Research Topics

Gordon J Florence

Summary

Affiliation: University of St Andrews
Country: UK

Publications

  1. Florence G, Gardner N, Paterson I. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin. Nat Prod Rep. 2008;25:342-75 pubmed publisher
  2. Florence G, Fraser A, Gould E, King E, Menzies S, Morris J, et al. Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors. ChemMedChem. 2014;9:2548-56 pubmed publisher
    ..Together, the biological potency and calculated lipophilicity values indicate that while there is room for improvement, these derivatives may represent a promising novel class of anti-HAT agents. ..
  3. Florence G, Morris J, Murray R, Osler J, Reddy V, Smith T. Synthesis and stereochemical assignment of (+)-chamuvarinin. Org Lett. 2011;13:514-7 pubmed publisher
    ..This constitutes the first total synthesis of (+)-chamuvarinin, defining the relative and absolute configuration of this unique annonaceous acetogenin. ..
  4. Florence G, Fraser A, Gould E, King E, Menzies S, Morris J, et al. Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors. ChemMedChem. 2016;11:1503-6 pubmed publisher
  5. Gould E, King E, Menzies S, Fraser A, Tulloch L, Zacharova M, et al. Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins. Bioorg Med Chem. 2017;25:6126-6136 pubmed publisher