Jonathan Flint

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Childhood sexual abuse and the development of recurrent major depression in Chinese women
    Jing Chen
    Huashan Hospital of Fudan University, Shanghai, People s Republic of China
    PLoS ONE 9:e87569. 2014
  2. pmc Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia
    I Mathieson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 17:634-41. 2012
  3. pmc Childhood sexual abuse and the risk for recurrent major depression in Chinese women
    E Cong
    Huashan Hospital, Fudan University, Shanghai, P R China
    Psychol Med 42:409-17. 2012
  4. pmc Suicidal risk factors of recurrent major depression in Han Chinese women
    Yuzhang Zhu
    The First Hospital of China Medical University, Shenyang, Liaoning, P R C
    PLoS ONE 8:e80030. 2013
  5. pmc Clinical predictors of familial depression in Han Chinese women
    Lina Wang
    Shandong Mental Health Center, Jinan, Shandong, People s Republic of China
    Depress Anxiety 29:10-5. 2012
  6. pmc A comparison of melancholic and nonmelancholic recurrent major depression in Han Chinese women
    Ning Sun
    No 1 Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Depress Anxiety 29:4-9. 2012
  7. pmc Clinical features of patients with dysthymia in a large cohort of han chinese women with recurrent major depression
    Wenqing Wu
    No 4 Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, P R China
    PLoS ONE 8:e83490. 2013
  8. ncbi request reprint The genetics of major depression
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN Electronic address
    Neuron 81:484-503. 2014
  9. pmc Association studies in outbred mice in a new era of full-genome sequencing
    Binnaz Yalcin
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Mamm Genome 23:719-26. 2012
  10. pmc Next-generation sequencing of experimental mouse strains
    Binnaz Yalcin
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Mamm Genome 23:490-8. 2012

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Childhood sexual abuse and the development of recurrent major depression in Chinese women
    Jing Chen
    Huashan Hospital of Fudan University, Shanghai, People s Republic of China
    PLoS ONE 9:e87569. 2014
    ..Our prior study in Han Chinese women has shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in our whole data set?..
  2. pmc Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia
    I Mathieson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 17:634-41. 2012
    ..5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia...
  3. pmc Childhood sexual abuse and the risk for recurrent major depression in Chinese women
    E Cong
    Huashan Hospital, Fudan University, Shanghai, P R China
    Psychol Med 42:409-17. 2012
    ..Studies in Western countries have repeatedly shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in China?..
  4. pmc Suicidal risk factors of recurrent major depression in Han Chinese women
    Yuzhang Zhu
    The First Hospital of China Medical University, Shenyang, Liaoning, P R C
    PLoS ONE 8:e80030. 2013
    ..The present findings indicate that specific factors act to increase the likelihood of suicide in MD. Our results may help improve the clinical assessment of suicide risk in depressed patients, especially for women. ..
  5. pmc Clinical predictors of familial depression in Han Chinese women
    Lina Wang
    Shandong Mental Health Center, Jinan, Shandong, People s Republic of China
    Depress Anxiety 29:10-5. 2012
    ..We investigated which clinical features of depressive illness index familial vulnerability in Han Chinese females with MD...
  6. pmc A comparison of melancholic and nonmelancholic recurrent major depression in Han Chinese women
    Ning Sun
    No 1 Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Depress Anxiety 29:4-9. 2012
    ..We report here the first detailed comparison of melancholic and nonmelancholic major depression (MD) in a Chinese population examining in particular whether these two forms of MD differ quantitatively or qualitatively...
  7. pmc Clinical features of patients with dysthymia in a large cohort of han chinese women with recurrent major depression
    Wenqing Wu
    No 4 Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, P R China
    PLoS ONE 8:e83490. 2013
    ..We ask whether these risk factors act in the same way in MDD with and without dysthymia...
  8. ncbi request reprint The genetics of major depression
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN Electronic address
    Neuron 81:484-503. 2014
    ..We consider evidence for the genetic heterogeneity of the disorder and the likelihood that subtypes exist that represent more genetically homogenous conditions than have hitherto been analyzed. ..
  9. pmc Association studies in outbred mice in a new era of full-genome sequencing
    Binnaz Yalcin
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Mamm Genome 23:719-26. 2012
    ..These resources constitute a major advance and make it possible to progress from a quantitative trait locus to a gene at an unprecedented speed...
  10. pmc Next-generation sequencing of experimental mouse strains
    Binnaz Yalcin
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Mamm Genome 23:490-8. 2012
    ....
  11. pmc High levels of RNA-editing site conservation amongst 15 laboratory mouse strains
    Petr Danecek
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK
    Genome Biol 13:26. 2012
    ..Recently the Mouse Genomes Project generated genome sequences for 17 laboratory mouse strains and rich catalogues of variants. We also generated RNA-seq data from whole brain RNA from 15 of the sequenced strains...
  12. pmc Candidate and non-candidate genes in behavior genetics
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Curr Opin Neurobiol 23:57-61. 2013
    ..These two areas intersect, in that new information about genetic effects from whole genome approaches, should (but does not always) inform the single locus analyses...
  13. pmc Epilogue: Lessons from the CONVERGE study of major depressive disorder in China
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK
    J Affect Disord 140:1-5. 2012
    ....
  14. pmc Heterozygosity increases microsatellite mutation rate, linking it to demographic history
    William Amos
    Department of Zoology, Downing Street, Cambridge, CB4 3DB, UK
    BMC Genet 9:72. 2008
    ..Here we test this hypothesis using both direct counting of microsatellite mutations in human pedigrees and an analysis of the relationship between microsatellite length and patterns of demographically-induced variation in heterozygosity...
  15. ncbi request reprint The genetic basis of neuroticism
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK
    Neurosci Biobehav Rev 28:307-16. 2004
    ..More recently, evidence has emerged supporting the view that the same genes influence variation in both rodent and human phenotypes...
  16. ncbi request reprint Strategies for mapping and cloning quantitative trait genes in rodents
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Nat Rev Genet 6:271-86. 2005
    ..We review the potential of these strategies to identify genes that underlie QTLs in rodents...
  17. pmc Genetic architecture of quantitative traits in mice, flies, and humans
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Genome Res 19:723-33. 2009
    ....
  18. doi request reprint Forum: Interactions between gene and environment
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Curr Opin Psychiatry 21:315-7. 2008
  19. pmc Mapping quantitative traits and strategies to find quantitative trait genes
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Methods 53:163-74. 2011
    ..2007) [2]...
  20. ncbi request reprint Applying mouse complex-trait resources to behavioural genetics
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 456:724-7. 2008
    ..Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches...
  21. doi request reprint Animal models of psychiatric disease
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Curr Opin Genet Dev 18:235-40. 2008
    ....
  22. pmc High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
    Guo Jen Huang
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:1133-40. 2009
    ..Approximately one third of cis-acting eQTLs and one half of trans-acting eQTLs are tissue specific. We have created an important systems biology resource for the genetic analysis of complex traits in a key model organism...
  23. ncbi request reprint Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus
    Janice M Fullerton
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
    Biol Psychiatry 63:874-83. 2008
    ..This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism...
  24. ncbi request reprint The prevalence, clinical correlates and structure of phobic fears in Han Chinese women with recurrent major depression
    Fuzhong Yang
    Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    J Affect Disord 157:92-9. 2014
    ..Phobic fears are common in the general population and among individuals with major depression (MD). We know little about the prevalence, clinical correlates, and structure of phobic fears in Chinese women with MD...
  25. pmc Commercially available outbred mice for genome-wide association studies
    Binnaz Yalcin
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 6:e1001085. 2010
    ..We demonstrate the colonies' potential by identifying a deletion in the promoter of H2-Ea as the molecular change that strongly contributes to setting the ratio of CD4+ and CD8+ lymphocytes...
  26. ncbi request reprint Genome-wide genetic association of complex traits in heterogeneous stock mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 38:879-87. 2006
    ..Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits...
  27. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  28. pmc The genomic landscape shaped by selection on transposable elements across 18 mouse strains
    Christoffer Nellåker
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Genome Biol 13:R45. 2012
    ..Despite their high prevalence, the different genomic and gene properties controlling whether TEs are preferentially purged from, or are retained by, genetic drift or positive selection in mammalian genomes remain poorly defined...
  29. pmc The fine-scale architecture of structural variants in 17 mouse genomes
    Binnaz Yalcin
    The Wellcome Trust Centre for Human Genetics, Oxford, UK
    Genome Biol 13:R18. 2012
    ..Next generation sequencing methods for SV detection are an advance on array-based methods, but are almost exclusively limited to four basic types: deletions, insertions, inversions and copy number gains...
  30. pmc Effects of environmental and physiological covariates on sex differences in unconditioned and conditioned anxiety and fear in a large sample of genetically heterogeneous (N/Nih-HS) rats
    Regina Lopez-Aumatell
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive Oxford, UK
    Behav Brain Funct 7:48. 2011
    ....
  31. ncbi request reprint Analysis of quantitative trait loci that influence animal behavior
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Neurobiol 54:46-77. 2003
    ..With advances in multivariate analyses, mapping can also test hypotheses about the psychological processes that give rise to behavioral variation...
  32. ncbi request reprint The architecture of parent-of-origin effects in mice
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK Electronic address
    Cell 156:332-42. 2014
    ..We propose that this gene network effect may account for some of the missing heritability seen when comparing sibling-based to population-based studies of the phenotypic effects of genetic variants. ..
  33. pmc Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model
    James O Groves
    The Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, United Kingdom
    PLoS Genet 9:e1003718. 2013
    ..The meta-analysis revealed remarkably high levels of heterogeneity among studies of hippocampal function. The source of this heterogeneity remains unclear and poses a challenge for studies of the function of adult neurogenesis...
  34. pmc A high-resolution single nucleotide polymorphism genetic map of the mouse genome
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e395. 2006
    ..Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication...
  35. ncbi request reprint The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Biol Psychiatry 58:738-42. 2005
    ..The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness...
  36. pmc Genetic and environmental effects on complex traits in mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genetics 174:959-84. 2006
    ..Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment...
  37. ncbi request reprint A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice
    Leah C Solberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford Roosevelt Drive, Oxford, OX3 7BN, UK
    Mamm Genome 17:129-46. 2006
    ....
  38. ncbi request reprint Identifying the genetic determinants of emotionality in humans; insights from rodents
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    Neurosci Biobehav Rev 31:115-24. 2007
    ..In this review we discuss the potential for using cross-species QTL concordance as a tool for QTL dissection in behaviour genetics, using an affect-related locus mapped to human chromosome 1 as an example...
  39. pmc Sequence-based characterization of structural variation in the mouse genome
    Binnaz Yalcin
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 477:326-9. 2011
    ..We identified 24 SVs that disrupt coding exons, acting as rare variants of large effect on gene function. One-third of the genes so affected have immunological functions...
  40. ncbi request reprint Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    Binnaz Yalcin
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1197-202. 2004
    ..We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait...
  41. pmc Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
    ..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease...
  42. ncbi request reprint Age at onset of recurrent major depression in Han Chinese women - a replication study
    Fuzhong Yang
    Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    J Affect Disord 157:72-9. 2014
    ..The relationship between age at onset (AAO) and major depression (MD) has been studied in US, European and Chinese populations. However, larger sample studies are needed to replicate and extend earlier findings...
  43. pmc Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
    Amelie Baud
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 45:767-75. 2013
    ....
  44. pmc Cofilin-1: a modulator of anxiety in mice
    Martin Goodson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 8:e1002970. 2012
    ..Our results indicate that similarity of function of mammalian genes can be used to recognize key genetic regulators of anxiety and potentially of other emotional behaviours...
  45. ncbi request reprint The genetic basis of emotional behaviour in mice
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, UK
    Eur J Hum Genet 14:721-8. 2006
    ..Ultimately, we describe a method of assessing gene candidacy, and show that given sufficient access to genetic diversity and recombination, progression from QTL to gene can be achieved even for low magnitude genetic effects...
  46. ncbi request reprint Management, presentation and interpretation of genome scans using GSCANDB
    Martin Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Bioinformatics 23:1545-9. 2007
    ..In order to achieve a successful outcome, it may be necessary to analyse the data in different ways and compare the results with genome annotations and other genome scans...
  47. ncbi request reprint Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Mamm Genome 15:77-82. 2004
    ..We conclude that interactions between loci do not necessarily vitiate the genetic analysis of behavior in at least one animal model of anxiety...
  48. pmc A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock
    Martina Johannesson
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:150-8. 2009
    ....
  49. pmc Mapping in structured populations by resample model averaging
    William Valdar
    Wellcome Trust Centre for Human Genetics, Roosevelt Dr, Oxford OX3 7BN, United Kingdom
    Genetics 182:1263-77. 2009
    ..The generality of our approach means it can potentially be applied to any population of unknown structure...
  50. ncbi request reprint The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association
    Saffron A G Willis-Owen
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Biol Psychiatry 58:451-6. 2005
    ..Several explanations have been posited to account for this discrepancy, including underpowered experimental design and variation in gender ratio, age, and ethnicity...
  51. pmc The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women
    Jing Xia
    Shengjing Hospital of China Medical University, No 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110817, PR China
    J Affect Disord 135:100-5. 2011
    ..The personality trait of neuroticism is a risk factor for major depressive disorder (MDD), but this relationship has not been demonstrated in clinical samples from Asia...
  52. ncbi request reprint Genetic variants in major depression
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Novartis Found Symp 289:23-32; discussion 33-42, 87-93. 2008
    ..Larger sample sizes and more sophisticated analytical approaches will be needed than have hitherto been applied...
  53. ncbi request reprint Genetic mapping of variation in spatial learning in the mouse
    Daniela Steinberger
    Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, United Kingdom
    J Neurosci 23:2426-33. 2003
    ..QTL that influence differences in fearful behavior (on chromosomes 1, 3, 7, 15, and 19) operate while mice are trained in the water maze apparatus...
  54. ncbi request reprint QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks
    William S J Valdar
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX4 7AD, UK
    Mamm Genome 14:830-8. 2003
    ..We found that quite modest generation times of 10-20 generations were optimal. Microsatellites were superior to SNPs only when the generation time was 30 or more and when the markers were widely spaced...
  55. ncbi request reprint Anxious, hypoactive phenotype combined with motor deficits in Gtf2ird1 null mouse model relevant to Williams syndrome
    Tomasz Schneider
    Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Behav Brain Res 233:458-73. 2012
    ..Our study strongly supports a role for GTF2IRD1 in the motoric and anxiety-related abnormalities seen in Williams-Beuren syndrome, and suggests basal ganglia and potentially cerebellar abnormalities in Gtf2ird1 mice...
  56. ncbi request reprint Genetic effects on an animal model of anxiety
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK
    FEBS Lett 529:131-4. 2002
    ..However, we are still some way from finding the molecular variants that explain the heritability of the trait...
  57. pmc Elusive copy number variation in the mouse genome
    Avigail Agam
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 5:e12839. 2010
    ..Yet there are large discrepancies between studies, so that the extent of the genome affected by CNVs is unknown. We combined molecular and aCGH analyses of CNVs in inbred mouse strains to investigate this question...
  58. ncbi request reprint Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse
    Jeffrey P Khoo
    Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Mol Genet Metab 82:251-4. 2004
    ..These new findings will extend the utility of the hph-1 mouse in studies of GTP-CH I deficiency...
  59. pmc Prospects for complex trait analysis in the mouse
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 9JN, UK
    Mamm Genome 19:306-8. 2008
  60. pmc The endophenotype concept in psychiatric genetics
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Psychol Med 37:163-80. 2007
    ..While endophenotype measures may afford greater reliability, it should not be assumed that they will also demonstrate simpler genetic architecture...
  61. ncbi request reprint Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens
    David A Keays
    Psychiatric Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Mamm Genome 17:230-8. 2006
    ..002). Where mutants are identified by genotypic methods, we show that backcrossing in the absence of marker-assisted selection is an inefficient means of eliminating linked confounding mutations...
  62. pmc Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans
    David A Keays
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Cell 128:45-57. 2007
    ..We identified two patients with de novo mutations in TUBA3, the human homolog of Tuba1. This study demonstrates the utility of ENU mutagenesis in the mouse as a means to discover the basis of human neurodevelopmental disorders...
  63. pmc Causes and consequences of chromatin variation between inbred mice
    Mona Hosseini
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    PLoS Genet 9:e1003570. 2013
    ..Our results show that whilst DNA sequence variation is not the major determinant of variation in open chromatin, where such variants exist they are likely to be causal for complex traits...
  64. ncbi request reprint Meta-analysis of genetic association studies
    Marcus R Munafo
    Cancer Research UK GPRG, Department of Clinical Pharmacology, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK
    Trends Genet 20:439-44. 2004
    ..If heterogeneity is adequately recognized and taken into account, meta-analysis can confirm the involvement of a genetic variant, but it is not a substitute for an adequately powered primary study...
  65. ncbi request reprint Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice
    Maria Grazia Turri
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Mamm Genome 15:69-76. 2004
    ..On the basis of these results and by the application of a QTL estimator, we show that the mean number of QTL influencing anxiety-related behavior in mice is 6, with a 95% upper limit of 14...
  66. pmc Simultaneous detection and fine mapping of quantitative trait loci in mice using heterogeneous stocks
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, United Kingdom
    Genetics 160:1609-18. 2002
    ..We show by simulation that a QTL accounting for 5% of the total variance can be detected and fine mapped with >50% probability to within 3 cM by genotyping approximately 1500 animals...
  67. ncbi request reprint The use of telomere probes to investigate submicroscopic rearrangements associated with mental retardation
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Curr Opin Genet Dev 13:310-6. 2003
    ....
  68. ncbi request reprint Intragenic enhancers act as alternative promoters
    Monika S Kowalczyk
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Mol Cell 45:447-58. 2012
    ..Distinguishing between meRNAs and mRNAs will transform our interpretation of dynamic changes in transcription both at the level of individual genes and of the genome as a whole...
  69. ncbi request reprint Dissecting quantitative traits in mice
    Richard Mott
    Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom email
    Annu Rev Genomics Hum Genet 14:421-39. 2013
    ..In combination with new rapid methods for producing transgenic mice that make it efficient to test candidate genes and variants, these advances significantly enhance the mouse genetics toolbox for dissecting quantitative traits. ..
  70. pmc Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism
    Jan Fullerton
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 72:879-90. 2003
    ..One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous...
  71. pmc Genome-wide association studies in mice
    Jonathan Flint
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Genet 13:807-17. 2012
    ..This Review gives an overview of the novel study designs for mouse GWASs, which dramatically improve both the statistical power and resolution compared to classical gene-mapping approaches...
  72. ncbi request reprint Animal models of anxiety and their molecular dissection
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Semin Cell Dev Biol 14:37-42. 2003
    ..One drawback of genetic validation is the difficulty inherent in identifying the molecular variants that influence the phenotype. I review genetic approaches that have the potential to overcome this problem...
  73. doi request reprint Is there an association between NPY and neuroticism?
    Colleen H Cotton
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 458:E6; discussion E7. 2009
    ..nature.com/news/2008/080709/full/454154a.html) about the efficacy and replicability of candidate driven versus genome wide approaches to psychiatric genetics...
  74. pmc SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data
    Thomas S Price
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Churchill Hospital Headington, Oxford OX3 7BN, UK
    Nucleic Acids Res 33:3455-64. 2005
    ..It is scalable and well-suited to high resolution whole genome array CGH studies that use array probes derived from large insert clones as well as PCR products and oligonucleotides...
  75. pmc A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus
    Guo Jen Huang
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 8:e1000561. 2010
    ..Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controls T cell development and homeostasis...
  76. ncbi request reprint Assessing publication bias in genetic association studies: evidence from a recent meta-analysis
    Marcus R Munafo
    Department of Clinical Pharmacology, Cancer Research UK, General Practice Research Group, University of Oxford, Oxford OX2 6HE, UK
    Psychiatry Res 129:39-44. 2004
    ....
  77. ncbi request reprint Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice
    Jon Krohn
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 9:e96450. 2014
    ..14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important. ..
  78. ncbi request reprint The use of subtelomeric probes to study mental retardation
    Samantha J L Knight
    The Wellcome Trust Centre for Human Genetics, Churchill Hospital, Headington, Oxford, Oxfordshire OX3 7BN, United Kingdom
    Methods Cell Biol 75:799-831. 2004
    ....
  79. ncbi request reprint Cancer in people with depression or anxiety: record-linkage study
    Michael J Goldacre
    Unit of Health Care Epidemiology, Dept of Public Health, University of Oxford, Old Road Campus, Old Road, Oxford, OX3 7LF, UK
    Soc Psychiatry Psychiatr Epidemiol 42:683-9. 2007
    ..It has been suggested that the risk of cancer may be higher in people with psychological disorders, like depression and anxiety, than in the general population...
  80. ncbi request reprint Multi-telomere FISH
    Samantha J L Knight
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Methods Mol Biol 204:155-79. 2002
  81. ncbi request reprint Enhanced early morning salivary cortisol in neuroticism
    Maria J Portella
    Department of Psychiatry, Warneford Hospital, Neurosciences Bldg, Oxford OX3 7JX, UK
    Am J Psychiatry 162:807-9. 2005
    ..This study compared waking cortisol levels in healthy subjects with high and low levels of neuroticism without a previous history of depression...
  82. ncbi request reprint A strategy for the integration of QTL, gene expression, and sequence analyses
    Robert Hitzemann
    Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
    Mamm Genome 14:733-47. 2003
    ..Overall, the method described should be widely applicable to the analysis of QTLs...
  83. ncbi request reprint QTL analysis of multiple behavioral measures of anxiety in mice
    Norman D Henderson
    Oberlin College, Oberlin, Ohio 44074, USA
    Behav Genet 34:267-93. 2004
    ..The use of factor analysis or within-test principal components for data reduction before genetic analysis was less satisfactory than using genetic dissection methods on the original measures and logically derived composites...
  84. ncbi request reprint New semidominant mutations that affect mouse development
    Debora Bogani
    Laboratory of Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX111 0RD, UK
    Genesis 40:109-117. 2004
    ..In one coat spotting mutant the homozygous condition is lethal before neural crest cell production commences. The mutated genes often function in processes additional to those alluded to by the heterozygous phenotype...
  85. pmc A quantitative trait locus influencing anxiety in the laboratory rat
    Alberto Fernandez-Teruel
    Medical Psychological Unit, School of Medicine, Universitat Autonoma de Barcelona, Barcelona E 08143, Spain
    Genome Res 12:618-26. 2002
    ..As the neural basis of fear is conserved across species, we suggest that the QTL may have relevance to trait anxiety in humans...
  86. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  87. doi request reprint Progress and prospects in rat genetics: a community view
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Genet 40:516-22. 2008
    ..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research...
  88. pmc Neuregulin 1 genotype and schizophrenia
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, Bristol BS8 1TU, UK
    Schizophr Bull 34:9-12. 2008
    ....
  89. ncbi request reprint Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
    Biol Psychiatry 59:224-9. 2006
    ..We report an investigation designed to replicate this finding...
  90. ncbi request reprint Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
    Timothy J Aitman
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nature 439:851-5. 2006
    ....
  91. ncbi request reprint No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
    Paul G Surtees
    Strangeways Research Laboratory and University of Cambridge, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    J Psychiatr Res 41:404-9. 2007
    ..A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status...
  92. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults
    Paul G Surtees
    J Psychiatr Res 41:707-10. 2007
  93. ncbi request reprint Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and females
    Regina Lopez-Aumatell
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Behav Brain Res 188:41-55. 2008
    ..The results of this first extensive behavioral evaluation of N/Nih-HS rats are discussed in terms of their potential usefulness for present and future neurobehavioral and genetic studies of fearfulness/anxiety...
  94. ncbi request reprint Characterization of embryonic globin genes of the zebrafish
    Alison Brownlie
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 255:48-61. 2003
    ..Our studies are the first to systematically evaluate the embryonic globins in the zebrafish and will ultimately be useful in evaluating zebrafish mutants with defects in hemoglobin production and switching...
  95. ncbi request reprint Fine scale mapping of a genetic locus for conditioned fear
    Christopher J Talbot
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Mamm Genome 14:223-30. 2003
    ..The region containing a gene or genes that influence variation in conditioned fear is approximately 1 megabase in size and contains only one gene of known function, a pre-B cell leukaemia factor...
  96. doi request reprint Bias in genetic association studies: effects of research location and resources
    Marcus R Munafo
    Psychol Med 38:1213-4. 2008
  97. ncbi request reprint Learned fear, emotional reactivity and fear of heights: a factor analytic map from a large F(2) intercross of Roman rat strains
    Raul Aguilar
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, School of Medicine, Autonomous University of Barcelona, Barcelona, Spain
    Brain Res Bull 57:17-26. 2002
    ..After discussing limitations of this apparently consistent behavioural map of anxiety, we advance some connections between those factors with quantitative trait loci candidates (genetic markers) as detected in the same sample...
  98. ncbi request reprint Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
    Biol Psychiatry 63:197-206. 2008
    ..Two variants in the dopamine D4 receptor (DRD4) gene have been reported to be associated with human approach-related traits such as novelty seeking and extraversion. However, the strength of evidence for this association remains uncertain...
  99. ncbi request reprint Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A)
    Karine Poirier
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Hum Mutat 28:1055-64. 2007
    ..All together, these results, in combination with previously reported data, strengthen the relevance of the known interaction between MTs and DCX, and highlight the importance of the MTs/DCX complex in the neuronal migration process...