Affiliation: University of Nottingham
- How atopic is atopic dermatitis?Carsten Flohr
Centre of Evidence Based Dermatology, University of Nottingham, United Kingdom
J Allergy Clin Immunol 114:150-8. 2004..The extent to which the phenotype of atopic dermatitis (AD) is truly atopic has been the subject of much debate...
- Dirt, worms and atopic dermatitisC Flohr
Department of Dermatology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
Br J Dermatol 148:871-7. 2003..At present, there is no clear evidence for a direct relationship between the two. This may be due to the overall small number of studies and insufficient methodological rigour in the existing body of research...
- How well do questionnaires perform compared with physical examination in detecting flexural eczema? Findings from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase TwoC Flohr
Centre for Evidence Based Dermatology, Institute of Clinical Research, University of Nottingham, Nottingham, UK
Br J Dermatol 161:846-53. 2009..Questionnaires are widely used in epidemiological studies to measure eczema symptom prevalence, but there are concerns regarding their accuracy if used as a diagnostic tool...
- Do helminth parasites protect against atopy and allergic disease?C Flohr
Institute of Clinical Research and Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
Clin Exp Allergy 39:20-32. 2009..Intervention studies with hookworm in parasite-naïve allergic individuals are currently ongoing in the United Kingdom to test the above hypotheses further...
- The role of atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies in Childhood Phase TwoCarsten Flohr
Centre of Evidence Based Dermatology and the Centre for Population Sciences, Institute of Clinical Research, University of Nottingham, Nottingham, United Kingdom
J Allergy Clin Immunol 121:141-147.e4. 2008..The association between allergic sensitization and eczema has been debated for years...
- Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in VietnamC Flohr
Centre for Population Studies, Institute of Clinical Research, University of Nottingham, Nottingham, UK
Clin Exp Allergy 40:131-42. 2010..Observational evidence suggests that infection with helminths protects against allergic disease and allergen skin sensitization. It is postulated that such effects are mediated by helminth-induced cytokine responses, in particular IL-10...
- The role of furry pets in eczema: a systematic reviewSinead M Langan
MRCP, Centre of Evidence Based Dermatology, Queen s Medical Centre, Nottingham NG7 2UH, England
Arch Dermatol 143:1570-7. 2007..To systematically search, summarize, and critically appraise the literature to examine whether pet exposure in early life is associated with an increased risk of eczema...
- How epidemiology has challenged 3 prevailing concepts about atopic dermatitisHywel Williams
Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK
J Allergy Clin Immunol 118:209-13. 2006..Collectively, these observations underline the importance of epidemiologic studies conducted at a population level to gain a more balanced understanding of the enigma of atopic dermatitis...
- Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?C Flohr
Department of Dermatology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, U K
Br J Dermatol 152:202-16. 2005..The so-called 'hygiene hypothesis' postulates an inverse relationship between atopic dermatitis (AD) and an environment that leads to increased pathogen exposure...
- Poor sanitation and helminth infection protect against skin sensitization in Vietnamese children: A cross-sectional studyCarsten Flohr
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
J Allergy Clin Immunol 118:1305-11. 2006..Geohelminth infection and poor hygiene may be protective against allergic sensitization...