Roger S Y Foo

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure
    Mehregan Movassagh
    Division of Cardiovascular Medicine, Addenbrooke s Centre for Clinical Investigation, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e8564. 2010
  2. pmc Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1
    Lee Siggens
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Centre of Clinical Investigation Building, Level 6, Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
    FASEB J 26:2117-24. 2012
  3. pmc High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure
    Mun Kit Choy
    Department of Medicine, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge, CB2 0QQ, UK
    Genome Med 2:37. 2010
  4. ncbi request reprint Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2
    Roger S Y Foo
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 282:5529-35. 2007
  5. ncbi request reprint Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes
    Dagmar Harzheim
    Department of Molecular Signaling, Babraham Institute, Cambridge, UK
    Channels (Austin) 4:67-71. 2010
  6. doi request reprint PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2
    Mun Kit Choy
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 20QQ, UK
    J Cell Physiol 222:635-9. 2010
  7. pmc Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated
    Mun Kit Choy
    Department of Medicine, University of Cambridge, ACCI Building Level 6, Cambridge CB20QQ, UK
    BMC Genomics 11:519. 2010
  8. ncbi request reprint Simplified apoptotic cascades
    Mehregan Movassagh
    Division of Cardiovascular Medicine, Addenbrooke s Hospital, University of Cambridge, ACCI Building Level 6, Hills Road, Box 110, Cambridge CB2 2QQ, UK
    Heart Fail Rev 13:111-9. 2008
  9. pmc Distinct epigenomic features in end-stage failing human hearts
    Mehregan Movassagh
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Level 6, Hills Rd, Cambridge, CB2 0QQ UK
    Circulation 124:2411-22. 2011
  10. pmc Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy
    Dagmar Harzheim
    Department of Molecular Signaling, Babraham Institute, Cambridge, CB22 3AT, United Kingdom
    Proc Natl Acad Sci U S A 106:11406-11. 2009

Collaborators

Detail Information

Publications13

  1. pmc Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure
    Mehregan Movassagh
    Division of Cardiovascular Medicine, Addenbrooke s Centre for Clinical Investigation, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e8564. 2010
    ....
  2. pmc Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1
    Lee Siggens
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Centre of Clinical Investigation Building, Level 6, Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
    FASEB J 26:2117-24. 2012
    ..The manipulation of OGG1 may be used in future studies to examine the direct contribution of oxidative DNA damage to the progression of heart failure...
  3. pmc High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure
    Mun Kit Choy
    Department of Medicine, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge, CB2 0QQ, UK
    Genome Med 2:37. 2010
    ..CONCLUSIONS : Our results uncover a mechanism by which transcription factors cooperate in a multi-molecular complex at a cis-regulatory element to control gene expression...
  4. ncbi request reprint Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2
    Roger S Y Foo
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 282:5529-35. 2007
    ..We conclude that MDM2 is a critical regulator of ARC levels in cardiomyocytes. Prevention of MDM2-induced degradation of ARC represents a potential therapeutic target to prevent cardiomyocyte apoptosis...
  5. ncbi request reprint Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes
    Dagmar Harzheim
    Department of Molecular Signaling, Babraham Institute, Cambridge, UK
    Channels (Austin) 4:67-71. 2010
    ....
  6. doi request reprint PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2
    Mun Kit Choy
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 20QQ, UK
    J Cell Physiol 222:635-9. 2010
    ..In summary, we propose that p53-induced HIF1A degradation is not exclusively MDM2-mediated, but reversible by PKB/Akt phosphorylation...
  7. pmc Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated
    Mun Kit Choy
    Department of Medicine, University of Cambridge, ACCI Building Level 6, Cambridge CB20QQ, UK
    BMC Genomics 11:519. 2010
    ..We hypothesize that DNA methylation at conserved consensus motifs prevents promiscuous or disorderly transcription factor binding...
  8. ncbi request reprint Simplified apoptotic cascades
    Mehregan Movassagh
    Division of Cardiovascular Medicine, Addenbrooke s Hospital, University of Cambridge, ACCI Building Level 6, Hills Road, Box 110, Cambridge CB2 2QQ, UK
    Heart Fail Rev 13:111-9. 2008
    ..Understanding the intricacies of apoptotic death pathways and determining the relevance of these to cardiomyopathy is therefore essential if cardiomyocyte apoptosis is to be a pharmacological target for heart failure therapy...
  9. pmc Distinct epigenomic features in end-stage failing human hearts
    Mehregan Movassagh
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Centre for Clinical Investigation, Level 6, Hills Rd, Cambridge, CB2 0QQ UK
    Circulation 124:2411-22. 2011
    ..A consistent profile of gene expression changes in end-stage cardiomyopathy led us to hypothesize that distinct global patterns of the epigenome may also exist...
  10. pmc Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy
    Dagmar Harzheim
    Department of Molecular Signaling, Babraham Institute, Cambridge, CB22 3AT, United Kingdom
    Proc Natl Acad Sci U S A 106:11406-11. 2009
    ..Our data establish that increased InsP(3)R expression is a general mechanism that underlies remodeling of Ca(2+) signaling during heart disease, and in particular, in triggering ventricular arrhythmia during hypertrophy...
  11. ncbi request reprint Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy
    Roger S Y Foo
    Division of Cardiovascular Medicine, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, UK
    J Cell Physiol 209:1-7. 2006
    ..Our findings identify the signalling pathways by which HO-1 gene transfer protects against apoptosis and suggest that overexpression of HO-1 in cardiomyopathies may delay the transition from myocyte hypertrophy to heart failure...
  12. ncbi request reprint Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs
    Alison J Deary
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Hypertens 20:771-7. 2002
    ....