Thomas Foltynie

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Critical aspects of clinical trial design for novel cell and gene therapies
    Zinovia Kefalopoulou
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2011:804041. 2011
  2. pmc Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective' connectivity
    Joshua Kahan
    1 Sobell Department for Motor Neurosciences and Movement Disorders, UCL Institute of Neurology, London, UK
    Brain 137:1130-44. 2014
  3. pmc Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series
    T Foltynie
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2013:362908. 2013
  4. pmc Genotype and phenotype in Parkinson's disease: lessons in heterogeneity from deep brain stimulation
    Aikaterina Angeli
    Sobell Department of Motor Neuroscience, University College London UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 28:1370-5. 2013
  5. doi request reprint Exenatide as a potential treatment for patients with Parkinson's disease: first steps into the clinic
    Thomas Foltynie
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK Electronic address
    Alzheimers Dement 10:S38-46. 2014
  6. doi request reprint Parkinson's disease: an update on pathogenesis and treatment
    Tom Foltynie
    National Hospital for Neurology and Neurosurgery, Box 146, Queen Square, London, WC1N 3BG, UK
    J Neurol 260:1433-40. 2013
  7. ncbi request reprint Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Parkinsons Dis 3:139-44. 2013
  8. doi request reprint Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease
    Tessel Boertien
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1835-43. 2011
  9. doi request reprint Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson's disease
    Anam Anzak
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK
    Neuroimage 64:284-9. 2013
  10. doi request reprint Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus
    Raul Martínez-Fernández
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1922-30. 2011

Collaborators

Detail Information

Publications21

  1. pmc Critical aspects of clinical trial design for novel cell and gene therapies
    Zinovia Kefalopoulou
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2011:804041. 2011
    ....
  2. pmc Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective' connectivity
    Joshua Kahan
    1 Sobell Department for Motor Neurosciences and Movement Disorders, UCL Institute of Neurology, London, UK
    Brain 137:1130-44. 2014
    ..Our findings highlight the distributed effects of stimulation on the resting motor network and provide a framework for analysing effective connectivity in resting state functional MRI with strong a priori hypotheses. ..
  3. pmc Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series
    T Foltynie
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2013:362908. 2013
    ..Since LCIG is an expensive option, development of the most appropriate future commissioning of this therapy in the absence of Class 1 evidence requires careful scrutiny of the outcomes of its use in a broad range of published series...
  4. pmc Genotype and phenotype in Parkinson's disease: lessons in heterogeneity from deep brain stimulation
    Aikaterina Angeli
    Sobell Department of Motor Neuroscience, University College London UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 28:1370-5. 2013
    ..DBS cohorts include large numbers of gene positive PD patients and can be clinically instructive in the exploration of genotype-phenotype relationships. ..
  5. doi request reprint Exenatide as a potential treatment for patients with Parkinson's disease: first steps into the clinic
    Thomas Foltynie
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK Electronic address
    Alzheimers Dement 10:S38-46. 2014
    ..Data emerging from the laboratory suggest that agonists for the glucagonlike peptide 1 (GLP-1) receptor may have biological properties relevant to PD pathogenesis and progression...
  6. doi request reprint Parkinson's disease: an update on pathogenesis and treatment
    Tom Foltynie
    National Hospital for Neurology and Neurosurgery, Box 146, Queen Square, London, WC1N 3BG, UK
    J Neurol 260:1433-40. 2013
    ..This review aims to highlight the most relevant updates in the PD field, with emphasis on research that may help lead towards an improvement in the treatment of this condition...
  7. ncbi request reprint Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Parkinsons Dis 3:139-44. 2013
    ..However, it is unclear whether bilateral deep brain stimulation of the subthalamic nucleus also causes impairment in decision making...
  8. doi request reprint Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease
    Tessel Boertien
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1835-43. 2011
    ..In this review we discuss the published evidence from functional imaging studies of patients with subthalamic nucleus-deep brain stimulation to date, together with how these data inform the mechanism of action of deep brain stimulation...
  9. doi request reprint Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson's disease
    Anam Anzak
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK
    Neuroimage 64:284-9. 2013
    ..These results are consistent with a frequency-specific role of the STN in executive processes such as suppression of habitual responses and 'switching-on' of more controlled processing strategies...
  10. doi request reprint Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus
    Raul Martínez-Fernández
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1922-30. 2011
    ....
  11. doi request reprint The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia?
    James Gratwicke
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurosci Biobehav Rev 37:2676-88. 2013
    ..Controlled trials of deep brain stimulation of the nucleus basalis of Meynert for Parkinson's disease dementia and Alzheimer's disease are required to evaluate potential efficacy and the mechanisms of possible cognitive changes. ..
  12. ncbi request reprint Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease: Two Case Reports
    Zinovia Kefalopoulou
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, England
    JAMA Neurol 71:83-7. 2014
    ....
  13. ncbi request reprint Parkinson's disease, insulin resistance and novel agents of neuroprotection
    Iciar Aviles-Olmos
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 136:374-84. 2013
    ..Our aim is to highlight this converging evidence and stimulate further hypothesis-testing studies specifically with reference to the potential development of novel neuroprotective agents in Parkinson's disease...
  14. doi request reprint The risk of hardware infection in deep brain stimulation surgery is greater at impulse generator replacement than at the primary procedure
    Joshua Pepper
    Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK
    Stereotact Funct Neurosurg 91:56-65. 2013
    ..We examined all patients who underwent DBS procedures over the last 9 years in our centre to assess the infection rate and possible factors related to surgery that may predispose to infection...
  15. pmc Exenatide and the treatment of patients with Parkinson's disease
    Iciar Aviles-Olmos
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, United Kingdom
    J Clin Invest 123:2730-6. 2013
    ....
  16. pmc Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging
    Christian Lambert
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 60:83-94. 2012
    ....
  17. pmc Understanding and prevention of "therapy-" induced dyskinesias
    Iciar Aviles-Olmos
    Unit of Functional Neurosurgery Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N3BG, UK
    Parkinsons Dis 2012:640815. 2012
    ..In this paper we discuss the details of what is understood regarding the development of dyskinesias with relevance to cell and gene therapy and potential strategies to minimize their occurrence...
  18. doi request reprint Reducing hemorrhagic complications in functional neurosurgery: a large case series and systematic literature review
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
    J Neurosurg 116:84-94. 2012
    ..Estimating the true incidence of and risk factors for hemorrhage in functional neurosurgery is a challenging issue...
  19. pmc Screening for VPS35 mutations in Parkinson's disease
    Una Marie Sheerin
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:838.e1-5. 2012
    ..No other potentially disease-causing mutations were identified. We conclude that the VPS35 c.1858G>A mutation is an uncommon cause of familial Parkinson's disease in our population...
  20. ncbi request reprint Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination
    Anna Sadnicka
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 28:1874-7. 2013
    ....
  21. doi request reprint Urinary incontinence following deep brain stimulation of the pedunculopontine nucleus
    Iciar Aviles-Olmos
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Acta Neurochir (Wien) 153:2357-60. 2011
    ..Proximity between caudal PPN and brainstem structures implicated in control of micturition is a possible explanation...