Kevin C F Fone

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Fos expression in the prefrontal cortex and ventral striatum after exposure to a free-operant timing schedule
    L Valencia-Torres
    Psychopharmacology Section, Division of Psychiatry, University of Nottingham, UK
    Behav Brain Res 235:273-9. 2012
  2. ncbi request reprint Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity
    Kevin C F Fone
    School of Biomedical Sciences, Queen s Medical Centre, Nottingham University, Nottingham NG7 2UH, UK
    Psychopharmacology (Berl) 159:437-44. 2002
  3. doi request reprint An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 55:1015-22. 2008
  4. doi request reprint Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neurosci Biobehav Rev 32:1087-102. 2008
  5. ncbi request reprint Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Science, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Curr Opin Pharmacol 5:87-93. 2005
  6. ncbi request reprint Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats
    Kevin C F Fone
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, Nottingham, UK
    Pharmacol Biochem Behav 71:815-23. 2002
  7. doi request reprint Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats
    Massimiliano Bianchi
    Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Eur Neuropsychopharmacol 19:778-90. 2009
  8. doi request reprint Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: further evaluation of a potential model of ADHD
    Katherine N Hewitt
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 57:678-86. 2009
  9. doi request reprint Increased dopamine D2High receptors in rats reared in social isolation
    Madeleine V King
    Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Synapse 63:476-83. 2009
  10. doi request reprint Influence of social isolation in the rat on serotonergic function and memory--relevance to models of schizophrenia and the role of 5-HT₆ receptors
    Charles A Marsden
    School of Biomedical Sciences, Medical School, Queen s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 61:400-7. 2011

Collaborators

Detail Information

Publications32

  1. pmc Fos expression in the prefrontal cortex and ventral striatum after exposure to a free-operant timing schedule
    L Valencia-Torres
    Psychopharmacology Section, Division of Psychiatry, University of Nottingham, UK
    Behav Brain Res 235:273-9. 2012
    ..It is suggested that the ventral striatum may be engaged during performance on timing schedules that entail operant choice, irrespective of whether they belong to the immediate or retrospective categories...
  2. ncbi request reprint Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity
    Kevin C F Fone
    School of Biomedical Sciences, Queen s Medical Centre, Nottingham University, Nottingham NG7 2UH, UK
    Psychopharmacology (Berl) 159:437-44. 2002
    ..However, few studies have examined the long-term behavioural consequence of MDMA and it is unclear whether such changes occur in the absence of neurotoxicity...
  3. doi request reprint An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 55:1015-22. 2008
    ..Thus both 5-HT(6) receptor agonist and antagonist compounds show promise as pro-cognitive agents in pre-clinical studies but the explanation for their paradoxical analogous effect is currently unclear, and is discussed in this article...
  4. doi request reprint Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neurosci Biobehav Rev 32:1087-102. 2008
    ....
  5. ncbi request reprint Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder
    Kevin C F Fone
    Institute of Neuroscience, School of Biomedical Science, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Curr Opin Pharmacol 5:87-93. 2005
    ....
  6. ncbi request reprint Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats
    Kevin C F Fone
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, Nottingham, UK
    Pharmacol Biochem Behav 71:815-23. 2002
    ..A comparison of the brain region-dependent alteration in serotonergic function produced by hypercorticosterone in the rat with that seen in depression is discussed...
  7. doi request reprint Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats
    Massimiliano Bianchi
    Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Eur Neuropsychopharmacol 19:778-90. 2009
    ..These findings show that early-life experience induces behavioural changes paralleled by alterations in cytoskeletal and neurochemical functions...
  8. doi request reprint Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: further evaluation of a potential model of ADHD
    Katherine N Hewitt
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 57:678-86. 2009
    ....
  9. doi request reprint Increased dopamine D2High receptors in rats reared in social isolation
    Madeleine V King
    Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Synapse 63:476-83. 2009
    ..These findings support both the hypothesis that elevated D(2) (High) is a common feature of multiple animal models of psychosis, and the validity of isolation rearing as a neurodevelopmental model of a "schizophrenia-like" state...
  10. doi request reprint Influence of social isolation in the rat on serotonergic function and memory--relevance to models of schizophrenia and the role of 5-HT₆ receptors
    Charles A Marsden
    School of Biomedical Sciences, Medical School, Queen s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 61:400-7. 2011
    ..Thus drugs acting at 5-HT(6) receptors may offer a novel approach to treat neurodevelopmental cognitive symptoms, including those seen in schizophrenia...
  11. doi request reprint The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats
    Allison L McIntosh
    School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Psychopharmacology (Berl) 228:31-42. 2013
    ..Rearing rats in isolation from weaning is an established preclinical neurodevelopmental model which induces behavioural deficits with apparent translational relevance to some core symptoms of schizophrenia...
  12. doi request reprint Blockade of dopamine D₃ but not D₂ receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment
    David J G Watson
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Int J Neuropsychopharmacol 15:471-84. 2012
    ..These data support further investigation of the potential use of dopamine D₃ receptor antagonists to treat schizophrenia...
  13. ncbi request reprint Behavioural and pharmacological magnetic resonance imaging assessment of the effects of methylphenidate in a potential new rat model of attention deficit hyperactivity disorder
    Katherine N Hewitt
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Psychopharmacology (Berl) 180:716-23. 2005
    ..Whereas the mechanism is not fully understood it is suggested to involve restoration of impaired dopamine function found in ADHD...
  14. doi request reprint Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats
    Ratchanee Rodsiri
    School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Psychopharmacology (Berl) 213:365-76. 2011
    ..3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia...
  15. doi request reprint E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat
    Ian Kendall
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham Medical School, Nottingham, UK
    Psychopharmacology (Berl) 213:413-30. 2011
    ..This study investigated the effects of 5-HT(6) receptor agonists and antagonists on a rodent model of recognition memory...
  16. doi request reprint Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast
    Neil Easton
    School of Biomedical Sciences, Medical School, Institute of Neuroscience, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Neuropharmacology 57:653-64. 2009
    ....
  17. ncbi request reprint 5-ht6 receptors
    Marie L Woolley
    Institute of Neuroscience, School of Biomedical Science, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Curr Drug Targets CNS Neurol Disord 3:59-79. 2004
    ..Taken together, this wealth of information warrants the use of the upper case nomenclature for the 5-ht(6) receptor to be approved and its true status recognised...
  18. ncbi request reprint Pre-treatment with 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting changes in 5-HT2A receptor-mediated glucose utilization in the rat brain
    Eleanor J Bull
    Institute of Neuroscience, Queen s Medical Centre, University of Nottingham, UK
    J Psychopharmacol 20:272-80. 2006
    ....
  19. ncbi request reprint Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790
    Marie L Woolley
    Institute of Neuroscience, School of Biomedical Science, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Psychopharmacology (Berl) 170:358-67. 2003
    ..Accumulating evidence suggests a potential role for the 5-HT(6 )receptor in cognitive function and the potential use of 5-HT(6) receptor antagonists in the treatment of learning and memory disorders...
  20. ncbi request reprint A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory
    Madeleine V King
    Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Trends Pharmacol Sci 29:482-92. 2008
    ....
  21. ncbi request reprint Differential effects of the D- and L- isomers of amphetamine on pharmacological MRI BOLD contrast in the rat
    Neil Easton
    School of Biomedical Sciences, Medical School, Institute of Neuroscience, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK
    Psychopharmacology (Berl) 193:11-30. 2007
    ..The effects of these isomers on brain activity has not been examined using neuroimaging...
  22. pmc Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex
    David J G Watson
    School of Biomedical Sciences, Queen s Medical Centre, The University of Nottingham, Nottingham, UK
    Neuropsychopharmacology 37:770-86. 2012
    ..These data have important implications for exploitation of dopaminergic mechanisms in the treatment of schizophrenia and other CNS disorders, and support the potential therapeutic utility of dopamine D(3) receptor antagonism...
  23. doi request reprint The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat
    Caitlin A Jones
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Psychopharmacology (Berl) 214:269-83. 2011
    ..The type II metabotropic glutamate receptor (mGluR2/3) is a novel, potential therapeutic target requiring evaluation in appropriate preclinical models of schizophrenia...
  24. ncbi request reprint Effects of 5-HT2A receptor stimulation on the discrimination of durations by rats
    Karim Asgari
    Psychopharmacology Section, Division of Psychiatry bSchool of Biomedical Sciences, University of Nottingham, UK
    Behav Pharmacol 17:51-9. 2006
    ..The results indicate that the mixed 5-HT2A/2C receptor agonist DOI disrupts temporal discrimination via stimulation of 5-HT2A receptors...
  25. ncbi request reprint DR4004, a putative 5-HT(7) receptor antagonist, also has functional activity at the dopamine D2 receptor
    Helen A Kogan
    School of Biomedical Sciences, Queen s Medical Centre, Nottingham University, Nottingham, NG7 2UH, UK
    Eur J Pharmacol 449:105-11. 2002
    ..This study confirms that DR4004 has high affinity for the 5-HT(7) receptor but suggests that dopamine D2 receptor activity contributes to some of the in vivo effects...
  26. ncbi request reprint Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: gender-dependent effects
    Helge A Slotten
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, Nottingham, UK
    Brain Res 1097:123-32. 2006
    ..The MS paradigm caused long-term gender dependent effects on behaviour and HPA axis status. The consistent gender differences confirm and expand existing results showing altered anxiety and stress reactivity in male and female rats...
  27. doi request reprint Behavioural and neurochemical comparison of chronic intermittent cathinone, mephedrone and MDMA administration to the rat
    Sinead E Shortall
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Eur Neuropsychopharmacol 23:1085-95. 2013
    ..At the doses examined, mephedrone, cathinone, and MDMA induced similar effects on behaviour and failed to induce neurotoxic damage when administered intermittently over 3 weeks...
  28. doi request reprint Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus
    Massimiliano Bianchi
    Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, United Kingdom
    Synapse 63:359-64. 2009
    ..Our findings demonstrate that fluoxetine administration modulates microtubule dynamics in rat hippocampus. The cytoskeletal effect exerted by fluoxetine may eventually culminate in promoting events of structural neuronal remodeling...
  29. ncbi request reprint Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT2A receptor responsivity
    Eleanor J Bull
    Institute of Neuroscience, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Neuropharmacology 46:202-10. 2004
    ....
  30. pmc Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition
    Madeleine V King
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Neuropsychopharmacology 39:464-76. 2014
    ..Future use of this nonpharmacological VGLUT1 knockdown mouse model could improve our understanding of glutamatergic neurobiology and aid assessment of novel therapies for cognitive deficits such as those seen in schizophrenia. ..
  31. doi request reprint Phencyclidine withdrawal disrupts episodic-like memory in rats: reversal by donepezil but not clozapine
    Romain Le Cozannet
    School of Psychology, University of Nottingham, Nottingham, UK
    Int J Neuropsychopharmacol 13:1011-20. 2010
    ....
  32. ncbi request reprint The effects of pharmacological blockade of the 5-HT(6) receptor on formalin-evoked nociceptive behaviour, locomotor activity and hypothalamo-pituitary-adrenal axis activity in rats
    David P Finn
    Department of Pharmacology and Therapeutics, National University of Ireland, Galway, University Road, Galway, Ireland
    Eur J Pharmacol 569:59-63. 2007
    ....