Gordon J Florence

Summary

Affiliation: University of St Andrews
Country: UK

Publications

  1. pmc Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
    Gordon J Florence
    EaStCHEM School of Chemistry and School of Biology, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    ChemMedChem 11:1503-6. 2016
  2. pmc Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors
    Gordon J Florence
    EaStCHEM School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST UK
    ChemMedChem 9:2548-56. 2014
  3. doi request reprint Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues
    Gordon J Florence
    EaStCHEM School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    Chemistry 19:8309-20. 2013
  4. doi request reprint Synthesis of the originally proposed structure of palmerolide C
    Gordon J Florence
    EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    Chemistry 18:14250-4. 2012
  5. pmc Synthesis and stereochemical assignment of (+)-chamuvarinin
    Gordon J Florence
    School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    Org Lett 13:514-7. 2011
  6. doi request reprint Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
    Gordon J Florence
    School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews KY16 9 ST, United Kingdom
    Nat Prod Rep 25:342-75. 2008
  7. ncbi request reprint The trypanosome alternative oxidase: a potential drug target?
    Stefanie K Menzies
    Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife, Scotland KY16 9ST, UK
    Parasitology . 2016
  8. ncbi request reprint 1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, U K
    Org Lett 5:35-8. 2003
  9. ncbi request reprint Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK
    Angew Chem Int Ed Engl 46:6167-71. 2007
  10. ncbi request reprint A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrol
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    J Org Chem 70:150-60. 2005

Collaborators

Detail Information

Publications15

  1. pmc Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
    Gordon J Florence
    EaStCHEM School of Chemistry and School of Biology, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    ChemMedChem 11:1503-6. 2016
    ....
  2. pmc Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors
    Gordon J Florence
    EaStCHEM School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST UK
    ChemMedChem 9:2548-56. 2014
    ..Together, the biological potency and calculated lipophilicity values indicate that while there is room for improvement, these derivatives may represent a promising novel class of anti-HAT agents...
  3. doi request reprint Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues
    Gordon J Florence
    EaStCHEM School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    Chemistry 19:8309-20. 2013
    ....
  4. doi request reprint Synthesis of the originally proposed structure of palmerolide C
    Gordon J Florence
    EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    Chemistry 18:14250-4. 2012
    ..Compound 1 was shown to be a diastereomer of palmerolide C, and the structural revision of the natural product is proposed...
  5. pmc Synthesis and stereochemical assignment of (+)-chamuvarinin
    Gordon J Florence
    School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
    Org Lett 13:514-7. 2011
    ..This constitutes the first total synthesis of (+)-chamuvarinin, defining the relative and absolute configuration of this unique annonaceous acetogenin...
  6. doi request reprint Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
    Gordon J Florence
    School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews KY16 9 ST, United Kingdom
    Nat Prod Rep 25:342-75. 2008
    ....
  7. ncbi request reprint The trypanosome alternative oxidase: a potential drug target?
    Stefanie K Menzies
    Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife, Scotland KY16 9ST, UK
    Parasitology . 2016
    ..We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target...
  8. ncbi request reprint 1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, U K
    Org Lett 5:35-8. 2003
    ..The 1,3-diol 7 is employed as a common building block for the C(1)-C(5), C(9)-C(16), and C(17)-C(24) subunits. [reaction--see text]..
  9. ncbi request reprint Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK
    Angew Chem Int Ed Engl 46:6167-71. 2007
  10. ncbi request reprint A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrol
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    J Org Chem 70:150-60. 2005
    ....
  11. ncbi request reprint A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel
    Donnette A Dabydeen
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Cancer Chemother Pharmacol 53:397-403. 2004
    ..To determine whether inhibitors of microtubule assembly inhibit polymerization induced by discodermolide and epothilone B, as well as paclitaxel, and to quantitatively measure such effects...
  12. ncbi request reprint Discodermolide interferes with the binding of tau protein to microtubules
    Santwana Kar
    MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, UK
    FEBS Lett 539:34-6. 2003
    ....
  13. ncbi request reprint Total synthesis and stereochemical reassignment of (+)-dolastatin 19
    Ian Paterson
    University Chemical Laboratory, Cambridge, UK
    Org Lett 8:2131-4. 2006
    ....
  14. ncbi request reprint Stereocontrolled total synthesis of (-)-aurisides A and B
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK
    Angew Chem Int Ed Engl 44:1130-3. 2005
  15. doi request reprint Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea
    Ian Paterson
    University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK
    Chem Asian J 3:367-87. 2008
    ..This constitutes the first chemical synthesis of any member of the reidispongiolide/sphinxolide family of marine macrolides and unequivocally establishes the relative and absolute configuration...