pulmonary and renal angiotensin-converting enzyme in pigsA J Forhead
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Mol Cell Endocrinol 185:127-33. 2001..Renal ACE increased between 10-12 weeks and 10-12 months. Postnatal changes in tissue ACE may have consequences for cardiovascular, pulmonary and renal function in pigs...
Developmental regulation of hepatic and renal gluconeogenic enzymes by thyroid hormones in fetal sheep during late gestationAlison J Forhead
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 548:941-7. 2003..Therefore, in fetal sheep, thyroid hormones are important for the prepartum rises in G6P and PEPCK activities in the liver and kidney and may mediate, in part, the maturational effects of cortisol...
Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheepAlison J Forhead
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Endocrinol 208:137-45. 2011....
Role of thyroid hormones in the developmental control of tissue glycogen in fetal sheep near termAlison J Forhead
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Exp Physiol 94:1079-87. 2009..Therefore, thyroid hormones are important in the developmental control of hepatic and cardiac glycogen content in the ovine fetus near term and may mediate, in part, the maturational effects of cortisol...
Role of cortisol in the ontogenic control of pulmonary and renal angiotensin-converting enzyme in fetal sheep near termA J Forhead
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 526:409-16. 2000..4. Therefore, these findings suggest that the ontogenic rise in ACE concentration observed in the lungs of the sheep fetus near term is induced, at least in part, by the prepartum cortisol surge...
The hungry fetus? Role of leptin as a nutritional signal before birthAlison J Forhead
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 587:1145-52. 2009..Some of these actions are involved in the growth and development of the fetus and others have long-term consequences for the control of energy balance in adult life...
Effects of dexamethasone on the glucogenic capacity of fetal, pregnant, and non-pregnant adult sheepK L Franko
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
J Endocrinol 192:67-73. 2007..These findings show that maternal dexamethasone treatment increases the glucogenic capacity of both the mother and fetus and has major implications for glucose availability both before and after birth...
Regulation of glucogenesis by thyroid hormones in fetal sheep during late gestationA L Fowden
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
J Endocrinol 170:461-9. 2001....
Pancreatic alpha cell function in the fetal foal during late gestationA L Fowden
Department of Physiology, University of Cambridge, UK
Exp Physiol 84:697-705. 1999..These observations indicate that equine pancreatic alpha cells are functional in utero but that they are unresponsive to variations in glycaemia until after birth...
Maturation of pancreatic beta-cell function in the fetal horse during late gestationA L Fowden
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Endocrinol 186:467-73. 2005..Primarily, these prepartum maturational changes were in the mechanisms of glucose-stimulated insulin secretion, which would enable the beta cells to regulate glycaemia at the higher glucose levels observed postnatally...
Adrenal glands are essential for activation of glucogenesis during undernutrition in fetal sheep near termA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing St, Cambridge, CB2 3EG, UK
Am J Physiol Endocrinol Metab 300:E94-102. 2011..They may also be involved in regulating insulin sensitivity in utero...
The effects of birth weight on basal cardiovascular function in pigs at 3 months of ageK R Poore
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 539:969-78. 2002..These data show that basal MAP in 3-month-old pigs is negatively associated with BW and positively correlated to disproportionate size at birth. This effect was associated with an increase in basal plasma noradrenaline concentrations...
Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in uteroA J Forhead
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
Am J Physiol Endocrinol Metab 278:E1166-74. 2000....
Control of growth hormone receptor and insulin-like growth factor-I expression by cortisol in ovine fetal skeletal muscleJ Li
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 541:581-9. 2002..These observations have important implications for muscle development both before and after birth, particularly during conditions which alter intrauterine cortisol exposure...
Ontogenic and nutritionally induced changes in fetal metabolism in the horseA L Fowden
Departments of Physiology and Clinical Veterinary Medicine, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 528:209-19. 2000..Different species therefore adopt different strategies in meeting the nutritional demands of the growing fetus during the second half of gestation...
Effects of maternal dietary manipulation during different periods of pregnancy on hepatic glucogenic capacity in fetal and pregnant rats near termK L Franko
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23EG, UK
Nutr Metab Cardiovasc Dis 19:555-62. 2009..However, whether these abnormalities are present before birth remain unknown...
Differential effects of prenatal stress and glucocorticoid administration on postnatal growth and glucose metabolism in ratsK L Franko
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Endocrinol 204:319-29. 2010..Dex and saline treatments of pregnant rats have differential sex-linked effects on the growth and glucose metabolism of their offspring, which indicates that the programming actions of natural and synthetic glucocorticoids may differ...
Functional significance and cortisol dependence of the gross morphology of ovine placentomes during late gestationJ W Ward
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, United Kingdom
Biol Reprod 74:137-45. 2006..These findings have important implications for the placental control of fetal growth and development, particularly during adverse intrauterine conditions...
Developmental changes in pulmonary and renal angiotensin-converting enzyme concentration in fetal and neonatal horsesS J O'Connor
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
Reprod Fertil Dev 14:413-7. 2002..Therefore, premature delivery in this species may interrupt the onset of ACE production in the fetal lungs and circumvent the normal maturation of the renin-angiotensin system...
Effect of cortisol on blood pressure and the renin-angiotensin system in fetal sheep during late gestationA J Forhead
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG
J Physiol 526:167-76. 2000..These findings show that, in the sheep fetus during late gestation, the RAS becomes more important in the maintenance of resting blood pressure when plasma cortisol concentration is elevated, whether endogenously or exogenously...
Programming placental nutrient transport capacityA L Fowden
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 572:5-15. 2006....
Thyroid hormones and the mRNA of the GH receptor and IGFs in skeletal muscle of fetal sheepA J Forhead
Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, United Kingdom
Am J Physiol Endocrinol Metab 282:E80-6. 2002..These findings show, in the sheep fetus, that thyroid hormones may influence the growth and development of skeletal muscle via changes in the local activity of the somatotrophic axis...
Effect of dexamethasone on pulmonary and renal angiotensin-converting enzyme concentration in fetal sheep during late gestationHeiner Zimmermann
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
Am J Obstet Gynecol 189:1467-71. 2003..70, P<.05). CONCLUSION: The rise in pulmonary ACE seen in dexamethasone-treated sheep fetuses may contribute, in part, to the glucocorticoid-induced increase in blood pressure...
Hypothalamic-pituitary-adrenal axis function in pony foals after neonatal ACTH-induced glucocorticoid overexposureJ K Jellyman
Department of Physiology, Development and Neuroscience, University of Cambridge, UK
Equine Vet J Suppl 44:38-42. 2012..The effects of overexposure to glucocorticoids during early life of the foal on the subsequent HPA programming of the hypothalamic-pituitary-adrenal axis are unknown...
Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in ovine placenta by fetal cortisolK A Clarke
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
J Endocrinol 172:527-34. 2002..These findings have important implications, not only for glucocorticoid exposure in utero, but also for the local actions of cortisol within the placental tissues that are involved in initiating parturition in the sheep...
Effects of pituitary hormone deficiency on growth and glucose metabolism of the sheep fetusA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge, United Kingdom
Endocrinology 148:4812-20. 2007..They also suggest that fetal metabolism is altered when gestational length is extended...
The Endocrinology of equine parturitionA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge
Exp Clin Endocrinol Diabetes 116:393-403. 2008..However, further studies are required to establish the causes and consequences of the rise and fall in maternal progestagens and the extent to which initiation of equine labour depends on the fetal HPA axis...
Cortisol influences the ontogeny of both alpha- and beta-subunits of the cardiac sodium channel in fetal sheepA I Fahmi
Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, UK
J Endocrinol 180:449-55. 2004..These findings could have implications for the aetiology of sudden infant death syndrome and for the intrauterine programming of adult cardiovascular disease...
Endocrine mechanisms of intrauterine programmingA L Fowden
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Reproduction 127:515-26. 2004..Endocrine changes may, therefore, be both the cause and the consequence of intrauterine programming...
Postnatal insulin secretion and sensitivity after manipulation of fetal growth by embryo transfer in the horseA J Forhead
Department of Physiology, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
J Endocrinol 181:459-67. 2004..More specifically, it is overgrowth, not growth retardation in utero that alters equine beta cell function in the immediate neonatal period...
Developmental control of plasma leptin and adipose leptin messenger ribonucleic acid in the ovine fetus during late gestation: role of glucocorticoids and thyroid hormonesDeirdre M O'Connor
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
Endocrinology 148:3750-7. 2007..Developmental changes in circulating and PAT leptin may mediate the maturational effects of cortisol in utero and have long-term consequences for appetite regulation and the development of obesity...
Developmental programming of the ovine placentaA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Soc Reprod Fertil Suppl 67:41-57. 2010..Thus, the placental epigenome provides both a memory of environmental conditions experienced during development and an index of the future well being of the offspring...
Ontogeny of uteroplacental progestagen production in pregnant mares during the second half of gestationJ C Ousey
Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, United Kingdom
Biol Reprod 69:540-8. 2003..These findings demonstrate that uteroplacental progestagen production changes during the second half of gestation, which may have important implications for the maintenance of pregnancy and the onset of labor in the mare...
The placenta and intrauterine programmingA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Neuroendocrinol 20:439-50. 2008....
Hormones as epigenetic signals in developmental programmingAbigail L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Exp Physiol 94:607-25. 2009....
Endocrine regulation of feto-placental growthAbigail L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building Downing Street, Cambridge CB2 3EG, UK
Horm Res 72:257-65. 2009..This review examines the role of hormones in feto-placental growth with particular emphasis on insulin, the insulin-like growth factors and glucocorticoids...
Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and humanGusztav Belteki
Department of Obstetrics and Gynaecology, University of Cambridge, and Neonatal Intensive Care Unit, Addenbrooke s Hospital, Box 223, Cambridge CB2 0SW, United Kingdom
J Clin Endocrinol Metab 95:3798-805. 2010..Although prematurity is associated with oxidative stress, no effective antioxidant therapy has yet been identified...
Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestineSarah L Kempster
Dept of Obstetrics and Gynaecology, Univ of Cambridge, Box 223, Cambridge, CB2 0SW, United Kingdom
Am J Physiol Gastrointest Liver Physiol 300:G253-63. 2011....
Development of cardiovascular function in the horse fetusDino A Giussani
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 565:1019-30. 2005....
Postnatal cardiovascular function after manipulation of fetal growth by embryo transfer in the horseDino A Giussani
Department of Physiology and Clinical Veterinary Medicine, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 547:67-76. 2003..These findings suggest that deviations in the pattern and rate of fetal growth both above and below the normal trajectory may influence cardiovascular function in postnatal life...
Endocrine and metabolic programming during intrauterine developmentAbigail L Fowden
Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
Early Hum Dev 81:723-34. 2005..It also considers how changes in these endocrine systems contribute to the programming of metabolism in later life...
Intrauterine programming of physiological systems: causes and consequencesAbigail L Fowden
Department of Physiology, University of Cambridge, Cambridge, UK
Physiology (Bethesda) 21:29-37. 2006..Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age...
Endocrine adaptations in the foal over the perinatal periodA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Equine Vet J Suppl 44:130-9. 2012....
Glucose transporter 1 localisation throughout pregnancy in the carnivore placenta: light and electron microscope studiesF B P Wooding
Physiology Department, Cambridge University, Downing Street, Cambridge CB2 3EG, UK
Placenta 28:453-64. 2007..GT1 is invariably present on both apical and basal surfaces of the cyto- and syncytiotrophoblast in all carnivore species examined and the pattern of development is described from implantation to term...
Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspringS J M Lisle
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Br J Nutr 90:33-9. 2003..42, n 28, P<0.05) and 16 months of age (r-0.64, n 28, P<0.05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number...
Long-term programming of blood pressure by maternal dietary iron restriction in the ratRohan M Lewis
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
Br J Nutr 88:283-90. 2002..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero...
Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparationAndrew J W Fletcher
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 562:493-505. 2005..These changes in myocardial responsiveness are not solely dependent on preparturient elevations in fetal plasma cortisol concentration...
Localization and control of expression of VEGF-A and the VEGFR-2 receptor in fetal sheep intestinesKatrina Holmes
Department of Obstetrics and Gynecology, University of Cambridge, Cambridge, CB2 2QQ, UK
Pediatr Res 63:143-8. 2008..These data show that intestinal VEGF-A is up-regulated with advancing gestation in a glucocorticoid-dependent manner--novel findings consistent with a role for VEGF-A stimulated angiogenesis in preparing the fetal gut for birth...
Endocrine adaptations in the foal over the perinatal periodA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK Rossdale and Partners, Beaufort Cottage Stables, High Street, Newmarket, UK
Equine Vet J 44:130-9. 2012....
Plasma angiotensin-converting enzyme (ACE) concentration in Thoroughbred racehorsesR R C Coomer
Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 ES, UK
Equine Vet J 35:96-8. 2003
A light and electron microscopical study of the Tragulid (mouse deer) placentaF B P Wooding
Department of Physiology Development and Neuroscience, Cambridge University, Downing Street, Cambridge CB2 3EG, UK
Placenta 28:1039-48. 2007..This intimate fetomaternal confrontation has not been shown in any other ruminant, and could be a relic of the evolutionary development of the synepitheliochorial from the original basic eutherian endo- or hemo-chorial placenta...
Hypothalamic-pituitary-adrenal axis function in pony foals after neonatal ACTH-induced glucocorticoid overexposureJ K Jellyman
Department of Physiology, Development and Neuroscience, University of Cambridge, UK
Equine Vet J 44:38-42. 2012..The effects of overexposure to glucocorticoids during early life of the foal on the subsequent HPA programming of the hypothalamic-pituitary-adrenal axis are unknown...
